Russia's brutal February 2022 invasion of Ukraine has attracted widespread condemnation across the West. Government and media circles present the conflict as a simple dichotomy between an evil empire and an innocent victim. In this concise, accessible and highly informative primer, Medea Benjamin and Nicolas Davies insist the picture is more complicated. Yes, Russia's aggression was reckless and, ultimately, indefensible. But the West's reneging on promises to halt eastward expansion of NATO in the wake of the collapse of the Soviet Union played a major part in prompting Putin to act. So did the U.S. involvement in the 2014 Ukraine coup and Ukraine's failure to implement the Minsk peace agreements. The result is a conflict that is increasingly difficult to resolve, one that could conceivably escalate into all-out war between the United States and Russia-the world's two leading nuclear powers. Skillfully bringing together the historical record and current analysis, War In Ukraine looks at the events leading up to the conflict, surveys the different parties involved, and weighs the risks of escalation and opportunities for peace. For anyone who wants to get beneath the heavily propagandized media coverage to an understanding of a war with consequences that could prove cataclysmic, reading this timely book will be an urgent necessity.

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http: //moltox. cas. psu. edu and select "Courses. " The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

A companion to American Theatre Ensembles Volume 1, this volume charts the development and achievements of theatre companies working after 1995, bringing together the diffuse generation of ensembles working within a context of media saturation and epistemological and social fragmentation. Ensembles examined include Rude Mechs, The Builders Association, Pig Iron, Radiohole, The Civilians and 600 Highwaymen. Introductory chapters provide a sweeping overview of ensemble-based creation within the general historical and cultural contexts of the period, followed by a detailed study of the evolution of ensemble-based work. Contributors examine matters such as influence, funding, production and legacies, as well as the forms of collective devising and creation, while presenting close readings of the companies' most prominent works. The volume features detailed case studies of the 6 companies from the period and cover: * A history of development and methods * Key productions and projects * Critical reception * A chronology of significant productions US ensemble companies since 1995 have revolutionized the form and content of contemporary performance, influencing experimental as well as mainstream practice. This volume provides the first encompassing study of this vital development in contemporary American theatre by mapping its evolution and key developments.

Across two volumes, Mike Vanden Heuvel and a strong roster of contributors present the history, processes, and achievements of American theatre companies renowned for their use of collective and/or ensemble-based techniques to generate new work. This first study considers theatre companies that were working between 1970 and 1995: it traces the rise and eventual diversification of activist-based companies that emerged to serve particular constituencies from the countercultural politics of the 1960s, and examines the shift in the 1980s that gave rise to the next generation of company-based work, rooted in a new interest in form and the more mediated and dispersed forms of politics. Ensembles examined are Mabou Mines, Theatre X, Goat Island, Lookingglass, Elevator Repair Service, and SITI Company. Preliminary chapters provide a sweeping overview of ensemble-based creation within the general historical and cultural contexts of the period, followed by a detailed study of the evolution of ensemble-based work. The case studies consider factors such as influence, funding, production, and legacies, as well as the forms of collective devising and creation, while surveying the continuing work of significant long-running companies. Contributors provide detailed case studies of the 6 companies from the period and cover: * A chronicle of development and methods * Key productions and projects * Critical reception and legacy * A chronological overview of significant productions From the long history of collective theatre creation, with its sources in social crises, urgent aesthetic experimentation and utopian dreaming, American ensemble-based theatre has emerged at several key points in history to challenge the primacy of author-based and director-produced theatre. As the volume demonstrates, US ensemble companies have collectively revolutionized the form and content of contemporary performance, influencing experimental, as well as mainstream practice.

'We need to organise politically to defend the weak, empower the many and prepare the ground for reversing the absurdities of capitalism.' - Yanis Varoufakis 'Capitalism over the past twenty-five years has been an incredible moral good.' - David Brooks The Munk debate on capitalism There is a growing belief that the capitalist system no longer works. Inequality is rampant. The environment is being destroyed for profits. In some western nations, life expectancy is even falling. Political power is wielded by wealthy elites and big business, not the people. But for proponents of capitalism, it is the engine of progress, not just making all of us materially better off, but helping to address everything from women's rights to political freedoms. We seem to stand at a crossroads: do we need to fix the system as a matter of urgency, or would it be better to hold our nerve?

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select "Courses. " The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

The twenty-fifth semi-annual Munk Debate, held on December 4, 2019, pits editorial director and publisher of the Nation Katrina vanden Heuvel and former finance minister of Greece Yanis Varoufakis against Harvard professor Arthur Brooks and New York Times columnist David Brooks to debate whether the capitalist system is broken. "We need to organise politically to defend the weak, empower the many, and prepare the ground for reversing the absurdities of capitalism." -- Yanis Varoufakis In Western societies, the capitalist system is facing a level of distrust not seen in decades. Economic inequality is rampant. Life expectancy is falling. The environment is being destroyed for profit. Political power is wielded by wealthy elites and big business. For capitalism's critics, it is clear that the system is not designed to help average people. Their solution is a top-to-bottom reform of the "free market" along more socialist and democratic lines. For proponents of capitalism, however, this system has been the greatest engine of economic and social progress in history. Not only has capitalism made all of us materially better off, its ideals are responsible for everything from women's rights to a cleaner environment to political freedoms. The answer to society's current ills is more capitalism, more economic freedom, and more free markets. The twenty-fifth semi-annual Munk Debate, held on December 4, 2019, pits editorial director and publisher of the Nation Katrina vanden Heuvel and former finance minister of Greece Yanis Varoufakis against Harvard professor Arthur Brooks and New York Times columnist David Brooks to debate whether the capitalist system is broken.

Volume 14 in the series "Comprehensive Toxicology" extends and complements the previously published 13-volume set. This volume will be available separately.

Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy." Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response.

Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation.

A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

1737 was a year in which Voltaire was in great danger from his political enemies and in place of literary work, threw himself into Newtonian metaphysics, focussing on an "Essai sur la nature du feu, et sur sa propagation" for the prestigious Academie des sciences annual essay prize. Clarifying his 'systeme de morale' on human happiness and liberty, Voltaire wrote seven "Discours en vers sur l'homme" and was also inspired to write "Le Songe de Platon", a conte philosophique contesting Plato's social ideas. He also began the tragedy most acclaimed during his lifetime, the classically-inspired "Merope".

Hope and History is both a memoir and a call-to-action for the renewal of faith in democracy and America. US Ambassador William J. vanden Heuvel presents his most important public speeches and writings, compiled and presented over eight decades of adventure and public service, woven together with anecdotes of his colorful life as a second-generation American, a soldier, a lawyer, a political activist, and a diplomat. He touches upon themes that resonate as much today as they did when he first encountered them: the impact of heroes and mentors; the tragedy of the Vietnam War; the problems of racism and desegregation in America; tackling the crisis in America's prisons; America and the Holocaust; and the plight and promise of the United Nations. Along the way, he allows us to share his journey with some of the great characters of American history: Eleanor Roosevelt, William J. "Wild Bill" Donovan, President John F. Kennedy and RFK, Harry S. Truman, and Jimmy Carter. Throughout, vanden Heuvel persuades us that there is still room for optimism in public life. He shows how individuals, himself among them, have tackled some of America's most intractable domestic and foreign policy issues with ingenuity and goodwill, particularly under the leadership of President Franklin D. Roosevelt and those who sought and still seek to follow in his footsteps. He is not afraid to challenge the hatred and bigotry that are an unfortunate but undeniable part of the American fabric. He exhorts us to embrace all the challenges and opportunities that life in the United States can offer.

Providing accurate and objective information to help make the right decisions during a divorce in Wisconsin, this guide provides answers to 360 queries such as What is the mediation process in Wisconsin and is it required? How quickly can one get a divorce? Who decides who gets the cars, the pets, and the house? What actions might influence child custody? How are bills divided and paid during the divorce? How much will a divorce cost? and Will a spouse have to pay some or all attorney fees? Structured in a question-and-answer format, this divorce handbook provides clear and concise responses to help build confidence and give the peace of mind needed to meet the challenges of a divorce proceeding in the state of Wisconsin.

The Decades of Modern American Drama series provides a comprehensive survey and study of the theatre produced in each decade from the 1930s to 2009 in eight volumes. Each volume equips readers with a detailed understanding of the context from which work emerged: an introduction considers life in the decade with a focus on domestic life and conditions, social changes, culture, media, technology, industry and political events; while a chapter on the theatre of the decade offers a wide-ranging and thorough survey of theatres, companies, dramatists, new movements and developments in response to the economic and political conditions of the day. The work of the four most prominent playwrights from the decade receives in-depth analysis and re-evaluation by a team of experts, together with commentary on their subsequent work and legacy. A final section brings together original documents such as interviews with the playwrights and with directors, drafts of play scenes, and other previously unpublished material. The major playwrights and their works to receive in-depth coverage in this volume include: * David Rabe: The Basic Training of Pavlo Hummel; Sticks and Bones; and Streamers; * Sam Shepard: Curse of the Starving Class; Buried Child; and True West; * Ntozake Shange: For colored girls who have considered suicide/when the rainbow is enuf; Spell #7; and Boogie-Woogie Landscapes * Richard Foreman: Sophia = (Wisdom) Part 3; The Cliffs; Pandering to the Masses: A Misrepresentation; and Rhoda in Potatoland (Her Fall-Starts).