This book analyses the complexity of South and Southeast Asia in international health, taking into account the impact of the geopolitics of the Cold War on the development of public health and development in the regions. In light of the recent health pandemic, which has mobilized experts and governments and led to a securitized approach to global health, this book offers a regional approach to global health histories. The chapters provide case studies ranging from the Cold War to the present time and covering countries from across South and Southeast Asia. Contributors analyse issues related to disease control, an adjunct to wider Cold War geopolitics. They also examine the responses of regional organizations, particularly the ASEAN (Association of Southeast Asian Nations) and SAARC (South Asian Association for Regional Cooperation), towards COVID-19. Collectively, the book illustrates how narrowly-conceived global health programs implemented by aid agencies failed to account for the local, national or regional contexts. Situating health in South and Southeast Asia in broader global contexts, the book will be a valuable contribution to the History of Medicine and Health and Political Economy of South and Southeast Asia.