Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein-protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.

These lecture notes provide a fresh approach to investigating singularly perturbed systems using asymptotic and geometrical techniques. It gives many examples and step-by-step techniques, which will help beginners move to a more advanced level. Singularly perturbed systems appear naturally in the modelling of many processes that are characterized by slow and fast motions simultaneously, for example, in fluid dynamics and nonlinear mechanics. This book's approach consists in separating out the slow motions of the system under investigation. The result is a reduced differential system of lesser order. However, it inherits the essential elements of the qualitative behaviour of the original system. Singular Perturbations differs from other literature on the subject due to its methods and wide range of applications. It is a valuable reference for specialists in the areas of applied mathematics, engineering, physics, biology, as well as advanced undergraduates for the earlier parts of the book, and graduate students for the later chapters.