The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J. H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initial chapter, seeks to out line the problem as the clinicians see it. It appears that the phenomenon of true resistance to a drug, as the biochemist would recognise it, is an important cause of the failure which clinicians experience in treating the disease. The extent of the contribution of this phenomenon to the failure of treatment cannot easily be evaluated at the present time, but it is hoped that the development and application of new and more sophisticated techniques for the analysis of cellular sub populations may help to give a more exact estimate and to shed some light on the causes of failure of many of the present therapeutic techniques."

2021 Publication Award in Biography from the Wyoming State Historical Society Westerners International Co-Founders Book Award, second place George W. T. Beck, an influential rancher and entrepreneur in the American West, collaborated with William F. "Buffalo Bill" Cody to establish the town of Cody, Wyoming, in the 1890s. He advanced his financial investments in Wyoming through his numerous personal and professional contacts with various eastern investors and politicians in Washington DC. Beck's family-his father a Kentucky senator and his mother a grandniece of George Washington-and his adventures in the American West resulted in personal associates who ranged from western legends Buffalo Bill, Jesse James, and Calamity Jane to wealthy American elites such as George and Phoebe Hearst and Theodore Roosevelt. This definitive edition of Beck's memoir provides a glimpse of early life in Wyoming, offering readers a rare perspective on how community boosters cooperated with political leaders and wealthy financiers. Beck's memoir, introduced and annotated by Lynn J. Houze and Jeremy M. Johnston, offers a unique and sometimes amusing view of financial dealings in eastern boardrooms, as well as stories of Beck's adventures with Buffalo Bill in Wyoming. Beck's memoir demonstrates not only his interest in developing the West but also his humor and his willingness to collaborate with a variety of people.

2021 Publication Award in Biography from the Wyoming State Historical Society Westerners International Co-Founders Book Award, second place George W. T. Beck, an influential rancher and entrepreneur in the American West, collaborated with William F. "Buffalo Bill" Cody to establish the town of Cody, Wyoming, in the 1890s. He advanced his financial investments in Wyoming through his numerous personal and professional contacts with various eastern investors and politicians in Washington DC. Beck's family-his father a Kentucky senator and his mother a grandniece of George Washington-and his adventures in the American West resulted in personal associates who ranged from western legends Buffalo Bill, Jesse James, and Calamity Jane to wealthy American elites such as George and Phoebe Hearst and Theodore Roosevelt. This definitive edition of Beck's memoir provides a glimpse of early life in Wyoming, offering readers a rare perspective on how community boosters cooperated with political leaders and wealthy financiers. Beck's memoir, introduced and annotated by Lynn J. Houze and Jeremy M. Johnston, offers a unique and sometimes amusing view of financial dealings in eastern boardrooms, as well as stories of Beck's adventures with Buffalo Bill in Wyoming. Beck's memoir demonstrates not only his interest in developing the West but also his humor and his willingness to collaborate with a variety of people.