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Extensive basic research and clinical trials have in some aspect of
reproductive physiology, gyne been conducted on inert and medicated
intrauterine cology, or family planning. There is in this volume
devices. In the last decade, substantial progress has an attempt to
provide a total coverage of current been made in understanding the
modes of action progress in medicated intrauterine devices. The and
the physiological mechanisms of IUDs - pro volume is intended for a
broad readership, includ gress resulting from modern techniques and
in ing physicians, medical workers, medical personnel,
strumentation in microanatomy, immunology, pa and administrators in
family planning. It is hoped thology, endocrinology, biochemistry
and biophy that this volume will serve as a stimulus to basic sics.
Such studies, however, are scattered in such a scientists and
clinicians concerned with intrauterine wide spectrum of journals
that the clinician and devices to intensify their research toward
better family planner can hardly keep up to date with the
contraceptive techniques. advances. An attempt is made in this
volume to coordinate physiological and clinical parameters. Little
is September 1980 known about the possible role of diet, diseases
and environmental factors. E. S. E."
This volume contains a collection of papers based on presentations
made at the Reproductive Health Care International Symposium held
in Maui, Hawaii, USA, October 1982. The papers evaluate biologic
interactions be tween intrauterine contraceptive devices and the
host, examine the risks associated with the use of these devices
and describe aspects of technical progress in the field. The
contributing authors bring their knowledge and expertise from four
corners of the world to the readers. The editors wish to express
their appreciation to the authors for their valuable contributions,
to Carolyn K. Osborn for helpful assistance in editing the
manuscripts and to MTP Press for accurate preparation and fine
presentation of the material. It is hoped that this volume will
serve to expand knowledge and generate further interest among its
readers in the dynamic and fascinating field of intrauterine
contraception. April, 1984 H.M. Hasson, MD Chicago, Illinois, USA
ix 1 Ultrastructure of the decidual response to a progesterone
releasing IUD U.M. SPORNITZ. K.S. LUDWIG and M. MALL-HAEFELI
INTRODUCTION The ever-increasing world-wide use of the IUD has
prompted intensive research into the physiology of its
contraceptive action. From these studies it has become clear that
the alterations in morphology as well as in the physiological
milieu produced by the IUD are manifold and differ greatly with the
type of IUD used."
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