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Borna disease was first described over 200 years ago, in what is
now Southeastern Germany, as a fatal neurologic affliction of
horses and was considered a curiosity for many decades. The
causative agent was unknown, and the animal species infected in
nature were limited to horses and sheep. Today, as described in
this volume, the host range has extended to all warm-blooded
animals, the genes and proteins of the virus have been identified,
and many of the mechanisms responsible for behavioral disturbances
are understood. Serologic studies suggest that BDV or related
agents are likely to play a role in human neuropsychiatric
diseases.
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