The study of antigen presenting cells being established within the human eye is universal knowledge, however, on going research has shown us that antigen-presenting cells play a key role in the protection against and the encouragement of disease within the human eye. It has also been shown that antigen presenting cells have a conclusive role in various ocular disorders, including but not limited to, glaucoma, infections, inflammation, and age related macular degeneration. With proof that interactions between T-cells and antigen-presenting cells can result in an immunological tolerance, future therapies are guaranteed to target antigen presenting cells to reduce the immune tolerance to the structure of the eye. Within this text, you will find description based chapters, with current up to date knowledge, explaining the role of antigen-presenting cells and each key ocular disorder relating to them.