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Diagnostic Molecular Pathology: A Guide to Applied Molecular
Testing, Second Edition assembles a group of experts to discuss the
molecular basis and mechanisms of major human diseases and disease
processes and how the molecular features of disease can be
harnessed to develop practical molecular tests for disease
detection, diagnosis and prognosis. The book explains how molecular
tests are utilized in the treatment of patients in personalized
medicine, highlights new technologies and approaches of applied
molecular pathology, and discusses how this discovery-based
research yields new and useful biomarkers and tests. As it is
essential to stay up-to-date on new molecular diagnostics in this
changing field, this book covers critically important areas in the
practice of personalized medicine and reflects our understanding of
the pathology, pathogenesis and pathophysiology of human disease.
This streamlined "essential" version of the Molecular Pathology
(2009) textbook extracts key information, illustrations and
photographs from the main textbook in the same number and
organization of chapters. It is aimed at teaching students in
courses where the full textbook is not needed, but the concepts
included are desirable (such as graduate students in allied health
programs or undergraduates). It is also aimed at students who are
enrolled in courses that primarily use a traditional pathology
textbook, but need the complementary concepts of molecular
pathology (such as medical students). Further, the textbook will be
valuable for pathology residents and other postdoctoral fellows who
desire to advance their understanding of molecular mechanisms of
disease beyond what they learned in medical/graduate school.
Offers an essentialintroduction to molecular genetics and the
"molecular" aspects of human diseaseTeaches from the perspective of
"integrative systems biology," which encompasses the intersection
of all molecular aspects of biology, as applied to understanding
human diseaseIn-depth presentation of the principles and practice
of molecular pathology: molecular pathogenesis, molecular
mechanisms of disease, and how the molecular pathogenesis of
disease parallels the evolution of the disease using
histopathology. "Traditional" pathology section provides
state-of-the-art information on the major forms of disease, their
pathologies, and the molecular mechanisms that drive these
diseases.Explains the practice of "molecular medicine" and the
translational aspects of molecular pathology: molecular
diagnostics, molecular assessment, and personalized medicineStudent
web site hosts "self-assessment" questions; Professor web site
hosts all figures from bookEach chapter ends with Key Summary
Points and Suggested Readings
"
This book covers the concepts of molecular medicine and
personalized medicine. Subsequent chapters cover the topics of
genomics, transcriptomics, epigenomics, and proteomics, as the
tools of molecular pathology and foundations of molecular medicine.
These chapters are followed by a series of chapters that provide
overviews of molecular medicine as applied broadly to neoplastic,
genetic, and infectious diseases, as well as a chapter on molecular
diagnostics. The volume concludes with a chapter that delves into
the promise of molecular medicine in the personalized treatment of
patients with complex diseases, along with a discussion of the
challenges and obstacles to personalized patient care. The
Molecular Basis of Human Cancer, Second Edition, is a valuable
resource for oncologists, researchers, and all medical
professionals who work with cancer.
In 1994 I coedited a book, Molecular Pathology: Ap- efforts. It
should be evident that molecular pathology and proaches to
Diagnosing Human Disease in the Clinical diagnostics impact almost
every conceivable subspecialty Laboratory, that coined the phrase
"molecular pathology" in laboratory medicine and, particularly in
the case of to refer to applications of molecular biology in the
tradi- pharmacogenomics, have led to the development of new tional
areas of laboratory medicine. That compilation of areas of
investigation. clinical molecular techniques included 11 chapters
and an What is less evident is the burden placed upon the epilogue
on "New Directions for the Clinical Laboratory. " laboratorians
directing these efforts. Issues regarding Chapter headings
included: automation, neoplasia, heri- training, certification,
continuing education, and re- table diseases, and infectious
diseases. bursement (just to name a few) have demanded enormous
Three years later, in 1997, Bill Coleman and Greg Tson- time and
effort from professional organizations and g- galis edited
Molecular Diagnostics: For the Clinical ernmental agencies. In
addition, because conventional Laboratorian, which contained 18
chapters and introduced approaches cannot always be applied to
molecular di- the new areas of RT-PCR and In Situ PCR, and included
nostics, unique solutions for quality assurance and quality a
section on gene therapy. Now, ten years after the intro- control
must be developed. These challenges have eng- duction of molecular
pathology, we are looking at the dered committees, subcommittees,
taskforces, and second edition of Bill Coleman and Greg Tsongalis'
text.
Diagnostic Molecular Pathology: A Guide to Applied Molecular
Testing is organized around disease types (genetic disease,
infectious disease, neoplastic disease, among others). In each
section, the authors provide background on disease mechanisms and
describe how laboratory testing is built on knowledge of these
mechanisms. Sections are dedicated to general methodologies
employed in testing (to convey the concepts reflected in the
methods), and specific description of how these methods can be
applied and are applied to specific diseases are described. The
book does not present molecular methods in isolation, but considers
how other evidence (symptoms, radiology or other imaging, or other
clinical tests) is used to guide the selection of molecular tests
or how these other data are used in conjunction with molecular
tests to make diagnoses (or otherwise contribute to clinical
workup). In addition, final chapters look to the future (new
technologies, new approaches) of applied molecular pathology and
how discovery-based research will yield new and useful biomarkers
and tests. Diagnostic Molecular Pathology: A Guide to Applied
Molecular Testing contains exercises to test readers on their
understanding of how molecular diagnostic tests are utilized and
the value of the information that can be obtained in the context of
the patient workup. Readers are directed to an ancillary website
that contains supplementary materials in the form of exercises
where decision trees can be employed to simulate actual clinical
decisions.
Essential Concepts in Molecular Pathology, Second Edition, offers
an introduction to molecular genetics and the "molecular" aspects
of human disease. The book illustrates how pathologists harness
their understanding of these entities to develop new diagnostics
and treatments for various human diseases. This new edition offers
pathology, genetics residents, and molecular pathology fellows an
advanced understanding of the molecular mechanisms of disease that
goes beyond what they learned in medical and graduate school. By
bridging molecular concepts of pathogenesis to the clinical
expression of disease in cell, tissue and organ, this fully
updated, introductory reference provides the background necessary
for an understanding of today's advances in pathology and medicine.
As the molecular basis of human disease becomes better
characterized, and the implications for understanding the molecular
basis of disease becomes realized through improved diagnostics and
treatment, Molecular Pathology, Second Edition stands out as the
most comprehensive textbook where molecular mechanisms represent
the focus. It is uniquely concerned with the molecular basis of
major human diseases and disease processes, presented in the
context of traditional pathology, with implications for
translational molecular medicine. The Second Edition of Molecular
Pathology has been thoroughly updated to reflect seven years of
exponential changes in the fields of genetics, molecular, and cell
biology which molecular pathology translates in the practice of
molecular medicine. The textbook is intended to serve as a
multi-use textbook that would be appropriate as a classroom
teaching tool for biomedical graduate students, medical students,
allied health students, and others (such as advanced
undergraduates). Further, this textbook will be valuable for
pathology residents and other postdoctoral fellows that desire to
advance their understanding of molecular mechanisms of disease
beyond what they learned in medical/graduate school. In addition,
this textbook is useful as a reference book for practicing basic
scientists and physician scientists that perform disease-related
basic science and translational research, who require a ready
information resource on the molecular basis of various human
diseases and disease states.
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Searchlights (Paperback)
George W (George William) B Coleman
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R636
R528
Discovery Miles 5 280
Save R108 (17%)
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Ships in 10 - 15 working days
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Laboratory Exercises in Molecular Pathology is organized by major
organ systems and disease type, presenting exercises that distill
essential disease-specific information (related to frequency, risk
factors, disease manifestations) and a description of disease
pathogenesis (molecular and cellular) that is based upon accepted
principles from today's literature. Each exercise is illustrated
with (1) gross specimens, (2) microscopic histopathology, (3)
immunohistochemistry and/or in situ hybridization (when
applicable), (4) laboratory techniques to probe the molecular
nature of the pathological lesions, and (5) molecular diagnostics
(when applicable). In addition, each exercise contains one or more
cases studies to provide students with exposure to the clinical
workup of a patient that are based upon physical examination
findings, traditional pathological analysis, and state-of-the-art
molecular assessment. The laboratory techniques included emphasize
the dissection of molecular and cellular pathogenesis of the
disease in question. Hence, students will see examples of
laboratory results that illustrate how pathways were elucidated.
Further, the sections on molecular diagnostics illustrate how
molecular testing exploits what is known about molecular
pathogenesis in a specific disease setting.
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