This exceptional reference examines current and emerging topical and transdermal drug delivery systems and their influence on the uptake, absorption, and potency of released compounds. It presents detailed information on such important topics as the kinetic properties and chemical interactions of the skin, drug candidate, and transport vehicle to avoid skin irritation and inflammation, and enhance drug performance and distribution. Containing more than 1,700 references, tables, and equations. Transdermal drug delivery, 2nd Ed. is a timely source for industrial, clinical, and research pharmacists.

Offering a step-by-step, practical approach to this challenging area of dermatology, Procedures in Cosmetic Dermatology: Lasers, Lights, and Energy Devices, 5th Edition, enables you to master the up-to-date cosmetic techniques that produce the superior results your patients expect. Edited by expert clinicians Drs. Elizabeth L. Tanzi, Jeffrey S. Dover, and Leah K. Spring, it provides an overview of the underlying scientific principles of lasers and lights in dermatology, as well as the latest treatment options-all abundantly illustrated and evidence based. A substantial video library demonstrating applications and technical aspects helps you successfully incorporate the latest procedures into your practice. Provides current, authoritative guidance on popular procedures including laser hair removal, tattoo removal, vascular lesions, pigmented lesions, non-ablative fractional laser rejuvenation, ablative laser resurfacing, tissue tightening, and body contouring. Contains five new chapters: Treatment of Skin with Intense Pulsed Light Sources, Radiofrequency Microneedling, Photodynamic Therapy, Muscle Toning and Contouring, and Treatment of Acne with Light and Energy-Based Devices. Features a greatly expanded video library with more than three dozen new videos, demonstrating modalities such as photodynamic therapy, IPL, radiofrequency microneedling, a wide range of lasers, and cryolipolysis. Covers special considerations when treating skin of color, as well as complications and legal considerations of laser, light, and energy-based treatments. Includes procedural how-to's, step-by-step advice on proper techniques, case studies, and pearls and pitfalls. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Contains current American Association of Pharmaceutical Scientists/Food and Drug Administration (AAPS/FDA) guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption This up-to-the-minute reference provides comprehensive coverage of the latest advances in the development, preparation, and application of topical and transdermal therapeutic systems-exploring the biochemistry and treatment of various skin diseases as well as the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation. Offers contemporary discussions on the bioequivalence of dermatological and transdermal dosage forms With more than 1800 useful references and 350 illustrations, tables, and equations, Dermatological and Transdermal Formulations is an essential source for cosmetic and pharmaceutical scientists, dermatologists, toxicologists, agrochemists, regulatory agency personnel, and upper-level undergraduate and graduate students in these disciplines.

Since skin forms the interface between the human body and the environment, its mechanical properties are important in health and disease. Bioengineering of the Skin: Skin Biomechanics gives a thorough introduction in the biological basis of skin biomechanics. It explains the non-invasive methods that allow measurement of the mechanical properties of the skin focusing on commercially available instruments.

Written by internationally leading experts in the field of non-invasive measurement technology of the skin, this volume describes the anatomy, biochemistry, physiology, and pathology of skin biomechanics. It explains in detail how to measure skin mechanic properties and how to use these measurements in the development of drugs and cosmetics.

This book includes 200 clinical cases which present as emergencies. Congenital and acquired conditions affecting all body systems in infants and children are covered, including allergy, abuse, burns, fractures and other trauma, feeding problems, foreign bodies, genetic disorders, infections, poisoning, haematology, oncology, and much more. Cases appear in random order, reflecting actual practice in emergency medicine, and reinforcing skills in investigation, diagnosis, and treatment. It is superbly illustrated with high-quality radiographic images and photographs and is indispensable for all health professionals dealing with emergencies involving children.

The highly anticipated update of the complete textbook of dermatologic science and practice focusing on the care of patients with moderately to heavily pigmented skin - 21 new chapters with more than 900 photographs! Dermatology for Skin of Color, Second Edition is a comprehensive reference that thoroughly details every aspect of dermatologic science as it applies to skin of color - from the development of the skin to the biology of hair and nails. All commonly encountered dermatologic problems of Africans, Asians, Arabs, Native Americans, and other peoples are covered, as are other diseases with significant skin manifestations. This second edition is significantly expanded with 21 new chapters covering dermatology for geriatric, adolescent, and pregnant patients, as well as depigmenting agents, viral infections, cutaneous manifestation of internal malignancy, neurofibromatosis, tuberous sclerosis, photoaging, photosensivity, laser treatment for skin-tightening, toxins and fillers, cosmetic practices in Mexico, effects of tattooing and piercing, sickle cell disease, drug eruptions, and the biology of oral mucosa. It also features many more clinical pictures and improved organization. Extensively illustrated with more than 900 full-color photos, Dermatology for Skin of Color provides comprehensive coverage of medical, surgical, and cosmetic treatment options, pediatric dermatology, differences between skin of color and Caucasian skin, differences between ethnic groups with skin of color, and important basic science information on the structure and function of skin of color. In addition, folk remedies and over-the-counter treatments specifically targeting this population are covered.

Skin lesions are often the first sign for an endocrine disease. Their description is thus of relevance for early diagnosis and treatment of endocrine disease for specialists in endocrinology as well as in dermatology.

Lavishly illustrated, this book describes the clinical and histological features of skin lesions observed in endocrine diseases. All features are reader-friendly structured and written in the language of dermatologists in order to enable a simple association between the features observed and the endocrine etiology.

This concise, comprehensive guide is divided into two sections; nails and the skin. Each section includes information on the types of infections, aetiology, diagnostic procedures, such as sampling techniques, and therapy, including topical, systemic and adjunctive.

Principles of Polymer Science and Technology in Cosmetics and Personal Care

Practitioners of aesthetic medicine and surgery already have a series of textbooks instructing on how to treat the standard patient. Unfortunately, they also have patients who do not conform to the average-those who are of a different age, or sex, ethnicity, or medical history, or who have special social requirements. Aesthetic Rejuvenation Challenges and Solutions: A World Perspective pools the expertise of top aesthetic practitioners who look at those complicated areas that tend to be ignored in the more standard textbooks and provides advice on managing these areas of special challenge that arise in clinical practice. The book contains extensive material on "non-standard" and "non-textbook" patients. It discusses how to evaluate these patients, and when to decide that a patient is not suited for a particular procedure. It discusses the treatment of patients of different ethnic groups, and provides guidance on how to manage patient expectations and deal with dissatisfied patients.

The standard-setting text in oncology for 40 years, DeVita, Hellman and Rosenberg's Cancer: Principles and Practice of Oncology, 12th Edition, provides authoritative guidance and strategies for managing every type of cancer by stage and presentation. Drs. Vincent T. DeVita, Jr., Theodore S. Lawrence, and Steven A. Rosenberg oversee an outstanding team of expert contributing authors who keep you up to date and fully informed in this fast-changing field. This award-winning reference is also continually updated on Health Library and VitalSource platforms for the life of the edition. Integrates basic science into individual cancer chapters for more efficient reference Features quarterly updates that include late-breaking developments in oncology such as new drugs and clinical trials, as well as new case studies and interactive algorithms Offers balanced, multidisciplinary advice from a surgeon, a medical oncologist, and a radiation oncologist Provides updated content on immunotherapy and genetics throughout Includes important related topics such as cancer screening and prevention, palliative care, supportive oncology, and quality of life issues Now available in a convenient single volume, or a seven-multivolume option for portability and ease of use Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Skin reactions to drugs are a ubiquitous problem-the most commonly observed drug sensitivity observed in a wide range of specialties. Skin Reactions to Drugs emphasizes the mechanisms and clinical and laboratory proof of a cause-and-effect relationship between drugs and adverse reactions. It discusses the technique of drug challenge, which has been extensively developed in Finland, but not commonly practiced in the rest of the world.
In this textbook, 12 of the most common drug eruptions are described both clinically and histologically. It features a chapter on systemic contact dermatitis and also addresses cutaneous adverse drug reactions that appear in HIV-infected patients. 40 full-color photographs provide vivid examples of the reactions being discussed. A highly practical resource for practicing physicians and other health care workers, Skin Reactions to Drugs represents the platinum standard of research conducted on the causation of certain adverse reactions of skin.

There are many changes in the skin, hair, and nails during and after pregnancy. Patients are certainly aware that those changes are occurring, but few physicians and even fewer patients know how to predict the course of those changes. Pigmentary changes occur, but are they permanent? Can they be prevented or reversed? Hair may become thicker during pregnancy, only to fall out in the postpartum period. When will hair stop falling out? Will it grow back? What hormonal changes are occurring to produce these effects on the skin, hair, and nails? Will those hormonal changes affect other organs? Some cutaneous manifestations of pregnancy are common and recognized by most physicians. Abdominal striae, for example, are easily identified, but physicians have many questions about them. Why do they develop? Can they be prevented or treated? Other cutaneous manifestations of pregnancy are less common and recognized by few. For example, pruritic urticarial papules and plaques of pregnancy is a debilitating condition that is treatable once diagnosed. Even more important than the treatment, the knowledge imparted to a worried mother that her child will be fine and that the condition is se- limited is priceless; but the condition must first be recognized by the patient's physician. All of these questions and conditions are addressed in this extraordinary book. Pigm- tary disorders are addressed in detail in Chap. 2.

This book demonstrates evidence of a new microorganism infecting a person complaining of a dermopathy and fibers spontaneously exiting the dermis who was diagnosed with delusional parasitosis. The organism is likely a fungus that lives beneath the epidermis with the ability to infect common fibers including cotton, feathers and hair follicles.

This unique reference provides concise, single-source coverage of the clinical, research, and therapeutic aspects of dermatological problems associated with bacteria, fungi, and viruses.
Introduces many novel antifungal, antibacterial, and antiviral agents
Highlighting the molecular biology as well as risk - benefit ratios of new diagnostic and treatment modalities, Cutaneous Infection and Therapy
evaluates the role of antimicrobial soaps in personal hygiene and research on preoperative skin preparation and infection rates
discusses reasons for the reduced risk of infection using occlusive wound dressings
explains the epidemiology, presentation, pathophysiology, and treatment of athlete's foot and fungal diseases of the scalp
presents new oral antifungals for the treatment of onychomycosis
examines the advantages and disadvantages of preparations to treat superficial fungal infections
addresses oral candidiasis in HIV infection and the resistance to antifungal therapy in AIDS patients
reviews the patterns of candidiasis in children and current approaches to antifungal therapy
covers the epidemiology, implications, and management of herpes in pregnant women and newborns
and much more

This is a highly illustrated guide to the diagnosis and management of nail conditions in children. With new material on genetics and on developments such as dermoscopy, it will be invaluable as a reliable clinical reference for both dermatologists and pediatricians, as well as those in family practice.

Offering a step-by-step, practical approach to sought-after cosmetic procedures, Procedures in Cosmetic Dermatology: Soft Tissue Augmentation, 5th Edition, enables you to master the up-to-date cosmetic techniques that produce the superior results your patients expect. Edited by expert clinicians Drs. Jean Carruthers and Alastair Carruthers, along with Jeffrey S. Dover, Murad Alam, and Omar Ibrahim, it covers the different classes of fillers including how to choose a filler, treatment areas by location including different injection techniques, and reversals, as well as an entire section on complications-all abundantly illustrated and evidence based. A substantial video library helps you successfully incorporate the latest procedures into your practice. Provides complete, clear descriptions and rationales for using dermal fillers to combat loss of facial fat, muscle, and bone density. Logically organized content begins with general injection techniques and facial considerations, followed by numerous options of filler material and chapters for each treatment area. Contains new chapters on transgender beautification using fillers, vascular compromise in soft tissue augmentation, HA microdroplet for skin quality enhancement, pros and cons of temporary fillers, filler injection techniques, and calcium hydroxylapatite ultradilute, HA dilution. Features high-quality images and 29 new treatment demonstration videos. Devotes entire sections to adverse effects, safety improvement, and the management of complications. Includes numerous before-and-after photos, treatment illustrations indicating exact injection points, case studies, pearls and pitfalls, and user-friendly flow diagrams on adverse event treatment protocols. Other recent titles in the Procedures in Cosmetic Dermatology Series: Botulinum Toxin, 5th Edition [9780323830751] Lasers, Lights, and Energy Devices, 5th Edition [9780323829052] Hair Restoration [9780323829212] Cosmetic Procedures in Skin of Color [9780323831444]

Darkening patches on the skin can result in great distress for the patient. However, definitive diagnosis between the many possible causes and effective treatment can be very hard for the medical practitioner to achieve. This is the first major professional reference with systematic coverage of diagnosis and the various treatment options, and it will be an indispensable clinical reference.

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents. Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents Drug Delivery Approaches to Modulate Dermatokinetics of Drugs Conventional Methods of Cutaneous Drug Sampling Cutaneous Microdialysis Sampling Substrates by Skin Permeabilization Spectroscopic Techniques in Dermatokinetics Studies Regulatory Perspective of Dermatokinetic Studies

This paper explains how Iran developed its nuclear programme to the point where it threatens to achieve a weapons capability within a short time frame, and analyses Western policy responses aimed at forestalling that capability. Key questions are addressed: will the world have to accept an Iranian uranium-enrichment programme, and does having a weapons capability mean having the Bomb? For nearly two decades, Western strategy on the Iran nuclear issue emphasised denial of supply. Since 2002, there has also been a demand-side dimension to the strategy, aimed at changing Iran's cost benefit calculations through inducements and pressure. But the failure of these policies to prevent Iran from coming close to achieving a nuclear-weapons capability has promoted suggestions for fallback strategies that would grant legitimacy to uranium enrichment in Iran in exchange for intrusive inspections and constraints on the programme. The paper assesses these 'second-best options in terms of their feasibility and their impact on the proliferation risks of diversion of nuclear material and knowledge, clandestine development and NPT break-out, and the risk of stimulating a proliferation cascade in the Middle East and beyond. It concludes that the risks are still best minimised by reinforcing the binary choice presented to Iran of cooperation or isolation, and strengthening denial of supply.

This book, containing 'best of five' multiple choice format MCQs, is specifically designed as a revision aid for postgraduate examinations in dermatology. It will save postgraduates from making their own notes and allow them more time to concentrate on looking after patients.

The new edition of a concise yet thorough illustrated review of the diagnosis and treatment of many forms of psoriasis now includes the many new therapies available and in development, as well as more material on psoriasis as a systemic disease and on comorbidities. This will be of interest to all dermatologists in training and practice, as well as primary care physicians.

Can you Imagine this?Do you remember the last time, if you ever had a minor burn, you watched as a small part of your skin peeled off? Picture what it would be like if your whole skin peeled off. How would you feel about yourself?Stories about the skin are fascinating and compelling. The skin is the largest organ in the body and is vital for life support, but how much do we know about it and what can happen to it?This book is an inspirational collection of tales from Dr Robert Norman's 18 Years as a dermatologist in Tampa, Florida. Based on real-life experience Dr Norman explains ailments of the skin, including melanoma, warts, albinism and toxic epidermal necrolsis, exploring the condition's history and etiology, and talks us through diagnosis with his patient stories. He also discusses topical issues in dermatology such as the importance of cancer prevention and the 'mad science' of cosmetic surgery.The Women Who Lost Her Skin is invaluable reading for practicing and aspiring dermatologists and practitioners in primary care. It is also a jolly good read for anyone who has ever wondered about the mysterious stretchy covering of our bodies.

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Based on hospital clinical trials examining the use of signal and image processing techniques, Surface Imaging for Biomedical Applications bridges the gap between engineers and clinicians. This text offers a thorough analysis of biomedical surface imaging to medical practitioners as it relates to the diagnosis, detection, and monitoring of skin conditions and disease. Written from an engineer's perspective, the book discusses image acquisition methods, image processing, and pattern recognition techniques. It focuses on a variety of techniques used in recent years for image processing and pattern recognition (principal component analysis, independent component analysis, singular value decomposition, texture modeling, inverse model analysis, polynomial surface fitting, and classification techniques), and considers interventional and non-invasive procedures used to diagnose skin-related disease. It examines the biological causation of four skin disorders (psoriasis, vitiligo, ulcer, and acne), provides basic terminologies in surface imaging, and details the outcome of various clinical observations and other research. It also details numerous measurement parameters related to surface imaging (body surface, skin color, tissue characteristic, thickness, roughness, volume of skin, and retinal changes). Discusses the development of a psoriasis severity measurement tool Provides material on assessing segmented repigmentation areas in vitiligo patients via VT-Scan Introduces a volume ulcer assessment using non-invasive 3D imaging Presents an automated system for acne grading that is based on capturing the images of various body parts using the DSLR camera Includes the MATLAB (R) codes for various pattern recognition techniques applied during the assessment/measurement at the end of each chapter This interdisciplinary reference highlights the importance of disease diagnosis and monitoring, and is suitable for medical practitioners, biomedical engineers, and core image processing researchers.