Perinatal factors are critical in the 'programming' of behavioral, endocrine and immunologic outcomes of adult life. Exposure to many factors in utero can drive fetal development along specific trajectories. Perinatal factors can also affect many diverse systems that have significant implications for long-term health outcomes. The findings from basic research are so diverse and suggest implications in many different arenas. Bringing together these findings, this book explores the evidence linking the role of early life events to long-term physical and psychological health outcomes. It pulls the research together and communicates the findings to the wider scientific and clinical communities.

With notable expansion in the clinical interaction between hematologists and obstetricians over the last decade, understanding and managing the clinical manifestations of hemato-obstetric science has become increasingly important. A new reference work in this growing field, this text is a key tool in the diagnosis and treatment of these conditions, providing the reader with a user-friendly, authoritative source of information, which incorporates best practice within internationally accepted guidelines. Clearly presented and easy to use, each chapter includes: * pathophysiology * presentation * differential diagnosis * diagnostic tests and difficulties * maternal, fetal, and potential management complications * implications for screening and future management * tables summarizing the key points in diagnosis and management. A practical, reader-friendly book, this text will be an important resource for clinical staff involved in the management of pregnancy - from trainees in obstetrics, hematology and vascular medicine, to general practitioners involved in day-to-day maternity care, as well as midwifery staff and specialists in hematology, obstetrics and vascular medicine.

'Breast is best' is today's prevailing mantra. However, women - particularly first-time mothers - frequently feel unsupported when they come to feed their baby. This new experience often takes place in the impersonal and medicalized surroundings of a hospital maternity ward where women are 'seen to' by overworked midwives. Using a UK-based ethnographic study and interview material, this book provides a new, radical and critical perspective on the ways in which women experience breastfeeding in hospitals. It highlights that, in spite of heavy promotion of breastfeeding, there is often a lack of support for women who begin to breastfeed in hospitals, thus challenging the current system of postnatal care within a culture in which neither service-user nor provider feel satisfied. Incorporating recommendations for policy and practice on infant feeding, Breastfeeding in Hospital is highly relevant to health professionals and breastfeeding supporters as well as to students in health and social care, medical anthropology and medical sociology, as it explores practice issues while contextualising them within a broad social, political and economic context.

At the cutting-edge of maternal and neonatal management and research, this reference presents the most recent advances in fetal DNA/RNA, embryoscopy/fetoscopy, open fetal surgery, and ethnic population screening to manage pre-existing and newly detected maternal medical complications, detect genetic and congenital abnormalities, prevent preterm births, and optimize pregnancy outcomes. With illustrative color photographs, this source offers contributions by esteemed professionals at respected institutions around the globe and covers legal issues concerning prenatal assessment and diagnosis.

In the last 15 years, fertility treatment has become mainstream medical practice. With this evolution has come a change in focus from effectiveness ('success rates') to safety, patient acceptability and ethical questions. It is recognized that effectiveness also depends crucially on safety and good risk management. The purpose of this book is to address this wider change in focus. Reducing Risk in Fertility Treatment examines risk in assisted conception, covering a wide range of topics and areas. 'Risk' refers to situations in which an outcome of value to people is uncertain. Specifically for the purpose of this book, 'Risk' means situations where patients or professionals or society as a whole is at risk of an adverse outcome in relation to fertility treatment. It therefore encompasses clinical complications, risks inherent in laboratory practice, reputational and business risks to clinics and ethical risks to society as a whole. It will be an essential resource for all clinic staff to consult in reducing the risk associated with their work. It will provide practical resources such as 'how to' guides, but also a theoretical discussion of uncertainty where this exists. The book is primarily directed to practitioners in the area of fertility treatment, namely clinicians, embryologists, nurses, counsellors and administrators. However, it is likely also to be relevant to policy-makers, commissioners of health services, researchers in this field and biomedical ethicists.

At various stages in their life cycle, women with epilepsy have different needs from men and need a more female-orientated service. However, services for people with epilepsy remain androcentric and largely ignore that 50% of the recipients of epilepsy care in the United Kingdom are female. Indeed, 40% of those women engaged with epilepsy services are of childbearing potential. Epilepsy and its treatment can affect or compromise the menstrual cycle, contraception, fertility, pregnancy, child development in the womb, post-birth childcare and menopause, just as these life stages can affect epilepsy and its management. Based on audited clinical experience over the last 10 years at one of the very few clinics for women with epilepsy in the United Kingdom and on the curriculum of the Birmingham University Masters Course in Epilepsy, this book attempts to address these issues for women with epilepsy using evidence-based recommendations for care where possible and indicating those many areas where evidence is lacking and further research is needed. Written from the point of view of women with epilepsy, this text 1) is the only other current book on topic (Morrell) biased towards US practice. 2) includes helpful Action Plans and Review Plans for rapid reference. 3) is authored by the Director of the Birmingham University MSc Course in Epilepsy and Editor-in-Chief of "Seizure: the European Journal of Epilepsy."

This volume provides a broad background of the basic sciences, clinical and therapeutic aspects, and management of uterine cervical cancer. It offers state-of-the-art information on the molecular genetics, biology, and clinical aspects of premalignant lesions of the uterine cervix, and provides a better understanding of the molecular and cellular events that underlie uterine cervical cancer. Uterine Cervical Cancer: Clinical and Therapeutic Perspectives contains extensive, updated information on the promising new developments in the diagnosis and management of uterine cervical cancer. It will serve as an invaluable resource for all clinicians and basic medical scientists caring for women with uterine cervical cancer, including attending surgeons, physicians, clinical fellows, and residents in the disciplines of gynecologic oncology, medical oncology, and surgical oncology.

With collaboration of Dr. Lucky Jain, Consulting Editor, Dr. Caplan has assembled articles devoted to the most current clinical advances in necrotizing enterocolitis. He has invited expert authors from top institutions to contribute timely reviews on the following topics: Biomarker Discovery: New markers that improve early diagnostic capability; Probiotics: State of the art; NEC Pathophysiology: How microbiome data alters our understanding; Effect of Human Milk on NEC; Influence of Growth Factors on the Development of NEC; Can Fish Oil Reduce the Incidence of NEC by Altering the Inflammatory Response; Oral Mother's Milk: State of the art and influence on NEC; Does Surgical Management Alter the Outcome of NEC; Epidemiology of NEC: New considerations and influence of PRBC transfusions and anemia; Role of Abdominal Ultrasound in Diagnosis of NEC; and Modifiable Risk Factors in NEC: 2018. Readers will come away with the scientific and medical information they need to make clinical decisions to improve patient outcomes.

The only gynecological text that combines a medical reference and surgical procedural atlas into one volume has been fully updated and revised A cost-effective option to purchasing two separate textbooks, this lavishly illustrated guide brings you fully up to date on the latest topics, including minimally invasive procedures, benign gynecology, and the subspecialties of urogynecology, gynecologic oncology, and reproductive endocrinology. With 1,200 photos and illustrations-including 450 full-color figures depicting operative techniques, Williams Gynecology provides comprehensive coverage of the full spectrum of gynecologic healthcare and disease management, including benign general gynecology; reproductive endocrinology, infertility, and menopause; female pelvic medicine and reconstructive surgery; and gynecologic oncology. Its extensive use of treatment algorithms, differential diagnosis boxes, and other elements, make finding the right answers a quick, efficient process. The Aspects of Gynecologic Surgery and Atlas of Gynecologic Surgery section covers benign gynecologic conditions, minimally invasive surgery, surgeries for female pelvic reconstruction, and surgeries for gynecologic malignancies.

A new, full color book on the integrated management of vulvovaginal disease, The Vulva and Vagina Manual presents the most complete published classification of vulvovaginal disease, based on the etiology of 275 conditions. Covering the management of benign, malignant, and functional diseases, including those of a psychosexual nature, each disease featured has a descriptive summary, pathological features, and treatment guidelines, thus ensuring that the book is easy to use and follow. Written by authors from a variety of backgrounds - gynecology, dermatology, pathology and psychology -- and backed by the International Society for the Study of Vulvovaginal Disease, this multidisciplinary work is undoubtedly an important resource for gynecologists, dermatologists, obstetricians, midwives, genitourinary physicians, STD physicians and all those treating vulvovaginal disease.

Careful evaluation of the placenta can often give much insight into disorders of pregnancy in the mother and fetus. The techniques of gross placental examination are not difficult, but a systematic approach is necessary to be complete. Color Atlas of Gross Placental Pathology, Second Edition is designed to aid in the careful and thorough gross examination of the placenta by providing an illustrated manual of examination that includes normal variations, abnormal findings, as well as unusual pathology. This work features 186 illustrations, of which 154 are in color. Cynthia G. Kaplan, MD is Associate Professor of Pathology at the State University of New York at Stony Brook in Stony Brook, New York.

This authoritative reference compiles the latest studies on the epidemiology, diagnosis, and treatment of uterine cancer and offers an extensive review of the molecular pathogenesis of endometrial and uterine disorders-analyzing patterns of disease presentation as population demographics change and considering the challenges this will place on future healthcare procedures.