A comprehensive look at the long tradition of psychedelic magic and religion in Western Civilization. Unbeknownst--or unacknowledged--by many, there is a long tradition of psychedelic magic and religion in Western civilization. As Thomas Hatsis reveals, the discovery of the power of psychedelics and entheogens can be traced to the very first prehistoric expressions of human creativity, with a continuing lineage of psychedelic mystery traditions from antiquity through the Renaissance to the Victorian era and beyond. Describing how, when, and why different peoples in the Western world utilized sacred psychedelic plants, Hatsis examines the full range of magical and spiritual practices that include the ingestion of substances to achieve altered states. He discusses how psychedelics facilitated divinatory dream states for our ancient Neolithic ancestors and helped them find shamanic portals to the spirit world. Exploring the mystery religions that adopted psychedelics into their occult rites, he examines the role of entheogens in the Mysteries of Eleusis in Greece, the worship of Isis in Egypt, and the psychedelic wines and spirits that accompanied the Dionysian mysteries. From ancient priestesses and Christian gnostics, to alchemists, wise-women, and Victorian magicians, Hatsis shows how psychedelic practices have been an integral part of the human experience since Neolithic times.