Aqueous solubility is one of the major challenges in the early
stages of drug discovery. One of the most common and effective
methods for enhancing solubility is the addition of an organic
solvent to the aqueous solution. Along with an introduction to
cosolvency models, the Handbook of Solubility Data for
Pharmaceuticals provides an extensive database of solubility for
pharmaceuticals in mono solvents and binary solvents. Aqueous
solubility data can be found in the Handbook of Aqueous Solubility
Data by Samuel Yalkowsky and Yan He. Visit www.crcpress.com for
more information.
In addition to the experimental efforts to measure the
solubility of drugs in mono and mixed solvents, this book discusses
the advantages and limitations of a number of mathematical models
used to predict the solubility in mono or mixed solvent systems. It
covers the pharmaceutical cosolvents and other organic solvents
that are used in syntheses, separations, and other pharmaceutical
processes. The solutes featured include the available data for
official drugs, drug candidates, precursors of drugs, metabolites,
and degradation products of pharmaceuticals. The author also
presents the solubilities of amino acids since they play an
important role in peptide drug properties.
Collecting drug solubilities in various cosolvents, this
time-saving handbook includes the mixtures and model constants
needed to predict undetermined solubilities. It describes
mathematical models that enable data to be derived and provides
estimates on how drugs are likely to behave in a given cosolvent. A
software program and associated user manual are available on the
author s website.
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