Modelling and simulation technologies have improved dramatically
over the past decade and their applications in toxicity prediction
and risk assessment are of great importance. Such approaches will
become increasingly necessary as industrial chemicals advance and
as new pharmaceuticals enter the market. In this comprehensive
discussion of predictive toxicology and its applications, leading
experts express their views on the technologies currently available
and the potential for future developments. The book covers a wide
range of topics including the in silico, in vitro and in vivo
approaches being used in the safety assessment of chemical
substances. It reflects the growing and urgent need to strengthen
our ability to predict the risks posed by industrial and
pharmaceutical chemicals in humans. Extensive information on the
use of current animal models used for various toxicities and
target-mediated toxicities is included. Also discussed are the
recently introduced regulatory initiatives.
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