Skeletal muscle is a highly plastic tissue that constitutes
approximately thirty percent of total body mass and adapts rapidly
to changing functional demands. Many factors including age, gender
and physical activity levels have previously been reported to
affect the structure or metabolic characteristics of skeletal
muscle. This book reviews the literature describing the
maladaptations that occur in skeletal muscle in response to the
most common lifestyle associated chronic diseases: heart failure
and non-insulin dependent diabetes mellitus and discuss the
mechanisms behind the maladaptations as well as potential therapies
to halt or reverse the changes.
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