This book synthesizes the major research advances in molecular,
biochemical and translational aspects of aging and heart failure
over the last four decades and addresses future directions in
management and drug discovery. It presents clinical issues and
molecular mechanisms related to heart failure, including the
changing demographics in the aging population with heart failure;
hypertension and prevention of diastolic heart failure in the aging
population; polypharmacy and adverse drug reactions in the aging
population with heart failure; changes in the heart that accompany
advancing age from humans to molecules; aging-associated
alterations in myocardial inflammation and fibrosis and
aging-related changes in mitochondrial function and implications
for heart failure therapy. The book succinctly summarizes the large
volume of data on these key topics and highlights novel pathways
that need to be explored. Featuring contributions from leading
clinician-scientists, Aging and Heart Failure: Mechanisms and
Management is an authoritative resource on the major clinical
issues in heart failure therapy in the elderly for cardiologists,
gerontologists and internists.
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