It is now over ten years since we edited the first edition of
HLA-B27 in the Development of Spondyloarthropathies (SpA). It is
obvious that over this period an enormous amount of information
concerning SpA and HLA-B27 has accumulated, and this has been
reflected in the knowledge of molecular mechanism of the
spondyloarthropathies. Discussion for such a book took initial form
at the outstanding 4th Gent Symposium on SpA in October 2006, but
was not formally commissioned by Landes Bioscience until early
2007. Molecular Mechanisms of Spondyloarthropathies aims to
synthesize this growing knowledge and present all the current
studies concerning the basic research of SpA. Over the last decade,
enormous progress has been made in the understanding of the
molecular and cellular processes that lead to disease pathology.
Recognition of the pathways involved in the pathogenic mechanisms
of disease and the potential to target specific immune effector
functions have opened the door to a wide range of innovative
treatment opportunities for the SpA. Thus, we believe that the
understanding of the specific molecular mechanisms involved would
help to design highly specific drugs in the future. The
contributors are among the best in their field and reflect the
state of the art of research and current opinion of rheumatologists
and immunologists.
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