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Canine Parvovirus: A New Pathogen (Paperback)
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Canine Parvovirus: A New Pathogen (Paperback)
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Canine parvovirus (CPV), a new virus of the Canidae first appeared
during the 1970s, but disease caused by this virus was not reported
until 1978. Then within a few months the virus crossed national and
continental boundaries causing high fatality in domestic dog
populations. A similar pattern of transmission was seen in sylvatic
canines but infection was largely subclinical. Between 1979 and
1981 CPV was replaced worldwide by an antigenic variant designated
CPV-2a. The epidemiological advantage of this variant over CPV is
not understood. CPV is a new pathogen of dogs that has attracted an
impressive body of research. However aspects of the biology of this
virus remain unclear, not least of which is the questionof its
possible origin. This book presents an up to date and comprehensive
review of the natural history of CPV and its control by
prophylactic vaccination. Particular attention is paid to the
techniques used to examine the relationship between CPV and other
parvoviruses. CPV is thought to be a variant of the virulent cat
virus FPV (feline parvovirus) and at least one other variant is
known MEV (mink enteritis virus). Theories on the genesis of CPV
are discussed. An attempt to correlate the evidence and an
hypothetical mechanism by which such a variant could have been
selected is offered. This hypothesis is complemented by serological
evidenceof CPV seroconversion in clinically normal dogs some years
prior to the virulent pandemic. Many animal parvoviruses are known
and in 1989/1990, no less than 6 new viruses were described. CPV
may have arisen from an FPV vaccine strain. The use of modified
live vaccines for the control of these viruses is questioned and
alternative strategies discussed. A consise chapter on human
parvoviruses describes the ever increasing role of B19 in human
disease, including that of an opportunistic pathogen in AIDS
patients.
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