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Hormone Toxicity in the Newborn (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R2,957
Discovery Miles 29 570
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Hormone Toxicity in the Newborn (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Monographs on Endocrinology, 31
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The account of "neonatal sterilization" is the story of the
advocates of direct effect of steroids on the gonads and those who
believed in the indirect influence, mediated through the
hypothalamus and/or the pituitary gland. As often happens in
biology, both convictions represent the same image seen from
different perspectives. Prof DC Johnson (Kansas City, KS)
reminisced the beginning of the story in a letter to me. I am
paraphrasing parts of the letter with his permission. "As a
starting point we could pick the life-long research of Emil
Steinach ... " Steinach recognized the influence of testes on the
develop ment of accessory sex organs in 1894, described
virilization of females and feminization of males in 1913, and
identified the controlling influence of the hypophysis on the
gonads in 1928. He reviewed his work in a book Sex and Life, Forty
Years of Biological and Medical Experience (E Steinach and L
Loebe!; Faber and Faber, London, 1940). He got on the wrong road in
later years and that is the reason everybody seems to have
forgotten him. He presented his hypothesis that estrogen has a
direct effect upon the testes, i. e. hormone antagonism, at the 1st
International Congress on Sex Research in 1926.
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