This volume represents a part of the scientific proceedings of the
Sixth Annual Meeting of the American Section of the International
Society for Heart Research that was held in Oklahoma City from
September 13-15, 1984. The chapters have been grouped according to
the content of invited symposia on cardiovascular topics ranging
from electrophysiology, autonomic control of the circulation, aging
of the myocardium, mechanisms of cardiovascular injury, cultured
heart cell studies, etc. Abstracts of all the papers presented at
this meeting are included in Volume 16 (Supp. 1) of the Journal of
Molecular and Cellular Cardiology. Since our understanding of the
pathobiology of cardiovascular injury requires integrating
knowledge from both basic and clinical sciences, the information
presented in this volume extends from fundamental biochemical
processes to pharmacological agents required to treat complex
cardiac arrhythmias. At the molecular level, the structural lipids
of the sarcolemma may be altered during myocardial ischemia; the
role of free radicals in this process is one emerging area of
active study. At the subcellular level, plasma membranes provide
the anatomical basis for maintenance of optimal potentials of
excitable cells; the anatomy and physiology of the sarcolemma
ultimately determines the response to drugs and metabolic
perturbants. At the cellular level, much progress has been made in
our understanding of cultured and adult myocytes during ischemia
and hypoxia; in particular, the electrophysiology of these model
systems is well understood and several chapters address this
approach.
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