Cytokines in Severe Sepsis and Septic Shock (Paperback, Softcover reprint of the original 1st ed. 1999)

t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon stration of microorganisms in the circulation has led to a new definition and under standing of sepsis, mainly as the systemic response of the host to an often unde tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.

General

Imprint:	Birkhauser Verlag AG
Country of origin:	Switzerland
Series:	Progress in Inflammation Research
Release date:	October 2012
First published:	1999
Editors:	H. Redl
Dimensions:	240 x 170 x 20mm (L x W x T)
Format:	Paperback
Pages:	372
Edition:	Softcover reprint of the original 1st ed. 1999
ISBN-13:	978-3-03-489759-4
Categories:	Books > Medicine > General issues > General
LSN:	3-03-489759-6
Barcode:	9783034897594

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