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Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Vertebrates > Mammals > Primates
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Nonhuman Primate Models in Preclinical Research - Basics and Regulatory Principles -- Volume 1 (Hardcover)
Loot Price: R3,966
Discovery Miles 39 660
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Nonhuman Primate Models in Preclinical Research - Basics and Regulatory Principles -- Volume 1 (Hardcover)
Expected to ship within 10 - 15 working days
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Due to the phylogenetic relationship and close genetic and
biological similarities with humans, non-human primates (NHP) are
regularly used in biomedical and behavioural research. However,
because of their highly developed cognitive abilities and social
skills, the use of these animals in biomedical research is debated
more and more. Although it is acknowledged that in specific
research areas NHP are still essential, it is recognized that the
use of these animals can only be done under strict conditions under
the most optimal welfare aspects. Welfare aspects include housing
conditions, non-invasive methods and application of the 3Rs policy.
Although many refinement methods have been described in nationally
and internationally accepted guidelines on animal laboratory
practice, recognition of the guidelines is unfortunately not
universal. The present book covers a wide range of NHP models in
preclinical research and welfare issues. The following chapters
will cover: refinement of the use of NHP in biomedical research;
NHP ethics and regulations in Europe; biological basis differences
in the human and NHP; the major histocompatibility complex (MHC)
immunology in NHP; stem cell biology in NHP; neuro and gliogenesis
in an NHP ischemia stroke model; NHP models in autoimmune disease,
organ transplantation and infectious disease research; viral
diseases in NHP; NHP models in Parkinson's disease, in
neurodegenerative disorders research and in cardio-cerebrovascular
disease research; islet transplantation; ophthalmic diseases
research and neurophysiology in NHP; transgenic engineering in NHP;
NHP models of cancers; NHP models in respiratory disease research;
NHP models in clinical and non-clinical pharmacology; NHP models in
lung transplantation; and aging research in NHP. This book
encapsulates a large volume of knowledge scientists have achieved
in the field of nonhuman primate models in preclinical research.
The editors have invited experts from the United States, Canada,
and Europe to contribute 23 chapters in their respective fields of
their expertise.
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