Infectious fungal diseases continue to take their toll in terms
of human suffering and enormous economic losses. Invasive
infections by opportunistic fungal pathogens are a major cause of
morbidity and mortality in immuno-compromised individuals. At the
same time, plant pathogenic fungi have devastating effects on crop
production and human health. New strategies for antifungal control
are required to meet the challenges posed by these agents, and such
approaches can only be developed through the identification of
novel biochemical and molecular targets. However, in contrast to
bacterial pathogens, fungi display a wealth of lifestyles and modes
of infection. This diversity makes it extremely difficult to
identify individual, evolutionarily conserved virulence
determinants and represents a major stumbling block in the search
for common antifungal targets. In order to activate the infection
programme, all fungal pathogens must undergo appropriate
developmental transitions that involve cellular differentiation and
the introduction of a new morphogenetic programme. How growth, cell
cycle progression and morphogenesis are co-ordinately regulated
during development has been an active area of research in fungal
model systems such as budding and fission yeast. By contrast, we
have only limited knowledge of how these developmental processes
shape fungal pathogenicity, or of the role of the cell cycle and
morphogenesis regulators as true virulence factors. This book
combines state-of-the-art expertise from diverse pathogen model
systems to update our current understanding of the regulation of
fungal morphogenesis as a key determinant of pathogenicity in
fungi.
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