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Fundamentals of Systems Biology - From Synthetic Circuits to Whole-cell Models (Hardcover)
Loot Price: R5,660
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Fundamentals of Systems Biology - From Synthetic Circuits to Whole-cell Models (Hardcover)
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For decades biology has focused on decoding cellular processes one
gene at a time, but many of the most pressing biological questions,
as well as diseases such as cancer and heart disease, are related
to complex systems involving the interaction of hundreds, or even
thousands, of gene products and other factors. How do we begin to
understand this complexity? Fundamentals of Systems Biology: From
Synthetic Circuits to Whole-cell Models introduces students to
methods they can use to tackle complex systems head-on, carefully
walking them through studies that comprise the foundation and
frontier of systems biology. The first section of the book focuses
on bringing students quickly up to speed with a variety of modeling
methods in the context of a synthetic biological circuit. This
innovative approach builds intuition about the strengths and
weaknesses of each method and becomes critical in the book's second
half, where much more complicated network models are addressed
including transcriptional, signaling, metabolic, and even
integrated multi-network models. The approach makes the work much
more accessible to novices (undergraduates, medical students, and
biologists new to mathematical modeling) while still having much to
offer experienced modelers--whether their interests are microbes,
organs, whole organisms, diseases, synthetic biology, or just about
any field that investigates living systems.
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