The effort to sequence the human genome is now moving toward a c-
clusion. As all of the protein coding sequences are described, an
increasing emphasis will be placed on understanding gene function
and regulation. One important aspect of this analysis is the study
of how transcription factors re- late transcriptional initiation by
RNA polymerase II, which is responsible for transcribing nuclear
genes encoding messenger RNAs. The initiation of Class II
transcription is dependent upon transcription factors binding to
DNA e- ments that include the core or basal promoter elements,
proximal promoter elements, and distal enhancer elements. General
initiation factors are involved in positioning RNA polymerase II on
the core promoter, but the complex - teraction of these proteins
and transcriptional activators binding to DNA e- ments outside the
core promoter regulate the rate of transcriptional initiation. This
initiation process appears to be a crucial step in the modulation
of mRNA levels in response to developmental and environmental
signals. Transcription Factor Protocols provides step-by-step
procedures for key techniques that have been developed to study DNA
sequences and the protein factors that regulate the transcription
of protein encoding genes. This volume is aimed at providing
researchers in the field with the well-detailed protocols that have
been the hallmark of previous volumes of the Methods in Molecular
(TM) Biology series.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
Methods in Molecular Biology, 130 |
| Release date: |
November 2010 |
| First published: |
2000 |
| Editors: |
Martin J. Tymms
|
| Dimensions: |
229 x 152 x 16mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
306 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2000 |
| ISBN-13: |
978-1-61737-081-6 |
| Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Medical genetics
|
| LSN: |
1-61737-081-9 |
| Barcode: |
9781617370816 |
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