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Quorum Quenching - A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
Loot Price: R6,170
Discovery Miles 61 700
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Quorum Quenching - A Chemical Biological Approach for Microbial Biofilm Mitigation and Drug Development
Series: Chemical Biology, Volume 22
Expected to ship within 10 - 15 working days
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Antibiotic resistance is a global health concern. Strains of
pathogenic microorganisms that have developed resistance to
multiple antibiotics, such as MRSA, are extremely difficult to
treat, and alternative methods for tackling pathogenic
microorganisms are in demand. One potential target for new
therapeutics is inhibition of quorum sensing: how microorganisms
communicate and form biofilms in a density-dependent manner.
Inhibiting this system via ‘quorum quenching’ (QQ) is a
promising route to new pharmaceuticals and for controlling biofilm
formation and growth. Quorum sensing also provides interesting
possibilities in synthetic biology for producing novel products,
biosensors, bioactive molecules, and so on. This book covers the
biology of quorum sensing and quenching, and potential sources of
QQ enzymes and other inhibitors, as well as an overview of their
mechanism and potential biotech applications. The book also covers
the potential for new drug development from QQ, covering a range of
related topics including protein engineering, imaging and
computational studies, and integrated systems. This book is an
ideal companion to researchers in chemical biology and medicinal
chemistry, particularly those interested in biofilm formation,
quorum sensing, novel antimicrobial development, synthetic biology
and enzymology.
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