The long QT syndrome has become the focus of considerable
scientific attention in recent years because of the discovery of
several genes responsible for its development. These discoveries
have demonstrated the genetic heterogeneity of the syndrome and
have given both the clinician and researcher the opportunity to
relate phenotypic variants to different genotypes responsible for
distinctly different ion channel abnormalities.These analyses -
which are comprehensively reviewed and explored here for the first
time - are now beginning to suggest treatment strategies specific
to each genotype. The full power of such precise diagnosis promises
highly targeted and very successful therapy. In the author's own
words, there is the progressive realization that behind the surface
of an infrequent disease may lie the key to understanding the
mechanisms by which modulation of autonomic function may enhance or
prevent the occurrence of life-threatening arrhythmias.The aim of
the Clinical Approaches to Tachyarryhthmias series is to update the
physician, cardiologist, and all those responsible for the the care
of patients with cardiac arrhythmias. In this volume, one of the
foremost research pioneers in the field provides a clear and
comprehensively considered account of this syndrome's history,
significance, and exciting current status. Readers will gain a
better understanding of why the long QT syndrome has been the focus
for numerous theories of arrhythmogenesis, why it has been the test
bed for many antiarrhythmic treatments, and why it remains the
paradigm for the diagnosis and management of cardiac arrhythmias.
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