Limiting genome replication to once per cell cycle is vital for
maintaining genome stability. Although polyploidization is of
physiologically importance for several specialized cell types,
inappropriate polyploidization is believed to promote aneuploidy
and transformation. A growing body of evidence indicates that the
surveillance mechanisms that prevent polyploidization are
frequently perturbed in cancers. Progress in the past several years
has unraveled some of the underlying principles that maintain
genome stability. This book brings together leaders of the field to
overview subjects relating to polyploidization and cancer.
General
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