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This book provides biomedical engineers with the premiere reference on medical instrumentation as well as a comprehensive overview of the basic concepts. The revised edition features new material on infant apnea monitors, impedance pneumography, the design of cardiac pacemakers, and disposable defibrillator electrodes and their standards. Each chapter includes new problems and updated reference material that cover the latest medical technologies. The chapters have also been revised with new material in medical imaging, providing biomedical engineers with the most current techniques in the field.
Required reading in many medical and healthcare institutions, How to Read a Paper is a clear and wide-ranging introduction to evidence-based medicine and healthcare, helping readers to understand its central principles, critically evaluate published data, and implement the results in practical settings. Author Trisha Greenhalgh guides readers through each fundamental step of inquiry, from searching the literature to assessing methodological quality and appraising statistics.
One of the most notable trends in biomedical science in recent years has been the increasing use of molecular techniques as part of the diagnosis of disease. As such, there is a growing need for students to understand the technological basis of molecular analysis and to have a comprehensive appreciation of their use in diagnosis. Combining coverage of molecular techniques with their application to diagnostic pathology, this book provides students with a thorough and up to date appreciation of the scope of molecular analysis, the principles of the technology used, and thematic diagnostic application. As part of the Fundamentals of Biomedical Science series, the book provides a unique blend of theory and practice, featuring a range of learning features to help students assimilate the information presented quickly and effectively. It will be relevant to undergraduate students on a wide variety of biomedical pathways, cutting across traditional discipline boundaries to provide a unified overview of molecular diagnostics.
This book reviews the progress made in salivary diagnostics during the past two decades and identifies the likely direction of future endeavors. After an introductory section describing the histological and anatomical features of the salivary glands and salivary function, salivary collection devices and diagnostic platforms are reviewed. The field of "salivaomics" is then considered in detail, covering, for example, proteomics, the peptidome, DNA and RNA analysis, biomarkers, and methods for biomarker discovery. Salivary diagnostics for oral and systemic diseases are thoroughly discussed, and the role of salivary gland tissue engineering for future diagnostics is explored. The book closes by considering legal issues and barriers to salivary diagnostic development. Advances in Salivary Diagnostics will be an informative and stimulating reference for both practitioners and students.
The Pacific Symposium on Biocomputing (PSB) 2015 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2015 will be held from January 4 - 8, 2015 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2015 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
How new biomedical technologies-from prenatal testing to gene-editing techniques-require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities-especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich-an award-winning poet and memoirist, and the father of a young woman with Down syndrome-delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on "three-parent IVF," a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.
The bright colour of haemoglobin has, from the very beginning,
played a significant role in both the investigation of this
compound as well as in the study of blood oxygen transport.
Numerous optical methods have been developed for measuring
haemoglobin concentration, oxygen saturation, and the principal
dyshaemoglobins in vitro as well as in vivo. Modern applications
include pulse oximeters, fibre optic oximeters, multiwavelength
haemoglobin photometers ('co-oximeters') and instruments for near
infrared spectroscopy in vivo. Knowledge of the light absorption
spectra of the common haemoglobin derivatives is a prerequisite for
the development and understanding of these techniques.
Screening programmes involve the systematic offer of testing for populations or groups of apparently healthy people to identify individuals who may be at future risk of a particular medical condition or disease, with the aim of offering intervention to reduce their risk. For many years, screening was practised without debate, and without evidence, but in the 1960s serious challenges were raised about many of the screening procedures then being practised. Benefits and harms of screening must be measured in high quality trials, and the benefits of screening must be weighed alongside the negative side-effects. Concerns were raised about potential and actual harm arising when people without a health problem received dangerous and unnecessary investigations and treatments as a result of routine screening tests. Controversy raged, and it took some 50 years to achieve widespread recognition that evidence-based and quality assured programme delivery was essential, coupled with provision of balanced informed to enable informed choice for potential participants. Commercially motivated provision of poor quality and non-evidence based screening tests is increasing and screening remains a highly contested topic that has relevance in all health systems including for the general public and media. This book serves as a practical and comprehensive guide to all aspects of screening. Following the international success of the first edition, this second edition brings extensive updates and new case study material. The first section deals with concepts, methods, and evidence, charts the story of screening back to 1861, and covers all aspects of a screening programme and how to research the full consequences. The second section is a practical guide to sound policy-making and to high quality delivery of best value screening. The controversies, paradoxes, uncertainties, and ethical dilemmas of screening are explained, and each chapter is packed with examples, real-life case histories, helpful summary points, and self-test questions. Reference is made to the NHS, a leader in screening, but the primary focus is on universal principles, making the book highly relevant across the globe.
`Bad Science' hilariously exposed the tricks that quacks and journalists use to distort science, becoming a 400,000 copy bestseller. Now Ben Goldacre puts the $600bn global pharmaceutical industry under the microscope. What he reveals is a fascinating, terrifying mess. Doctors and patients need good scientific evidence to make informed decisions. But instead, companies run bad trials on their own drugs, which distort and exaggerate the benefits by design. When these trials produce unflattering results, the data is simply buried. All of this is perfectly legal. In fact, even government regulators withhold vitally important data from the people who need it most. Doctors and patient groups have stood by too, and failed to protect us. Instead, they take money and favours, in a world so fractured that medics and nurses are now educated by the drugs industry. The result: patients are harmed in huge numbers. Ben Goldacre is Britain's finest writer on the science behind medicine, and `Bad Pharma' is the book that finally prompted Parliament to ask why all trial results aren't made publicly available - this edition has been updated with the latest news from the select committee hearings. Let the witty and indefatigable Goldacre show you how medicine went wrong, and what you can do to mend it.
This third volume in the "Progress in Hypertension" series is dedicated to the memory of Professor Kozo Okamoto the creator of spontaneously hypertensive rats (SHR), stroke-prone spontaneously hypertensive rats (SHRSP) and malignant stroke-prone spontaneously hypertensive rats (M-SHRSP). The papers in this volume deal with pathophysiology and pharmacology of SHR. The contributions describe new trends in SHR research from haemodynamic characteristics to immunological views. The emphasis is placed on the development of transgenic rats and the use of tissue culture studies to elaborate SHR characteristics. The possible use of SHRSP as a model of cerebrovascular dementia can also serve as a novel concept to facilitate the study of vascular dementia. The role of excitatory amino SHR are also covered in this book.
Both a comprehensive lab manual and a practical workbook, the Study Guide and Laboratory Manual for Physical Examination and Health Assessment 8th Edition, gives you the tools you need to master physical examination and health assessment skills. Corresponding to the best-selling Jarvis textbook, this guide features reading assignments, terminology reviews, application activities, review questions, clinical learning objectives, regional write-up sheets, and narrative summary forms, with answers at the back to facilitate both learning and review. The 8th Edition has been thoroughly updated throughout with a fresh focus on interprofessional collaboration to prepare you for the skills laboratory and interprofessional collaborative practice. Authoritative review and guidance for laboratory experiences personally written by Dr. Jarvis to give you a seamlessly integrated study and clinical experience. Consistent format throughout text includes Purpose, Reading Assignment, Terminology Review, Study Guide, and Review Questions in each chapter. Essential review and guidance for laboratory experiences familiarizes you with physical examination forms and offers practice in recording narrative accounts of patient history and examination findings. Study Guide in each chapter includes short-answer and fill-in-the-blank questions. The only full-color illustrated lab manual available for a nursing health assessment textbook enhances learning value with full-color anatomy and physiology labeling activities and more. NEW! Updated content throughout corresponds to the 8th edition of the Jarvis textbook and reflects the latest research and evidence-based practice. NEW! Enhanced integration of interprofessional collaboration exercises helps you create an SBAR report based on a brief case.
The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
This short memoir mixes science with human interest. It charts the author's journey working at the forefront of In Vitro Fertilisation (IVF), test tube baby research. It recounts the challenges that went into establishing IVF in the wake of Steptoe and Edwards and provides a cautionary tale of how necessary it is to pay attention to what's going on in your own family. There are no other published books that detail the development of IVF in the UK from the perspective of someone who was at the cutting edge, but it is told from a very human and personal view point to appeal to a wide variety of readers. The author started as a homeless teenager from Grimsby and later became one of the founding fathers of IVF. Throughout the 1980s and 90s and for years after that, he played a key part in its scientific progress. The dedication to bring children into the lives of thousands of infertile families, came at a cost of losing his own family.
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Massage, aromatherapy, reflexology and a variety of relaxation techniques are frequently used in hospices, supportive care settings and some hospitals. However, there are still gaps and limitations in the choices offered to patients. HEARTS (Hands-on, Empathy, Aromas, Relaxation, Textures, Sound) was devised to bridge this gap for complementary therapists, patients, carers and health care professionals. HEARTS can be used either on its own, or integrated with a conventional complementary therapy. It can also be used easily by health care workers (and carers) who are not qualified in any therapies. By discussing principles which may influence the effectiveness of touch and relaxation therapies, the book emphasises that there are 'easy' approaches that can be utilised when working with distressed and vulnerable patients. By developing an understanding of touch, aromas and the sound of the human voice, Combining Touch and Relaxation Skills for Cancer Care guides practitioners in helping their patients achieve a state of relaxation and calm as quickly and easily as possible.
This is a new edition of a well-established textbook which demonstrates the theory and practice of one of the most popular models used in both university and clinical practice settings. Fully updated throughout, Karen Holland, Jane Jenkins and their colleagues explain how the Roper-Logan-Tierney Model can help today's student learn how to care for patients in a variety of health care contexts and use it as a framework for their nursing practice. Helpfully presented in two parts, the book initially shows how the model can be used to identify the factors which affect the human lifespan and how health and illness work to influence the dependence-independence continuum. The second part then examines each of the 'activities of living', clearly demonstrating their interconnectivity and how they are influenced, in turn, by biological, psychological, sociocultural, environmental and politico-economic influences. Discussion and 'real-life' examples throughout show how this helpful framework can be used as a basis for nursing assessment, planning, delivery and evaluation of care. Rich with thought provoking exercises, Applying the Roper-Logan-Tierney Model in Practice, third edition, retains its helpful problem solving approach which strongly encourages further learning and reflection. The volume will be ideal for all pre-registration nursing students, as well as others such as Nursing Associates, who wish to improve their knowledge and understanding of evidence-based nursing care. New edition of a successful textbook which explains the theory and practice of one of the most popular models of nursing Structured approach to a core range of 'activities of living' clearly illustrate how they interconnect and may be promoted, or compromised, by health and illness, and influenced by external factors Explains the theory to show how it can be applied in practice to assess, plan, deliver and evaluate individualised nursing care A helpful case study approach enables readers see how the model works in 'real life' Written by experts who actively encourage a problem-solving approach to nursing care and practice Additional exercises are designed to encourage further learning and reflective practice, as well as develop skills in literature searching and evidence-based care Helpful appendices include a range of reference material such as the Care Plan Documentation and Audit Tool, Laboratory Reference Values, the Roper-Logan Tierney Assessment Schedule and other commonly used nursing documentation Ideal for use in a variety of contemporary health care delivery environments including the acute and community-based settings Presents the latest evidence-base for safe and effective nursing practice Ideal for use in a variety of contemporary Health Care Delivery settings, both in the UK and overseas
With an introduction by author of The Tidal Zone, Sarah Moss
The Immortal Life of Henrietta Lacks is the true story behind the HBO film starring Oprah Winfrey and Rose Byrne.
Her name was Henrietta Lacks, but scientists know her as HeLa. Born a poor black tobacco farmer, her cancer cells – taken without her knowledge – became a multimillion-dollar industry and one of the most important tools in medicine. Yet Henrietta’s family did not learn of her ‘immortality’ until more than twenty years after her death, with devastating consequences . . .
Rebecca Skloot’s fascinating account is the story of the life, and afterlife, of one woman who changed the medical world for ever. Balancing the beauty and drama of scientific discovery with dark questions about who owns the stuff our bodies are made of, The Immortal Life of Henrietta Lacks is an extraordinary journey in search of the soul and story of a real woman, whose cells live on today in all four corners of the world.
Nursing and Healthcare Research at a Glance is perfect for nursing and healthcare students, as well as newly qualified practitioners and anyone looking for a refresher or introduction to research. Covering a broad range of topics gathered under key sections, this essential book combines informative diagrams and images to provide memorable information for students on one page, and accessible, clearly written text on the facing page. It includes information on a range of quantitative and qualitative research methods, the process of gaining ethical permission, conducting research with special groups including children, and successfully conducting reviews of the literature. Key features include: * Clear and informative full colour illustrations throughout * An emphasis on need-to-know research information for busy students and healthcare staff * A wide range of research methods, currently used in modern healthcare research * An impressive line-up of specialist and well-known experts in the field of health and nursing research This book provides quick access to the principles and reality of research and its implementation within the education and practice environment. It is essential reading for anyone in health service education and service settings with limited time who need to draw on research evidence.
Dermatopathology is a specialized branch of pathology in which there has been great progress as new techniques have become available to evaluate the pathology of the skin. Many of the advances in our knowledge and understanding of the skin and the diseases that affect it have been made by people with experience of both diagnostic pathology and clinical dermatology. With significant numbers of large textbooks available, there is a need to provide practical clinical information and concise criteria for pathologic diagnosis for pathologists and dermatologists looking for up-to-date diagnostic and management options.
* A step-by-step look at a growing and difficult to understand
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