Patient-focused healthcare, driven by COVID-19 experiences, has become a hallmark for providing healthcare services to patients across all modalities of care and in the home. The ability to capture real-time patient data, no matter the location, via remote patient monitoring, and to transmit that data to providers and organizations approved by the consumer/patient, will become a critical capability for all healthcare providers. Of all the remote patient monitoring product designs, wearable medical devices are emerging as the best positioned to support the evolving patient-focused healthcare environment. This book is for those who are evaluating, selecting, implementing, managing, or designing wearable devices to monitor the health of patients and consumers. This book will provide the knowledge to understand the issues that mitigate the risk of wearable technologies so people can deliver successful projects using these technologies. It will discuss their use in remote patient monitoring, the advantages and disadvantages of different types of physiological sensors, different wireless communication protocols, and different power sources. It will describe issues and solutions in cybersecurity and HIPAA compliance, as well as setting them up to be used in healthcare systems and by patients.

Translating research into practice involves creating interventions that are relevant to improving the lives of a target population. Community engaged research has emerged as an evidence-based approach to better address the complex issues that affect the health of marginalized populations. Written by leading community-engaged researchers across disciplines, each chapter covers a different topic with comprehensive guides for start-to-finish planning and execution. The book provides a training curriculum that supports a common vision among stakeholders as well as a survey of methods based on core MPH curriculum. Practical appendices and homework samples can be found online. Public Health Research Methods for Partnerships and Practice will appeal to researchers and practitioners in community or government sectors interested in conducting community-engaged work.

This volume focuses on how waste biomass can be transformed into useful biomaterials, food and feed, fuel, and chemicals by using various processes such as chemical, physical, thermal, biological, and biotechnological procedures. Biomass from biowastes, such as agriculture crop residues, wood processing residues, forest residues, food waste, industrial waste, and municipal solid waste, have emerged as potential substrates for bioenergy production. This volume explores the key features of biotechnology for waste biomass utilization, presenting scientific and technical literature on sustainable waste biomass management as well as for biomass conversion for biofuels, chemicals, and other new commercial products. It discusses a variety of novel biotechnical applications and interventions, including microbial fermentation and anaerobic digestion, biotechnological modes of xylooligosaccharides production, multifaceted utilization of microalgal biomass, vermiculture and vermicomposting, and more. Key features: Provides the most recent information about waste biomass utilization for the production of biofuels and biochemicals Shows a wide range of novel technologies in the field of biotechnology towards waste biomass utilization Focuses on the utilization of microbial resources for waste biomass conversion into value-added products Explores methods for food wastes and crop wastes conversion into biofuels and biochemicals Provides the scientific information describing various examples and case studies which aid gaining knowledge to researchers and academicians With chapters from eminent researchers who have significant global experience in the field of waste biomass management, this volume delivers a wealth of valuable information for researchers involved in bioenergy utilization. It will also be an essential source for academicians, researchers, economists, policymakers, and policy analysts.

Statistical Design, Monitoring, and Analysis of Clinical Trials, Second Edition concentrates on the biostatistics component of clinical trials. This new edition is updated throughout and includes five new chapters. Developed from the authors' courses taught to public health and medical students, residents, and fellows during the past 20 years, the text shows how biostatistics in clinical trials is an integration of many fundamental scientific principles and statistical methods. The book begins with ethical and safety principles, core trial design concepts, the principles and methods of sample size and power calculation, and analysis of covariance and stratified analysis. It then focuses on sequential designs and methods for two-stage Phase II cancer trials to Phase III group sequential trials, covering monitoring safety, futility, and efficacy. The authors also discuss the development of sample size reestimation and adaptive group sequential procedures, phase 2/3 seamless design and trials with predictive biomarkers, exploit multiple testing procedures, and explain the concept of estimand, intercurrent events, and different missing data processes, and describe how to analyze incomplete data by proper multiple imputations. This text reflects the academic research, commercial development, and public health aspects of clinical trials. It gives students and practitioners a multidisciplinary understanding of the concepts and techniques involved in designing, monitoring, and analyzing various types of trials. The book's balanced set of homework assignments and in-class exercises are appropriate for students and researchers in (bio)statistics, epidemiology, medicine, pharmacy, and public health.

This combination manual and downloadable resources provide much-needed training on the proper handling of rats used in biomedical research. The downloadable resources include narrated video clips that demonstrate and describe each procedural technique. The manual contains handouts with color illustrations and descriptive text for each technique, including the purpose and application of the procedure, recommended skills, and necessary supplies. It can be used as a training resource and refresher for lab animal veterinarians, veterinary technicians, animal care staff, trainers, and research investigators and staff who work with rats.

By the year 2050, the world's population is expected to reach nine billion. To feed and sustain this projected population, world food production must increase by at least 50 percent on much of the same land that we farm today. To meet this staggering challenge, scientists must develop the technology required to achieve an "evergreen" revolution -- one that increases crop productivity without degrading natural resources. With 30 percent new material, the updated and revised third edition of Growth and Mineral Nutrition of Field Crops covers all aspects of crop growth and mineral nutrition that contribute to sustainable, high-yield agriculture. Bringing together international scientific knowledge of crop production and the impacts of agriculture on the environment, this book: * Includes two new chapters on remediation of heavy-metal contaminated soils and cover crops * Covers theoretical and practical aspects of mineral nutrition of field crops * Provides recommendations for judicious use of fertilizers, which will reduce cost of crop production and enhance high crop yields without risking environmental pollution * Provides growth patterns for annual crops and forages * Includes a handful of color pictures of nutrient deficiencies for easy diagnostic purposes To make the book as practical as possible, each chapter is supported by experimental results and extensive references. A large number of figures and tables are also included to save readers time when researching. The overall emphasis of this reference is on the soil's ability to sustain high crop yields and a healthy human population.

For most biomedical researchers and academics, preparing conference abstracts and posters is an important part of professional life. With good preparation and practice, all scientists can produce abstracts that act as effective ambassadors for their research. A well designed poster can help you to enhance your professional reputation in addition to communicating your data. This book aims to help you achieve these objectives. This book is designed for you to use when you are actually preparing a conference abstract or poster. It is intended to answer the most frequent questions, and to help you avoid the most common problems and pitfalls. Just dip into any chapter and you will find a range of tips relevant to the abstract or poster you are preparing right now. As a researcher and academic, you need to be able to disseminate and communicate your research work and findings. While many will view writing for peer-reviewed journals as the pinnacle of the academic communication hierarchy, being able to write and present conference abstracts and posters is also extremely important. Taking your work to conferences allows you to meet experts from all around the world, to exchange ideas in person and to network with potential employers and collaborators. 'This book is a gem of useful, practical tips covering the entire process - from reading the abstract submission guidelines, through to writing and laying out your poster and creating e-posters. If you are a novice this is the ideal book to guide you through every step. And, even if you consider yourself an expert, there is bound to be some useful information you can glean from the 500 or so tips. By reading this book, in sequence, or by dipping into relevant chapters, you will have all the necessary help with preparing abstracts and posters right at your fingertips' - Catherine Dunbar in her Foreword.

Examines harmonization of the US Federal Food, Drug, and Cosmetic Act with international regulations as they apply to human drug and device development, research, manufacturing, and marketing. The Second Edition focuses on the new drug approval process, cGMPs, GCPs, quality system compliance, and corresponding documentation requirements. Written in a jargon-free style, it draws information from a wide range of resources. It demystifies the inner workings of the FDA and facilitates an understanding of how it operates with respect to compliance and product approval. FDA Regulatory Affairs: provides a blueprint to the FDA and drug, biologic, and medical device development offers current, real-time information in a simple and concise format contains a chapter highlighting the new drug application (NDA) process discusses FDA inspection processes and enforcement options includes contributions from experts at companies such as Millennium and Genzyme, leading CRO's such as PAREXEL and the Biologics Consulting Group, and the FDA Three all-new chapters cover: clinical trial exemptions advisory committees provisions for fast track

Research in Psychotherapy is a comprehensive synthesis and assessment of the psychotherapeutic research literature for the use of both researchers and those in clinical practice. It is designed as a general reference work, an instruction guide, and a source of information about specific aspects and problems of research.

The book consists of three parts. Part 1 discusses principles and methods of research as they are applied to psychotherapy. It provides general background material and principles to help non-researchers appreciate some of the important problems that are encountered. In Part 2, existing research on the effects of psychotherapy and the determinants and correlates of outcome are clustered and reviewed. Chapters 4 to 7 are concerned strictly with a review and appraisal of controlled studies that were designed to evaluate the effects of psychotherapy. Chapters 8 to 13 deal with a large body of research on various factors associated with therapeutic outcome--method, style, and technique variables; patient, therapist, and time variables. Part 3 is concerned with research on aspects of the therapeutic process and on the effect of many of these same variables on the therapeutic interchange as distinct from the outcome of therapy. Also discussed is research on various therapeutic phenomena and conditions about which so much has been written and so little really known.

Research in Psychotherapy was written in the conviction that clinical practice should be influenced by research and that rigorous research that meets acceptable experimental standards can be done on the field of psychotherapy.

'Bad Science' hilariously exposed the tricks that quacks and journalists use to distort science, becoming a 400,000 copy bestseller. Now Ben Goldacre puts the $600bn global pharmaceutical industry under the microscope. What he reveals is a fascinating, terrifying mess. Doctors and patients need good scientific evidence to make informed decisions. But instead, companies run bad trials on their own drugs, which distort and exaggerate the benefits by design. When these trials produce unflattering results, the data is simply buried. All of this is perfectly legal. In fact, even government regulators withhold vitally important data from the people who need it most. Doctors and patient groups have stood by too, and failed to protect us. Instead, they take money and favours, in a world so fractured that medics and nurses are now educated by the drugs industry. The result: patients are harmed in huge numbers. Ben Goldacre is Britain's finest writer on the science behind medicine, and 'Bad Pharma' is the book that finally prompted Parliament to ask why all trial results aren't made publicly available - this edition has been updated with the latest news from the select committee hearings. Let the witty and indefatigable Goldacre show you how medicine went wrong, and what you can do to mend it.

Key Features: Provides botanical descriptions, distribution and pharmacological investigations of notable medicinal and herbal plants used to prevent or treat diabetes. Discusses phytochemical and polyherbal formulations for the management of diabetes and other related complications. Contains reports on antidiabetic plants and their potential uses in drug discovery based on their bioactive molecules.

In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: With Applications in R provides a full treatment of random effects joint models for longitudinal and time-to-event outcomes that can be utilized to analyze such data. The content is primarily explanatory, focusing on applications of joint modeling, but sufficient mathematical details are provided to facilitate understanding of the key features of these models. All illustrations put forward can be implemented in the R programming language via the freely available package JM written by the author. All the R code used in the book is available at: http://jmr.r-forge.r-project.org/

*Provides an overview of statistical and analytic methodologies in real-world evidence to generate insights on healthcare, with a special focus on the pharmaceutical industry *Examines timely topics of high relevance to industry such as bioethical considerations, regulatory standards and compliance requirements *Highlights emerging and current trends, and provides guidelines for best practices *Illustrates methods through examples and use-case studies to demonstrate impact *Provides guidance on software choices and digital applications for successful analytics.

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research.

FUNDAMENTALS OF BIOSTATISTICS leads you through the methods, techniques, and computations of statistics necessary for success in the medical field. Every new concept is developed systematically through completely worked out examples from current medical research problems.

*A focus on normal theory linking average power, expected power, predictive power, assurance, conditional Bayesian power and Bayesian power. *Extensions of the concepts to binomial, and time-to-event outcomes and non-inferiority trials *An investigation into the upper bound on average power, assurance and Bayesian power based on the prior probability of a positive treatment effect *Application of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program, or to the successful outcome of an interim analysis *Prior distribution of power and sample size *Extension of the basic approach to proof-of-concept trials with dual success criteria *Investigation of the connection between conditional and predictive power at an interim analysis and power and assurance *Introduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect, and an unconditional version.

For students and researchers new to mixed methods, A Concise Introduction to Mixed Methods Research 2e by renowned author John W. Creswell provides a brief and practical introduction to mixed methods. Many graduate students and researchers in the social, behavioral and health sciences may not have the time or resources to read long treatises or stacks of journal articles on mixed methods research. This text quickly describes the basics of setting up and conducting a study using this methodology. Chapters are short and follow the process of research, from ensuring skills for conducting research, acknowledging the steps in planning a study, designing studies with increasing complexity, planning sampling strategies and integration, and writing up the results of your study. Get started in mixed methods quickly with this brief primer.

Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning of bio-implant interface reactions will have a tremendous impact on future design and prospects of implant treatments.

Bio-Implant Interface: Improving Biomaterials and Tissue Reactions brings together a remarkable panel of scientists to present the state of the art in our understanding of interactions at the interface between biomaterials and living tissue. Much of the focus is on the importance of the implant surface's topography and chemistry to its interaction with the biological environment. Biomineralization along with the biological content of the interface and its role in directing cellular response along desired pathways also receive particular attention.

The pursuit of new and better designs for improved biocompatibility and patient response to implants continues to challenge clinicians and scientists alike. This book offers a unique opportunity to bring yourself up to date on recent advances in the field and new strategies for controlling the bio-implant interface.

Learn the best new approaches from the world's leading OT educators This timely book presents the most effective, innovative approaches to teaching the next generation of occupational therapists and occupational therapy assistants. Examining both fieldwork and classroom programs, Occupational Therapy in Health Care presents tested, state-of-the-art programs from leaders in the field. Its practical approaches focus on vital issues of teaching, including professional collaboration, measuring learning outcomes, emerging trends in the field, and student development. Its practical approaches focus on vital issues of teaching and fieldwork education: interactive reasoning collaborative learning the influence of learning styles student group leadership in fieldwork developing research competencies understanding disability in context establishing community partnerships academic leadership environmental scanning regarding emerging issues

Learn the best new approaches from the world's leading OT educators This timely book presents the most effective, innovative approaches to teaching the next generation of occupational therapists and occupational therapy assistants. Examining both fieldwork and classroom programs, Occupational Therapy in Health Care presents tested, state-of-the-art programs from leaders in the field. Its practical approaches focus on vital issues of teaching, including professional collaboration, measuring learning outcomes, emerging trends in the field, and student development. Its practical approaches focus on vital issues of teaching and fieldwork education: interactive reasoning collaborative learning the influence of learning styles student group leadership in fieldwork developing research competencies understanding disability in context establishing community partnerships academic leadership environmental scanning regarding emerging issues

Adopting a proactive approach and focusing on emerging radiation-generating technologies, "Health Physics in the 21st Century" meets the growing need for a presentation of the relevant radiological characteristics and hazards. As such, this monograph discusses those technologies that will affect the health physics and radiation protection profession over the decades to come.

After an introductory overview, the second part of this book looks at fission and fusion energy, followed by a section devoted to accelerators, while the final main section deals with radiation on manned space missions. Throughout, the author summarizes the relevant technology and scientific basis, while providing over 200 problems plus solutions to illustrate and amplify the text.

Twelve appendices add further background material to support and enrich the topics addressed in the text, making this invaluable reading for students and lecturers in physics, biophysicists, clinical, nuclear and radiation physicists, as well as physicists in industry.

Study the latest research findings by international experts!This comprehensive volume presents state-of-the-art scientific research on the therapeutic uses of cannabis and its derivatives. All too often, discussions of the potential medical uses of this substance are distorted by political considerations that have no place in a medical debate. Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential features fair, equitable discussion of this emerging and controversial medical topic by the world's foremost researchers.Cannabis and Cannabinoids examines the benefits, drawbacks, and side effects of medical marijuana as a treatment for various conditions and diseases. This book discusses the scientific basis for marijuana's use in cases of pain, nausea, anorexia, and cachexia. It also explores its possible benefits in glaucoma, ischemia, spastic disorders, and migraine.Cannabis and Cannabinoids examines all facets of the medical use of marijuana, including: botany history biochemistry pharmacology clinical use toxicology side effectsCannabis and Cannabinoids is a reference work that will become indispensable to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public. No other book available offers this comprehensive, even-handed look at a deeply divisive subject.

Whether used to help students learn how to perform research or how to critically appraise research reports for use in practice, this authoritative, approachable textbook shows how nursing research is applicable across today's changing healthcare field. AJN award-winning authors Denise Polit and Cheryl Beck detail the latest methodologic innovations that have arisen in nursing, medicine, and the social sciences in their signature user-friendly style, accompanied by the helpful learning features, pedagogy, and clean design that have made this book a classic. The updated 11th Edition adds two new chapters designed to help students ensure the accuracy and effectiveness of research methods and the relevance and applicability of nursing inquiries. Extensively revised content throughout strengthens students' ability to locate and rank clinical evidence, verify the authoritativeness of systematic reviews, and distinguish interpretive approaches from aggregative approaches using meta-aggregation. NEW! Quality Improvement and Improvement Science chapter provides methods and frameworks to help students develop and assess improvement projects. NEW! Applicability, Generalizability, and Relevance: Toward Practice-Based Evidence chapter details cutting-edge strategies to meet the growing need for patient-centered, practice-based evidence. UPDATED! Revised content throughout reflects the latest methodologic approaches to ranking evidence, verifying systematic reviews, using meta-aggregation, and more. Critical appraisal guidelines help students focus on specific aspects of a report for the most effective appraisal. Clear, user-friendly writing style introduces concepts logically and clarifies difficult ideas. Specific research tips translate abstract notions into practical strategies to help students confidently apply chapter lessons in real-life situations. Research examples throughout the text illustrate key points and stimulate critical thinking. A comprehensive index provides fast, efficient access to precise information. Tables, figures, and bulleted summaries reinforce essential chapter concepts at a glance.

This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an underlying cohort or target population of interest. This enables various extended designs to be introduced and analysed with a similar approach: extreme sampling on the outcome (extreme case-control design) or on the exposure (exposure-enriched, exposure-density, countermatched), designs that re-use prior controls and augmentation sampling designs. Further extensions exploit aggregate data for efficient cluster sampling, accommodate time-varying exposures and combine matched and unmatched controls. Self-controlled designs, including case-crossover, self-controlled case series and exposure-crossover, are also presented. The test-negative design for vaccine studies and the use of negative controls for bias assessment are introduced and discussed. This book is intended for graduate students in biostatistics, epidemiology and related disciplines, or for health researchers and data analysts interested in extending their knowledge of study design and data analysis skills. This book Bridges the gap between epidemiology and the more mathematically oriented biostatistics books. Assembles the wealth of epidemiological knowledge about observational study designs that is scattered over several decades of scientific publications. Illustrates the performance of methods in real research applications. Provides guidelines for implementation in standard software packages (Stata, R). Includes numerous exercises, covering simple mathematical proofs, consideration of proposed or published designs, and practical data analysis.

Electronic Assistive Technology (EAT) is a subset of a wider range of products and services known as Assistive Technology (AT). AT is designed to support and enable people with disabilities, either acquired or congenital, to participate in activities with greater independence and safety. With a global aging population, it has an important role to play in enabling and supporting those with disability and their carers. Handbook of Electronic Assistive Technology discusses a range of commonly available or emerging electronic assistive technologies. It provides historical background, advice when assessing for these devices and references different models of provision. It includes both medical and engineering aspects of provision. It is anticipated that the book will support students, trainees, and newly qualified Assistive Technology Practitioners to develop their understanding of the field, by considering the variables that could potentially influence the decision-making process when assessing for and providing this equipment. It also provides a reference point for those already practicing in this field and offers coverage of a broader range of technologies than clinicians may be exposed to, in their daily work This is the first reference book to focus on a comprehensive set of electronic assistive technologies and discuss their clinical application.