Animal Models for Medications Screening to Treat Addiction, the latest volume in the International Review of Neurobiology series, provides a comprehensive overview of the state-of-the-art research on the topic. It reviews the current knowledge and understanding in the field, presenting a starting point for researchers and practitioners entering the field.

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes.

In this issue of Clinics in Laboratory Medicine, guest editors Drs. Christopher P. Holstege and Joshua D. King bring their considerable expertise to the topic of COVID-19 Molecular Testing and Clinical Correlates. Top experts in the field cover key topics such as point-of-care molecular assays for SARS-CoV-2; strategies for scaling up SARS-CoV-2 molecular testing capacity; cycle threshold values from SARS-CoV-2 PCR assays; and more. Contains 12 relevant, practice-oriented topics including analytic and clinical performance of major commercial SARS-CoV-2 PCR assays in the United States; isothermal assays for SARS-CoV-2 detection; rapid antigen assays for SARS-CoV-2; approaches to deployment of molecular testing for SARS-CoV-2 in resource-limited settings; and more. Provides in-depth clinical reviews on COVID-19 molecular testing and clinical correlates, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Safely handle urine and body fluids | Process and analyze them effectively Here’s a comprehensive and highly visual introduction to the theoretical knowledge and practical skills needed to safely handle and analyze non-blood body fluids. The authors’ focused and reader-friendly approach begins with an emphasis on safety; introduces automation in urinalysis and body fluids analysis; and presents the foundational concepts of renal function and urinalysis. Then, step by step, you’ll learn the critical lab procedures for the examination of urine, cerebrospinal fluid, semen, synovial fluid, serous fluid, bronchoalveolar lavage fluid, amniotic fluid, feces, and vaginal secretions.

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma.

Aphasia, Volume 185 covers important advances in our understanding of how language is processed in the brain and how lesions or degeneration in the left hemisphere affect language processing. This new release reviews research regarding how language recovers from brain injury, along with new interventions developed to enhance recovery, including language rehabilitation, noninvasive brain stimulation and medications. Sections cover neuroanatomy and neurophysiology of language networks, focus on mechanisms of recovery (and decline) of language, and include chapters on intervention, including recently developed behavioral therapies, brain stimulation, medications, and a review of studies of treatment for both post-stroke aphasia and primary progressive aphasia.

Bioengineering is the application of engineering principles to address challenges in the fields of biology and medicine encompassing the principles of engineering design to the full spectrum of living systems. In surgery, recent advances in minimal invasive surgery and robotics are the culmination of the work that both engineers and surgeons have achieved in the medical field through an exciting and challenging interface. This interface rests on the medical curiosity and engineering solutions that lead eventually to collaboration and development of new ideas and technologies. Most recently, innovation by surgeons has become a fundamental contribution to medical research in the surgical field, and it is through effective communication between surgeons and biomedical engineers and promoting collaborative initiatives that translational research is possible. Bioengineering for Surgery explores this interface between surgeons and engineers and how it leads to innovation processes, providing clinical results, fundraising and prestige for the academic institution. This book is designed to teach students how engineers can fit in with their intended environment and what type of materials and design considerations must be taken into account in regards to medical ideas.

In recent years, there have been significant progress in computational intelligence and image processing with machine learning and deep learning as important components of modern artificial intelligence. All these progresses face challenges in dealing with Covid-19 pandemic for detection and treatment.This comprehensive compendium provides not only updated advances of computational intelligence and image processing in the detection and treatment of Covid-19, but also other medical applications such as in cancer detection and cardiovascular diseases, etc. More traditional approaches such as 2D segmentation and 3D reconstruction are included.The useful reference text is an updated version of the edited title, Computer Vision in Medical Imaging (World Scientific, 2014) and its companion volume, Frontiers of Medical Imaging (World Scientific, 2015). The book is written for engineers, scientists and the medical community to meet the increased challenges in medical applications.

Sudden Cardiac Death (SCD) is a sudden, unexpected death caused by loss of heart function (sudden cardiac arrest) and Sudden Cardiac Arrest (SCA) occurs when the electrical system to the heart malfunctions and suddenly becomes very irregular. Death can often be a result if not handled quick enough or effectively. New technologies seek to help with this issue. Data processing is a crucial step to developing prognostic models. Some of the challenges in data processing are non-linear prediction models, a large number of patients and numerous predictors with complicated correlations. In traditional hypothesis-driven statistical analysis it is difficult to overcome these challenges. Current approaches to predict cardiovascular risk fail to identify many people who would benefit from preventive treatment, while others receive unnecessary intervention. So, there is an emergent need of an adaptation of AI technologies such as Machine Learning and Deep Learning Techniques to overcome the challenges. The Machine Learning (ML) approaches have great potential in increasing the accuracy of cardiovascular risk prediction and to avoid unnecessary treatment. The application of ML techniques may have the potential to improve Heart Failure outcomes and management, including cost savings by improving existing diagnostic and treatment support systems. Moreover, ML algorithms can also be applied to predict SCD. Also, Machine Learning offers an opportunity to improve accuracy by exploiting complex interactions between risk factors. The book addresses the impact and power of technology driven approaches for prevention and detection of SCA and SCD. It will provide insights on causes and symptoms of SCA and SCD and evaluate whether AI Technologies can improve the accuracy of cardiovascular risk prediction. It will explore the current issues and future technology driven solutions for SCA and SCD prevention and detection.

Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including taxane-anti-androgens cross-resistance in advanced prostate cancer and proteasome inhibitors in the treatment of multiple myeloma.

Membrane Proteins - Production and Function Characterization a volume of Methods in Enzymology, encompasses chapters from the leading experts in the area of membrane protein biology. The chapters provide a brief overview of the topics covered and also outline step-by-step protocol. Illustrations and case example images are included wherever appropriate to help the readers understand the schematics and general experimental outlines.

Volume 69 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Principles of Measurement and Transduction of Biomedical Variables is a comprehensive text on Biomedical Transducers covering principles of functioning, application examples and new technology solutions. It presents measurement methods of biomedical variables and their transduction to an electrical variable such as voltage. This can then be more easily quantified, processed and visualized as numerical values and graphics; for instance, in a video monitor or liquid crystal display. A different type of transducer is presented in every chapter, such as the functioning principle, transducer block diagram, modeling equations and basic applications in biomedical engineering.
It shows technical and theoretical principles to measure biomedical variables as arterial blood pressure, blood flow, temperature and CO2 concentration in exhaled air. Coverage of these principles will enable you to know how to construct main type of transducers with biomedical applications. Prof. Button s book brings together universal concepts and current technical information on how sensors and transducers function which makes this book an ideal resource for teaching measurement and transduction of biomedical variables in undergraduate and postgraduate Biomedical Engineering programs.
Learn how to design transducers through practical examples and applied informationCovers MEMS and laser sensorsGet an overview of the range of devices and techniques available plus advantages and shortcomings for each transducer type"

Poor clinical trial designs result in failed studies wasting research funds and limiting the advancement of cures for disorders. Clinical Trial Design Challenges in Mood Disorders outlines classic problems researchers face in designing clinical trials and discusses how best to address them for the most definitive and generalizable results. Traditional trial designs are included as well as novel analytic techniques. The book examines information on high placebo response, the generalizability of studies conducted in the developing world, the duration of maintenance studies, and the application of findings into clinical practice. With representation from contributors throughout the world and from academia, industry, regulatory agencies, and advocacy groups, this book will contribute toward improved clinical trial design and valid, precise, and reliable answers about what works better and faster for patients.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2013 impact factor is 4.36.