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Books > Medicine > General issues > Medical equipment & techniques
Blood transfusion is a field where there have been, and continues
to be, significant advances in science, technology and most
particularly governance. This book aims to provide you with a
comprehensive overview of both the scientific and managerial
aspects of blood transfusion medicine. The book is intended to
equip biomedical, clinical and allied medical professionals with
practical tools to allow for an informed practice in the field of
blood transfusion science. Dr. Erhabor Osaro 2013
The delivery and availability of information resources is a vital
concern to professionals across multiple fields. This is
particularly vital to data intensive professions, where easy
accessibility to high-quality information is a crucial component of
their research. Library and Information Services for Bioinformatics
Education and Research is an authoritative reference source for the
latest scholarly material on the role of libraries for the
effective delivery of information resources to optimize the study
of biological data. Highlighting innovative perspectives across a
range of topics, such as user assessment, collection development,
and information accessibility, this publication is ideally designed
for professionals, managers, computer scientists, graduate
students, and practitioners actively involved in the field of
bioinformatics.
This book addresses the structural and biological properties of
dental and peridental tissue structures and covers their
mineralization process. The book contains a description of
dentines, cementum, enamel and bone, including collagens, as well
as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids,
and MMPs). The mechanisms of mineralization are described in detail
and the book is focused on matrix vesicles, collagen mineralization
and the role of non-collagenous extracellular matrix components
either as promoters or inhibitors of mineralization. In addition,
the matrix components (non-collagenous) of enamel (amelogenin,
ameloblastin, enamelin, MMP4, MMP20 and other proteases) are
reviewed and their respective roles in dental tissues
biomineralizations and tissue turnover are discussed. Additionally,
environmental factors involved in enamel / dentin defects are
adressed. With state-of-the-art contributions from experts in the
respective domains, the book is a useful introduction to the field
for junior scientists, interested in dental and peridental tissue
biomineralization. It is also an interesting read for advanced
scientists and clinicians working in dental research, giving them a
broader view of the topic beyond their area of specialization. The
series Biology of Extracellular Matrix is published in
collaboration with the American Society for Matrix Biology.
Practical Biostatistics: A Step-by-Step Approach for Evidence-Based
Medicine, Second Edition presents a complete resource of
biostatistical knowledge meant for health sciences students,
researchers and health care professionals. The book's content
covers the investigator's hypothesis, collective health,
observational studies, the biostatistics of intervention studies,
clinical trials and additional concepts. Chapters are written in a
didactic way, making them easier to comprehend by readers with
little or no background on statistics. Evidence-based medicine aims
to apply the best available evidence gained from the scientific
method to medical decision-making using statistical analyses of
scientific methods and outcomes to drive further experimentation
and diagnosis. With a detailed outline of implementation steps
complemented by a review of important topics, this book can be used
as a quick reference or hands-on guide on how to effectively
incorporate biostatistics in clinical trials and research projects.
This book provides an interdisciplinary look at emerging trends in
signal processing and biomedicine found at the intersection of
healthcare, engineering, and computer science. It examines the
vital role signal processing plays in enabling a new generation of
technology based on big data, and looks at applications ranging
from medical electronics to data mining of electronic medical
records. Topics covered include analysis of medical images, machine
learning, biomedical nanosensors, wireless technologies, and
instrumentation and electrical stimulation. Biomedical Signal
Processing: Innovation and Applications presents tutorials and
examples of successful applications, and will appeal to a wide
range of professionals, researchers, and students interested in
applications of signal processing, medicine, and biology.
A two-in-one text providing teaching lab students with an overview
of immunology as well as a lab manual complete with current
standard exercises. Section I of this book provides an overview of
the immune system and immunity, and includes review questions,
problem sets, case studies, inquiry-based questions, and more to
provide students with a strong foundation in the field. Section II
consists of twenty-two lab exercises focused on key concepts in
immunology, such as antibody production, cell separation, cell
function, immunoassays, Th1/Th2 cytokine detection, cell and tissue
culture methods, and cell and molecular biology techniques.
Appendices include safety information, suggested links and
readings, and standard discipline processes, protocols, and
instructions.
The third edition of this innovative work again provides a unique
perspective on the clinical discovery process by providing input
from experts within the NIH on the principles and practice of
clinical research. Molecular medicine, genomics, and proteomics
have opened vast opportunities for translation of basic science
observations to the bedside through clinical research. As an
introductory reference it gives clinical investigators in all
fields an awareness of the tools required to ensure research
protocols are well designed and comply with the rigorous regulatory
requirements necessary to maximize the safety of research subjects.
Complete with sections on the history of clinical research and
ethics, copious figures and charts, and sample documents it serves
as an excellent companion text for any course on clinical research
and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in
Human Subjects Research, Clinical Research from the Patient's
Perspective, The Clinical Researcher and the Media, Data Management
in Clinical Research, Evaluation of a Protocol Budget, Clinical
Research from the Industry Perspective, and Genetics in Clinical
ResearchAddresses the vast opportunities for translation of basic
science observations to the bedside through clinical researchDelves
into data management and addresses how to collect data and use it
for discoveryContains valuable, up-to-date information on how to
obtain funding from the federal government
This open access book introduces the National Health Insurance
(NHI) system of Taiwan with a particular emphasis on its
application of digital technology to improve healthcare access and
quality. The authors explicate how Taiwan integrates its strong
Information and Communications Technology (ICT) industry with 5G to
construct an information system that facilitates medical
information exchange, collects data for planning and research,
refines medical claims review procedures and even assists in
fighting COVID-19. Taiwan's NHI, launched in 1995, is a
single-payer system funded primarily through payroll-based
premiums. It covers all citizens and foreign residents with the
same comprehensive benefits without the long waiting times seen in
other single-payer systems. Though premium rate adjustment and
various reforms were carried out in 2010, the NHI finds itself at a
crossroads over its financial stability. With the advancement of
technologies and an aging population, it faces challenges of
expanding coverage to newly developed treatments and diagnosis
methods and applying the latest innovations to deliver telemedicine
and more patient-centered services. The NHI, like the national
health systems of other countries, also needs to address the
privacy concerns of the personal health data it collects and the
issues regarding opening this data for research or commercial use.
In this book, the 12 chapters cover the history, characteristics,
current status, innovations and future reform plans of the NHI in
the digital era. Topics explored include: Income Strategy Payment
Structure Pursuing Health Equity Infrastructure of the Medical
Information System Innovative Applications of the Medical
Information Applications of Big Data and Artificial Intelligence
Digital Health Care in Taiwan is essential reading for academic
researchers and students in healthcare administration, health
policy, health systems research, and health services delivery, as
well as policymakers and public officials in relevant government
departments. It also would appeal to academics, practitioners, and
other professionals in public health, health sciences, social
welfare, and health and biotechnology law.
For courses in Microbiology Lab and Nursing and Allied Health
Microbiology Lab A Flexible Approach to the Modern Microbiology Lab
Easy to adapt for almost any microbiology lab course, this
versatile, comprehensive, and clearly written manual is
competitively priced and can be paired with any undergraduate
microbiology text. Known for its thorough coverage, straightforward
procedures, and minimal equipment requirements, the Eleventh
Edition incorporates current safety protocols from governing bodies
such as the EPA, ASM, and AOAC. The new edition also includes
alternate organisms for experiments for easy customisation in
Biosafety Level 1 and 2 labs. New lab exercises have been added on
Food Safety and revised experiments, and include options for
alternate media, making the experiments affordable and accessible
to all lab programs. Ample introductory material, engaging clinical
applications, and laboratory safety instructions are provided for
each experiment along with easy-to-follow procedures and flexible
lab reports with review and critical thinking questions.
A suitable drug delivery system is an essential element in
achieving efficient therapeutic responses of drug molecules. With
this desirability in mind, the book unites different techniques
through which extremely small-sized particles can be utilized as a
successful carrier for curing chronic as well as life-threatening
diseased conditions. This is a highly informative and prudently
organized book, providing scientific insight for readers with an
interest in nanotechnology. Beginning with an overview of
nanocarriers, the book impetuses on to explore other essential ways
through which these carriers can be employed for drug delivery to
varieties of administrative routes. This book discusses the
functional and significant features of nanotechnology in terms of
Lymphatic and other drug targeting deliveries. The book is
presenting depth acquaintance for various vesicular and particulate
nano-drug delivery carriers, utilized successfully in
Pharmaceutical as well as in Cosmeceutical industries along with
brief information on their related toxicities. In addition, the
work also explores the potential applications of nanocarriers in
biotechnology sciences for the prompt and safe delivery of nucleic
acid, protein, and peptide-based drugs. An exclusive section in the
book illuminates the prominence and competent applicability of
nanotechnology in the treatment of oral cancer. The persistence of
this book is to provide basic to advanced information for different
novel carriers which are under scale-up consideration for the
extensive commercialization. The book also includes recent
discoveries and the latest patents of such nanocarriers. The
cutting-edge evidence of these nanocarriers available in this book
is beneficial to students, research scholars, and fellows for
promoting their advanced research.
This book draws a unique perspective on the regulation of access to
clinical trial data as a case on research and knowledge
externalities. Notwithstanding numerous potential benefits for
medical research and public health, many jurisdictions have
struggled to ensure access to clinical trial data, even at the
level of the trial results. Pro-access policy initiatives have been
strongly opposed by research-based drug companies arguing that
mandatory data disclosure impedes their innovation incentives.
Conventionally, access to test data has been approached from the
perspective of transparency and research ethics. The book offers a
complementary view and considers access to individual patient-level
trial data for exploratory analysis as a matter of research and
innovation policy. Such approach appears to be especially relevant
in the data-driven economy where digital data constitutes a
valuable economic resource. The study seeks to define how the rules
of access to clinical trial data should be designed to reconcile
the policy objectives of leveraging the research potential of data
through secondary analysis, on the one hand, and protecting
economic incentives of research-based drug companies, on the other
hand. Overall, it is argued that the mainstream innovation-based
justification for exclusive control over the outcomes of research
and development can hardly rationalise trial sponsors' control over
primary data from trials. Instead, access to such data and its
robust analysis should be prioritised.
Oligonucleotides represent one of the most significant
pharmaceutical breakthroughs in recent years, showing great promise
as diagnostic and therapeutic agents for malignant tumors,
cardiovascular disease, diabetes, viral infections, and many other
degenerative disorders. The Handbook of Analysis of
Oligonucleotides and Related Products is an essential reference
manual on the practical application of modern and emerging
analytical techniques for the analysis of this unique class of
compounds. A strong collaboration among thirty leading analytical
scientists from around the world, the book provides readers with a
comprehensive overview of the most commonly used analytical
techniques and their advantages and limitations in assuring the
identity, purity, quality, and strength of an oligonucleotide
intended for therapeutic use. Topics discussed include: Strategies
for enzymatic or chemical degradation of chemically modified
oligonucleotides toward mass spectrometric sequencing Purity
analysis by chromatographic or electrophoretic methods, including
RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of
sequence-related impurities in oligonucleotides by mass
spectrometry and chromatography Structure elucidation by
spectroscopic methods (IR, NMR, MS) as well as base composition and
thermal melt analysis (Tm) Approaches for the accurate
determination of molar extinction coefficient of oligonucleotides
Accurate determination of assay values Assessment of the overall
quality of oligonucleotides, including microbial analysis and
determination of residual solvents and heavy metals Strategies for
determining the chemical stability of oligonucleotides The use of
hybridization techniques for supporting pharmacokinetics and drug
metabolism studies in preclinical and clinical development Guidance
for the presentation of relevant analytical information towards
meeting current regulatory expectations for oligonucleotide
therapeutics This resource provides a practical guide for applying
state-of-the-art analytical techniques in research, development,
and manufacturing settings.
The book Heat Shock Proteins in Cancer Therapeutics provides the
most comprehensive review on contemporary knowledge on the role of
HSP in various types of cancer therapeutics. Using an integrative
approach, the contributors provide a synopsis of the most current
updates on the state of HSP in cancer therapeutics. The heat shock
response pathway is a highly conserved cellular process. Heat shock
factors are a master transcriptional regulator responsible for
expression of several important heat shock proteins, which can
effectively protect critical client proteins from misfolding and
degradation, thus maintaining intracellular integrity under
stressed conditions. Recent studies have demonstrated the direct
connections between heat shock response players and tumor cell
survival, validating heat shock response players as novel molecular
targets in anticancer treatment. Although many hurdles in clinical
application still need to be effectively addressed, such as
undesirable drug toxicity and off target effects; narrow
therapeutic window; poor PK/PD profiles, etc. Recent reports on
synergistic drug combination, advanced prodrug design, smart
nanoparticle packaging, and RNA aptamer selection offer promising
solutions to overcome these challenges. Future advancements in this
fast-growing area can potentially lead to the next generation of
cancer therapeutics. Key basic and clinical research laboratories
from major universities, academic medical hospitals, biotechnology
and pharmaceutical laboratories around the world have contributed
chapters that review present research activity and importantly
project the field into the future. The book is a must read for
graduate students. medical students, basic science researchers and
postdoctoral scholars in the fields of Cancer Biology, Oncology,
Translational Medicine, Clinical Research, Biotechnology, Cell
& Molecular Medicine, Pharmaceutical Scientists and Researchers
involved in Drug Discovery.
This new edition provides an update on the molecular mechanisms
that regulate spermatogenesis. In addition to the rodent as a study
model, chapters also include research on studies in humans. It
includes the latest approaches of studying spermatogenesis, such as
the use of bioinformatics, molecular modeling and others which are
not commonly found in published materials. It also reviews the
latest developments in the field, such as studies on the role of
regulatory RNAs on spermatogenesis. Due to the declining fertility
rate among men, a brand new chapter highlights the impact of
environmental toxicants on spermatogenesis.
This second edition brings together a variety of method used in the
field of cardiovascular development research. Chapters guide
readers through protocols on lymphatic development, lymphatic
staining techniques, lymphatic endothelial, tissue clearing
techniques, and muscle cell isolation and culture. Written in the
highly successful Methods in Molecular Biology series format,
chapters include introductions to their respective topics, lists of
the necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and tips on troubleshooting and
avoiding known pitfalls Authoritative and practical, Cardiovascular
Development: Methods and Protocols, Second Edition seeks to aid
scientists in understanding new state-of-the-art techniques in the
field of cardiovascular development research.
This book compiles the latest research on the multifarious roles of
microbial enzymes, and provides an overview of microbial enzymes
and biotechnologies. It discusses the use of microbial enzymes in
innovative areas like nanomedicine and synthetic biotechnology, as
well as the use of starch digesting enzymes and bioactive proteins
as biotherapeutics, all of which have applications in modern drug
discovery processes. The book also examines the concept of
microbial biotransformation and protein engineering, and covers
topics such as the immobilization of therapeutic enzymes,
bioengineering of enzymes for bioactive compounds, the production
of hydrolytic and oxidative enzymes from plant raw materials, and
prebiotics and probiotics. Given its multidisciplinary scope, this
book will appeal to researchers and industry experts in the fields
of microbiology, biotechnology and molecular medicine.
This book provides an in-depth description and discussion of
different multi-modal diagnostic techniques for cancer detection
and treatment using exact optical methods, their comparison, and
combination. Coverage includes detailed descriptions of modern
state of design for novel methods of optical non-invasive cancer
diagnostics; multi-modal methods for earlier cancer diagnostic
enhancing the probability of effective cancer treatment; modern
clinical trials with novel methods of clinical cancer diagnostics;
medical and technical aspects of clinical cancer diagnostics, and
long-term monitoring. Biomedical engineers, cancer researchers, and
scientists will find the book to be an invaluable resource.
Introduces optical imaging strategies; Focuses on multimodal
optical diagnostics as a fundamental approach; Discusses novel
methods of optical non-invasive cancer diagnostics.
This book presents the essentials of behavioral test methodology
needed for effective study planning and high quality behavioral
data collection on laboratory mice. The broad scope of behavioral
testing in relation to the neurosciences is discussed, as are
thefine details of varioustest situations. Mistakes made in past
research are scrutinized and lessons are drawn about how to avoid
them in future work. Diverse factors that can influence the results
of behavioral experiments are discussed, ranging from the specific
parameters employed in a test to the laboratory environment outside
the test situation itself. Throughout the book, emphasis is placed
on special issues that arise when testing genetically different
mice, including inbred strains and mice with targeted mutations.
This knowledge will assist an investigator who lacks formal
training in behavioral psychology to build a behavioral testing lab
and insure that its output meets current standards of good practice
in behavioral neuroscience research.
The book will be a convenient manual of procedures for daily use
in studies of mouse behavior. It will be of interest even to
experienced behavioural researchers, but of particular value to
scientists just beginning work with mice, including undergraduate
and graduate students as well as postdoctoral investigators who
want to collect phenotypic data with knockout and other genetically
defined mice. Constructed from materials used in a long running
course on Advanced Animal Behavior at University of North
Carolina-Greensboro, the book is an ideal text for a course on
behavioral testing.
A guide to running a behavioral testing lab, including the many
aspects of mouse research beyond the confines of the specific
testDiagrams and photographs are shown for many kinds of apparatus
and test situations with sufficient details such as dimensions to
enable building of replicasProvides step-by-step instructions on
planning and executing behavioral experiments in order to run them
successfullyA companion website will provide access to statistical
utilities in Excel and test protocols, examples of real documents
used for published studies, and video clips of the mice behaviors
resulting from various tests"
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