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Books > Professional & Technical > Biochemical engineering > Biotechnology
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Handbook of Analysis of Oligonucleotides and Related Products (Paperback)
Loot Price: R2,440
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Handbook of Analysis of Oligonucleotides and Related Products (Paperback)
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Oligonucleotides represent one of the most significant
pharmaceutical breakthroughs in recent years, showing great promise
as diagnostic and therapeutic agents for malignant tumors,
cardiovascular disease, diabetes, viral infections, and many other
degenerative disorders. The Handbook of Analysis of
Oligonucleotides and Related Products is an essential reference
manual on the practical application of modern and emerging
analytical techniques for the analysis of this unique class of
compounds. A strong collaboration among thirty leading analytical
scientists from around the world, the book provides readers with a
comprehensive overview of the most commonly used analytical
techniques and their advantages and limitations in assuring the
identity, purity, quality, and strength of an oligonucleotide
intended for therapeutic use. Topics discussed include: Strategies
for enzymatic or chemical degradation of chemically modified
oligonucleotides toward mass spectrometric sequencing Purity
analysis by chromatographic or electrophoretic methods, including
RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of
sequence-related impurities in oligonucleotides by mass
spectrometry and chromatography Structure elucidation by
spectroscopic methods (IR, NMR, MS) as well as base composition and
thermal melt analysis (Tm) Approaches for the accurate
determination of molar extinction coefficient of oligonucleotides
Accurate determination of assay values Assessment of the overall
quality of oligonucleotides, including microbial analysis and
determination of residual solvents and heavy metals Strategies for
determining the chemical stability of oligonucleotides The use of
hybridization techniques for supporting pharmacokinetics and drug
metabolism studies in preclinical and clinical development Guidance
for the presentation of relevant analytical information towards
meeting current regulatory expectations for oligonucleotide
therapeutics This resource provides a practical guide for applying
state-of-the-art analytical techniques in research, development,
and manufacturing settings.
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