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Books > Science & Mathematics > Biology, life sciences > Molecular biology

Molecular Biology of the Cell (Paperback, Seventh Edition): Bruce Alberts, Rebecca Heald, Alexander Johnson, David Morgan,... Molecular Biology of the Cell (Paperback, Seventh Edition)
Bruce Alberts, Rebecca Heald, Alexander Johnson, David Morgan, Martin Raff, …
R2,565 Discovery Miles 25 650 Ships in 12 - 17 working days

For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before-for both in-person and online classes.

Understanding Development (Paperback): Alessandro Minelli Understanding Development (Paperback)
Alessandro Minelli
R393 R325 Discovery Miles 3 250 Save R68 (17%) Ships in 10 - 15 working days

Developmental biology is seemingly well understood, with development widely accepted as being a series of programmed changes through which an egg turns into an adult organism, or a seed matures into a plant. However, the picture is much more complex than that: is it all genetically controlled or does environment have an influence? Is the final adult stage the target of development and everything else just a build-up to that point? Are developmental strategies the same in plants as in animals? How do we consider development in single-celled organisms? In this concise, engaging volume, Alessandro Minelli, a leading developmental biologist, addresses these key questions. Using familiar examples and easy-to-follow arguments, he offers fresh alternatives to a number of preconceptions and stereotypes, awakening the reader to the disparity of developmental phenomena across all main branches of the tree of life.

Molecular Biology of the Cell (Hardcover, Seventh Edition): Bruce Alberts, Rebecca Heald, Alexander Johnson, David Morgan,... Molecular Biology of the Cell (Hardcover, Seventh Edition)
Bruce Alberts, Rebecca Heald, Alexander Johnson, David Morgan, Martin Raff, …
R8,674 R6,485 Discovery Miles 64 850 Save R2,189 (25%) Ships in 12 - 17 working days

For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts, and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before-for both in-person and online classes.

The Chemical Biology of Thrombin (Paperback): Roger L. Lundblad The Chemical Biology of Thrombin (Paperback)
Roger L. Lundblad
R1,503 Discovery Miles 15 030 Ships in 9 - 15 working days

This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin

Bioinformatics - A Practical Guide to Next Generation Sequencing Data Analysis (Hardcover): Hamid D. Ismail Bioinformatics - A Practical Guide to Next Generation Sequencing Data Analysis (Hardcover)
Hamid D. Ismail
R4,511 Discovery Miles 45 110 Ships in 12 - 17 working days

- The book discusses the recent techniques in NGS data analysis which is the most needed material by biologists (students and researchers) in the wake of numerous genomic projects and the trend toward genomic research. - The book includes both theory and practice for the NGS data analysis. So, readers will understand the concept and learn how to do the analysis using the most recent programs. - The steps of application workflows are written in a manner that can be followed for related projects. - Each chapter includes worked examples with real data available on the NCBI databases. Programming codes and outputs are accompanied with explanation. - The book content is suitable as teaching material for biology and bioinformatics students. Meets the requirements of a complete semester course on Sequencing Data Analysis Covers the latest applications for Next Generation Sequencing Covers data reprocessing, genome assembly, variant discovery, gene profiling, epigenetics, and metagenomics

Learning from the COVID-19 Pandemic - Implications on Education, Environment, and Lifestyle (Paperback): R.C. Sobti, Vipin... Learning from the COVID-19 Pandemic - Implications on Education, Environment, and Lifestyle (Paperback)
R.C. Sobti, Vipin Sobti, Aditi Sobti
R1,393 Discovery Miles 13 930 Ships in 9 - 15 working days

1. Discusses implications of COVID on education, environment, and lifestyle 2. Elucidates life-style transformation strategy to counter COVID 3. Focuses on transformative strategy to overcome COVID impact

Hormonal Regulation of Farm Animal Growth (Paperback, New): K. L Hossner Hormonal Regulation of Farm Animal Growth (Paperback, New)
K. L Hossner
R1,378 Discovery Miles 13 780 Ships in 12 - 17 working days

This book describes the cellular and molecular mechanisms that control farm animal growth, including development and body composition. The emphasis is on circulating hormones, local growth factors and gene transcription factors which regulate growth and differentiation of skeletal muscle, bone and adipose tissue. Overall, this book will be an important resource for students that have a limited background in cell, molecular and developmental biology and the effect of endocrine and growth factors on the growth process.

Introduction to Biomolecular Structure and Biophysics - Basics of Biophysics (Hardcover, 1st ed. 2017): Gauri Misra Introduction to Biomolecular Structure and Biophysics - Basics of Biophysics (Hardcover, 1st ed. 2017)
Gauri Misra
R5,395 Discovery Miles 53 950 Ships in 12 - 17 working days

This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into the recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small angle X-ray scattering (SAXS) and Cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques of important biomolecules.

Cellular Osmolytes - From Chaperoning Protein Folding to Clinical Perspectives (Hardcover, 1st ed. 2017): Laishram... Cellular Osmolytes - From Chaperoning Protein Folding to Clinical Perspectives (Hardcover, 1st ed. 2017)
Laishram Rajendrakumar Singh, Tanveer Ali Dar
R5,304 Discovery Miles 53 040 Ships in 12 - 17 working days

This book provides essential information on improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. The protein folding solvent environment mainly consists of salts, small molecule compounds, metabolites, molecular chaperones and other chemical species. Therefore, subtle change in the composition of the environment will alter the protein folding process. The importance of the solvent environment in protein folding is precisely due to the fact that various disease-causing proteopathies can be reversed by manipulating the solvent environment of the malfolded proteins. Hostile environmental stresses represent one of the basic causes of such challenges in protein folding or misfolding. Since cells commonly encounter extreme environmental fluctuations, it is crucial that they equip themselves with strategies to circumvent the hostile environmental conditions. Nature has developed many strategies to ensure that the complex and challenging protein folding reaction occurs with adequate efficiency and fidelity for the success of the organism. Among the strategies employed in a wide range of species and cell types is the elaboration of small organic molecules called osmolytes. Additionally, recent advances have also revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and vaccine flocculation. In fact, a large pool of data has been generated regarding their potential for the therapeutic intervention of neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteostasis failure. Reflecting the multiple applications of these small molecules in the health and other industries, this book combines contributions by respected leaders in the field and will help to inspire college students, basic researchers, and clinicians to translate these biological roles of osmolytes into clinical practice. It will also shed light on some important future prospects of osmolytes like their role as drug excipients and provide a deeper understanding of their mechanism of action in the prevention of neuro-degenerative diseases.

Learning from the COVID-19 Pandemic - Implications for Science, Health, and Healthcare (Paperback): R.C. Sobti, Aastha Sobti Learning from the COVID-19 Pandemic - Implications for Science, Health, and Healthcare (Paperback)
R.C. Sobti, Aastha Sobti
R1,399 Discovery Miles 13 990 Ships in 9 - 15 working days

Highlights the impact of Covid 19 on science, health and health care system Includes evolution, structure, and mode of infection by virus as well as strategies to attack various organs in the body. Describes emergence of various strains of virus Emphasis new techniques to detect and control the virus Discusses vaccine development to control the pandemic

Mitochondrial Intoxication (Paperback): Marcos Roberto De Oliveira Mitochondrial Intoxication (Paperback)
Marcos Roberto De Oliveira
R3,724 Discovery Miles 37 240 Ships in 12 - 17 working days

Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.

The Guinea Pig Model - An Alternative Method for Vaccine Potency Testing (Paperback): Viviana Parreño The Guinea Pig Model - An Alternative Method for Vaccine Potency Testing (Paperback)
Viviana Parreño
R1,234 Discovery Miles 12 340 Ships in 9 - 15 working days

This book summarizes the development and statistical validation of a guinea pig model as an alternative for potency testing of the viral antigens included in combined vaccines applied in cattle to control the respiratory, reproductive, and neonatal calf diarrhea syndromes. The model allows, in one serum sample, to test the vaccine quality for all the viral antigens included in aqueous as well as in oil-adjuvanted formulations of bovine vaccines. The methodology proposed for the control of bovine herpes virus, parainfluenza, and rotavirus were recommended by CAMEVET as guidelines for the 30 countries in the forum, including the US. Key Features Reviews combined vaccines used for cattle Summarizes animal models used for vaccine testing Focuses on bovine herpesviruses, rotaviruses, parainfluenza, and bovine viral diarrhea virus Provides guidance on the effectiveness of the Guinea Pig model for testing vaccine immunogenicity

Practical Skills in Biomolecular Science (Paperback, 6th edition): Rob Reed, David Holmes, Jonathan Weyers, Allan Jones Practical Skills in Biomolecular Science (Paperback, 6th edition)
Rob Reed, David Holmes, Jonathan Weyers, Allan Jones
R1,549 Discovery Miles 15 490 Ships in 12 - 17 working days

An essential companion for students across a range of disciplines, including biochemistry, biomedical sciences, microbiology and molecular biology throughout your entire degree programme, this sixth edition of Practical Skills in Biomolecular Sciences, has been updated and expanded to provide you with a complete and easy-to-read guide. It's an all-in-one solution for the key practical skills needed for all cellular and molecular life sciences, including: comprehensive coverage of study and examination skills; fundamental laboratory methods; investigative and analytical techniques and analysis and presentation of data. This new edition comes with increased coverage on laboratory skills, new chapters on working with bacteria, eukaryotic microbes and viruses, and on assaying biomolecules, as well as new sections on online learning in a post-COVID world. In addition, 250 new and updated illustrations, tables, and tips - including 25 new 'how to' boxes - have been added, along with numerous end-of-chapter study exercises (with answers provided on the companion website) to support self-evaluation.

Molecular, Cellular, and Metabolic Fundamentals of Human Aging (Paperback): Evandro Fei Fang, Linda Hildegard Bergersen, Brian... Molecular, Cellular, and Metabolic Fundamentals of Human Aging (Paperback)
Evandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour
R3,034 Discovery Miles 30 340 Ships in 12 - 17 working days

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion. The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.

Microbiology of the Everglades Ecosystem (Paperback): James A Entry, Andrew D Gottlieb, Krish Jayachandran, Andrew Ogram Microbiology of the Everglades Ecosystem (Paperback)
James A Entry, Andrew D Gottlieb, Krish Jayachandran, Andrew Ogram
R1,452 Discovery Miles 14 520 Ships in 12 - 17 working days

The first synthesis of current research regarding Everglades microbial community structure and function, this book provides an understanding of the physical and chemical factors affecting the structure of microbial communities, including nutrient effects, sea level rise, and other potential stressors. The book integrates traditional research on algal and bacterial structure and function, helping to provide a more holistic understanding of the varying microbial communities throughout the Everglades. From periphyton, to soils and detritus, to flocculent organic matter, Microbiology of the Everglades Ecosystem covers new and emerging methods and their global application.

Landmark Experiments in Protein Science (Paperback): Pascal Leclair Landmark Experiments in Protein Science (Paperback)
Pascal Leclair
R1,534 Discovery Miles 15 340 Ships in 9 - 15 working days

Describes landmark experiments in cell biology and biochemistry Discusses the "How" and "Why" of historically important experiments Includes primary, original data and graphs Emphasizes biological techniques, which helps understand how many of the experiments performed were possible. Documents, chronologically, how each result fed into the next experiments.

Forensic DNA Analyses Made Simple - A Guide for the Curious (Paperback): Omar Bagasra Forensic DNA Analyses Made Simple - A Guide for the Curious (Paperback)
Omar Bagasra; Illustrated by Mohammad Saffar; Ewen McLean
R1,184 Discovery Miles 11 840 Ships in 9 - 15 working days

• Provides self-Learning about DNA Fingerprinting • Includes sections on how to analyze and interpret DNA fingerprinting • Covers legal and medicolegal issues and case analyses • Teaches novice legal community about DNA fingerprints • Summarizes for a general audience the role of ancestry, DNA and what that means.

Dynamics of Visual Motion Processing - Neuronal, Behavioral, and Computational Approaches (Mixed media product, 2010):... Dynamics of Visual Motion Processing - Neuronal, Behavioral, and Computational Approaches (Mixed media product, 2010)
Guillaume S. Masson, Uwe J. Ilg
R4,440 Discovery Miles 44 400 Ships in 10 - 15 working days

Motion processing is an essential piece of the complex brain machinery that allows us to reconstruct the 3D layout of objects in the environment, to break camouflage, to perform scene segmentation, to estimate the ego movement, and to control our action. Although motion perception and its neural basis have been a topic of intensive research and modeling the last two decades, recent experimental evidences have stressed the dynamical aspects of motion integration and segmentation. This book presents the most recent approaches that have changed our view of biological motion processing. These new experimental evidences call for new models emphasizing the collective dynamics of large population of neurons rather than the properties of separate individual filters. Chapters will stress how the dynamics of motion processing can be used as a general approach to understand the brain dynamics itself.

RNA, the Epicenter of Genetic Information - A new understanding of molecular biology (Paperback): John Mattick, Paulo Amaral RNA, the Epicenter of Genetic Information - A new understanding of molecular biology (Paperback)
John Mattick, Paulo Amaral
R1,271 Discovery Miles 12 710 Ships in 9 - 15 working days

Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

Systems Approach to Astrobiology (Paperback): Vera M. Kolb, Benton C. Clark Systems Approach to Astrobiology (Paperback)
Vera M. Kolb, Benton C. Clark
R1,520 Discovery Miles 15 200 Ships in 9 - 15 working days

Features Surveys of the systems approach to analysing and understanding multifaceted, complex problems in astrobiology, written by two scientists who also have engineering backgrounds. Systems applications to areas important to astrobiology, such as chemical evolution, prebiotic chemistry, geochemical/geophysical settings conducive to emergence of life, robotic space exploration, and much more. Wide appeal for all readers interested in the origin and occurrence of life in our Solar System and beyond.

Learning from the COVID-19 Pandemic - Implications for Science, Health, and Healthcare (Hardcover): R.C. Sobti, Aastha Sobti Learning from the COVID-19 Pandemic - Implications for Science, Health, and Healthcare (Hardcover)
R.C. Sobti, Aastha Sobti
R3,624 Discovery Miles 36 240 Ships in 12 - 17 working days

Highlights the impact of Covid 19 on science, health and health care system Includes evolution, structure, and mode of infection by virus as well as strategies to attack various organs in the body. Describes emergence of various strains of virus Emphasis new techniques to detect and control the virus Discusses vaccine development to control the pandemic

Learning from the COVID-19 Pandemic - Implications on Education, Environment, and Lifestyle (Hardcover): R.C. Sobti, Vipin... Learning from the COVID-19 Pandemic - Implications on Education, Environment, and Lifestyle (Hardcover)
R.C. Sobti, Vipin Sobti, Aditi Sobti
R3,618 Discovery Miles 36 180 Ships in 12 - 17 working days

1. Discusses implications of COVID on education, environment, and lifestyle 2. Elucidates life-style transformation strategy to counter COVID 3. Focuses on transformative strategy to overcome COVID impact

Hox Modules in Evolution and Development (Hardcover): David E. K. Ferrier Hox Modules in Evolution and Development (Hardcover)
David E. K. Ferrier
R2,749 Discovery Miles 27 490 Ships in 9 - 15 working days

Few, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom. This is complemented by the distinctive organisation of these genes in the genome, with them frequently being found as clusters in which gene position is linked to when and where the individual genes are expressed, particularly during embryogenesis. This book provides the latest overviews of Hox gene organisation and function for major clades of animals from across the animal kingdom. With the rapidly increasing availability of high-quality whole genome sequences from an ever-expanding range of species, it is becoming increasingly evident that there is great diversity in the organisation of Hox genes. These great strides in genome sequencing are wedded to important developments in our ability to detect expression and disrupt gene function in species that are not traditionally genetically-amenable animals. These technical developments are integrated with wide taxon-sampling in this volume to provide new perspectives on the roles of Hox genes in understanding fundamental issues such as embryo patterning, mechanisms of gene regulation, homology, evolvability, evolutionary novelties, phylogeny, the role of gene and genome duplications in evolution, and ancestral states for major clades of animals. Key features Integrative overviews from major animal groups including, arthropods, vertebrates, echinoderms, mollusks and other spiralians. Perspectives gleaned from the latest genome sequence and gene expression data. Individual chapters written by world-leading experts in Hox genes and evo-devo in each animal group. Related Titles Scholtz, G., ed. Evolutionary Developmental Biology of Crustacea (ISBN 978-9-0580-9637-1) Mattick, J. & P. Amaral. RNA, The Epicenter of Genetic Information (ISBN 978-0-3675-6778-1) Bard, J. Evolution: The Origins and Mechanisms of Diversity (ISBN 978-0-3673-5701-6)

Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression (Hardcover): Shabir Ahmad Ganai Natural HDAC Inhibitors for Epigenetic Combating of Cancer Progression (Hardcover)
Shabir Ahmad Ganai
R2,669 Discovery Miles 26 690 Ships in 9 - 15 working days

General compendium of HDAC inhibitors with deep emphasis on toxicity issues of synthetic HDAC inhibitors Various groups of natural HDAC inhibitors, their representatives and premier sources Cyclic tetrapeptides of natural origin and their importance as cancer chemotherapeutic agents Hydroxamates and depsipeptides from natural sources and their promising role in cancer therapy Natural Flavonoids, their HDAC inhibitory tendency and marvellous anticancer activity Non-flavonoid natural HDAC inhibitors and their pleasing cytotoxic effects towards cancer models Combined therapy involving natural flavonoids with other anticancer molecules for synergistic and additive benefits against cancer models Non-flavonoid HDAC inhibitors and conventional drugs in collaborative mode against aggressive malignancies Nanotechnology based delivery of natural HDAC inhibitors for greater therapeutic efficacy over traditional combinatorial therapy

Molecular Exercise Physiology - An Introduction (Paperback, 2nd edition): Adam Sharples, James Morton, Henning Wackerhage Molecular Exercise Physiology - An Introduction (Paperback, 2nd edition)
Adam Sharples, James Morton, Henning Wackerhage
R1,807 Discovery Miles 18 070 Ships in 9 - 15 working days

Second edition of the only comprehensive and student-friendly introduction to molecular exercise physiology available 12 chapter structure around which a complete single-semester course can be built Explains the concepts of exercise physiology at a molecular level in clear, accessible language and relates them to real practical and applied outcomes Covers applications in both sport and health-related physical activity Includes new chapters on the molecular aspects of exercise and cancer, and exercise and metabolic and cardiovascular diseases Every chapter includes useful features such as learning objectives, summaries, structured guides to further reading, review questions, overviews of work by key researchers and box discussions of important contemporary debates

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