Human Placental Trophoblasts: Impact of Maternal Nutrition explores the vital roles of trophoblasts play in fetal growth and pregnancy, giving you new insight into the modulation of placental trophoblast functions by nutrients. It also reviews the role of fatty acids, folic acids, and specific vitamins in this aspect. The book highlights the critical role of nutrients on human placental development and its' in utero programming effects on the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, hypertension, and obesity in later life. The book begins with discussions of the central process of placentation and its regulation on size and growth of the fetus. It also covers the effects of key macronutrients on placental growth, metabolism, transport, and secretory function. The text details important vitamins and few micronutrients and their roles in the feto-placental growth and development. It includes information on the influence of maternal lifestyle and environmental factors on regulation of the growth, metabolism and gene expression in the feto-placental unit. A review of the genes linked to the process of placentation rounds out the coverage. An examination of a broad range of evidence in the areas of placental growth, function, and its impact on feto-placental outcome, the book presents new knowledge on nutrition and its relevance with early human development. This includes not only the effects of maternal nutrients on possible neonatal growth and development but also their regulation by maternal lifestyle associated factors. A fine blending of epidemiology, clinical nutrition, perinatal and neonatal medicine, and biochemistry and molecular biology areas of research activities, the book helps you to understand the impact of maternal nutrition on placentation and its relevance with pregnancy outcome and fetal programming of adult health and disease.

Published in 1975: This volume contains the completed section of the Handbook of Biochemistry and Molecular Biology with data pertaining to Lipids, Carbohydrates, and Steroids.

The over-riding premise for biotechnology in this book is bringing novel products to market to substantially advance patient care and disease mitigation. Biotechnology, over its relatively brief existence of 40 years, has experienced a mercurial growth. The vast educational need for biotechnology information in this rapidly burgeoning field is a basic rationale here. However a more prominent underpinning is that, bringing biotech products to market for patient care involves success in the following four areas of engagement simultaneously - scientific advances for healthcare technologies, novel and varied products for untreated diseases, regulatory authorities, and biotech companies. Features Comprehensive coverage of biotechnology science topics used in development and manufacturing Addresses all the scientific technologies within biotechnology responsible for products on the market and the pipeline Presents business issues such as marketing and sales of the products, as well as companies engaged, and how biotech business has evolved

Documents the utility of Next Generation Sequencing and RNAseq to a wide array of aquatic environmental and physiological issues as well as to human health. Provides insights into the ways transcriptomics of aquatic animals and fish ecology can contribute to the understanding of human diseases Gives an account of the evolution of the techniques used to determine the transcriptome in crustacean aquaculture. Describes the mechanisms of genetic interaction between different pathogens and the human host and their effects modifying gene expression levels. Intended for undergraduate and graduate students interested in subjects related to physiology of aquatic animals, aquaculture, ecology and phylogeny of fishes, and human health.

This volume and its companion Volume 351 will supplement Volume 194 of MIE. The guides are specifically designed to meet the needs of graduate students and postdocs as well as researchers. Whether an established researcher or newcomer to the field, these volumes will contain all the up-to-date methods needed to study "Genes in Yeast." Procedures are included to enable newcomers to set up a yeast laboratory and to master basic manipulations. Relevant background and reference information will be given for proven procedures that can be used as a guide for developing protocols in a number of disciplines.

Provides up to date fundamental information about probiotics Reveals the recent applications of probiotics in food and feed industries Discusses in depth the role of microbiota in human and animal wellness Comprises chapters by international experts in the field of probiotics

Chromatin immunoprecipitation sequencing (ChIP-seq), which maps the genome-wide localization patterns of transcription factors and epigenetic marks, is among the most widely used methods in molecular biology. Practical Guide to ChIP-seq Data Analysis will guide readers through the steps of ChIP-seq analysis: from quality control, through peak calling, to downstream analyses. It will help experimental biologists to design their ChIP-seq experiments with the analysis in mind, and to perform the basic analysis steps themselves. It also aims to support bioinformaticians to understand how the data is generated, what the sources of biases are, and which methods are appropriate for different analyses.

Systems-Level Modelling of Microbial Communities: Theory and Practice introduces various aspects of modelling microbial communities and presents a detailed overview of the computational methods which have been developed in this area. This book is aimed at researchers in the field of computational/systems biology as well as biologists/experimentalists studying microbial communities, who are keen on embracing the concepts of computational modelling. The primary focus of this book is on methods for modelling interactions between micro-organisms in a community, with special emphasis on constraint-based and network-based modelling techniques. A brief overview of population- and agent-based modelling is also presented. Lastly, it covers the experimental methods to understand microbial communities, and provides an outlook on how the field may evolve in the coming years.

Large scale cultivation of macrofungi is possible with fermentation, using easily accessible lignocellulosic agricultural residues utilising economical methods to generate substantial biomass, food and biofuels. Bioconversion of lignocellulosic wastes by macrofungi generates value-added fungal nutritional biomass for humans and livestock. Besides commercial cultivation techniques, other topics covered include healing potential of mushrooms, industrial opportunities, mycelium-based products, forest wild mushrooms and industrial applications of white rot fungi. This book addresses the various applications of macrofungi. It encourages readers to explore non-conventional sources of nutrition as well as bioactive metabolites to serve as nutraceuticals. The volume emphasizes the significance of macrofungi as source of bioactive compounds to remedy human lifestyle diseases especially cancers and cardiovascular ailments along with immunostimulation potential by Cordyceps. This book also emphasises on the role of mushrooms as a source of cosmeceuticals, source of flavors, essence, scents and perfumes.

Provides information on biofouling control with broad significance and applicability in various industrial and research areas Discusses microbially induced corrosion on biofuel transporting pipelines Includes data from experiments conducted to overcome a biofouling and biocorrosion Gives out attention to metallic coatings and environmental considerations. Explores novel technologies preventing biofouling on metallic and polymeric substrates

Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems.
Key Features
* Comprehensive treatment of a topical research field
* Authored by world leaders in the field
* Covers structural biology and physiology
* Covers different experimental and biological systems
* Chapters on plant and microbial systems
* Extensive treatment of mammalian physiology and pathophysiology
* Structural analysis excellently illustrated

This book entitled "Genetics, Genomics and Breeding of Bamboos" provides a comprehensive overview on the economically and ecologically important non-timber plant group bamboo. The book focuses on the most recent advances in bamboo research in diverse fields including botany, genetic resources, traditional and molecular breeding, disease and pest resistance, tissue culture and genetic transformation and genomics perspective. The different chapters are authored by internationally reputed experts on this plant and is a good source of information for students, scientists, farmers, and bamboo resource management advisers on this plant, which is gaining increase importance on international commerce.

Imparts the techniques of commercial cultivation of mushrooms. Offers methods of macrofungal bioconversion of agrowastes. Provides a broad outline on macrofungal biofuel production. Furnishes outline on industrial potentials of white rot fungi by fermentation. Discusses bioactive metabolites and their application in remediating human lifestyle diseases. Converses nutritional benefits of macrofungi like vitamins, proteins, amino acids, minerals and polysaccharides. Communicates bioactive metabolites like perfumes, cosmeceuticals and pigments for food and textile industries. Denotes insight on industrial applications of wild mushrooms, mycelium-based products and wild mushrooms from forest to market. Proposes the prospects of melanin from higher fungi and their ex situ conservation, structural and functional attributes of melanin from termitophilic Agaricales.

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Uses chemical engineering principles for the study of fermentation processes Provides detailed coverage of stoichiometry and kinetics of fermentation processes Discusses pertinent oxygen transfer theory and its applications Concisely covers microorganisms' biochemistry and metabolism Includes solved examples and problems with solutions manual

Basic curiosity-driven biomedical science has delivered many of today's most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today's classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Forensic DNA Applications: An Interdisciplinary Perspective, Second Edition is fully updated to outline the latest advances in forensic DNA testing techniques and applications. It continues to fill the need for a reference book for people working in the field of forensic molecular biology testing and research as well as individuals investigating and adjudicating cases involving DNA evidence, whether they be civil or criminal cases. DNA techniques have greatly impacted obvious traditional forensic areas, but such advances have also positively affected myriad new areas of research and inquiry. It is possible today to think about solving forensic problems that were simply unheard of even a few years ago. As such, the book pulls all relevant research and applied science together into a detailed and comprehensive collection. Part I begins with the history and development of DNA typing and profiling for criminal and civil purposes. It discusses the statistical interpretation of results with case examples, mitochondrial DNA testing, Y single nucleotide polymorphisms (SNPs) and short tandem repeats (STRs), and X SNP and STR testing. It also explores low copy number DNA typing, mixtures, and quality assurance and control. Part II moves on to cover the various uses and applications of analyzing collected physical evidence, victim identification in mass disasters, analyzing animal DNA, forensic botany, and other unique applications. Part III is dedicated to the latest advances and developments in human molecular biology and Part IV looks at policies and laws and ethics governing DNA evidence, and its utilization in various cases and the courts. Forensic DNA Applications, Second Edition covers cutting-edge research and advancements in the field and is the most up-to-date reference available. Edited and contributed to by the world's foremost leaders in the field, it is a must-have reference for established professionals, and an essential resource to legal professionals—lawyers and judges dealing with civil and criminal cases involving DNA technology—as well as students entering the fields of genetics and forensic DNA analysis.

Completely updated and rewritten, with 150 new figures Genomes from a wide variety of organisms included, from viruses to humans Techniques fully integrated into the text, including those investigating the genome, transcriptome, and proteome Coverage of expression, regulation, and evolution is on a genomic scale Short answer questions and in-depth problems at the end of each chapter Same structure as Genomes 3 but streamlined

Viruses do not behave as other microbes; their life cycles require infecting healthy cells, commandeering their cellular apparatus, replicating and then killing the host cell. Methods for virus detection and identification have been developed only in the past few decades. These recently developed methods include molecular, physical, and proteomic techniques. All these approaches (Electron Microscopy, Molecular, Direct Counting, and Mass Spectrometry Proteomics) to detection and identification are reviewed in this succinct volume. It is written in approachable language with enough detail for trained professionals to follow and want to recommend to others. Key Features Covers common detection methods Reviews the history of detection from antiquity to the present Documents the strengths and weaknesses of various detection methods Describes how to detect newly discovered viruses Recommends specific applications for clinical, hospital, environmental, and public health uses

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition presents exhaustive coverage of amino acids in the nutrition, metabolism and health of humans and other animals. Substantially revised, expanded and updated to reflect scientific advances, this book introduces the basic principles of amino acid biochemistry and nutrition, while highlighting the current knowledge of the field and its future possibilities. The book begins with the basic chemical concepts of amnio acids, peptides and proteins, and their digestion and absorption. Subsequent chapters cover cell-, tissue-, and species-specific synthesis and catabolism of amino acids and related bioactive metabolites, and the use of isotopes to study amino acids metabolism in cells and the body. The book details protein turnover, physiological functions of amino acids, as well as both the regulation and inborn errors of amino acid metabolism. The book concludes with a presentation on human and animal dietary requirements of amino acids and evaluates dietary protein quality. Features: Encompasses a comprehensive coverage of basic to applied concepts in amino acid metabolism in humans and other animals. Highlights important roles of dietary amino acids and protein intake in growth, physical performance and health, including sarcopenia mitigation and immunity. Discusses concerns over the excess intakes of amino acids or protein in the development of diseases, including cardiovascular disorders, diabetes and cancers, as well as bone integrity Each chapter contains select references to provide comprehensive reviews and original experimental data on the topics discussed. Each chapter is backed by original experimental data on various topics discussed and contains select references to aid the reader further in research. Written by Distinguished Professor of Animal Nutrition, Guoyao Wu, Ph.D., this book is an authoritative reference for students and researchers in both biomedicine and agriculture.

The European Molecular Biology Open Software Suite (EMBOSS) is a high quality package of open source software tools for molecular biology. It includes over 200 applications integrated with a range of popular third party software packages under a consistent and powerful command line interface. The tools are available from a wide range of graphical interfaces, including easy to use web interfaces and powerful workflow software. The EMBOSS Administrator's Guide is the official, definitive and comprehensive guide to EMBOSS installation and maintenance: * Find all the information needed to configure, install and maintain EMBOSS, including recent additions for version 6.2 * Step-by-step instructions with real-world examples - saves readers time and helps them avoid the pitfalls on all the common platforms * In-depth reference to database configuration - learn how to set up and use databases under EMBOSS * Includes EMBOSS Frequently Asked Questions (FAQ) with answers - quickly find solutions to common problems

Summarizes signaling pathways regulated by redox reactions Reveals how redox pathways affect cancer and tumor cell metastasis Chapters by an internationals team of leading researchers Chapters describe redox regulation influences developmental processes and these processes originated even before there was much oxygen in the atmosphere

Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage

Sugarcane is the most important plant source for sugar and alcohol production and is cultivated in more than 80 countries in tropical and subtropical areas. However, environmental factors negatively influence its yield and jeopardize the prospect to meet the increasing demand for sugar, other sugarcane derived by products and bioethanol. The development of stress tolerant plants is fundamental for the maintenance and increase of crop yields. Biotechnology to Enhance Sugarcane Productivity and Stress Tolerance provides a comprehensive account of both theoretical and practical aspects of sugarcane production. It contains extensive coverage of genome mapping and molecular breeding in sugarcane and presents the status of the elucidation and improvement of plant genomes of economic interest. Through 14 chapters written by eminent scientists with global influence, this book examines various methods for sugarcane improvement through biotechnology. The book focuses on genetic and physical mapping, positioning, cloning, and monitoring of desirable genes using biotechnological approaches for high sugarcane productivity and the development of stress tolerance. Additional information includes the bioengineering of sugarcane, procedures to boost productivity, genetics and assessments for resistance to drought and salinity, genetics for high yields, and various topics of research on sugarcane genetics. It serves as a detailed reference source for cane growers, sugar and sugarcane technologists, students, and professors.

Diseases of Edible Oilseed Crops presents an unprecedentedly thorough collection of information on the diseases of cultivated annual oilseed crops, including peanut, rapeseed-mustard, sesame, soybean, sunflower, and safflower. Written by internationally recognized researchers, this book covers and integrates worldwide literature in the field up to 2014, setting it apart from other books that are only of regional importance. The book focuses on major diseases of economic importance to each crop. Each chapter is devoted to a type of crop and a profile of affecting diseases according to geographical occurrence, epidemiology, symptoms, causal pathogens, host-pathogen interactions, biotechnological aspects, and the latest approaches to understanding host-pathogen interactions. It also includes discussions on developments on controversial subjects in research in order to stimulate thinking and further conversation with an eye toward improvements and resolutions. Research on oilseed crop diseases has expanded tremendously in the past 30 years, primarily as an effort to reduce losses to various stresses, including crop diseases. In the war against hunger and malnutrition, it is necessary to enhance and update knowledge about crop diseases and managing them. By compiling decades of information from previously scattered research into a single globally minded volume, Diseases of Edible Oilseed Crops provides these much-needed updates and enhancements.