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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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The Lymphatic System in Health and Disease (Hardcover)
Loot Price: R1,830
Discovery Miles 18 300
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The Lymphatic System in Health and Disease (Hardcover)
Series: Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease
Expected to ship within 10 - 15 working days
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The lymphatic system develops and functions in parallel with the
blood circulatory system (termed the "hemovasculature") and
accomplishes transport of interstitial fluids, dietary lipids, and
reverse transport of cholesterol, immune cells, and
antigens-providing a critical homeostatic fluid balance and
transmission of immune cells and mediators back to the
cardiovascular system. Although the daily flow of lymph (normally
1-2 L/day under unstressed conditions) is far lower than that of
daily blood flow (which is 7,500 L/day), without the adequate
functioning of the lymphatics, virtually all organs and tissues
would acutely suffer many different physical and inflammatory
stresses ranging from edema to organ system failure. Although blood
and lymphatic vessels often form in anatomic parallels to one
another, our knowledge of the workings of the lymphatic system, the
fine structure of lymphatic networks, how they function in
different organs, and how they are regulated physiologically and
immunologically are far from parallel; our knowledge of the
lymphatic system still remains at only a tiny fraction of what is
understood about the cardiovascular system. Although both the
cardiovascular and lymphatic systems are important transport
systems, what they transport and how they transport and propel
these very different cargoes could not be more dissimilar. This
book provides an overview of the history of the discovery (and
re-discovery) of the components of the lymphatic system, lymphatic
anatomy, physiological functions of lymphatics, molecular features
of the lymphatic system, and clinical perspectives involving
lymphatics which may be of interest to scientists, clinicians,
patients, and the lay public. We provide a current understanding of
some of the more important structural similarities and differences
between lymphatics and the blood vascular system, their coordinated
control by angiogenic and hemangiogenic growth factors and other
modulators, the fate and lineage determinants which control
lymphatic development, and the roles that lymphatics may play in
several different diseases.
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