This is the story of a race - not against other vaccines or other scientists, but against a deadly and devastating virus.

On 1 January 2020, Sarah Gilbert, Professor of Vaccinology at Oxford University, read an article about four people in China with a strange pneumonia. Within two weeks, she and her team had designed a vaccine against a pathogen that no one had ever seen before. Less than 12 months later, vaccination was rolled out across the world to save millions of lives from Covid-19. In Vaxxers, we hear directly from Professor Gilbert and her colleague Dr Catherine Green as they reveal the inside story of making the Oxford AstraZeneca vaccine and the cutting-edge science and sheer hard work behind it.

This is their story of fighting a pandemic as ordinary people in extraordinary circumstances. Sarah and Cath share the heart-stopping moments in the eye of the storm; they separate fact from fiction; they explain how they made a highly effective vaccine in record time with the eyes of the world watching; and they give us hope for the future.

Vaxxers invites us into the lab to find out how science will save us from this pandemic, and how we can prepare for the inevitable next one.

In the twenty-first century, humanity is reaching new heights of scientific understanding - and at the same time appears to be losing its mind. How can a species that discovered vaccines for Covid-19 in less than a year produce so much fake news, quack cures and conspiracy theorizing?

In Rationality, Pinker rejects the cynical cliché that humans are simply an irrational species - cavemen out of time fatally cursed with biases, fallacies and illusions. After all, we discovered the laws of nature, lengthened and enriched our lives and set the benchmarks for rationality itself. Instead, he explains, we think in ways that suit the low-tech contexts in which we spend most of our lives, but fail to take advantage of the powerful tools of reasoning we have built up over millennia: logic, critical thinking, probability, causal inference, and decision-making under uncertainty. These tools are not a standard part of our educational curricula, and have never been presented clearly and entertainingly in a single book - until now.

Rationality matters. It leads to better choices in our lives and in the public sphere, and is the ultimate driver of social justice and moral progress. Brimming with insight and humour, Rationality will enlighten, inspire and empower.

You make hundreds of decisions every day, from what to eat for breakfast to how to influence people, and not one of them could be made without the essential component of emotion.

It has long been held that thinking and feeling are separate and opposing forces in our behaviour. But as best-selling author Leonard Mlodinow tells us, extraordinary advances in psychology and neuroscience have proven that emotions are as critical to our well-being as thinking.

How can you connect better with others? How can you improve your relationship to frustration, fear, and anxiety? What can you do to live a happier life? The answers lie in understanding emotions.

Taking us on a journey from the labs of pioneering scientists to real-world scenarios that have flirted with disaster, Mlodinow shows us how our emotions help, why they sometimes hurt, and what we can make of the difference. Cutting-edge research and deep insights into our evolution, biology, and neuroscience promise to help us understand our emotions better and maximize their benefits.

Told with characteristic clarity and fascinating stories, Mlodinow's exploration of the new science of feelings is an essential guide to making the most of one of nature's greatest gifts to us.

Wat Moet Ons Met Ons Kerk Doen? is 'n poging om te probeer verstaan waar ons as Afrikaners teologies vandaan kom, watter kragte en magte ons en ons Kerk gevorm het en hoe ons Kerk tans daar uitsien.

Die N.G.Kerk was 'n belangrike en rigtinggewende rolspele in die opheffing van die Afrikaner na die Britse vergrype tydens en na die Tweede Vryheidsoorlog. Tans word die N.G.Kerk ervaar as 'n instansie wat ongevoelig teenoor die geestelike behoeftes van haar lidmate staan.

Hierdie is 'n moet-lees boek vir:

• Lidmate wat ons Kerk graag wil help om 'n gesonde, geestelike tuiste vir Suid-Afrikaners van die 21ste eeu te bied.
• Die klakkelose napraters van die dogma wat dink ons Kerk is steeds op die regte pad.
• Die plastiekpredikante van die radio en televisie wat met eentonige reëlmaat soetsappige, sogenaamd godsdienstige, pleisters plak.
• Diegene wat reeds ons Kerk tot die ashoop van die geloof verdoem het.

Begon, Townsend, and Harper's "Ecology" has long been regarded as the definitive textbook on all aspects of ecology. This new edition provides a comprehensive treatment of the subject, from the first principles of ecology to the current state of the field, and aims to improve students' preparedness to address the environmental problems of the new millennium.

Thoroughly revised and updated, this fourth edition includes: three new chapters on applied ecology, reflecting a rigorous, scientific approach to the ecological problems now facing mankinddiscussion of over 800 new studies, updating the text throughoutan updated, user-friendly design with margin notes and chapter summaries that serve as study aidsdedicated website at www.blackwellpublishing.com/begon

The resulting textbook is easy to use, lucid and up-to-date, and is the essential reference for all students whose degree program includes ecology and for practicing ecologists.

WHEN we eat may be as important as WHAT we eat.

Like most people, you probably wake up, get hungry for meals and doze off in bed around the same time every day. If you’ve ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off kilter. But for some people, that imbalance—difficulty sleeping at night, hunger at odd times, or sudden fatigue at noon—is a constant. If you're one of those people, Dr. Satchin Panda, one of the leading researchers on circadian rhythms, has a plan to reset your body clock.

Beginning with an in-depth explanation of the circadian clock—why it’s important, how it works, and how to know it isn’t working—The Circadian Code outlines lifestyle changes to make to get back on track. It's a concrete plan to enhance weight loss, improve sleep, optimize exercise, and manage technology so that it doesn’t interfere with your body’s natural rhythm. Dr. Panda’s life changing methods show you how to prevent and reverse ailments like diabetes, cancer, and dementia, as well as microbiome conditions like acid reflux, heartburn, and irritable bowel disease.

Exploring evolution, animal behaviour and human psychology, The Social Instinct reveals how and why cooperation has shaped and defined humankind - and what happens when it goes wrong. The first book by a brilliant evolutionary biologist, drawing on decades of research in the field.

The science of cooperation tells us not only how we got here, but also where we might end up. Cooperation explains how strands of DNA gave rise to modernday nation states. It defines our extraordinary ecological success as well as many of the most surprising features of what make us human: not only why we live in families, why we have grandmothers and why women experience the menopause, but also why we become paranoid and jealous, and why we cheat.

Nichola Raihani also introduces us to other species who, like us, live and work together. From the pied babblers of the Kalahari to the cleaner fish of the Great Barrier Reef, they happen to be some of the most fascinating and extraordinarily successful species on this planet. What do we have in common with these other species, and what is it that sets us apart?

Written at a time of global pandemic, when the challenges and importance of cooperation have never been greater, The Social Instinct is an exhilarating, farreaching and thought-provoking journey through all life on Earth, with profound insights into what makes us human and how our societies work.

'Gow reinvents what it means to be a guardian of the countryside.'-Guardian 'Gow has a fire in his belly. We need more like him.'-BBC Wildlife magazine Birds, Beasts and Bedlam recounts the adventures of farmer-turned-rewilder Derek Gow, who is saving Britain's much-loved but dangerously threatened species, from the water vole to beaver, wildcat to white stork and tree frog to glow worm. Derek tells us all about the realities of rewilding; how he reared delicate roe deer and a sofa-loving wild boar piglet, moved a raging bison bull across the country, got bitten by a Scottish wildcat, returned honking skeins of graylag geese to the land and water that was once theirs, and restored the white stork to the Knepp Estate with Charlie Burrell and Isabella Tree. Derek's first book, Bringing Back the Beaver, was a riotously funny and subversive account of his single-handed reintroduction of the beaver in Britain. Birds, Beasts and Bedlam, a natural successor to Gerald Durrell's A Zoo in My Luggage, tells the story of Derek's rewilding journey and his work to save many more species by transforming his Devon farm into a wildlife breeding centre. He now houses beavers, white storks, water voles, lynx, wildcats and harvest mice, with the aim of releasing them into the wild one day. Tearing down fences literally and metaphorically, Derek Gow is the one person with the character and strength of will to defy authority, bend the rules - and save our wildlife. 'The radical rewilder.'-The Times 'Derek Gow wants his farm to be a breeding colony, a seedbed for a denuded island.'-The New Yorker

Your brain is a collection of maps. That is no metaphor: scrawled across your brain's surfaces are actual schematic images of the sights, sounds, and actions that hold the key to your survival. Scientists first began uncovering these maps over a century ago, but we are only now beginning to unlock their secrets. Our inner cartography distorts and shapes our experience of the world, supporting complex thought, and making technology-enabled mind-reading a reality. The maps in our brain invite us to view ourselves from a startling new perspective. In Brainscapes, Rebecca Schwarzlose combines unforgettable real-life stories, cutting-edge research, and vivid illustrations to reveal brain maps' surprising lessons about our place in the world - and the world's place within us.

Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

Year One of Practice Transition: The Necessary Guide to Success is a practical guide for both established physicians transitioning from one practice opportunity to another, and those transitioning from formal residency or fellowship training. This book is an up-to-date look at how to achieve a successful practice, offering insights from top experts who have navigated transition through various phases and circumstances.

Collected for the first time, these Dune novellas by bestselling authors Brian Herbert and Kevin J. Anderson shine a light upon the darker corners of the Dune universe. Spanning space and time, Sands of Dune is essential reading for any fan of the series. The world of Dune has shaped an entire generation of science fiction. From the sand blasted world of Arrakis, to the splendor of the imperial homeworld of Kaitain, readers have lived in a universe of treachery and wonder. Now, these stories expand on the Dune universe, telling of the lost years of Gurney Halleck as he works with smugglers on Arrakis in a deadly gambit for revenge; inside the ranks of the Sardaukar as the child of a betrayed nobleman becomes one of the Emperor's most ruthless fighters; a young firebrand Fremen woman, a guerrilla fighter against the ruthless Harkonnens, who will one day become Shadout Mapes.

Methodological Approaches for Sleep and Vigilance Research examines experimental procedures used to study the sleep-wake cycle, with topics covered by world leaders in the field. The book focuses on techniques commonly used in the sleep field, including polysomnography, electrophysiology, single- and multi-unit spiking activity recording, brain stimulation, EEG power spectra, optogenetics, telemetry, and wearable and non-wearable tracking devices. Further chapters on imaging techniques, questionnaires for sleep assessment, genome-wide association studies, artificial intelligence and big data are also featured. This discussion of significant conceptual advances into experimental procedures is suitable for anyone interested in the neurobiology of sleep.

Blood gas tests are a group of tests that are widely used and essential for the evaluation and management of a patient's ventilation, oxygenation, and acid-base balance, often in emergent situations, and along with blood gases are other critical care analytes measured on blood: calcium, magnesium, phosphate, and lactate. Blood Gases and Critical Care Testing: Clinical Interpretations and Laboratory Applications, Third Edition, serves as your single most important reference for understanding blood gases and critical care testing and interpretation. The third edition of this classic book is a complete revision and provides the fundamentals of blood gas (pH, pCO2, pO2) and other critical care tests (calcium, magnesium, phosphate, and lactate), including the history, the definitions, the physiology, and practical information on sample handling, quality control and reference intervals. Case examples with clear clinical interpretations of critical care tests have been included to all chapters. This book will serve as a valuable and convenient resource for clinical laboratory scientists in understanding the physiology and clinical use of these critical care tests and for providing practical guidelines for successful routine testing and quality monitoring of these tests.

Wound Healing, and the Myofibroblast: A Historical and Biological Perspective is the fruit of an interdisciplinary and international collaboration involving a historian of medicine (Dr. Zampieri), a physician (Dr. Coen), and a researcher (Prof. Gabbiani, world-renowned for his discovery of the myofibroblast). This book aims to draw a concise yet complete description of the conceptual evolution of wound healing, fibrosis and fibrosis-related pathologies from antiquity to present time, as well as commenting on the role of the myofibroblast and the key cell type essential for tissue repair and fibrosis (from its identification in 1971 throughout its 50-years-old history). By viewing this complex and century-long history from different perspectives, the book's authors aim to draw an exhaustive overview, with the hope of inspiring new and fruitful basic and clinical research.

Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects.

Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.

Retinal Computation summarizes current progress in defining the computations performed by the retina, also including the synaptic and circuit mechanisms by which they are implemented. Each chapter focuses on a single retinal computation that includes the definition of the computation and its neuroethological purpose, along with the available information on its known and unknown neuronal mechanisms. All chapters contain end-of-chapter questions associated with a landmark paper, as well as programming exercises. This book is written for advanced graduate students, researchers and ophthalmologists interested in vision science or computational neuroscience of sensory systems. While the typical textbook's description of the retina is akin to a biological video camera, the real retina is actually the world's most complex image processing machine. As part of the central nervous system, the retina converts patterns of light at the input into a rich palette of representations at the output. The parallel streams of information in the optic nerve encode features like color, contrast, orientation of edges, and direction of motion. Image processing in the retina is undeniably complex, but as one of the most accessible parts of the central nervous system, the tools to study retinal circuits with unprecedented precision are up to the task. This book provides a practical guide and resource about the current state of the field of retinal computation.

For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis?, spinal muscular atrophy, multiple sclerosis, Parkinson's disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it.

Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products derived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients. This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedical field interested in understanding more about natural products with anticancer potential.

'Gow reinvents what it means to be a guardian of the countryside.'-Guardian 'This authentic, impassioned manifesto-cum-memoir will hopefully have a major impact on what is likely to be a long-running controversy.'-The Spectator 'Gow has a fire in his belly. We need more like him.'-BBC Wildlife Magazine A Waterstones Best Nature Writing Book of 2020 'Bringing Back the Beaver is a hilarious, eccentric and magnificent account of a struggle . . . to reintroduce a species crucial to the health of our ecosystems.'-George Monbiot Bringing Back the Beaver is farmer-turned-ecologist Derek Gow's inspirational and often riotously funny first-hand account of how the movement to rewild beavers into the British landscape became the single most dramatic and subversive nature conservation act of the modern era. Since the early 1990s - in the face of outright opposition from government, landowning elites and even some conservation professionals - Gow has imported, quarantined and assisted the reestablishment of beavers in waterways across England and Scotland. With a foreword by bestselling author of Wilding, Isabella Tree, Bringing Back the Beaver makes a passionate case as to why the return of one of nature's great problem solvers will be critical as part of a sustainable fix for the UK's growing flooding problems, whilst ensuring the creation of essential landscapes that enable the broadest spectrum of Britain's wildlife to thrive. 'It is wonderful to see that beavers are now officially back on the list of native species, having been absent for so long . . . far too long!'-Dame Judi Dench

'Punchy, funny and invigorating ... Pinker is the high priest of rationalism' Sunday Times 'If you've ever considered taking drugs to make yourself smarter, read Rationality instead. It's cheaper, more entertaining, and more effective' Jonathan Haidt, author of The Righteous Mind In the twenty-first century, humanity is reaching new heights of scientific understanding - and at the same time appears to be losing its mind. How can a species that discovered vaccines for Covid-19 in less than a year produce so much fake news, quack cures and conspiracy theorizing? In Rationality, Pinker rejects the cynical cliche that humans are simply an irrational species - cavemen out of time fatally cursed with biases, fallacies and illusions. After all, we discovered the laws of nature, lengthened and enriched our lives and set the benchmarks for rationality itself. Instead, he explains, we think in ways that suit the low-tech contexts in which we spend most of our lives, but fail to take advantage of the powerful tools of reasoning we have built up over millennia: logic, critical thinking, probability, causal inference, and decision-making under uncertainty. These tools are not a standard part of our educational curricula, and have never been presented clearly and entertainingly in a single book - until now. Rationality matters. It leads to better choices in our lives and in the public sphere, and is the ultimate driver of social justice and moral progress. Brimming with insight and humour, Rationality will enlighten, inspire and empower. 'A terrific book, much-needed for our time' Peter Singer

Biometals in Autism Spectrum Disorders focuses on trace metals and autism. Compared to other references examining ASDs or metallomics, this book presents findings of abnormal metal homeostasis in ASD, providing an overview of current findings on trace metal biology, its role in ASD etiology, and how abnormal trace metal biology may be a common factor of several genetic and non-genetic causes of ASDs that were once considered unrelated. This comprehensive resource opens new vistas for the development of new therapies based on the targeted manipulation of trace metal homeostasis that will generate new awareness surrounding trace metal levels during pregnancy.

Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area.