This is the story of a race - not against other vaccines or other scientists, but against a deadly and devastating virus.

On 1 January 2020, Sarah Gilbert, Professor of Vaccinology at Oxford University, read an article about four people in China with a strange pneumonia. Within two weeks, she and her team had designed a vaccine against a pathogen that no one had ever seen before. Less than 12 months later, vaccination was rolled out across the world to save millions of lives from Covid-19. In Vaxxers, we hear directly from Professor Gilbert and her colleague Dr Catherine Green as they reveal the inside story of making the Oxford AstraZeneca vaccine and the cutting-edge science and sheer hard work behind it.

This is their story of fighting a pandemic as ordinary people in extraordinary circumstances. Sarah and Cath share the heart-stopping moments in the eye of the storm; they separate fact from fiction; they explain how they made a highly effective vaccine in record time with the eyes of the world watching; and they give us hope for the future.

Vaxxers invites us into the lab to find out how science will save us from this pandemic, and how we can prepare for the inevitable next one.

In the twenty-first century, humanity is reaching new heights of scientific understanding - and at the same time appears to be losing its mind. How can a species that discovered vaccines for Covid-19 in less than a year produce so much fake news, quack cures and conspiracy theorizing?

In Rationality, Pinker rejects the cynical cliché that humans are simply an irrational species - cavemen out of time fatally cursed with biases, fallacies and illusions. After all, we discovered the laws of nature, lengthened and enriched our lives and set the benchmarks for rationality itself. Instead, he explains, we think in ways that suit the low-tech contexts in which we spend most of our lives, but fail to take advantage of the powerful tools of reasoning we have built up over millennia: logic, critical thinking, probability, causal inference, and decision-making under uncertainty. These tools are not a standard part of our educational curricula, and have never been presented clearly and entertainingly in a single book - until now.

Rationality matters. It leads to better choices in our lives and in the public sphere, and is the ultimate driver of social justice and moral progress. Brimming with insight and humour, Rationality will enlighten, inspire and empower.

You make hundreds of decisions every day, from what to eat for breakfast to how to influence people, and not one of them could be made without the essential component of emotion.

It has long been held that thinking and feeling are separate and opposing forces in our behaviour. But as best-selling author Leonard Mlodinow tells us, extraordinary advances in psychology and neuroscience have proven that emotions are as critical to our well-being as thinking.

How can you connect better with others? How can you improve your relationship to frustration, fear, and anxiety? What can you do to live a happier life? The answers lie in understanding emotions.

Taking us on a journey from the labs of pioneering scientists to real-world scenarios that have flirted with disaster, Mlodinow shows us how our emotions help, why they sometimes hurt, and what we can make of the difference. Cutting-edge research and deep insights into our evolution, biology, and neuroscience promise to help us understand our emotions better and maximize their benefits.

Told with characteristic clarity and fascinating stories, Mlodinow's exploration of the new science of feelings is an essential guide to making the most of one of nature's greatest gifts to us.

A groundbreaking exploration of the neuroscience of spirituality and a bold new paradigm for health, healing, and resilience.

Whether it's meditation or a walk in nature, reading a sacred text or saying a prayer, there are many ways to tap into a heightened awareness of the world around us and our place in it. Lisa Miller draws on decades of clinical experience and award-winning research to show that humans are universally equipped with this capacity for spirituality, and that our brains become more resilient and robust as a result of it. Bringing scientific rigour to the most intangible aspect of our lives, Miller's counterintuitive findings reveal the measurable positive effects of spirituality: for better decision-making, a healthier brain and an inspired life.

Brimming with inspiration and compassion, this landmark book revolutionizes our understanding of spirituality, mental health and how to find meaning and purpose in life.

A true-life scientific adventure story, this thrilling book takes the reader deep into South African caves to discover fossil remains that compel a monumental reframing of the human family tree.

In the summer of 2022, Lee Berger lost 50 pounds in order to wriggle though impossibly small openings in the Rising Star cave complex in South Africa—spaces where his team has been unearthing the remains of Homo naledi, a proto-human likely to have coexisted with Homo sapiens some 250,000 years ago. The lead researcher on the site, still Berger had never made his way into the dark, cramped, dangerous underground spaces where many of the naledi fossils had been found. Now he was ready to do so.

Once inside the cave, Berger made shocking new discoveries that expand our understanding of this early hominid—discoveries that stand to alter our fundamental understanding of what makes us human. So what does it all mean?

Join Berger on the adventure of a lifetime as he explores the Rising Star cave system and begins the complicated process of explaining these extraordinary finds—finds that force a rethinking of human evolution, and discoveries that Berger calls “the Rosetta stone of the human mind.”

Professor Steve Peters is a Consultant Psychiatrist and author of the bestselling self-help book, The Chimp Paradox. He has years of experience as a clinician, an educator and has worked with some of the world's most successful athletes. His new book 'A Path through the Jungle' will help you to become robust and resilient. Professor Peters explains complex neuroscience in straightforward terms with his Chimp Management Mind Model Robust: Becoming robust means having plans in place to manage your own mind and whatever situations you meet in life. Resilient: is being able to bounce back and manage the challenges of life. Resilience is a skill. A Path through the Jungle offers a structured programme with exercises and practical real-life examples. This book will help you to improve in areas such as: * Managing stress and anxiety * Improved relationships * Emotional management * Grief and loss * Self-confidence * Peace of mind * Happiness * Managing stress

In the past few years, the subject of climate change has frequently garnered headlines due to the usual political controversy surrounding it. However, setting aside the argument as to whether climate change is a man-made effect or not, we cannot deny the fact that humanity has been discharging carbon increasingly into the atmosphere for centuries. Likewise, similar reports on the growing Great Pacific Garbage Patch-and the general accumulation of plastics everywhere-are alarming. Moreover, it has also been recently demonstrated that microplastics are finally entering the food webs which include the human consumer. Air, soil, and water pollution are increasing; in some ways forcing certain countries and governments to modify their politics, while also creating new opportunities and opening new niches for the marketing of products, such as air and water filters. With current techniques, it is not possible to completely eliminate all toxic and hazardous waste, which means that security deposits are necessary. Security deposits are storage areas prepared for certain toxic and dangerous industrial waste, so that its harmful properties cannot affect the natural environment and human health-at least, in any case, for a very long time. Due to their geomorphological composition, topography, and hydrographic conditions, there are sites that can be used as waste deposits, given their natural isolation and projected stability for hundreds of years. Thus, they become security deposits. In addition, every day new materials and construction techniques are developed that allow for a total isolation of the waste. A relatively new view in the material life cycle is the reuse of the generated waste as new resources. This helps to mitigate the cost increases in raw materials, energy, and regulations regarding waste disposal, which have caused the industry to rethink its production methods, leading to a better use of raw materials and energy. Clean technologies are those used by the industry to reduce the need for treatment or disposal of waste and to reduce the demand for raw materials, energy, and water. For the proper implementation of clean technologies, industries and municipalities must develop a deep understanding of their own processes and activities, and must analyze the characteristics of their equipment and make any possible modifications. An environmental evaluation of the situation provides suitable information on the efficiency of each component and its integration in the whole process, on the proportion of waste, on energy consumption, and on how to reorganize or modify to improve cost-efficiency in economic and environmental terms, which in a middle term view results in synergistic goals. With this concise introduction to the world of waste and pollutant treatment technologies, the editors believe it is clear that the solutions are to be developed on a case-by-case basis; because the larger the number of mixed pollutants, the more complex and intimated the process will be. This book presents a series of selected approaches that can be used to approach different cases, also depending upon budget and viability of a sustainable approach. This book serves as a source of information, triggers ideas, and fosters interaction between all the players taking action in sustainable development initiatives.

Levels of mycotoxin contamination in agricultural commodities are regulated in more than 100 countries, and exposure to these naturally occurring toxins presents serious risks to the health of humans and animals with negative impacts to commodity values. This symposium series book presents significant scientific developments in the multifaceted approach to reducing exposure to these naturally occurring toxins. A broad-spectrum of subject matter of the multidisciplinary field of mycotoxin research is conveniently compiled in this single volume, and general themes include prevention, control, exposure, molecular biology, biosynthesis, analytical methodology, and emerging techniques. The book opens with an overview of prevention of mycotoxin production by means of biological control and human exposure to contaminated foods, including tofu, apples, figs, and a broad range of fruits.
The second section focuses on molecular biological approaches to control mycotoxin exposure. Topics covered include genomic approaches, detoxification, structure-activity studies of biosynthetic precursors, and mycotoxin biosynthesis. The success of these strategies is supported by the reduction of mycotoxin occurrence and incidence in foods. Accurate estimates of mycotoxin concentration in foods are important for food safety and wholesomeness.
The final section covers analytical approaches, including sampling plans for foods and dietary supplements, extraction efficiency of mycotoxins from naturally contaminated grains, traditional detection methods such as chromatography/mass spectrometry, and emerging techniques such as the use of molecularly imprinted polymers for purification and isolation and cyclodextrins for fluorescent enhancement of several mycotoxins.

Measuring metabolic rates is central to important questions in many areas of scientific research. Unfortunately these measurements are anything but straightforward, and numerous pitfalls await the novice and even the experienced investigator.
Measuring Metabolic Rates de-mystifies the field, explaining every common variation of metabolic rate measurement, from century-old manometric methods through ingenious syringe-based techniques, direct calorimetry, aquatic respirometry, stable-isotope metabolic measurement and every type of flow-through respirometry. Each variation is described in enough detail to allow it to be applied in practice. Background information on different analyzer and equipment types allows users to choose the best instruments for their application. Respirometry equations - normally a topic of terror and confusion to researchers - are derived and described in enough detail to make their selection and use effortless.
Vital topics such as manual and automated baselining, implementing multi-animal systems, and the correct analysis and presentation of metabolic data are covered in enough detail to turn a respirometry neophyte into a hardened metabolic warrior, ready to take on the task of publication in peer-reviewed journals.

The human pathogens Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. N. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock. Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. In contrast, there are no current vaccination prospects for N. gonorrhoeae, the causative agent of sexually transmitted gonorrhoea. Historically, infections caused by N. gonorrhoeae were treated with antibiotics. However, the recent advent of new strains with resistance to all known antibiotics is causing such treatment regimes to fail, necessitating the need for new and more effective control strategies. In this book, leading Neisseria authorities review the most important research on pathogenic Neisseria to provide a timely overview of the field. The topics covered include: the link between pathogenesis and important metabolic pathways * vaccine development * antibiotic resistance * transcriptomics of regulatory networks * regulatory small RNAs * interactions with neutrophils * advances in humanized mouse models. An essential guide for research scientists, advanced students, clinicians, and other professionals working with Neisseria, the book is a recommended text for all microbiology libraries.

The third edition of The Basics of Bioethics continues to provide a balanced and systematic ethical framework to help students analyze a wide range of controversial topics in medicine, and consider ethical systems from various religious and secular traditions. The Basics of Bioethics covers the "Principalist" approach and identifies principles that are believed to make behavior morally right or wrong. It showcases alternative ethical approaches to health care decision making by presenting Hippocratic ethics as only one among many alternative ethical approaches to health care decision-making. The Basics of Bioethics offers case studies, diagrams, and other learning aids for an accessible presentation. Plus, it contains an all-encompassing ethics chart that shows the major questions in ethics and all of the major answers to these questions.

A creative memoir by the 2019 Wellcome Prize winner Will Eaves chronicles a year spent writing a sonata from scratch, in full recognition of the likelihood of failure, to see what can be learned about ambition and limitation. And time. The Point of Distraction explores the way that second-string activities bring one's main interests in life into focus, considering artists as critics, writers as musicians. Staring at your creative pursuit straight on can render it impossible, but if you let it occupy the space of distraction, to your side, it lives and breathes. This novel memoir touches on neuroscience, musical theory and will power.

This volume presents state-of-the-art empirical studies working in a paradigm that has become known as human behavioral ecology. The emergence of this approach in anthropology was marked by publication by Aldine in 1979 of an earlier collection of studies edited by Chagnon and Irons entitled Evolutionary Biology and Human Social Behavior: An Anthropological Perspective. During the two decades that have passed since then, this innovative approach has matured and expanded into new areas that are explored here.

The book opens with an introductory chapter by Chagnon and Irons tracing the origins of human behavioral ecology and its subsequent development. Subsequent chapters, written by both younger scholars and established researchers, cover a wide range of societies and topics organ-ized into six sections. The first section includes two chapters that provide historical background on the development of human behavioral ecology and com-pare it to two complementary approaches in the study of evolution and human behavior, evolutionary psychology, and dual inheritance theory. The second section includes five studies of mating efforts in a variety of societies from South America and Africa. The third section covers parenting, with five studies on soci-eties from Africa, Asia, and North America. The fourth section breaks somewhat with the tradition in human behavioral ecology by focusing on one particularly problematic issue, the demographic transition, using data from Europe, North America, and Asia. The fifth section includes studies of cooperation and helping behaviors, using data from societies in Micronesia and South America. The sixth and final section consists of a single chapter that places the volume in a broader critical and comparative context.

The contributions to this volume demonstrate, with a high degree of theoretical and methodological sophistication--the maturity and freshness of this new paradigm in the study of human behavior. The volume will be of interest to anthropologists and other professions working on the study of cross-cultural human behavior.

This book is about pleasure. It's also about pain. Most important, it's about how to find the delicate balance between the two, and why now more than ever finding balance is essential.

We're living in a time of unprecedented access to high-reward, high-dopamine stimuli: drugs, food, news, gambling, shopping, gaming, texting, sexting, Facebooking, Instagramming, YouTubing, tweeting... The increased numbers, variety, and potency is staggering. The smartphone is the modern-day hypodermic needle, delivering digital dopamine 24/7 for a wired generation. As such we've all become vulnerable to compulsive overconsumption.

In Dopamine Nation, Dr. Anna Lembke, psychiatrist and author, explores the exciting new scientific discoveries that explain why the relentless pursuit of pleasure leads to pain...and what to do about it. Condensing complex neuroscience into easy-to-understand metaphors, Lembke illustrates how finding contentment and connectedness means keeping dopamine in check. The lived experiences of her patients are the gripping fabric of her narrative. Their riveting stories of suffering and redemption give us all hope for managing our consumption and transforming our lives. In essence, Dopamine Nation shows that the secret to finding balance is combining the science of desire with the wisdom of recovery.

A BOOK OF THE YEAR GUARDIAN, THE ECONOMIST, NEW STATESMAN, FINANCIAL TIMES, BLOOMBERG Anil Seth's radical new theory of consciousness challenges our understanding of perception and reality, doing for brain science what Dawkins did for evolutionary biology. 'A brilliant beast of a book.' DAVID BYRNE 'Hugely important.' JIM AL-KHALILI 'Masterly . . . An exhilarating book: a vast-ranging, phenomenal achievement that will undoubtedly become a seminal text.' GAIA VINCE, GUARDIAN Being You is not as simple as it sounds. Somehow, within each of our brains, billions of neurons work to create our conscious experience. How does this happen? Why do we experience life in the first person? After over twenty years researching the brain, world-renowned neuroscientist Anil Seth puts forward a radical new theory of consciousness and self. His unique theory of what it means to 'be you' challenges our understanding of perception and reality and it turns what you thought you knew about yourself on its head. 'Seth thinks clearly and sharply on one of the hardest problems of science and philosophy, cutting through weeds with a scientist's mind and a storyteller's skill.' ADAM RUTHERFORD 'A page-turner and a mind-blower . . . Beautifully written, crystal clear, deeply insightful.' DAVID EAGLEMAN 'If you read one book about conciousness, it must be Seth's. JULIAN BAGGINI, WALL STREET JOURNAL 'Amazing.' RUSSELL BRAND 'Gripping.' ALEX GARLAND 'I loved it.' MICHAEL POLLAN 'Fascinating.' FINANCIAL TIMES 'Awe-inspring.' NEW STATESMAN 'Brilliant.' CLAIRE TOMALIN, NEW YORK TIMES

'Gow reinvents what it means to be a guardian of the countryside.'-Guardian 'This authentic, impassioned manifesto-cum-memoir will hopefully have a major impact on what is likely to be a long-running controversy.'-The Spectator 'Gow has a fire in his belly. We need more like him.'-BBC Wildlife Magazine A Waterstones Best Nature Writing Book of 2020 'Bringing Back the Beaver is a hilarious, eccentric and magnificent account of a struggle . . . to reintroduce a species crucial to the health of our ecosystems.'-George Monbiot Bringing Back the Beaver is farmer-turned-ecologist Derek Gow's inspirational and often riotously funny first-hand account of how the movement to rewild beavers into the British landscape became the single most dramatic and subversive nature conservation act of the modern era. Since the early 1990s - in the face of outright opposition from government, landowning elites and even some conservation professionals - Gow has imported, quarantined and assisted the reestablishment of beavers in waterways across England and Scotland. With a foreword by bestselling author of Wilding, Isabella Tree, Bringing Back the Beaver makes a passionate case as to why the return of one of nature's great problem solvers will be critical as part of a sustainable fix for the UK's growing flooding problems, whilst ensuring the creation of essential landscapes that enable the broadest spectrum of Britain's wildlife to thrive. 'It is wonderful to see that beavers are now officially back on the list of native species, having been absent for so long . . . far too long!'-Dame Judi Dench

The evolution of a classic The new 12th edition of Introduction to Genetic Analysis takes this cornerstone textbook to the next level. The hallmark focuses on genetic analysis, quantitative problem solving, and experimentation continue in this new edition while incorporating robust updates to the science. Introduction to Genetic Analysis is now supported in Achieve, Macmillan's new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for biology students. It houses all of our renowned assessments, multimedia assets, e-books, and instructor resources in a powerful new platform.

A Best Book of 2020: The Washington Post * NPR * Chicago Tribune * Smithsonian A "remarkable" (Los Angeles Times), "seductive" (The Wall Street Journal) debut from the new cohost of Radiolab, Why Fish Don't Exist is a dark and astonishing tale of love, chaos, scientific obsession, and--possibly--even murder. "At one point, Miller dives into the ocean into a school of fish...comes up for air, and realizes she's in love. That's how I felt: Her book took me to strange depths I never imagined, and I was smitten." --The New York Times Book Review David Starr Jordan was a taxonomist, a man possessed with bringing order to the natural world. In time, he would be credited with discovering nearly a fifth of the fish known to humans in his day. But the more of the hidden blueprint of life he uncovered, the harder the universe seemed to try to thwart him. His specimen collections were demolished by lightning, by fire, and eventually by the 1906 San Francisco earthquake--which sent more than a thousand discoveries, housed in fragile glass jars, plummeting to the floor. In an instant, his life's work was shattered. Many might have given up, given in to despair. But Jordan? He surveyed the wreckage at his feet, found the first fish that he recognized, and confidently began to rebuild his collection. And this time, he introduced one clever innovation that he believed would at last protect his work against the chaos of the world. When NPR reporter Lulu Miller first heard this anecdote in passing, she took Jordan for a fool--a cautionary tale in hubris, or denial. But as her own life slowly unraveled, she began to wonder about him. Perhaps instead he was a model for how to go on when all seemed lost. What she would unearth about his life would transform her understanding of history, morality, and the world beneath her feet. Part biography, part memoir, part scientific adventure, Why Fish Don't Exist is a wondrous fable about how to persevere in a world where chaos will always prevail.

Sentient assembles a menagerie of zoological creatures – from land, air, sea and all four corners of the globe – to understand what it means to be human. Through their eyes, ears, skins, tongues and noses, the furred, finned and feathered reveal how we sense and make sense of the world, as well as the untold scientific revolution stirring in the field of human perception.

The harlequin mantis shrimp can throw a punch that can fracture aquarium walls but, more importantly, it has the ability to see a vast range of colours. The ears of the great grey owl have such unparalleled range and sensitivity that they can hear twenty decibels lower than the human ear. The star-nosed mole barely fills a human hand, seldom ventures above ground and poses little threat unless you are an earthworm, but its miraculous nose allows it to catch those worms at astonishing speed – as little as one hundred and twenty milliseconds. Here, too, we meet the four-eyed spookfish and its dark vision; the vampire bat and its remarkable powers of touch; the bloodhound and its hundreds of millions of scent receptors, as well as the bar-tailed godwit, the common octopus, giant peacocks, cheetahs and golden orb-weaving spiders. Each of these extraordinary creatures illustrates the sensory powers that lie dormant within us.

In this captivating book, Jackie Higgins explores this evolutionary heritage and, in doing so, enables us to subconsciously engage with the world in ways we never knew possible.

WINNER OF THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2022 'Exhilaratingly whizzes through billions of years . . . Gee is a marvellously engaging writer, juggling humour, precision, polemic and poetry to enrich his impossibly telescoped account . . . [making] clear sense out of very complex narratives' - The Times 'Henry Gee makes the kaleidoscopically changing canvas of life understandable and exciting. Who will enjoy reading this book? - Everybody!' Jared Diamond, author of Guns, Germs, and Steel For billions of years, Earth was an inhospitably alien place - covered with churning seas, slowly crafting its landscape by way of incessant volcanic eruptions, the atmosphere in a constant state of chemical flux. And yet, despite facing literally every conceivable setback that living organisms could encounter, life has been extinguished and picked itself up to evolve again. Life has learned and adapted and continued through the billions of years that followed. It has weathered fire and ice. Slimes begat sponges, who through billions of years of complex evolution and adaptation grew a backbone, braved the unknown of pitiless shores, and sought an existence beyond the sea. From that first foray to the spread of early hominids who later became Homo sapiens, life has persisted, undaunted. A (Very) Short History of Life is an enlightening story of survival, of persistence, illuminating the delicate balance within which life has always existed, and continues to exist today. It is our planet like you've never seen it before. Life teems through Henry Gee's words - colossal supercontinents drift, collide, and coalesce, fashioning the face of the planet as we know it today. Creatures are engagingly personified, from 'gregarious' bacteria populating the seas to duelling dinosaurs in the Triassic period to magnificent mammals with the future in their (newly evolved) grasp. Those long extinct, almost alien early life forms are resurrected in evocative detail. Life's evolutionary steps - from the development of a digestive system to the awe of creatures taking to the skies in flight - are conveyed with an alluring, up-close intimacy.