Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment, Volume 261, the latest release in the Neuropharmacology of Neuroprotection series, presents the latest research on the topic of Progress in Brain Research. This series highlights new advances in the field, providing comprehensive and timely chapters written by an international board of esteemed authors.

Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim's appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies.

The Beans and the Peas: From Orphan to Mainstream Crops presents a comprehensive literature resource on the most important food legume crops previously known as "orphans," but which are increasingly becoming mainstream as their production opportunities have been improved through genetic improvement and biotechnology, and their role as an important nutrient source gains urgency. This book focuses on 12 important food legumes and discusses all relevant aspects on their economic importance, crop statistics, botany, and their general description. It also provides exhaustive information on plant genetic resources and their use, genetic improvement, resistance to biotic and abiotic stresses, improved varieties, agronomy, seed system, and use of information and communication tools in each individual food legume. Development of innovative biotechnological tools, genetic transformation, and the genome sequencing information has also been covered in each chapter providing the readers with state-of-the-art information on pulses. All chapters have been supported by relevant figures, illustrations, and tables, which make the contents accessible and easy to understand. Each of the chapters has been authored by globally known scientists/researchers presenting up-to-date information on various aspects of food legumes. This book provides a current and comprehensive treatise to the readers and will be tremendously helpful in furthering their academic and research pursuits.

Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation, and dissemination of pragmatic randomized trials, also sometimes referred to as practical or hybrid randomized trials. While less restrictive and more generalizable than traditional randomized controlled trials, such trials have specific challenges which are addressed in this book. The book contains chapters encompassing common designs along with advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize pragmatic randomized trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed. This comprehensive resource is valuable not only for pharmacoepidemiologists, biostatisticians and clinical researchers, but also across the biomedical field for those who are interested in applying pragmatic randomized clinical trials in their research.

Written by leading experts in their respective fields, Principles and Applications of Soil Microbiology 3e, provides a comprehensive, balanced introduction to soil microbiology, and captures the rapid advances in the field such as recent discoveries regarding habitats and organisms, microbially mediated transformations, and applied environmental topics. Carefully edited for ease of reading, it aids users by providing an excellent multi-authored reference, the type of book that is continually used in the field. Background information is provided in the first part of the book for ease of comprehension. The following chapters then describe such fundamental topics as soil environment and microbial processes, microbial groups and their interactions, and thoroughly addresses critical nutrient cycles and important environmental and agricultural applications. An excellent textbook and desk reference, Principles and Applications of Soil Microbiology, 3e, provides readers with broad, foundational coverage of the vast array of microorganisms that live in soil and the major biogeochemical processes they control. Soil scientists, environmental scientists, and others, including soil health and conservation specialists, will find this material invaluable for understanding the amazingly diverse world of soil microbiology, managing agricultural and environmental systems, and formulating environmental policy.

Human sexuality touches us all, pun intended. We all either enjoy it, struggle with it, or may have been victims of it. Sexuality is not just about sex, but about human sexual function, the physiology of sex, the hormones involved and how they affect us, and the cultural norms related to it. Sexual function and dysfunction are closely tied to one's self-esteem, self-respect, and to relationships with intimate partners. Human Sexuality: Function, Dysfunction, Paraphilias, and Relationships, explores the interplay of intimacy and sexuality; how it can enhance relationships, and how it can negatively affect them, or be affected by them. When individuals or partners encounter sexual problems or dysfunctions it can have a long-lasting affect both biologically and psychologically. Dr. Rokach explores the causes and the reasons that these dysfunctions are maintained, and successful treatment methods. Chapters on sexual offenses and paraphilias and what treatment options are available to sexual offenders are also included. This book is the first book to place sexuality where it belongs, within the context of relationships demonstrating how sexuality relates to intimacy by both enhancing and negatively affecting it.

5-HT Interaction with Other Neurotransmitters: Experimental Evidence and Therapeutic Relevance, Part B, Volume 260 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Serotonin-noradrenalin interactions, Electrophysiological and neurochemical evidence for an interaction of serotonin on noradrenergic neurons, Serotonin and cannabinoid system, 5-HT/CB interaction in the CNS in health and disease, Serotonin2A receptors and Cannabinoids, CB1/5-HT/GABA in food intake, A close interaction between serotonergic system and BDNF in the mechanism of action of antidepressant, 5-HT/ Ach, Interaction of 5-HT2A/2C ligands and nicotine, and more.

Eutectic Solvents and Stress in Plants, Volume 97 in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters surrounding NADES: from simple systems to complex colloidal mixtures, DES nanostructures with water, micelle and DES interaction, Dissolving proteins protein physics, Enzyme reactions in NADES, Protection against oxidation of metabolites, stability food, DES for pharmaceutical preparations, Cosmetics, Metabolons and bio-condensates: the essence of plant plasticity and the key elements in development of green production systems, Immediate in the whole plant during extreme conditions metabolomics, NADES in sees spores, and much more.

Is warfare a uniquely human behavior? Do you know how many human races there are? Have you ever wondered how evolution can be both a fact and a theory? How can we know about the distant past if we weren't there to witness it? How did we become who we are as a species, and what does that mean for other species and the rest of the planet? The Human Experiment: Origins and Evolution of Humanity touches on these and other big questions, and provides students with an introduction to what anthropologists know about the origins of the human condition. Topics include the study of anthropology; science, myth, religion and pseudoscience; evolution; common misconceptions about race; why anthropologists study nonhuman primates; and the emergence of biologically modern humans. Students learn about culture as human adaptation, peopling of the New World, the origins and consequences of food production, civilizations, and global warming. Designed to help students better understand the evolution of humankind, The Human Experiment is an ideal textbook for introductory anthropology courses. It provides a concise and accessible overview of the key developments in human prehistory and examples of how the knowledge of our shared past is continually being updated as new information is discovered.

No realm on Earth elicits thoughts of paradise more than the tropics. The tropical marine realm is special in myriad ways and for many reasons from seas of higher latitude, in housing iconic habitats such as coral reefs, snow white beaches, crystal clear waters, mangrove forests, extensive and rich seagrass meadows and expansive river deltas, such as the exemplar, the Amazon. But the tropics also has an even more complex side: tropical waters give rise to cyclones, hurricanes and typhoons, and unique oceanographic phenomena including the El Nino- Southern Oscillation which affects global climate patterns. Tropical Marine Ecology documents the structure and function of tropical marine populations, communities, and ecosystems in relation to environmental factors including climate patterns and climate change, and patterns of oceanographic phenomena such as tides and currents and major oceanographic features, as well as chemical and geological drivers. The book focuses on estuarine, coastal, continental shelf and open ocean ecosystems. The first part of the book deals with the climate, physics, geology, and chemistry of the tropical marine environment. The second section focuses on the origins, diversity, biogeography, and the structure and distribution of tropical biota. The third part explores the rates and patterns of primary and secondary production, and their drivers, and the characteristics of pelagic and benthic food webs. The fourth part examines how humans are altering tropical ecosystems via unsustainable fisheries, the decline and loss of habitat and fragmentation, Further, pollution is altering an earth already in the throes of climate change. Tropical Marine Ecology is an authoritative and comprehensive introduction to tropical marine ecology for advanced undergraduate and postgraduate students. It is also a rich resource and reference work for researchers and professional managers in marine science.

Many people have written biographies of Charles Darwin, but the story of his family and roots in Shrewsbury is little known. This book, containing original research, fills that gap. The key player is Charles' father, Dr Robert Darwin, a larger-than-life character whose financial acumen enabled Charles to spend his whole life on research unencumbered by money worries. Through Susannah, Charles' mother, we are introduced to the Wedgwood family, whose history was so closely interwoven with the Darwins. The stories of Charles' five siblings are detailed, and there is a wealth of local material, such as information on Shrewsbury School and its illustrious headmaster, Samuel Butler. The book is fully illustrated with contemporary and modern pictures, and will be of interest to anyone wanting to discover more about the development of Shrewsbury's most famous son.

Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural products derived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients. This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedical field interested in understanding more about natural products with anticancer potential.

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully.

Problems of Living: Perspectives from Philosophy, Psychiatry, and Cognitive-Affective Science addresses philosophical questions related to problems of living, including questions about the nature of the brain-mind, reason and emotion, happiness and suffering, goodness and truth, and the meaning of life. It draws on critical, pragmatic, and embodied realism as well as moral naturalism, and brings arguments from metaphysics, epistemology, and ethics together with data from cognitive-affective science. This multidisciplinary integrated approach provides a novel framework for considering not only the nature of mental disorders, but also broader issues in mental health, such as finding pleasure and purpose in life.

Paleocological Research on Easter Island: Insights on Settlement, Climate Changes, Deforestation and Cultural Shifts examines the area's climatic and ecological history, a topic not usually addressed in other literature. The book provides a thorough and synthetic account of all paleoecological works developed to date, including the latest discoveries. Finally, it attempts to match paleoecological evidence with the results of other disciplines creating a multidisciplinary framework. This approach to the field is ideal for researchers, university professors and graduate students in a varied range of disciplines and subdisciplines, including ecology, paleoecology, paleoclimatology, biogeography, sedimentology, and paleontology. Users will find synthesized information on Easter Island from the last millennia that will help pave the way towards an integrated interdisciplinary vision of the island's environmental-ecological-cultural system as a complex functional unit. Human and environmental deterministic views are avoided and the Easter Island enigmas are analyzed under a holistic perspective of continuous feedbacks and synergies among the different components of the system.

Advances in Ecological Research, Volume 63, the latest release in this ongoing series includes specific chapters on Tropical Ecosystems in the 21st Century. Chapters in this volume cover topics such as Landscape-scale expansion of agroecology to enhance natural pest control: a systematic review and Ecosystem services and the resilience of agricultural landscapes

Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more.

States and Processes for Mental Health: Advancing Psychotherapy Effectiveness presents a novel mechanism of action for psychotherapy, revealing how psychotherapy actually works by advancing key states and processes characterizing mental health. This new understanding is presented in three sections. The first section identifies 7 states and processes for mental health. The second section examines 15 major forms of psychotherapy and non-specific factors with a comprehensive overview of each, followed by an empirical and theoretical proof of concept showing how they do indeed enhance the states and processes for mental health. In the third section, the author explores conceptual and practical problems in the current approach to psychotherapy, whereby discrete forms of psychotherapy are oriented to remedying psychopathology. Dr. Bowins then offers a new trans-therapy approach applying general strategies and those derived from existing forms of psychotherapy, to advance each of the states and processes characterizing mental health.

Introduction to Deep Learning and Neural Networks with Python (TM): A Practical Guide is an intensive step-by-step guide for neuroscientists to fully understand, practice, and build neural networks. Providing math and Python (TM) code examples to clarify neural network calculations, by book's end readers will fully understand how neural networks work starting from the simplest model Y=X and building from scratch. Details and explanations are provided on how a generic gradient descent algorithm works based on mathematical and Python (TM) examples, teaching you how to use the gradient descent algorithm to manually perform all calculations in both the forward and backward passes of training a neural network.