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Nature in Silico - Population Genetic Simulation and its Evolutionary Interpretation Using C++ and R (Hardcover, 1st ed. 2022)
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Nature in Silico - Population Genetic Simulation and its Evolutionary Interpretation Using C++ and R (Hardcover, 1st ed. 2022)
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Dramatic advances in computing power enable simulation of DNA
sequences generated by complex microevolutionary scenarios that
include mutation, population structure, natural selection, meiotic
recombination, demographic change, and explicit spatial
geographies. Although retrospective, coalescent simulation is
computationally efficient-and covered here-the primary focus of
this book is forward-in-time simulation, which frees us to simulate
a wider variety of realistic microevolutionary models. The book
walks the reader through the development of a forward-in-time
evolutionary simulator dubbed FORward Time simUlatioN Application
(FORTUNA). The capacity of FORTUNA grows with each chapter through
the addition of a new evolutionary factor to its code. Each chapter
also reviews the relevant theory and links simulation results to
key evolutionary insights. The book addresses visualization of
results through development of R code and reference to more than
100 figures. All code discussed in the book is freely available,
which the reader may use directly or modify to better suit his or
her own research needs. Advanced undergraduate students, graduate
students, and professional researchers will all benefit from this
introduction to the increasingly important skill of population
genetic simulation.
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