We know the universe has a history, but does it also have a story of self-creation to tell? Yes, in Roy R. Gould’s account. He offers a compelling narrative of how the universe—with no instruction other than its own laws—evolved into billions of galaxies and gave rise to life, including humans who have been trying for millennia to comprehend it. Far from being a random accident, the universe is hard at work, extracting order from chaos. Making use of the best current science, Gould turns what many assume to be true about the universe on its head. The cosmos expands inward, not outward. Gravity can drive things apart, not merely together. And the universe seems to defy entropy as it becomes more ordered, rather than the other way around. Strangest of all, the universe is exquisitely hospitable to life, despite its being constructed from undistinguished atoms and a few unexceptional rules of behavior. Universe in Creation explores whether the emergence of life, rather than being a mere cosmic afterthought, may be written into the most basic laws of nature. Offering a fresh take on what brought the world—and us—into being, Gould helps us see the universe as the master of its own creation, not tethered to a singular event but burgeoning as new space and energy continuously stream into existence. It is a very old story, as yet unfinished, with plotlines that twist and churn through infinite space and time.

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field.

Fifty Years of Peeling Away the Lead Paint Problem: Saving Our Children's Future with Healthy Housing documents the history of childhood lead poisoning from paint between 1970 and 2022. Tracing the failure of the medical model (treatment after exposure) that marked the 1970s and 1980s and its replacement with a prevention housing-focused effort, the book documents the changes in health, housing and environmental science and policy. It is the first book to examine how the lead poisoning law in the U.S. was passed in 1992 and later implemented, with implications for the future, in particular, the emergence of a healthy housing movement. The book describes the roles played by Congress, various administrations, agencies, local governments, the private sector, researchers, and a popular citizen's movement, especially parents. The role of the courts is discussed, including a controversial lead paint case on research ethics in Baltimore through an environmental justice lens. This book is the first to examine another recent case in California, where ten local jurisdictions established a precedent by successfully suing the lead paint industry to help pay for abatement.

Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

Collective Memory, Volume 274 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of interesting topics, including Deriving testable hypotheses through an analogy between individual and collective memory and updated information on Collective future thinking: Current research and future directions.

William LaFleur (1936-2010), an eminent scholar of Japanese studies, left behind a substantial number of influential publications, as well as several unpublished works. The most significant of these examines debates concerning the practice of organ transplantation in Japan and the United States, and is published here for the first time. This provocative book challenges the North American medical and bioethical consensus that considers the transplantation of organs from brain dead donors as an unalloyed good. It joins a growing chorus of voices that question the assumption that brain death can be equated facilely with death. It provides a deep investigation of debates in Japan, introducing numerous Japanese bioethicists whose work has never been treated in English. It also provides a history of similar debates in the United States, problematizing the commonly held view that the American public was quick and eager to accept the redefinition of death. A work of intellectual and social history, this book also directly engages with questions that grow ever more relevant as the technologies we develop to extend life continue to advance. While the benefits of these technologies are obvious, their costs are often more difficult to articulate. Calling attention to the risks associated with our current biotech trajectory, LaFleur stakes out a highly original position that does not fall neatly onto either side of contemporary US ideological divides.

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

International Review on Neurobiology serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors.

Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more.

Plant Small RNA for Food Crops provides foundational insights into the role of small RNA in food crops in varying environmental conditions and how it can help in developing molecular frameworks to support agricultural sustainability to feed the world's population. Small RNA populations have been widely identified in various plants and have been reported to be involved in regulating the molecular functioning of plants and their responses for biotic and abiotic environmental factors. Until now, however, a detailed compilation of role of small RNAs in food crops growth, yield and environmental responses had been unavailable. This book provides a detailed description of role of various small RNAs whose utilization in a range of food crops may serve to improve sustainability, productivity, and maintenance during environmental stress conditions. It brings together the reported small RNAs along with their applications specific to food crops, but also covers recent studies, innovations and future perspectives.

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in different ways. Metals and organic compounds, both at high level acute exposure and long-term low-level exposure can affect motor functions, cognition, behavior and neurosensory functions. Sections cover Oil leakage in aircraft, aerotoxic syndrome, Organic solvents, WTC neurotoxicities, Environmental intolerance, Pesticides, Carbon monoxide, Mercury Neurotoxicity in Gold Miners, and the Current evolution of neurobehavioral methods.

Tabata Training: The Science and History of HIIT provides evidence and mechanism(s) that explain the beneficial effects Tabata training has on diseases like diabetes, cardiovascular diseases and colon cancer. The book also includes coverage of maximal oxygen uptake as an essential parameter of both sport and health-oriented fitness for researchers and exercisers. HIIT was first prepared for young adults, but nowadays, evidence has been accumulated to prescribe it to adult men and women. For kids, several papers have reported beneficial effects of Tabata training on normal and obese pupils of elementary to high school students as well as for physical education classes. Recent studies showed that not only improving sport performance, Tabata training contributes to good health outcomes in adults.

Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations' role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks.

Protein Interaction Networks, Volume 131 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Strategies to Mitigate the Toxicity of Cancer Therapeutics, Volume 155 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters, each of which is written by an international board of authors.

Application of Sampling and Detection Methods in Agricultural Plant Biotechnology describes detection methods for seed, plants and grain derived from biotechnology. This international handbook, based on a series of workshops carried out for governments in collaboration with ILSI and Co-published in partnership with the Cereals & Grains Association, provides the technical and practical information needed to develop, validate and use detection methods. This useful resource provides readers with the tools necessary to carry out reliable sampling, detection and interpretation of data.

Ecology and Biodiversity of Benthos provides insights into the characteristic features of marine and estuarine benthos that play an important role in coastal ecosystem functioning, a primary level in the food chain. The book provides the latest information on multidisciplinary reflections by various researchers studying the benthic community. Through the chapters, ecosystem services are explored as a way to share approaches and scientific methods to achieve knowledge-based sustainable planning and management of benthic ecosystems. This is a helpful guide for anyone working on marine and estuarine environments, and for those who need an introduction to benthic ecology. The book has a wide range of scientific coverage since it caters primarily to the requirement of marine ecologists, marine benthologists, EIA experts, aquatic researchers, scientists, teachers and research scholars. In addition to this, it also serves as a reference for postgraduate/undergraduate students studying aquatic ecosystems.

CO2 Acidification in Aquatic Ecosystems: An Integrative Approach to Risk Assessment focuses on the characterization of different aspects of ecosystem science to describe the situation of CO2 acidification in aquatic ecosystems. This extensive coverage looks at the effects of CO2 acidification throughout all oceans and coastal areas. In addition, the book describes integrative approaches based on global case studies to determine the effects associated with this kind of acidification. It allows the reader to understand the different sources of CO2 in the aquatic ecosystems and the different approaches and lines of evidence available to characterize the impact of this acidification. This book provides researchers, professors and post graduate students in oceanography and aquatic ecology with a new and complete tool set to address and understand the potential impacts of CO2 acidification in aquatic ecosystems.

Development and Commercialization of Biopesticides: Costs and Benefits provides a uniquely comprehensive view of the commercial production of biopesticides, from research to application, featuring case studies in various developed and developing countries of the world. The book offers guidance for future strategies to researchers, along with considerations for the industry's economic concerns, i.e., costs and benefits compared to conventional pesticides, future perspectives for application strategies, bioavailability and environmental safety, and impacts on intellectual property issues during commercialization. Finally, the book covers why the development of this industry must be strategic, comprehensive and forward-looking in order to be an accepted, safe and sustainable. There is no doubt that biopesticides are now in large-scale use, and a variety of novel techniques have been used to improve or modify existing biopesticides, which will further accelerate their development.

Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment. A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.

Wetlands are vital for human survival. They are among the world's most productive environments as they are cradles of biological diversity that provide the water and productivity upon which countless species of plants and animals depend for survival. Wetlands provide habitat for thousands of species of aquatic and terrestrial plants and animals as well as a number of societal benefits such as food and habitat for fish and wildlife, water quality improvement, flood storage, shoreline erosion control, economically beneficial natural products for human use, and opportunities for recreation, education, and research. According to the Federal Environmental Protection Agency's Office of Wetlands, more than one-third of the United States' threatened and endangered species live only in wetlands, and nearly half use wetlands at some point in their lives. This book offers a comprehensive look at the importance of wetland conservation, its challenges, and future aspects. The book highlights the challenges of wetland conservation and current scenarios of existing wetlands; the importance of the inland wetland and its conservation is particularly highlighted as it is critical and very important in the current existing wetland scenario. This book is critical for industries, academics, research scholars, and environmental consultants who are practicing wetland management.

Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.