Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.

This fully revised and updated second edition of Insect Pests of Potato now includes an opening section with a basic overview of agronomic and economic issues as they relate to potato production. It also features a new section that reviews potato production, as well as problems caused by insect pests and solutions to these problems, in all major potato-growing regions of the world. Further, a new section discusses theoretical foundations of potato pest management and includes chapters on ecological theory, evolutionary theory, and a case study on their applications to elucidate differences between Eastern and Western populations of Colorado potato beetle in North America. There is also a new chapter on the foundations of integrated pest management and their applications in controlling insect pests. The sections on the biology of main pests and on control methods now feature the latest information, including emphasis on recent advances in molecular biology and genomics. Information on the use of dsRNA technology for pest control is also included, as are new chapters on potato ladybirds and on hemipterous pests other than aphids and psyllids. This second edition provides improved integration and logical connections among chapters and expanded geographic scope of coverage making it the ideal reference on the topic.

Autophagy Dysfunction in Alzheimer's Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer's. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer's and other neurodegenerative diseases.

MRI Atlas of the Infant Rat Brain: Brain Segmentation features an entirely new coronal, sagittal and horizontal set of tissue cut in regular 9 m intervals with accompanying photographs of MRI data and color drawings of selected brain regions in the three planes. The use of the single brain allows for greater consistency between sections, while color masking offers advances in manual segmentation techniques with increased refinement in the definition of brain areas. Readers will benefit from uniform and consistent manual tissue segmentation of MRI data in an infant rat brain. This volume provides readers the first infant rat brain MRI atlas and a valuable resource in research analyses of the developing brain for structural and functional MRI analyses.

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

WINNER OF THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2022 'Exhilaratingly whizzes through billions of years . . . Gee is a marvellously engaging writer, juggling humour, precision, polemic and poetry to enrich his impossibly telescoped account . . . [making] clear sense out of very complex narratives' - The Times 'Henry Gee makes the kaleidoscopically changing canvas of life understandable and exciting. Who will enjoy reading this book? - Everybody!' Jared Diamond, author of Guns, Germs, and Steel For billions of years, Earth was an inhospitably alien place - covered with churning seas, slowly crafting its landscape by way of incessant volcanic eruptions, the atmosphere in a constant state of chemical flux. And yet, despite facing literally every conceivable setback that living organisms could encounter, life has been extinguished and picked itself up to evolve again. Life has learned and adapted and continued through the billions of years that followed. It has weathered fire and ice. Slimes begat sponges, who through billions of years of complex evolution and adaptation grew a backbone, braved the unknown of pitiless shores, and sought an existence beyond the sea. From that first foray to the spread of early hominids who later became Homo sapiens, life has persisted, undaunted. A (Very) Short History of Life is an enlightening story of survival, of persistence, illuminating the delicate balance within which life has always existed, and continues to exist today. It is our planet like you've never seen it before. Life teems through Henry Gee's words - colossal supercontinents drift, collide, and coalesce, fashioning the face of the planet as we know it today. Creatures are engagingly personified, from 'gregarious' bacteria populating the seas to duelling dinosaurs in the Triassic period to magnificent mammals with the future in their (newly evolved) grasp. Those long extinct, almost alien early life forms are resurrected in evocative detail. Life's evolutionary steps - from the development of a digestive system to the awe of creatures taking to the skies in flight - are conveyed with an alluring, up-close intimacy.

Neurosurgical Management of Psychiatric Disorders, Part B, Volume 267 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics such as the Neurosurgical Management of Tourette Syndrome, Stereotactic Surgeries for Opioid Addiction: Patient Selection and Results, Psychiatric Disorders as Indication for Surgical Management of Drug-Resistant Temporal Epilepsy, Surgery of Autism: Is it Possible?, Psychogenic Pain: Diagnosis and Management, Stereotactic Cingulotomy and Capsulotomy for Obsessive-Compulsive Disorders: Indications and Comparative Results, and much more.

Genomic Medicine Skills and Competencies discusses core and practical aspects of genetic and genomic education and training for medical field. Many aspects of genomic applications in science, biotechnology, clinical medicine and healthcare require core and specialist knowledge, skills development and competencies for carrying out diverse tasks. Several knowledge-based courses and opportunities for skills and competencies development and assessment are now available and the main required subjects are discussed in this volume. The book focuses on all major aspects of genetic and genomic education training that are currently offered and evaluated and is a valuable resource for researchers, clinicians, physicians, nurses, genetic counselors, bioinformatics technicians, and other professionals who are interested in learning more about such promising field.

Neurosurgical Management of Psychiatric Disorders, Part A, Volume 266, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume covering interesting chapters, including Pathophysiology and Animal Models of Psychiatric Disorders, Neuroimaging of Psychiatric Disorders, History of Psychosurgery, Ethics of Psychosurgery, Medicolegal Aspects and Regulatory Issues of Psychosurgery, Psychiatric Mimics of Neurosurgical Disorders, Seizures and Pseudoseizures: The Great Divide, Pitfalls of Psychiatric Patients Selection for Functional Neurosurgery, Modern Surgical Strategies for Management of Psychiatric Disorders, Neuromodulation for Behavioral Disorders, and more.

Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level from a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance. Combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making it essential to understand for multiple therapy options. The book is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of combinational therapies to treat triple negative breast cancer.

Elements of Marine Ecology, Fifth Edition focuses on marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. The text reflects ecological groupings such as the pelagic lifestyle vs. the benthic lifestyle. In addition, background oceanographic material, previously in various chapters, is consolidated in the first chapter. The broad definition of ecology is the study of organisms in relation to their surroundings. This book presents marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. This new edition has been thoroughly revised and updated to meet the needs of today's courses and now includes worldwide examples, all thoroughly updated with brand new chapters.

Value Addition in Food Products and Processing using Enzyme Technology offers an updated review regarding the potential impact of new enzymes and enzyme technology on the food sector. The book brings together novel sources and technologies regarding enzymes in value added food development, food production, food processing, food preservation, food engineering and food biotechnology. It will be extremely useful for different types of readers, including food scientists, academic and food biotechnologists, but will also be ideal for students studying food-related courses. This book includes concise and up-to-date research information from multiple independent scientific papers from around the world. This is a essential, multidisciplinary text for research and development professionals, research scientists, and academics in food, biotechnology, and agriculture industries. It addresses safety issues and includes the sources, screening, immobilization and application of food-grade enzymes in food.

Wetlands are vital for human survival. They are among the world's most productive environments as they are cradles of biological diversity that provide the water and productivity upon which countless species of plants and animals depend for survival. Wetlands provide habitat for thousands of species of aquatic and terrestrial plants and animals as well as a number of societal benefits such as food and habitat for fish and wildlife, water quality improvement, flood storage, shoreline erosion control, economically beneficial natural products for human use, and opportunities for recreation, education, and research. According to the Federal Environmental Protection Agency's Office of Wetlands, more than one-third of the United States' threatened and endangered species live only in wetlands, and nearly half use wetlands at some point in their lives. This book offers a comprehensive look at the importance of wetland conservation, its challenges, and future aspects. The book highlights the challenges of wetland conservation and current scenarios of existing wetlands; the importance of the inland wetland and its conservation is particularly highlighted as it is critical and very important in the current existing wetland scenario. This book is critical for industries, academics, research scholars, and environmental consultants who are practicing wetland management.

Silicon and Nano-silicon in Environmental Stress Management and Crop Quality Improvement: Progress and Prospects provides a comprehensive overview of the latest understanding of the physiological, biochemical and molecular basis of silicon- and nano-silicon-mediated environmental stress tolerance and crop quality improvements in plants. The book not only covers silicon-induced biotic and abiotic stress tolerance in crops but is also the first to include nano-silicon-mediated approaches to environmental stress tolerance in crops. As nanotechnology has emerged as a prominent tool for enhancing agricultural productivity, and with the production and applications of nanoparticles (NPs) greatly increasing in many industries, this book is a welcomed resource.

Applications of Biosurfactant in Agriculture explores the use of beneficial microorganisms as an alternative to current synthetic plant protection strategies. The book highlights a range of renewable raw substrates including agro-industrial waste as a dependable and cost-effective technology for the mass production of biosurfactant, emphasizes the formulation of biosurfactants using a full-factorial design, scientometric assessment, and presents mathematical modeling for the enhancement of production processes. Recent biotechnological techniques such as functional metagenomics that could help in the molecular characterization of novel biosurfactant with multifunctional activities majorly from uncultured and unexploited microbes available in the soil biosphere are also explored. This book identifies possible modes of action by which nutrients are normally released to plants through the formation of metal-biosurfactant complexes and presents recent research findings on the utilization of biosurfactants for the management of mycotoxins and microorganisms when evaluated in the field and in greenhouses. Finally, the book emphasizes the application of biosurfactants as a form of potent antibiotics for the management of several zoonotic diseases and in animal husbandry.

Advances in Agronomy, Volume 172, the latest release in this leading reference on the topic, contains a variety of updates and highlights new advances in the field, with each chapter written by an international board of authors.

Lipids in Plants and Algae: From Fundamental Science to Industrial Applications, Volume 101 provides in-depth reviews on the most important aspects of the field. Topics in this volume encompass the most recent data about the physical properties of membrane lipids, lipid biosynthesis and metabolism (including glycerolipids, fatty acids, sterols, N-acylethanolamines, prostaglandins, phytoprostane), lipid storage, acyl flux, the dynamic and transport of glycerolipids, and the conversion of fatty acids into hydrocarbons. Lipid metabolism and lipidomics in plants and algae are one of the most challenging areas in biology, not only for fundamental research but also for the sustainable production of valuable molecules for green chemistry, including biofuel and health.

Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines.

Agricultural Nanobiotechnology: Biogenic Nanoparticles, Nanofertilizers and Nanoscale Biocontrol Agents presents the most up-to-date advances in nanotechnology to improve the agriculture and food industry with novel nanotools for the controlling of rapid disease diagnostic and enhancement of the capacity of plants to absorb nutrients and resist environmental challenges. Highlighting the emerging nanofertilizers, nanopesticides and nanoherbicides that are being widely explored in order to overcome the limitations of conventional agricultural supplements, the book provides important insights to enable smart, knowledge-driven selection of nanoscale agricultural biomaterials, coupled with suitable delivery approaches and formulations will lead to promising agricultural innovation using nanotechnology. Agricultural Nanobiotechnology: Biogenic Nanoparticles, Nanofertilizers and Nanoscale Biocontrol Agents explores emerging innovations in nanobiotechnology for agriculture, food, and natural resources to address the challenges of food security, sustainability, susceptibility, human health, and healthy life. The book is ideal for the multidisciplinary scientists whose goal is to see the use of nanomaterials in agriculture to reduce the amount of spread chemicals, minimize nutrient losses in fertilization and to generate increased yield through pest and nutrient management.

Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer's Disease, Parkinson's Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington's Disease, spinocerebellar ataxia, SMA, ALS and prion disease.

Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions.

Defence from Invertebrates to Mammals: Focus on Tonic Immobility, Volume 273 in the Progress in Brain Research series, highlights new advances in the field. Chapters in this new release include Defensive responses in invertebrates, Introduction to defensive behavior in vertebrates, Neural circuits of fear and defensive behavior, Fear-associated factors modulating TI, Environmental, ecological and methodological factors of TI Modulation, The neuroethological approach to defense in rabbits, Neurophysiological mechanisms of TI, Neuromediators, brain areas and circuits involved in defense responses, Autonomic correlates of defense responses, Neuroendocrine correlates of stress and TI, Pain control during TI and other immobility models, and more.