Bioinformatics in Agriculture: Next Generation Sequencing Era is a comprehensive volume presenting an integrated research and development approach to the practical application of genomics to improve agricultural crops. Exploring both the theoretical and applied aspects of computational biology, and focusing on the innovation processes, the book highlights the increased productivity of a translational approach. Presented in four sections and including insights from experts from around the world, the book includes: Section I: Bioinformatics and Next Generation Sequencing Technologies; Section II: Omics Application; Section III: Data mining and Markers Discovery; Section IV: Artificial Intelligence and Agribots. Bioinformatics in Agriculture: Next Generation Sequencing Era explores deep sequencing, NGS, genomic, transcriptome analysis and multiplexing, highlighting practices forreducing time, cost, and effort for the analysis of gene as they are pooled, and sequenced. Readers will gain real-world information on computational biology, genomics, applied data mining, machine learning, and artificial intelligence. This book serves as a complete package for advanced undergraduate students, researchers, and scientists with an interest in bioinformatics.

Advances in Botanical Research, Volume 103 provides a timely and comprehensive update on the current knowledge of stomata development and operation in salt-grown plants. The range of topics covered includes evolution of stomata for adaptation to saline conditions, comparative analysis of proteomic, transcriptomic and metabolomic profiles of stomata guard cells between halophytes and glycophyte species and their reprogramming under salt stress, the molecular nature of the signals that control stomata aperture and their integration at the cellular and whole-plant level, and ecophysiological aspects of stomata operation in crop and halophytes species.

Genomics and the Global Bioeconomy, a new volume in the Translational and Applied Genomics series, empowers researchers, administrators, and sustainability leaders to apply genomics and novel omics technologies to advance the global bioeconomy and sustainability. Here, more than 15 international experts illustrate-with concrete examples across various industries and areas of global need-how genomics is addressing some of the most pressing global challenges of our time. Chapters offer an in-depth, case-based treatment of various topics, from genomics technologies supporting sustainability development goals to novel synthetic biology advancements improving biofuel production, conservation, sustainable food production, bioremediation, and genomic monitoring. Editors Catalina Lopez-Correa and Adrian Suarez-Gonzalez skillfully bring clarity to this diverse and increasingly impactful research, uniting various perspectives to inspire fresh innovation in driving the global bioeconomy.

Protein Design and Structure, Volume 130 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and proper controls to neuronal differentiation, phenotyping, screening, and considerations for moving to the clinic, these detailed descriptions of each stage of the pipeline will help everyone, regardless of stage in the pipeline. In recent years, drug discovery in the neurosciences has struggled to identify novel therapeutics for patients with varying indications, including epilepsy, chronic pain, and psychosis. Current treatment options for such patients are decades old and offer little relief with many side effects. One explanation for this lull in novel therapeutics is a lack of novel target identification for neurological disorders (and target identification requires exemplar preclinical data). To improve on the preclinical work that often relies on rodent modeling, the field has begun utilizing patient-derived induced pluripotent stem cells (iPSCs) to differentiate neurons in vitro for preclinical characterization of neurological disease and target identification.

Soybean Physiology and Genetics, Volume 102 presents comprehensive reviews on the latest development in soybean research, covering soybean genomics, physiology and genetics under biotic and abiotic stress, growth and development, nitrogen fixation and nutritional values, etc. Chapters in this new release cover Root Physiology and Morphology in Relationship to Stress Tolerance, Soybean Insects, Application of Genomic Studies in Soybean Breeding, Secondary metabolism in soybean, The roles of CLE peptides in nitrogen fixation in soybean, Seed morphology in soybean, Physiology and genetic regulations of oil and protein contents in soybean, Regulation of flowering and maturation in soybean, and much more. As soybeans are a key component in climate-smart agriculture because of their high nutritional value, large cultivation area, and nitrogen-fixing ability, this book fills a gap in information on this growing commodity.

Stromal Signaling in Cancer, Volume 154 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics surrounding cancer research. Each chapter is written by an international board of authors.

Neurodivergence and Architecture, Volume Five, the latest release in the Developments in Neuroethics and Bioethics series, focuses on the new and fascinating ethical and legal challenges posed by neurotechnology and its global regulation. Topics in this new release cover STS on architecture, Embodied Rhetoric/ Disability Studies, Autoethnography, Bioethics/Materialist Feminism, Advocacy, Cultural Commentary: Being Autistic Together, An autistic perspective on built spaces, Empty spaces and refrigerator boxes: making autistic spaces, On the Losing Myself Project, Neither Use nor Ornament (NUNO) project, Madness and (Be)coming Out Within and Through Spaces of Confinement, and more.

WINNER OF THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2022 'Exhilaratingly whizzes through billions of years . . . Gee is a marvellously engaging writer, juggling humour, precision, polemic and poetry to enrich his impossibly telescoped account . . . [making] clear sense out of very complex narratives' - The Times 'Henry Gee makes the kaleidoscopically changing canvas of life understandable and exciting. Who will enjoy reading this book? - Everybody!' Jared Diamond, author of Guns, Germs, and Steel For billions of years, Earth was an inhospitably alien place - covered with churning seas, slowly crafting its landscape by way of incessant volcanic eruptions, the atmosphere in a constant state of chemical flux. And yet, despite facing literally every conceivable setback that living organisms could encounter, life has been extinguished and picked itself up to evolve again. Life has learned and adapted and continued through the billions of years that followed. It has weathered fire and ice. Slimes begat sponges, who through billions of years of complex evolution and adaptation grew a backbone, braved the unknown of pitiless shores, and sought an existence beyond the sea. From that first foray to the spread of early hominids who later became Homo sapiens, life has persisted, undaunted. A (Very) Short History of Life is an enlightening story of survival, of persistence, illuminating the delicate balance within which life has always existed, and continues to exist today. It is our planet like you've never seen it before. Life teems through Henry Gee's words - colossal supercontinents drift, collide, and coalesce, fashioning the face of the planet as we know it today. Creatures are engagingly personified, from 'gregarious' bacteria populating the seas to duelling dinosaurs in the Triassic period to magnificent mammals with the future in their (newly evolved) grasp. Those long extinct, almost alien early life forms are resurrected in evocative detail. Life's evolutionary steps - from the development of a digestive system to the awe of creatures taking to the skies in flight - are conveyed with an alluring, up-close intimacy.

Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions.

Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Autophagy Dysfunction in Alzheimer's Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer's. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer's and other neurodegenerative diseases.

MRI Atlas of the Infant Rat Brain: Brain Segmentation features an entirely new coronal, sagittal and horizontal set of tissue cut in regular 9 m intervals with accompanying photographs of MRI data and color drawings of selected brain regions in the three planes. The use of the single brain allows for greater consistency between sections, while color masking offers advances in manual segmentation techniques with increased refinement in the definition of brain areas. Readers will benefit from uniform and consistent manual tissue segmentation of MRI data in an infant rat brain. This volume provides readers the first infant rat brain MRI atlas and a valuable resource in research analyses of the developing brain for structural and functional MRI analyses.

Defence from Invertebrates to Mammals: Focus on Tonic Immobility, Volume 273 in the Progress in Brain Research series, highlights new advances in the field. Chapters in this new release include Defensive responses in invertebrates, Introduction to defensive behavior in vertebrates, Neural circuits of fear and defensive behavior, Fear-associated factors modulating TI, Environmental, ecological and methodological factors of TI Modulation, The neuroethological approach to defense in rabbits, Neurophysiological mechanisms of TI, Neuromediators, brain areas and circuits involved in defense responses, Autonomic correlates of defense responses, Neuroendocrine correlates of stress and TI, Pain control during TI and other immobility models, and more.

Genomic Medicine Skills and Competencies discusses core and practical aspects of genetic and genomic education and training for medical field. Many aspects of genomic applications in science, biotechnology, clinical medicine and healthcare require core and specialist knowledge, skills development and competencies for carrying out diverse tasks. Several knowledge-based courses and opportunities for skills and competencies development and assessment are now available and the main required subjects are discussed in this volume. The book focuses on all major aspects of genetic and genomic education training that are currently offered and evaluated and is a valuable resource for researchers, clinicians, physicians, nurses, genetic counselors, bioinformatics technicians, and other professionals who are interested in learning more about such promising field.

Neurosurgical Management of Psychiatric Disorders, Part A, Volume 266, the latest release in the Progress in Brain Research series, highlights new advances in the field with this new volume covering interesting chapters, including Pathophysiology and Animal Models of Psychiatric Disorders, Neuroimaging of Psychiatric Disorders, History of Psychosurgery, Ethics of Psychosurgery, Medicolegal Aspects and Regulatory Issues of Psychosurgery, Psychiatric Mimics of Neurosurgical Disorders, Seizures and Pseudoseizures: The Great Divide, Pitfalls of Psychiatric Patients Selection for Functional Neurosurgery, Modern Surgical Strategies for Management of Psychiatric Disorders, Neuromodulation for Behavioral Disorders, and more.

This fully revised and updated second edition of Insect Pests of Potato now includes an opening section with a basic overview of agronomic and economic issues as they relate to potato production. It also features a new section that reviews potato production, as well as problems caused by insect pests and solutions to these problems, in all major potato-growing regions of the world. Further, a new section discusses theoretical foundations of potato pest management and includes chapters on ecological theory, evolutionary theory, and a case study on their applications to elucidate differences between Eastern and Western populations of Colorado potato beetle in North America. There is also a new chapter on the foundations of integrated pest management and their applications in controlling insect pests. The sections on the biology of main pests and on control methods now feature the latest information, including emphasis on recent advances in molecular biology and genomics. Information on the use of dsRNA technology for pest control is also included, as are new chapters on potato ladybirds and on hemipterous pests other than aphids and psyllids. This second edition provides improved integration and logical connections among chapters and expanded geographic scope of coverage making it the ideal reference on the topic.

Combinational Therapy in Triple Negative Breast Cancer discusses TNBC at the molecular level from a holistic approach, focusing on combinational strategies targeting various pathways involved in this specific cancer type. Using a monotherapy for the treatment of cancer, especially high-grade tumors like TNBC, is mostly worthless due to the inherent genetic instability of tumor cells to develop intrinsic and acquired resistance. Combination therapy presents more, or at least the same, effectiveness with lower doses of every single agent and decreases the likelihood of chemoresistance, making it essential to understand for multiple therapy options. The book is a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of combinational therapies to treat triple negative breast cancer.

Elements of Marine Ecology, Fifth Edition focuses on marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. The text reflects ecological groupings such as the pelagic lifestyle vs. the benthic lifestyle. In addition, background oceanographic material, previously in various chapters, is consolidated in the first chapter. The broad definition of ecology is the study of organisms in relation to their surroundings. This book presents marine ecology as a coherent science, providing undergraduate students with an essential foundation of knowledge in the structure and functioning of marine ecosystems. This new edition has been thoroughly revised and updated to meet the needs of today's courses and now includes worldwide examples, all thoroughly updated with brand new chapters.

Emerging Plant Growth Regulators in Agriculture: Roles in Stress Tolerance presents current PGR discoveries and advances for agricultural applications, providing a comprehensive reference for those seeking to apply these tools for improved plant health and crop yield. As demand for agricultural crops and improved nutritional requirement continue to escalate in response to increasing population, plant researchers have focused on identifying scientific approaches to minimize the negative impacts of climate change on agriculture crops. Among the various applied approaches, the application of plant growth regulators (PGRs) have gained significant attention for their ability to enhance stress tolerance mechanisms. This book was developed to provide foundational and emerging information to advance the discovery of novel, cost-competitive, specific and effective PGRs for applications in agriculture.

Silicon and Nano-silicon in Environmental Stress Management and Crop Quality Improvement: Progress and Prospects provides a comprehensive overview of the latest understanding of the physiological, biochemical and molecular basis of silicon- and nano-silicon-mediated environmental stress tolerance and crop quality improvements in plants. The book not only covers silicon-induced biotic and abiotic stress tolerance in crops but is also the first to include nano-silicon-mediated approaches to environmental stress tolerance in crops. As nanotechnology has emerged as a prominent tool for enhancing agricultural productivity, and with the production and applications of nanoparticles (NPs) greatly increasing in many industries, this book is a welcomed resource.

Applications of Biosurfactant in Agriculture explores the use of beneficial microorganisms as an alternative to current synthetic plant protection strategies. The book highlights a range of renewable raw substrates including agro-industrial waste as a dependable and cost-effective technology for the mass production of biosurfactant, emphasizes the formulation of biosurfactants using a full-factorial design, scientometric assessment, and presents mathematical modeling for the enhancement of production processes. Recent biotechnological techniques such as functional metagenomics that could help in the molecular characterization of novel biosurfactant with multifunctional activities majorly from uncultured and unexploited microbes available in the soil biosphere are also explored. This book identifies possible modes of action by which nutrients are normally released to plants through the formation of metal-biosurfactant complexes and presents recent research findings on the utilization of biosurfactants for the management of mycotoxins and microorganisms when evaluated in the field and in greenhouses. Finally, the book emphasizes the application of biosurfactants as a form of potent antibiotics for the management of several zoonotic diseases and in animal husbandry.