Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more.

The book presents conventional and modern breeding technologies in the vital areas of animal breeding, to stimulate more research, and to rapidly pass such modern techniques to scientific community. Various conventional breeding technologies used for selection and faster multiplication of superior cattle and buffalo germplasm have contributed significantly to increase in milk production, which were mainly due to the technologies developed in the areas of quantitative genetics and reproductive biology. These included methodologies for selection of females based upon their expected producing ability and young males based on the performance of progeny. Emerging developments in the areas of molecular marker systems in animals, genome maps, methods of detecting Quantitative Trait Loci (QTL) linkages, Marker Assisted Selection (MAS) etc., are latest tools to be used in breeding programmes for enhancing the rate of genetic progress. These modern techniques could be of great help for those traits, for which the conventional technologies have limitations in their use. Therefore, integration of molecular markers with conventional breeding technologies involving pedigree and phenotypic information are probable future breeding tools for genetic improvement of livestock and poultry.

Nonheme Iron Enzymes: Structures and Mechanisms, Volume 117, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors.

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.

One of Britain's foremost astrobiologists offers an accessible and game-changing account of life on Earth. __________________ Why is all life based on carbon rather than silicon? And beyond Earth, would life - if it exists - look like our own? __________________ The puzzles of life astound and confuse us like no other mystery. But in this groundbreaking book, Professor Charles Cockell reveals how nature is far more understandable and predictable than we would think. Breathing new life into Darwin's theory of natural selection, The Equations of Life puts forward an elegant account of why evolution has taken the paths it has. In a captivating journey into the forces that shape living things on Earth, Cockell explains that the fundamental laws of physics constrain nature at every turn. Fusing the latest in scientific research with fascinating accounts of the creatures that surround us, this is a compelling argument about what life can - and can't - be.

Mendel's groundbreaking paper, which laid the foundation for further research upon heritage and genetics, is published here complete with the original illustrations and charts. When Mendel released this paper in 1865, it was after years of rigorous study and comparison in plant specimens and their offspring. His conclusion that variant traits were hereditary and could be determined, with a good degree of accuracy, through probability analysis were revolutionary in natural science at the time. Mendel's assertions regarding acquired characteristics, demonstrated through the comparison of peas and their seeds, would spark great interest in the nature and mechanisms behind heredity between generations of organisms. Seeking to gain high quality results, Mendel prefaces his explanations by noting that he artificially fertilized the plants described in the work.

This collection vigorously addresses the religious implications of extreme human enhancement technology. Topics covered include cutting edge themes, such as moral enhancement, common ground to both transhumanism and religion, the meaning of death, desire and transcendence, and virtue ethics. Radical enhancement programs, advocated by transhumanists, could arguably have a more profound impact than any other development in human history. Reflecting a range of opinion about the desirability of extreme enhancement, leading scholars in the field join with emerging scholars to foster enhanced conversation on these topics.

Enzymes - Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors.

Environmental heat stress is associated with a marked decrease in orthostatic tolerance (OT), which is defined as the ability to stand or sit upright without symptoms of dizziness, lightheadedness, presyncope, or fainting. In most healthy humans, the autonomic nervous system makes rapid and balanced adjustments to heart rate and peripheral blood flow, such that most people are able to stand up "successfully" most of the time, in most environments. The goal of this book is to discuss various aspects of the sympathetic neural response to heat stress, how the sympathetic nervous system coordinates the successful integrative physiological response to orthostasis, and what happens when it encounters both challenges simultaneously. We include overviews of mechanisms of thermoregulation and blood pressure regulation in humans, with particular focus on control of cardiac output and neurovascular control mechanisms during heat stress. We discuss the implications that these changes have for distribution of peripheral blood flow and, in particular, for blood flow to the cerebral circulation. The added stressor of dehydration is also discussed, as it so often goes hand in hand with heat stress. We end with a brief presentation of countermeasures against the decreases in OT with heat stress.

The kidney is innervated with efferent sympathetic nerve fibers reaching the renal vasculature, the tubules, the juxtaglomerular granular cells, and the renal pelvic wall. The renal sensory nerves are mainly found in the renal pelvic wall. Increases in efferent renal sympathetic nerve activity reduce renal blood flow and urinary sodium excretion by activation of 1-adrenoceptors and increase renin secretion rate by activation of 1-adrenoceptors. In response to normal physiological stimulation, changes in efferent renal sympathetic nerve activity contribute importantly to homeostatic regulation of sodium and water balance. The renal mechanosensory nerves are activated by stretch of the renal pelvic tissue produced by increases in renal pelvic tissue of a magnitude that may occur during increased urine flow rate. Under normal conditions, the renal mechanosensory nerves activated by stretch of the sensory nerves elicits an inhibitory renorenal reflex response consisting of decreases in efferent renal sympathetic nerve activity leading to natriuresis. Increasing efferent sympathetic nerve activity increases afferent renal nerve activity which, in turn, decreases efferent renal sympathetic nerve activity by activation of the renorenal reflexes. Thus, activation of the afferent renal nerves buffers changes in efferent renal sympathetic nerve activity in the overall goal of maintaining sodium balance. In pathological conditions of sodium retention, impairment of the inhibitory renorenal reflexes contributes to an inappropriately increased efferent renal sympathetic nerve activity in the presence of sodium retention. In states of renal disease or injury, there is a shift from inhibitory to excitatory reflexes originating in the kidney. Studies in essential hypertensive patients have shown that renal denervation results in long-term reduction in arterial pressure, suggesting an important role for the efferent and afferent renal nerves in hypertension.

Although the human genome exists apart from society, knowledge about it is produced through socially-created language and interactions. As such, genomicists' thinking is informed by their inability to escape the wake of the 'race' concept. This book investigates how racism makes genomics and how genomics makes racism and 'race,' and the consequences of these constructions. Specifically, Williams explores how racial ideology works in genomics. The simple assumption that frames the book is that 'race' as an ideology justifying a system of oppression is persistently recreated as a practical and familiar way to understand biological reality. This book reveals that genomicists' preoccupation with 'race'-regardless of good or ill intent-contributes to its perception as a category of differences that is scientifically rigorous.

Biology of Aminoacyl-tRNA Synthetases, Volume 48 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on A narrative about our work on the endless frontier of editing, The puzzling evolution of aminoacyl-tRNA synthetases, Structural basis of the tRNA recognition by aminoacyl-tRNA synthetases, Catalytic strategies of aminoacyl-tRNA synthetases, Trans-editing by aminoacyl-tRNA synthetase-like editing domains, Adaptive and maladaptive mistranslation arising from aminoacyl-tRNA synthetases, Non-canonical inputs and outputs of tRNA aminoacylation, Structure and function of multi-tRNA synthetase complexes, Mitochondrial aminoacyl-tRNA synthetases, Non-canonical functions of human cytoplasmic tyrosyl-, tryptophanyl- and other aminoacyl-tRNA synthetases, and much more.