In the late seventeenth century, a team of scientists managed to free, for the first time, the soft tissues of the brain and nerves from the hard casing of the skull. In doing so, they not only engendered modern neuroscience, and with it the promise of knowing the mind through empirical study of the brain; they also unleashed a host of questions, problems, paradoxes, and--strangest of all--literary forms that are still with us today. Nervous Fictions is the first account of early neuroscience and of the peculiar literary forms it produced. Challenging the divide between science and literature, philosophy and fiction, Jess Keiser draws attention to a distinctive, but so far unacknowledged, mode of writing evident in a host of late seventeenth and eighteenth-century texts: the nervous fiction. Apparent not just in scientific work, but also in poetry (Barker, Blackmore, Thomson), narrative (Sterne, Smollett, ""it-narratives""), philosophy (Hobbes, Cavendish, Locke), satire (Swift, Pope, Arbuthnot), and medicine (Mandeville, Boswell), nervous fictions dissect the brain through metaphor, personification, and other figurative language. Nervous fictions stage a central Enlightenment problematic: the clash between mind and body, between our introspective sense of self as beings endowed with thinking, sensing, believing, willing minds and the scientific study of our brains as simply complex physical systems.

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library!

Multi-System Imaging Spectrum Associated with Neurologic Diseases covers over 200 classic multi-systemic entities associated with neurologic diseases with detailed discussion alongside illustrative photos for memory aids and clarification. Accompanying text explains the history and meaning of the descriptive or metaphoric sign. Uniquely written from a practical point of view, each case leads you through a radiology expert’s thought process in analyzing imaging pitfalls of different organs or systems. The cases highlight clinical presentation, relevant pathology, anatomy, physiology, and pertinent imaging features of common disease processes. Key information is distilled succinctly, with bulleted, detailed illustrations and images.

Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation.

Immunotherapy of Cancer, Volume 143, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Contributions from leading experts in the field make this a must have update on the topic.

Global temperatures and seawater levels rise; the world's smallest porpoise species looms at the edge of extinction; and a tiny emerald beetle from Japan flourishes in North America--but why does it matter? Who cares? With this concise, accessible, and up-to-date book, Charles J. Krebs answers critics and enlightens students and environmental advocates alike, revealing not why phenomena like these deserve our attention, but why they demand it. Highlighting key principles in ecology--from species extinction to the sun's role in powering ecosystems--each chapter introduces a general question, illustrates that question with real-world examples, and links it to pressing ecological issues in which humans play a central role, such as the spread of invasive species, climate change, overfishing, and biodiversity conservation. While other introductions to ecology are rooted in complex theory, math, or practice and relegate discussions of human environmental impacts and their societal implications to sidebars and appendices, Why Ecology Matters interweaves these important discussions throughout. It is a book rooted in our contemporary world, delving into ecological issues that are perennial, timeless, but could not be more timely.

Advances in Genetics, Volume 104, provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.

Genetic Engineering and Genome Editing for Zinc Biofortification of Rice provides the first single-volume, comprehensive resource on genetic engineering approaches, including novel genome editing techniques, that are carried out in rice, a staple crop for much of the world's population. Dietary zinc deficiency can lead to negative health outcomes, including increased risk of stunting, respiratory diseases, diarrhea, mortality during childhood, and preterm births in pregnancy. By providing a complete view of the need for zinc biofortification in rice, sections in this book discuss state-of-the-art scientific advances, and then go further, placing them in their proper scientific, regulatory and socioeconomic contexts. While zinc biofortification can be achieved through conventional breeding, genetic engineering and agronomic practices, this is the first reference to bring all the latest insights and understanding to a comprehensive resource that is based on real-world experience and targeted applications.

Colorectal Disorders and Diseases: An Infographic Guide provides a comprehensive and up-to-date overview of the most relevant diagnostic modalities, staging, classification systems and current therapeutic modalities for colorectal disorders and diseases. With coverage from incontinence, prolapse, anal fissures, and cancer, this reference offers a wide-ranging guide to colorectal disorders and diseases. The use of engaging infographics throughout provides an inviting "at-a-glace" perspective of the subject, allowing users to retain a large amount of information without the need to scroll through large text or complex algorithms. This is an important reference for clinicians, surgeons and medical students rotating in colorectal surgery as well as scientists that need a quick reference for research of colorectal issues including epidemiology, diagnosis and therapy.

Advances in Agronomy, Volume 156, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

New Therapeutic Strategies for Brain Edema and Cell Injury, Volume 145, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this volume presenting interesting chapters on the Blood-brain barrier breakdown and brain edema formation in Alzheimer’s disease, Blast brain Injury induced edema formation and therapeutic measures, Brain edema in Parkinson’s disease. Novel therapeutic strategies, Brain edema and blood-brain barrier breakdown in sleep deprivation. Therapeutic potential of cerebrolysin, Differential cell injury induced by NMDA antagonist MK 801 in early age, Anesthetics influence Brain edema in concussive head injury, and more.

Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management.

The Physiology of Dolphins explains the complex physiological problems of dolphins that are largely driven by technological developments of biologging tools. Sections cover the complete physiology of the mammal and include information on current threats for dolphins and whales from environmental pressures such as climate change, overfishing, pollution and our increasing human presence in the ocean. Users will find a collection of review chapters from leaders in the field of dolphin ecophysiology, making this comprehensive resource essential for instructors, researchers, and graduate students interested in the physiological and anatomical adaptations that make life possible for this charismatic marine mammal. This is an excellent reference providing easy to follow details of the latest available research methods and technologies that is expanding the field of physiology in marine mammals.

The lymphatic system develops and functions in parallel with the blood circulatory system (termed the "hemovasculature") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens-providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar. This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.

Social Cognition in Psychosis combines current research on phenotypes, neurobiology, and existing evidence on the assessment and treatment of various forms of psychoses. The book presents various treatment options, including assessment approaches, tools and training methods that aid in the rehabilitation of patients with psychotic disorders. Social cognition is a set of psychological processes related to understanding, recognizing, processing and appropriately using social stimuli in one's environment. Individuals with psychotic disorders consistently exhibit impairments in social cognition. As a result, social cognition has been an important target for intervention, with recent efforts trying to enhance early recovery among individuals with psychotic disorders.

Adolescent Psychosis: Clinical and Scientific Perspectives discusses new methodologies and novel scientific findings, with a comprehensive orientation into phenomenology, nosology, diagnostics and the history of adolescent early-onset psychosis research. This volume informs on psychotic disorders in adults and discusses recent epidemiological studies, along with co-morbid aspects associated with other neurodevelopmental syndromes and somatic diseases. The book also provides suggestions for future research to bridge neuroscience and the clinic using a translational perspective, from the clinic to the genes and relevant phenotypes, biomarkers, etiological aspects and clinical outcome. Topics discussed bring together expert researchers in the field to represent different translational perspectives and future possibilities.

Alternative Methods in Neurotoxicology, Volume Nine, the latest release in this series, provides an overview of important in vitro and non-vertebrate animal models available to study the neurotoxicity of a range of toxicants of occupational and environmental relevance. Chapters in this new release include Evaluation of mitochondrial function in neurotoxicology using alternative models, Planarians as a model to study neurotoxic agents, Role of Drosophila melanogaster in neurotoxicology studies: Responses to different harmful substances, Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans, Neurotoxicology of environmental toxicants using Caenorhabditis elegans as a model, Nauphoeta cinerea as an emerging model in neurotoxicology, and more. Other chapters cover Human Neural Stem Cells in Developmental Neurotoxicology: Current Scenario and Future Prospects, Use of Drosophila melanogaster for advances in developmental neurotoxicology studies, 3D neurospheres and neurotoxicity of organophosphorus and TCE, Genetic factors in methylmercury-induced neurotoxicity: what we have learned from Caenorhabditis elegans models, and more.

Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers. In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.

Brain-machine interfacing or brain-computer interfacing (BMI/BCI) is an emerging and challenging technology used in engineering and neuroscience. The ultimate goal is to provide a pathway from the brain to the external world via mapping, assisting, augmenting or repairing human cognitive or sensory-motor functions. In this book an international panel of experts introduce signal processing and machine learning techniques for BMI/BCI and outline their practical and future applications in neuroscience, medicine, and rehabilitation, with a focus on EEG-based BMI/BCI methods and technologies. Topics covered include discriminative learning of connectivity pattern of EEG; feature extraction from EEG recordings; EEG signal processing; transfer learning algorithms in BCI; convolutional neural networks for event-related potential detection; spatial filtering techniques for improving individual template-based SSVEP detection; feature extraction and classification algorithms for image RSVP based BCI; decoding music perception and imagination using deep learning techniques; neurofeedback games using EEG-based Brain-Computer Interface Technology; affective computing system and more.

Modern Intervention Tools for Rehabilitation addresses current advancements in rehabilitation to better equip clinicians and researchers in the field. This resource will equip professionals for better patient outcomes and improve future rehabilitation research quality. An interdisciplinary understanding of the rehabilitation field is crucial for improved patient care and outcomes, with relevance to patient care in other disciplines as well. With chapters dedicated to diagnostics, choosing appropriate techniques, managing medical treatment, and proper equipment care, readers will be well-equipped to decide on protocols, increase patient outcomes, and improve quality of life.

This book explores how predictive processing, which argues that our brains are constantly generating and updating hypotheses about our external conditions, sheds new light on the nature of the mind. It shows how it is similar to and expands other theoretical approaches that emphasize the active role of the mind and its dynamic function. Offering a complete guide to the philosophical and empirical implications of predictive processing, contributors bring perspectives from philosophy, neuroscience, and psychology. Together, they explore the many philosophical applications of predictive processing and its exciting potential across mental health, cognitive science, neuroscience, and robotics. Presenting an extensive and balanced overview of the subject, The Philosophy and Science of Predictive Processing is a landmark volume within philosophy of mind.

The Theory of Endobiogeny Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine offers researchers and clinicians a detailed introduction to the theory of Endobiogeny. The book presents a new approach to medicine that is at once scientific and humanistic, quantitative, and qualitative. The philosophical and experimental basis of a global complex systems approach to physiology is presented along with a mathematical approach to modeling the dynamism of the terrain. The importance of the history and physical examination are renewed as a source of "big data" readily available to clinicians for greater insight into the patient's state. Expansion of the therapeutic compendium is proposed based on a rational, clinical approach correlated to mathematical indicators of the physiologic state. What is proposed in this work is a fundamental shift in scientific thinking with a resulting expansion of the boundaries of clinical medicine for the 21st century and beyond.