The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation has played in adaptive evolution, as well as in developmental biology and susceptibility to disease. Here, Moyra Smith, a celebrated researcher in the field, sheds light on common themes in gene regulation across evolutionary timelines, illuminating new areas of focus and pathways for future research. Early chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time and in response to environmental and local conditions, and the role of epigenetics in adaptive evolution, with later chapters considering the role of adaptive gene regulation in healthy processes and developmental biology, as well as in disease biology. Throughout the book, a comparative approach is adopted across organisms, to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.

Insect Molecular Genetics: An Introduction to Principles and Applications, Fourth Edition provides the most recent advances and research in entomology and molecular genetics. It demonstrates the role molecular genetics plays in pest management and basic insect biology research, assuming readers have little to no prior knowledge on the subject. This newest edition features updates on the latest trends and discoveries, such as CRISPR-Cas genome editing methods, epigenetic inheritance, DNA amplification techniques, and molecular phylogenies. Certain chapter topics, including P-element mediated transformation and insect population molecular techniques, are condensed and updated to create a more comprehensive and concise read. This foundational text is a valuable resource for entomologists with limited training in molecular genetics, and will be an ideal source for pest control advisors who need to understand the vocabulary and methods that are used to solve entomological issues. Contains a new chapter on CRISPR-CAS and the basic biology of these systems related to arthropods Includes new and updated methods and examples of insect gene modification, along with discussions of regulatory and ethical issues Offers compiled and comprehensive terminology at the introductory level Illustrated with diagrams and tables to further explain key topics and concepts

Our Brains at War: The Neuroscience of Conflict and Peacebuilding suggests that we need a radical change in how we think about war, leadership, and politics. Most of us, political scientists included, fail to appreciate the extent to which instincts and emotions, rather than logic, factor into our societal politics and international wars. Many of our physiological and genetic tendencies, of which we are mostly unaware, can all too easily fuel our antipathy towards other groups, make us choose 'strong' leaders over more mindful leaders, assist recruitment for illegal militias, and facilitate even the most gentle of us to inflict violence on others. Drawing upon the latest research from emerging areas such as behavioral genetics, biopsychology, and social and cognitive neuroscience, this book identifies the sources of compelling instincts and emotions, and how we can acknowledge and better manage them so as to develop international and societal peace more effectively.

Epigenetics and Breeding, Volume 88, the latest release in the Advances in Botanical Research series, brings together the experiences and critical information teachers, researchers and managers must consider from both scientific and legal points-of-view as they relate to biotechnology. New chapters in this updated volume include sections on Epigenetic Mechanisms in Plants, Epigenomic Diversity and Applications to Breeding, Epigenetics in Breeding, EpiRILs: Lessons from Arabidopsis, Transposable Elements as a Tool for Plant Improvement, Epigenome Editing, Epigenetics and Grafting, Sexual and Non-sexual reproduction, Epigenetics in Cereals, and more.

Pulmonary Assessment and Management of Patients with Pediatric Neuromuscular Disease covers the broad medical problems and specific pulmonary conditions in patients with pediatric neuromuscular disease, ranging from the different types of neuromuscular disease, their pathophysiology, and assessment and management, including both novel disease modifying pharmacotherapies and state-of-the-art clinical management. This book provides evidence-based guidance for pediatric patients with neuromuscular disease, and is a valuable resource to pediatric pulmonologists, critical care physicians, and respiratory therapists who want an update and understanding on the cutting-edge therapies and standards of care for managing this population.

Stem Cell Laboratory Techniques: A Guide for Researchers and Students introduces the reader to stem cell culture, handling techniques and versatile applications used by researchers. Sections introduce stem cells, including definitions, types and basic use of stem cells in biomedical science research. The book explains laboratory procedures and techniques ranging from the extraction of stem cells from animals, cell seeding and culture, harvest and maintenance of stem cells, stem cell characterization, accurate recording, quality control, and more. In addition, it guides researchers on topics such as transcriptome analysis, proliferation study analysis, and microphysiological study. Final sections cover useful and recent applications in stem cells, such as gene editing techniques and the preparation of stem cells for in vitro study, as well as stem cell lab design and equipment used in the lab. Lastly, human and animal research ethics are discussed.

Hospitalization, Diagnosis, Treatment, and Surgery in Iran: The Lifecycle of Medical Sciences provides a complete understanding of the lifecycle of medicine in the underserved area of Iran. Coverage elucidates the importance of communication between scientists in different countries for the further development of research to advance hospitalization infrastructure, diagnosis and treatment of diseases, and surgery techniques and availability. Using a systematic timeline approach, coverage includes early medical sciences in present day Iran. Each chapter highlights important research, techniques and procedures throughout the lifecycle of medical sciences and includes topics from bloodletting and setting bones, to anesthesia and vaccines. The book's content emphasizes standard protocols based on international recognition to help developing countries adopt newer technologies.

Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN).

Social Cognition in Psychosis combines current research on phenotypes, neurobiology, and existing evidence on the assessment and treatment of various forms of psychoses. The book presents various treatment options, including assessment approaches, tools and training methods that aid in the rehabilitation of patients with psychotic disorders. Social cognition is a set of psychological processes related to understanding, recognizing, processing and appropriately using social stimuli in one's environment. Individuals with psychotic disorders consistently exhibit impairments in social cognition. As a result, social cognition has been an important target for intervention, with recent efforts trying to enhance early recovery among individuals with psychotic disorders.

Ophthalmic Pathology: The Evolution of Current Concepts examines how our current understanding of morphologic disease, nomenclature and classification over the last century came about. The book explores the historical context and the modern trends of ocular nosology, emphasizing the science of disease classification. Chapters highlight major studies and developments surrounding approximately 50 disorders whose diagnoses are established by pathology, corresponding to a historical road map of current nomenclature, methods of disease classification, and the role of diagnostic morphology. Using a streamlined, highly illustrated format, this book provides a unique historic and evolutionary perspective into current views on the morphology of eye disease.

Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications.

When we talk about ozone, the image that most often springs to mind is the ozone layer in the stratosphere that protects us from the sun's harmful ultraviolet (UV) rays. The depletion of this ozone layer increases surface UV levels, making its protection vital. However, ozone pollution can also be detrimental to the health of plants. Among various air pollutants, surface ozone primarily produced photochemically from anthropogenic precursor gases such as nitrous oxide from vehicles and volatile organic compounds (VOCs) from solvents is of particular concern due to the significant harm it can pose to both human and ecosystem health. The phytotoxicity of ozone has been shown to impair photosynthesis, reduce gas exchange, induce early leaf senescence (ageing) and hamper growth in both natural vegetation and crops. According to the business-as-usual emission scenario, ozone concentration would be expected to increase in developing countries, causing a negative impact to crop yield and ecosystem health. In this volume of Advanced Botanical Research, we will holistically explore the impact of ozone from micro and macro levels and from local to global levels. We invited researchers from developing countries who could contribute their first-hand research results, especially the impact of ozone on agriculture, which has a real impact on their daily lives.

This book explores how predictive processing, which argues that our brains are constantly generating and updating hypotheses about our external conditions, sheds new light on the nature of the mind. It shows how it is similar to and expands other theoretical approaches that emphasize the active role of the mind and its dynamic function. Offering a complete guide to the philosophical and empirical implications of predictive processing, contributors bring perspectives from philosophy, neuroscience, and psychology. Together, they explore the many philosophical applications of predictive processing and its exciting potential across mental health, cognitive science, neuroscience, and robotics. Presenting an extensive and balanced overview of the subject, The Philosophy and Science of Predictive Processing is a landmark volume within philosophy of mind.

Conceptual Development of Industrial Biotechnology for Commercial Production of Biopharmaceuticals and Vaccines provides insights on how to bring sustainability into biologic drug production. The cumulative facts and figures within in the book are helpful to promoters in monitoring value chain transfer process of super quality biologics for better return in profits. In addition, this is a useful reference for students, researchers and scientists in biotechnology, pharmaceutical science, medical sciences, and the R&D division of biotechnology-based industries. Conceptual development of biotechnology has taken new avenues with the integration of medical sciences, physical science, and engineering, hence this is a timely source. The current global market for vaccines, especially COVID-19, is tremendous. Bivalent oral polio vaccine, diphtheria, tetanus-containing, and measles-containing vaccines have a high demand internationally and recombinant DNA technology and protein engineering are helpful in the production of quality bio-products.