National Science Foundation (NSF) is a unique federal agency because it supports scientific research financially, but does not engage in scientific work itself. Its history is known only in part because the NSF is a vibrant, expanding, and living entity that makes the final telling of its story impossible. Much can be learned from its beginning as well as its component parts. If the founding of the NSF in 1950 was couched in an era of physics, especially atomic physics, certainly by the end of the 20th century and the beginning of the 21st, biology was, and remains, the queen of sciences for the predictable future. This book highlights the elite status of America's biological sciences as they were funded, affected, and, to a very real degree, interactively guided by the NSF. It examines important events in the earlier history of the Foundation because they play strongly upon the development of the various biology directorates. Issues such as education, applied research, medical science, the National Institutes of Health, the beginnings of biotechnology, and other matters are also discussed.

Reviews of Environmental Contamination and Toxicology attempts to provide concise, critical reviews of timely advances, philosophy and significant areas of accomplished or needed endeavor in the total field of xenobiotics, in any segment of the environment, as well as toxicological implications.

Stretching along 156 miles of Florida's East Coast, the Indian River Lagoon contains the St. Lucie estuary, the Mosquito Lagoon, Banana River Lagoon, and the Indian River. Nineteen canals and five man-made inlets have dramatically reshaped the region in the past two centuries, challenging the most biologically diverse estuarine system in the United States. Indian River Lagoon traces the winding story of the waterway, showing how humans have altered the area to fit their needs and also how the lagoon has influenced the cultures along its shores. Now stuck in transition between a place of labor and a place of recreation, the lagoon has become a chief focus of public concern. This book provides a much-needed bigger picture as debates continue over how best to restore this natural resource.

This Dictionary presents a broad range of topics relevant in present-day global bioethics. With more than 500 entries, this dictionary covers organizations working in the field of global bioethics, international documents concerning bioethics, personalities that have played a role in the development of global bioethics, as well as specific topics in the field.The book is not only useful for students and professionals in global health activities, but can also serve as a basic tool that explains relevant ethical notions and terms. The dictionary furthers the ideals of cosmopolitanism: solidarity, equality, respect for difference and concern with what human beings- and specifically patients - have in common, regardless of their backgrounds, hometowns, religions, gender, etc. Global problems such as pandemic diseases, disasters, lack of care and medication, homelessness and displacement call for global responses.This book demonstrates that a moral vision of global health is necessary and it helps to quickly understand the basic ideas of global bioethics.

The book reviews photosynthetic water oxidation and proton-coupled electron transfer in photosystem, focusing on the molecular vibrations of amino acid residues and water molecules. Photosynthetic water oxidation performed by plants and cyanobacteria is essential for the sustenance of life on Earth, not only as an electron source for synthesizing sugars from CO2, but also as an O2 source in the atmosphere. Water oxidation takes place at the Mn4CaO5 cluster in photosystem II, where a series of electron transfer reactions coupled with proton transfer occur using light energy. The author addresses the unresolved mechanisms of photosynthetic water oxidation and relevant proton-coupled electron transfer reactions using a combined approach of experimental and computational methods such as Fourier transform infrared difference spectroscopy and quantum chemical calculations. The results show that protonation and hydrogen-bond structures of water molecules and amino acid residues in the protein play important roles in regulation of the electron and proton transfer reactions. These findings and the methodology make a significant contribution to our understanding the molecular mechanism of photosynthetic water oxidation.

Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the "complexosome") is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the "interactomes") from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.

This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol ( 9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.

This innovative edited collection brings together leading international academics to explore the use of various non-prescription and prescription substances. From a psychosocial perspective, the authors discuss the complex reasons behind their adoption, the ways in which they are misused, and links between use and cognitive enhancement. While studies on substance use to date have examined the aetiology and effects in the context of sporting performance, addiction and recreational use, there has been little work which explores their wider misuse to improve cognitive enhancement. With medical sociology and social psychology at its core, this important volume shows the complex reasons behind the misuse of various substances, how these are connected to contemporary desire for increased mental performance, and why the potential health risks and possibly harmful side effects do not act as deterrents.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

This book highlights modern methods and strategies to improve cereal crops in the era of climate change, presenting the latest advances in plant molecular mapping and genome sequencing. Spectacular achievements in the fields of molecular breeding, transgenics and genomics in the last three decades have facilitated revolutionary changes in cereal- crop-improvement strategies and techniques. Since the genome sequencing of rice in 2002, the genomes of over eight cereal crops have been sequenced and more are to follow. This has made it possible to decipher the exact nucleotide sequence and chromosomal positions of agroeconomic genes. Most importantly, comparative genomics and genotyping-by-sequencing have opened up new vistas for exploring available biodiversity, particularly of wild crop relatives, for identifying useful donor genes.

The rhizosphere in soil environments refers to the narrow zone of soil influenced by the root and exudates. Microbial populations in the rhizosphere can be 10 - 100 times larger than the populations in the bulk soil. Therefore, the rhizosphere is bathed in root exudates and microbial metabolites and the chemistry and biology at the soil-root interface is governed by biotic (plant roots, microbes) and abiotic (physical and chemical) interactions.

The research on biotic and abiotic interactions in the rhizosphere should, thus, be an issue of intense interest for years to come. This book, which consists of 15 chapters, addresses a variety of issues on fundamentals of microscopic levels and the impact on food chain contamination and the terrestrial ecosystem.

It is an essential reference work for chemists and biologists studying environmental systems, as well as earth, soil and environmental scientists.
* 15 chapter book, which addresses a variety of issues on fundamentals of microscopic levels and the impact on food chain contamination and the terrestrial ecosystem

This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.

This book summarizes all different fields of cotton fiber, including genetics, fiber chemistry, soft materials, textile, and fashion engineering. It also contains some new applications such as biomaterials, nanocoated smart fabrics, and functional textiles. Moreover, the significant improvement recently in gene modification and gene technology is introduced. This book discusses all these aspects in a more straightforward way, and new illustrations will help readers to understand the contents. It is intended for undergraduate and graduate students who are interested in cotton science and processing technologies, researchers investigating the updated applications of cotton in various fields as well as industrialists who want to have a quick review of the cotton and its different stages.

This book highlights the impact of COVID-19 on sustainable waste management and air emission, using various case studies. The year 2020 was a historical year mainly due to the pandemic caused by COVID-19 and it influenced or affected the global economy, business models and the industrial sectors, thus impacting sustainability in various ways. Given that sustainability has many faces and facets, it is worthwhile to deal with the relation (or impact) of COVID-19 on various elements of sustainability. This book presents how COVID-19 has influenced waste management and air quality.

'Nobody bewitched by these mysteries can afford to ignore the solution proposed by Mark Solms' - Oliver Burkeman, Guardian 'A remarkable book. It changes everything' - Brian Eno How does the mind connect to the body? Why does it feel like something to be us? For one of the boldest thinkers in neuroscience, solving this puzzle has been a lifetime's quest. Now at last, the man who discovered the brain mechanism for dreaming appears to have made a breakthrough. The very idea that a solution is at hand may seem outrageous. Isn't consciousness intangible, beyond the reach of science? Yet Mark Solms shows how misguided fears and suppositions have concealed its true nature. Stick to the medical facts, pay close attention to the eerie testimony of hundreds of neurosurgery patients, and a way past our obstacles reveals itself. Join Solms on a voyage into the extraordinary realms beyond. More than just a philosophical argument, The Hidden Spring will forever alter how you understand your own experience. There is a secret buried in the brain's ancient foundations: bring it into the light and we fathom all the depths of our being.

What should we teach our children about where we come from? Is evolution a lie or good science? Is it incompatible with faith? Have scientists really detected evidence of a creator in nature?

From bestselling, Pulitzer Prize-winning author Edward Humes comes a dramatic story of faith, science, and courage unlike any since the famous Scopes Monkey Trial. Monkey Girl takes you behind the scenes of the recent war on evolution in Dover, Pennsylvania, when the town's school board decision to confront the controversy head-on thrust its students, then the entire community, onto the front lines of America's culture wars. Told from the perspectives of all sides of the battle, it is a riveting true story about an epic court case on the teaching of "intelligent design," and what happens when science and religion collide.

The Vanishing of a Species? is a serious treatise exploring the past evolution, present predicament and possible future extinction of a particular species on planet Earth. The species is Homo sapiens. The threat to the species is Homo sapiens. The author, a former professor of geology and geophysics, starts his exploration by putting man in context, both in terms of space and time. We find that in either case, man is not as pre-eminent as he may believe. While man is the most accomplished toolmaker this planet has ever seen, his technical progress is overpowering his social progress-an imbalance that sets the stage for his vanishing act, absent quick, corrective action. The author makes a compelling case that society's unrestricted material growth is the challenge of our times. Modern man's predicament refers broadly to man's collision course with nature-his attitude of ruthless exploitation leading to depletion of non-renewable resources, pollution of the environment, overpopulation, with its accompanying increase in human aggression, and other effects. After the agricultural and industrial-scientific revolutions, it is now time for the Human Revolution-a more realistic attitude on the part of man towards the universe, the earth and other forms of terrestrial life. Vanishing covers a wide spectrum from man's early beginnings to the modern problems of population increase, resource depletion, pollution, crime, and many more. The book addresses the roles that heredity (nature) and environment (nurture) play in shaping man's nature, and in particular, his current high level of aggression-a trait that stands in the way of the Human Revolution. The author calls for the humanists to communicate with the technologists through an interdisciplinary dialogue that may pave the way to the Human Revolution. Major works discussed in Vanishing include the Club of Rome's much reviewed 1972 work The Limits to Growth and updates thereto, as well as C.P. Snow's seminal 1959 lecture on The Two Cultures. Vanishing concludes that without the Human Revolution in short order, Homo sapiens may well turn out to be an evolutionary flash in the pan-occupying a dominating but fleeting position in earth history. Vanishing should appeal to all audiences. Recent economic turmoil around the globe, and increasing evidence of the serious strain placed on the earth by the demands of humankind, make the observations and recommendations raised within Vanishing deserving of the sober attention of all Homo sapiens interested in the survival and prosperity of their species.

This writing is called: Scientific Creation, Our Life - Beginning To End. As stated, all facts are not pragmatic or seen by human eye. Where did all nature and life start ? What is the beginning ? Was it by The Big Bang Theory, or Beginning by God ? or some Intelligent Designer ? The miraculous human body is investigated in time. In Catastrophic development of life and all nature, there was an Earth Canopy of translucent, crystalline, ice and a Great Global Flood, a deluge, scientifically verified. Then, all life and nature is discussed as always coming in a trinity, which is the characteristic of and mode of the great I.D.

Understanding the current state and dynamics of any forest is extremely difficult - if not impossible - without recognizing its history. Bialowieza Primeval Forest (BPF), located on the border between Poland and Belarus, is one of the best preserved European lowland forests and a subject of myriads of works focusing on countless aspects of its biology, ecology, management. BPF was protected for centuries (15th-18th century) as a game reserve of Polish kings and Lithuanian grand dukes. Being, at that time, a part of the Grand Duchy of Lithuania, BPF was subject to long-lasting traditional, multi-functional utilisation characteristic for this part of Europe, including haymaking on forest meadows, traditional bee-keeping and fishing in rivers flowing through forest. This traditional model of management came to an abrupt end due to political change in 1795, when Poland and Grand Duchy of Lithuania ceased to exist in effect of partitioning by neighbouring countries, and the territory of BPF was taken over by the Russian Empire. The new Russian administration, influenced by the German trends in forestry, attempted at introducing the new, science-based forestry model in the BPF throughout the 19th century. The entire 19th century in the history of BPF is a story of struggle between new trends and concepts brought and implemented by new rulers of the land, and the traditional perception of the forest and forest uses, culturally rooted in this area and originating from mediaeval (or older) practices. The book will show the historical background and the outcome of this struggle: the forest's history in the long 19th century focusing on tracking all cultural imprints, both material (artificial landscapes, introduced alien species, human-induced processes) and immaterial (traditional knowledge of forest and use of forest resources, the political and cultural significance of the forest) that shaped the forest's current state and picture. Our book will deliver a picture of a crucial moment in forest history, relevant not only to the Central Europe, but to the continent in general. Moment of transition between a royal hunting ground, traditional type of use widespread throughout Europe, to a modern, managed forest. Looking at main obstacles in the management shift, the essential difference in perceptions of the forest and goods it provides in both modes of management, and the implications of the management change for the state of BPF in the long 19th century could help in better understanding the changes that European forests underwent in general.

This book addresses multiple aspects of biological clocks in prokaryotes. The first part of the book deals with the circadian clock system in cyanobacteria, i.e. the pioneer of bacterial clocks. Starting with the history and background of cyanobacteria and circadian rhythms in microorganisms, the topics range from the molecular basis, structure and evolution of the circadian clock to modelling approaches, Kai systems in cyanobacteria and biotechnological applications. In the second part, emergent timekeeping properties of bacteria in microbiomes and bacteria other than cyanobacteria are discussed. Since the discovery of circadian rhythms in cyanobacteria in the late 1980s, the field has exploded with new information. The cyanobacterial model system for studying circadian rhythms (Synechococcus elongatus), has allowed a detailed genetic dissection of the bacterial clock due to state-of-the-art methods in molecular, structural, and evolutionary biology. Cutting-edge research spanning from cyanobacteria and circadian phenomena in other kinds of bacteria, to microbiomes has now given the field another major boost. This book is aimed at junior and senior researchers alike. Students or researchers new to the field of biological clocks in prokaryotes will get a comprehensive overview, while more experienced researchers will get an update on the latest developments.