This book provides an introduction to the significant role of physics in evolution, based on the ideas of matter and energy resource flow, organism self-copying, and ecological change. The text employs these ideas to create quantitative models for important evolutionary processes. Many fields of science and engineering have come up against the problem of complex design-when details become so numerous that computer power alone cannot make progress. Nature solved the complex-design problem using evolution, yet how it did so has been a mystery. Both laboratory experiments and computer-simulation attempts eventually stopped evolving. Something more than Darwin's ideas of heredity, variation, and selection was needed. The solution is that there is a fourth element to evolution: ecological change. When a new variation is selected, this can change the ecology, and the new ecology can create new opportunities for even more new variations to be selected. Through this endless cycle, complexity can grow automatically. This book uses the physics of resource flow to describe this process in detail, developing quantitative models for many evolutionary processes, including selection, multicellularity, coevolution, sexual reproduction, and the Serengeti Rules. The text demonstrates that these models are in conceptual agreement with numerous examples of biological phenomena, and reveals, through physics, how complex design can arise naturally. This will serve as a key text on the part physics plays in evolution, and will be of great interest to students at the university level and above studying biophysics, physics, systems biology, and related fields.

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume I, Part 1 covers fundamental topics such as the basic principles of ion permeation and selectivity, voltage-dependent, ligand-dependent and mechano-dependent ion channel activation mechanisms, the mechanisms for ion channel desensitization and inactivation and basic ion channel pharmacology and inhibition. Volume I, Part 2 aims to offer a practical guide of cardinal methods for researching ion channels, including heterologous expression and voltage-clamp and patch-clamp electrophysiology, isolation of native currents using patch-clamp, modelling ion channel gating, structures and its dynamics, crystallography and cryo- electron microscopy, fluorescence and paramagnetic resonance spectroscopy methods and genetics approaches in model organisms. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

Evolutionary Psychiatry challenges a medical model which has supplied few effective answers to long-standing conundrums. A comprehensive introduction to the new science of Darwinian Psychiatry, this second edition includes important fresh material on a number of disorders, along with an entirely new chapter on research.
Anthony Stevens and John Price argue that psychiatric symptoms are manifestations of ancient adaptive strategies which are no longer necessarily appropriate but which can best be understood and treated in an evolutionary and developmental context. Particularly important are the Stevens and Price propose to account for the worldwide existence of mood disorders and schizophrenia, as well as offering solutions for such puzzles as paedophilia, sado masochism and the function of dreams.
Readily accessible to both the specialist and non-specialist reader, Evolutionary Psychiatry describes in detail the disorders and conditions commonly encountered in psychiatric practice and shows how evolutionary theory can account for their biological origins and functional nature.

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In this eye-opening chronicle of scientific research on the brain in the early Cold War era, the acclaimed historian Andreas Killen traces the complex circumstances surrounding the genesis of our present-day fascination with this organ. The 1950s were a transformative, even revolutionary decade in the history of brain science. Using new techniques for probing brain activity and function, researchers in neurosurgery, psychiatry, and psychology achieved dramatic breakthroughs in the treatment of illnesses like epilepsy and schizophrenia, as well as the understanding of such faculties as memory and perception. Memory was the site of particularly startling discoveries. As one researcher wrote to another in the middle of that decade, “Memory was the sleeping beauty of the brain—and now she is awake.” Collectively, these advances prefigured the emergence of the field of neuroscience at the end of the twentieth century. But the 1950s also marked the beginning of the Cold War and a period of transformative social change across Western society. These developments resulted in unease and paranoia. Mysterious new afflictions—none more mystifying than “brainwashing”—also appeared at this time. Faced with the discovery that, as one leading psychiatrist put it, “the human personality is not as stable as we often assume,” many researchers in the sciences of brain and behavior joined the effort to understand these conditions. They devised ingenious and sometimes transgressive experimental methods for studying and proposing countermeasures to the problem of Communist mind control. Some of these procedures took on a strange life of their own, escaping the confines of the research lab to become part of 1960s counterculture. Much later, in the early 2000s, they resurfaced in the War on Terror. These stories, often told separately, are brought together by the historian Andreas Killen in this chronicle of the brain’s mid-twentieth-century emergence as both a new research frontier and an organ whose integrity and capacities—especially that of memory—were imagined as uniquely imperiled in the 1950s. Nervous Systems explores the anxious context in which the mid-century sciences of the brain took shape and reveals the deeply ambivalent history that lies behind our contemporary understanding of this organ.

While most books contain some information on related sensors topics, they are limited in their scope on biomedical sensors. Sensors in Biomedical Applications: Fundamentals, Design, Technology and Applications is the first systematized book to concentrate on all available and potential sensor devices of biomedical applications! Sensors in Biomedical Applications presents information on sensor types in a comprehensive and easy to understand format. The first four chapters concentrate on the basics, lending an understanding to operation and design principles of sensor elements. Introduced are sections on: basic terms, sensor technologies, sensor structure and sensing effects. The next three chapters describe application possibilities: physical sensors, sensors for measuring chemical qualities and biosensors. Finally, a chapter covers biocompatability, in addition to an appendix and glossary. Sensors in Biomedical Applications is the definitive reference book for a broad audience. All physicists, chemists and biologists interested in the chemical basis and effects of sensors will find this work invaluable. Biomedical engineers and sensor specialists will find the text useful in its pointed analysis of special design, processing and application problems. Physicians practicing with diagnostic tools will want to see the possibilities and limits of biomedical sensors. Finally, students of all of the above areas who wish to learn more about the basics of biomedical sensors need to have this book.

An in-depth review of important preparative methods for the synthesis and chemical modification of polymers, this authoritative second edition examines the advantages and limitations of various polymerization applications and procedures. It features new approaches and innovative strategies from the most prominent industry and academic laboratories, reflecting the burgeoning role of polymers in modern science and technology. The book analyzes biodegradable polymers for biomedical applications; investigates the use of polyolefins, polymeric dienes, aromatic polyethers, polymides, and metal-containing macromolecules; and covers polymers of acrylic acid, methacrylic acid, and maleic acid.

Have you ever wondered why psychologists still can't agree on what intelligence is? Or felt dismayed by debates around individual differences? Criticising the pitfalls of IQ testing, this book explains the true nature of intelligent systems, and their evolution from cells to brains to culture and human minds. Understanding Intelligence debunks many of the myths and misunderstandings surrounding intelligence. It takes a new look at the nature of the environment and the development of 'talent' and achievement. This brings fresh and radical implications for promoting intelligence and creativity, and prompts readers to reconsider their own possibilities and aspirations. Providing a broad context to the subject, the author also unmasks the ideological distortions of intelligence in racism and eugenics, and the suppressed expectations across social classes and genders. This book is a must-read for anyone curious about our own intelligence.

Epigenetic Principles of Evolution, Second Edition, fully examines the causal basis of evolution from an epigenetic point-of-view. By revealing the epigenetic uses of the genetic toolkit, this work demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theoretical perspective with examples from varied fields of biology, emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. Users will find a broader view of the epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic structures, such as DNA methylation, histone modifications, and patterns of miRNA, sRNA, and mRNA expression. This second edition is thoroughly updated to reflect new evidence and developing theories in the field of evolutionary epigenetics. New and revised chapters speak to the epigenetic basis of heredity, epigenetic regulation of animal structure and homeostasis, neural manipulation of gene expression, central control of gametogenesis, epigenetic control of early development, the origin of epigenetic information, evolutionary changes in response to environmental stressors, epigenetics of sympatric evolution, and the epigenetics of the Cambrian explosion, among other topics.

Humans have changed ecosystems more rapidly and extensively in the last 50 years than in any comparable period of human history. We have done this to meet the growing demands for food, fresh water, timber, fiber, and fuel. While changes to ecosystems have enhanced the well-being of billions of people, they have also caused a substantial and largely irreversible loss in diversity of life on Earth, and have strained the capacity of ecosystems to continue providing critical services.
Among the findings:
Approximately 60% of the services that support life on Earth are being degraded or used unsustainably. The harmful consequences of this degradation could grow significantly worse in the next 50 years.
Only four ecosystem services have been enhanced in the last 50 years: crops, livestock, aquaculture, and the sequestration of carbon.
The capacity of ecosystems to neutralize pollutants, protect us from natural disasters, and control the outbreaks of pests and diseases is declining significantly.
Terrestrial and freshwater systems are reaching the limits of their ability to absorb nitrogen.
Harvesting of fish and other resources from coastal and marine systems is compromising their ability to deliver food in the future.
Richly illustrated with maps and graphs, Current State and Trends presents an assessment of Earth's ability to provide twenty-four distinct services essential to human well-being. These include food, fiber, and other materials; the regulation of the climate and fresh water systems; underlying support systems such as nutrient cycling; and the fulfillment of cultural, spiritual, and aesthetic values. The volume pays particular attention to the current healthof key ecosystems, including inland waters, forests, oceans, croplands, and dryland systems, among others. It will be an indispensable reference for scientists, environmentalists, agency professionals, and students.

Trees and woodlands are an integral part of Britains heritage and culture, as well as an invaluable environmental and ecological resource. In an increasingly urbanized British population, romantic notions of bluebell-carpeted woods and deep-coloured wooded hillsides during autumn do not come easily. Instead, images of forgotten corners of land with a few sycamore trees and lots of brambles, or an area of dark, intimidating conifers are more common. The wide variety of types of woodland, whether closely managed or naturally-occuring, provide important habitats for a huge range of flora and fauna. This text explores the history and ecology of British woodlands, and explains why they are such a valuable resource. It offers a practical guide to issues of ecology of woodland habitats and organisms; conservation and management; coppicing, pasture woodland and commercial forestry; woodland grazing, ride management and recration in woodlands. Featuring illustrated species boxes as well as a full species list, notable sites with location maps and pictures, suggested projects and a full glossary, students and environmentalists should gain an understanding of the historical and present-day im

MXene, a two-dimensional (2D) transition metal carbide, nitride, and carbonitride, was discovered in 2011. MXene has great potential as a cocatalyst in the field of photocatalysis due to its unique properties and structure. MXene-Based Photocatalysts: Fabrication and Applications introduces readers to the fundamentals, preparation, microstructure characterization, and a variety of applications of MXene-based photocatalysts. The book is a comprehensive reference for MXene materials and provides an overview of the current literature on MXene-based photocatalysts. FEATURES Discusses preparation methods of MXenes Describes the morphology and microstructure of MXenes Offers strategies for fabricating MXene-based photocatalysts Details the reaction mechanism of MXene-based photocatalysts Covers applications in photocatalytic water-splitting, photocatalytic CO2 reduction, photocatalytic degradation, photocatalytic nitrogen fixation, and photocatalytic H2O2 production This book serves as an invaluable guide for advanced students, industry professionals, professors, and researchers in the field of materials science and engineering, photocatalysis, energy, and environmental applications.

Darwin's Pangenesis and its Rediscovery Part B explores Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation from over 150 years ago that strengthened his theory of evolution and explained many phenomena of life. Now, new discoveries on circulating DNA, mobile RNAs, prions and extracellular vesicles are providing striking evidence for the chemical existence of Darwin's imaginary gemmules. In addition, new evidence for the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis supposedly explains are progressing, and are hence explored in this comprehensive volume. Specific chapters in this new volume include Darwin and Mendel: The Historical Connection, Darwin's Pangenesis and Graft Hybridization, Darwin's Pangenesis and Medical Genetics, Darwin's Pangenesis and Certain Anomalous Phenomena, and Natural Selection and Pangenesis: The Darwinian Synthesis.

One of the major innovations of the Millennium Ecosystem Assessment is the incorporation of local and regional assessmentsu33 in alluin a global portrait of the planetAEs health. It is the first global assessment of ecosystems to include not only a diversity of ecosystems, but to draw on a wide range of cultural orientations and intellectual traditions, including those of indigenous peoples.
The Sub-global Assessments Working Group integrated information from multiple sources and found that biophysical factors such as land-use change, climate change and variability, pollution, and invasive species have a significant effect on human well-being across cultures. For example, in places where there are no other social safety nets, diminished human well-being tends to increase immediate dependence on ecosystem services, which can damage the capacity of those local ecosystems, which in turn appears to increase the probability of natural disaster or conflict.
Representing the baseline and framework for ongoing assessments of ecosystem and human well-being on a variety of scales around the world, Multiscale Assessments provides students, researchers, and policy-makers with the most comprehensive methodology for assessing ecosystems at local, national, and regional scales.

Sex is everywhere in modern society, yet it remains taboo. We all have questions about sex that are too uncomfortable to ask - how do we get reliable answers? In this go-to guide Drs Grant and Chamberlain use their clinical expertise to answer the questions you wish you could ask about sex. Questions like: Is my sex drive or sex behavior normal? Can someone have too much sex? Or too little? How has Internet dating and pornography changed sex? This go-to guide will help you understand common sexual issues, know when to worry (or not) about different sexual behaviors, and learn how our sex lives adapt to changing technology or in times of crisis. It also provides step-by-step advice for dealing with a range of sexual issues, and practical strategies for strengthening relationships.

This book provides a description on medicinal plants of Laos, including their role in maintaining health care among the population, their potential as a source for new medicinal compounds, their preservation, and their importance to the well being of the communities for present and future generations. The focus of this book is to draw on the rich culture, folklore, and environment of medicinal plants in the country. This is an opportunity to describe medicinal plants from a scientifically under-represented area, with the hope of being an important contribution to the knowledge of the region for both academics and scientists. Features Describes terrestrial medicinal plants from a scientifically under-represented region. Includes a wider variety of plants than previously published. Focuses on the rich culture, folklore, and environment of medicinal plants in Laos. Provides an important contribution to the knowledge of the region, and will benefit both academics and scientists in the field.

The past three decades have witnessed the great success of lithium-ion batteries, especially in the areas of 3C products, electrical vehicles, and smart grid applications. However, further optimization of the energy/power density, coulombic efficiency, cycle life, charge speed, and environmental adaptability are still needed. To address these issues, a thorough understanding of the reaction inside a battery or dynamic evolution of each component is required. Microscopy and Microanalysis for Lithium-Ion Batteries discusses advanced analytical techniques that offer the capability of resolving the structure and chemistry at an atomic resolution to further drive lithium-ion battery research and development. * Provides comprehensive techniques that probe the fundamentals of Li-ion batteries. * Covers the basic principles of the techniques involved as well as its application in battery research. * Describes details of experimental set-ups and procedure for successful experiments. This reference is aimed at researchers, engineers, and scientists studying lithium-ion batteries including chemical, materials, and electrical engineers, as well as chemists and physicists.

Medicinal Plant Responses to Stressful Conditions discusses the effects of multiple biotic and abiotic stressors on medicinal plants. It features information on biochemical, molecular, and physiological strategies used to mitigate or alleviate detrimental effects of biotic and abiotic stressors. The book contains chapters featuring medicinal plants of importance covering subjects including genomics, functional genomics, metabolomics, phenomics, proteomics, and transcriptomics under biotic and abiotic stress of medicinal plants and their molecular responses. It suggests exogenous application of different types of stimulants to enhance medicinal plant production in such conditions. Features: * Details all aspects of biotic and abiotic stressors in various important medicinal plant species. * Chapters cover evidence-based approaches in the diagnosis and management of medicinal plants under stressful conditions. * Includes information on ways to mitigate effects from high salinity, drought, temperature extremes, waterlogging, wind, high light intensity, UV radiation, heavy metals, or mineral deficiencies. A volume in the Exploring Medicinal Plants series, this book is an essential resource for plant scientists, botanists, environmental scientists, and anyone with an interest in herbal medicine

Compiles current research on nanomaterials as well as their versatile applications in plant biotic stress management Describes role of nanomaterials as enzyme-mimicking nanoparticles, nano-pesticides, nano-fertilizers, and nanomaterials Reviews day-to-day problems related to crop plants, their diagnostics and stress management Explores trends in nanomaterials utility towards diagnostics, enzyme-mimicking, crop protection and their possible role in plant disease management Includes pertinent nanomaterials including synthetic strategies, properties, chemistry, and applications

Biomass and Carbon Fuels in Metallurgy presents contemporary and new insights into the use of carbonaceous (Biomass) fuels in the metallurgical sector. The authors describe application of these fuels in different technological processes to produce pig iron, steel and ferroalloys. Emphasis is placed on biomass and its metallurgical utilization. Coverage includes the specification of fuels, their classification and the characteristics of their basic properties. The use of carbonaceous fuels in the production of various kinds of agglomerates (ferriferous, manganese and metalized) is also covered. Key Features: Provides a comprehensive view of carbonaceous fuels in various metallurgy processes Details experiments conducted on the use of traditional and alternative (biomass) carbonaceous fuels for the production of agglomerates. Demonstrates that the energy potential of biomass can also be successfully used in pyrometallurgical processes Describes applications of biomass-based fuels in different technological processes for the production of pig iron, steel and ferroalloys. Coverage includes the specification of fuels, their classification and the characteristics of their basic properties.

Trees and woodlands are an integral part of Britains heritage and culture, as well as an invaluable environmental and ecological resource. In an increasingly urbanized British population, romantic notions of bluebell-carpeted woods and deep-coloured wooded hillsides during autumn do not come easily. Instead, images of forgotten corners of land with a few sycamore trees and lots of brambles, or an area of dark, intimidating conifers are more common. The wide variety of types of woodland, whether closely managed or naturally-occuring, provide important habitats for a huge range of flora and fauna. This text explores the history and ecology of British woodlands, and explains why they are such a valuable resource. It offers a practical guide to issues of ecology of woodland habitats and organisms; conservation and management; coppicing, pasture woodland and commercial forestry; woodland grazing, ride management and recration in woodlands. Featuring illustrated species boxes as well as a full species list, notable sites with location maps and pictures, suggested projects and a full glossary, students and environmentalists should gain an understanding of the historical and present-day im

Darwin's Pangenesis and Its Rediscovery Part A highlights the findings of Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation that strengthened his theory of evolution and explained many phenomena of life. Now, new advances and the discovery of circulating cell-free DNA, mobile RNAs, prions and extracellular vesicles are providing new breakthroughs, thus increasing evidence on the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis suggests. Sections of note in this volume include the rationale, criticisms, influence and recent molecular evidence of Darwin's Pangenesis, as well as its relation to the inheritance of acquired characters, which is often included under the blanket term "transgenerational epigenetic inheritance."

Cerebral Lateralization and Cognition: Evolutionary and Developmental Investigations of Motor Biases, Volume 238, the latest release in the Progress in Brain Research series, discusses interdisciplinary research on the influence of cerebral lateralization on cognition within an evolutionary framework. Chapters of note in this release include Evolutionary Perspectives: Visual/Motor Biases and Cognition, Manual laterality and cognition through evolution: An archeological perspective, Laterality in insects, Motor asymmetries in fish, amphibians and reptiles, Visual biases and social cognition in animals, Mother and offspring lateralized social interaction across animal species, Manual bias, personality and cognition in common marmosets and other primates, and more.

Discusses the concepts of mechanical, thermal, and thermodynamic equilibrium and their applications. Covers the molecular basis for internal energy, entropy, thermodynamic equilibrium, and reversibility. Enables the reader to model irreversibility and determine the net loss in performance of a thermal system compared to an idealized system and approach an ideal one. Demonstrates entropy as a path independent property by use of reversible heat engines and reversible heat pumps interacting with a process between two states, the environment and the reservoir. Covers the role of reversibility from a thermodynamics standpoint and relates it to other areas, such as gas dynamics, combustion, propulsion, power plant engineering, and engines.

This comprehensive yet balanced work emphasizes the principles and rationale underlying recombinant DNA methodology while furnishing a general understanding of the experimental protocols-suggesting flexible approaches to resolving particular molecular necessities that are easily adaptable to readers' specific applications. Features summary tables presenting at-a-glance information on practices of recombinant DNA methodologies! Recombinant DNA Principles and Methodologies discusses basic and advanced topics requisite to the employment of recombinant DNA technology, such as -plasmid biology -nucleic acid biochemistry -restriction enzymes -cloning strategies -gel electrophoresis -southern and northern blotting -preparation of probes -phage lambda biology -cosmids and genome analysis -cloned gene expression -polymerase chain reaction -conventional and automated DNA sequencing -site-directed mutagenesis -and more! Elucidating the material with over 2250 edifying references, equations, drawings, and photographs, this state-of-the-art resource is a valuable hands-on guide for molecular and cell biologists, biochemists, bioprocess technologists, applied and industrial microbiologists, virologists, geneticists, chemical engineers, and upper-level undergraduate and graduate students in these disciplines.