Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Hematologic, Renal, and Immunologic Disorders, Seventh Edition thoroughly examines medical genetics and genomics as applied to hematologic, immunologic and endocrinologic disorders, with an emphasis on understanding the genetic mechanisms underlying these conditions, diagnostic approaches, and treatment methods. Here, genetic researchers, students and health professionals will find new and fully revised chapters on the genetics of red blood cell diseases, rhesus and other fetomaternal incompatibilities, immunodeficiency disorders, inherited complement deficiencies, celiac disease, and diabetes mellitus, as well as thyroid, parathyroid and gonad disorders, among other conditions. With regular advances in genomic technologies propelling precision medicine into the clinic, this book, which has served as the ultimate resource for clinicians integrating genetics into medical practice, continues to provide the most important information. With nearly 5,000 pages of detailed coverage, contributions from over 250 of the world's most trusted authorities in medical genetics, and a series of 11 volumes available for individual sale, this updated edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies.

This volume of Advances in Microbial Physiology continues the long tradition of topical and important reviews in microbiology

A wildly fun and scientifically sound exploration of what alien life must be like Scientists are confident that life exists elsewhere in the universe. Yet rather than taking a realistic approach to what aliens might be like, we imagine that life on other planets is the stuff of science fiction. The time has come to abandon our fantasies of space invaders and movie monsters and place our expectations on solid scientific footing. Using his own expert understanding of life on Earth and Darwin's theory of evolution--which applies throughout the universe--Cambridge zoologist Dr. Arik Kershenbaum explains what alien life must be like: how these creatures will move, socialize, and communicate. Might there be an alien planet with supersonic animals? A moon where creatures have a language composed of smells? Will aliens scream with fear, act honestly, or have technology? The Zoologist's Guide to the Galaxy answers these questions using the latest science to tell the story of how life really works, on Earth and in space.

The study of language is a field that has seen tremendous progress in the last two decades, and key to this progress is the accelerating trend toward integration of neurobiological approaches with the more established understanding of language within cognitive psychology, computer science, and linguistics. This volume serves as the definitive reference on the neurobiology of language, bringing these various advances together into a single volume of 100 concise entries. The organization includes sections on all of the area s major subfields, with each section covering both empirical data and theoretical perspectives. "Foundational" neurobiological coverage is also provided, including neuroanatomy, neurophysiology, genetics, linguistic and psycholinguistic data, and models.
Foundational reference for the current state of the field of the neurobiology of language
Enables brain and language researchers and students to stay up to date in fast moving field that crosses many disciplinary and subdisciplinary boundaries
Provides an accessible entry point for other scientists interested in the area but not actively working in it - i.e. speech therapists, neurologists, cognitive psychologists
Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available."

Analytical Ultracentrifugation, the latest volume in Methods in Enzymology, focuses on analytical ultracentrifugation. The scope of this technique has greatly expanded in recent years due to advances in instrumentation, algorithms and software. This volume describes the latest innovations in the field and in the applications of analytical ultracentrifugation in the analysis of macromolecules, macromolecular assemblies, and biopharmaceuticals.

Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of genetics. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing furture directions.

Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich and varied and exemplary of the abundant subject matter addressed by this long-running serial.

This book integrates findings from across domains in performance psychology to focus on core research on what influences peak and non-peak performance. The book explores basic and applied research identifying cognition-action interactions, perception-cognition interactions, emotion-cognition interactions, and perception-action interactions. The book explores performance in sports, music, and the arts both for individuals and teams/groups, looking at the influence of cognition, perception, personality, motivation and drive, attention, stress, coaching, and age. This comprehensive work includes contributions from the US, UK, Canada, Germany, and Australia.

Data Mining for Bioinformatics Applications provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. The text uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems, containing 45 bioinformatics problems that have been investigated in recent research. For each example, the entire data mining process is described, ranging from data preprocessing to modeling and result validation.

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.

This monograph is a summary of the conference on Eurytemora, gathering renowned researchers from all over the world to discuss new advances in Phylogeny, Biogeography, Taxonomy, and Ecology of this important group of estuarine crustaceans, held the 13-17 May 2019 in St. Petersburg, Russia. The present volume includes 17 selected papers, in which you will discover new aspects of the modern theory on the history and recent geographical distribution (biogeography) of an important group of estuarine crustaceans, revealing coincidences with a modern model of continental drift. The researchers suggest a new hypothesis on time and place of origin of continental calanoid copepods. The specialists show that studying external morphology in detail helps to increase identification and differentiation between closely related sibling species within the Eurytemora group. Several ecological questions on invasive and pseudocryptic copepod species are debated. Finally, the last chapter of this monography is devoted to taxa related to the Eurytemora group, Epischura, Temora, Temoropia, and Pseudodiaptomus. First published as a Special Issue of Crustaceana 93(3-5): 241-547.

Essential Clinically Applied Anatomy of the Peripheral Nervous System in the Limbs is designed to combine the salient points of the anatomy of the PNS with typical pathologies affecting the nerves of the upper and lower limbs. The book is a quick reference guide for those studying and treating neuromuscular disease such as neurologists, neurosurgeons, neuroradiologists, and clinical neurophysiologists. Readers will find easy-to-access facts about the anatomy of the nerves in the limbs, coupled with clinically applied scenarios relevant to that area being discussed, as well as clinical findings on examination. The book's purpose is to provide the reader with a succinct presentation of the relevant anatomy of the PNS in the limbs and how it is directly applicable to day-to-day clinical scenarios. It presents the reader with an easily accessible format to clinically applied PNS anatomy that is perfect for quick reference. Chapters review the nerves of the upper and lower limbs, and the origins, course, distribution and relevant pathologies affecting each. These pathologies present typical injuries to the nerves of the PNS, as well as clinical findings on examination and treatments.

Our species long lived on the edge of starvation. Now we produce enough food for all 7 billion of us to eat nearly 3,000 calories every day. This is such an astonishing thing in the history of life as to verge on the miraculous. "The Big Ratchet" is the story of how it happened, of the ratchets--the technologies and innovations, big and small--that propelled our species from hunters and gatherers on the savannahs of Africa to shoppers in the aisles of the supermarket.
The Big Ratchet itself came in the twentieth century, when a range of technologies--from fossil fuels to scientific plant breeding to nitrogen fertilizers--combined to nearly quadruple our population in a century, and to grow our food supply even faster. To some, these technologies are a sign of our greatness; to others, of our hubris. MacArthur fellow and Columbia University professor Ruth DeFries argues that the debate is the wrong one to have. Limits do exist, but every limit that has confronted us, we have surpassed. That cycle of crisis and growth is the story of our history; indeed, it is the essence of "The Big Ratchet." Understanding it will reveal not just how we reached this point in our history, but how we might survive it.

Two new volumes of Methods in Enzymology continue the legacy of this premier serial with quality chapters authored by leaders in the field. Circadian Rhythms and Biological Clocks Part A and Part B is an exceptional resource for anybody interested in the general area of circadian rhythms. As key elements of timekeeping are conserved in organisms across the phylogenetic tree, and our understanding of circadian biology has benefited tremendously from work done in many species, the volume provides a wide range of assays for different biological systems. Protocols are provided to assess clock function, entrainment of the clock to stimuli such as light and food, and output rhythms of behavior and physiology. This volume also delves into the impact of circadian disruption on human health. Contributions are from leaders in the field who have made major discoveries using the methods presented here.

We grow up thinking there are five senses, but we forget about the ten neglected senses of the body that both enable and limit our experience. Embodied explores the psychology of physical sensation in ten chapters: balance, movement, pressure (acting in gravity), breathing, fatigue, pain, itch, temperature, appetite, and expulsion (the senses of physical matter leaving the body). For each sense, two people are interviewed who live with extreme experiences of the sense being investigated; their stories bring to life how far physical sensations matter to us and how much they define what is possible in our life. How physical sensation shapes behavior and how behavior is shaped by sensation are examined. A final chapter presents a theory of what is common across the ten senses: of how we deal with being urged to act, and what happens when extreme sensation is inescapable.

The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths.