Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and Asia effectively synthesize perspectives from a spectrum of different scientific, societal, and global contexts, and offer pragmatic approaches to a range of topics, including oversight, governance and policy surrounding secondary genomic results, criteria for identifying results for return, communication and consent, stakeholders' attitudes and perspectives, disclosing results, and clinical, patient-centered protocols.

Microbiomics: Dimensions, Applications, and Translational Implications of Human and Environmental Microbiome Research describes a new, holistic approach to microbiomics. International experts provide in-depth discussion of current research methods for studying human, environmental, viral and fungal microbiomes, as well as the implications of new discoveries for human health, nutrition, disease, cancer research, probiotics and in the food and agricultural industries. Distinct chapters covering culturomics and sub-microbiomes, such as the viriome and mycetobiome, provide an integrative framework for the expansion of microbiomics into new areas of application, as well as crosspollination between research areas. Detailed case studies include the use of microbiomics to develop natural products with antimicrobial properties, microbiomic enhancements in food and beverage technology, microbes for bioprotection and biopreservation, microbial tools to reduce antibiotic resistance, and maintenance and cultivation of human microbial communities.

Ethical Futures and Global Science Fiction explores the ethical concerns and dimensions of representations of the future of global science fiction, focusing on the issues that dominate utopian, dystopian and science fiction literature. The essays examine recent visions of the future in science fiction and re-examine earlier texts through contemporary lenses. Across fourteen chapters, the collection considers authors from Algeria, Australia, Canada, China, Egypt, France, Germany, Haiti, India, Jamaica, Macedonia, Mexico, Russia, South Africa, the UK and USA. The volume delves into a range of ethical questions of immediate contemporary relevance, including environmental ethics, postcolonial ethics, social justice, animal ethics and the ethics of alterity.

BEST: Implementing Career Development Activities for Biomedical Research Trainees provides an instructional guide for institutions wanting to create, supplement or improve their career and professional development offerings. Each chapter provides an exclusive perspective from an administrator from the 17 Broadening Experiences in Scientific Training (BEST) institutions. The book can aid institutions who train graduate students in a variety of careers by teaching faculty and staff how to create and implement career development programming, how to highlight the effectiveness of offerings, how to demonstrate that creating a program from scratch is doable, and how to inform faculty and staff on getting institutional buy-in. This is a must-have for graduate school deans and faculty and staff who want to implement and institutionalize career development programing at their institutions. It is also ideal for graduate students and postdocs.

This book offers essential, systematic information on the assessment of the spatial association between two processes from a statistical standpoint. Divided into eight chapters, the book begins with preliminary concepts, mainly concerning spatial statistics. The following seven chapters focus on the methodologies needed to assess the correlation between two or more processes; from theory introduced 35 years ago, to techniques that have only recently been published. Furthermore, each chapter contains a section on R computations to explore how the methodology works with real data. References and a list of exercises are included at the end of each chapter. The assessment of the correlation between two spatial processes has been tackled from several different perspectives in a variety of applications fields. In particular, the problem of testing for the existence of spatial association between two georeferenced variables is relevant for posterior modeling and inference. One evident application in this context is the quantification of the spatial correlation between two images (processes defined on a rectangular grid in a two-dimensional space). From a statistical perspective, this problem can be handled via hypothesis testing, or by using extensions of the correlation coefficient. In an image-processing framework, these extensions can also be used to define similarity indices between images.

A unique chronology with entries describing the key events in the 3,000-year conflict between religion and science over the explanation and definition of life on Earth. Exhaustively researched and authoritative, Chronology of the Evolution-Creationism Controversy does what no other work does: it examines the conflict between the religious and scientific views of life on Earth in its full 3,000-year historical context, showing readers how this roiling debate has played out over the centuries. With hundreds of entries, Chronology of the Evolution-Creationism Controversy describes specific cultural, religious, and scientific events relevant to the evolution-creationism controversy from the first notions of creationism in ancient Egypt to the present. Within this historical approach, it identifies a number of recurring themes that have shaped the debate through the ages, including famous court cases, the recurrence of the "intelligent design" argument, disagreements over the age of the Earth, and the impact of technological advances on both the scientific and faith-based viewpoints. While approaching the subject globally throughout, the book's second half focuses on tensions between science and religious thought in the United States since the early 1900s. Comprises over 1,400 chronologically arranged entries on important political, legal, and social events in the ongoing controversy between science- and faith-based views of the Earth and life Offers a thorough bibliography spanning historical aspects of the controversy, creationist literature, and resources from evolutionary biology Includes a one-of-a-kind glossary for easy access to definitions of relevant terms used by both anti-evolutionists and scientists Provides an extensive index serving as a reference tool and as a way to explore recurring themes Presents detailed appendices on estimating Earth's age, the geologic timescale, major species of known Hominines, and key legal decisions involving the teaching of evolution and creationism

In The Power of Habit , award-winning New York Times  business reporter Charles Duhigg takes us to the thrilling edge of scientific discoveries that explain why habits exist and how they can be changed.

With penetrating intelligence and an ability to distill vast amounts of information into engrossing narratives, Duhigg brings to life a whole new understanding of human nature and its potential for transformation. Along the way we learn why some people and companies struggle to change, despite years of trying, while others seem to remake themselves overnight.

We visit laboratories where neuroscientists explore how habits work and where, exactly, they reside in our brains. We discover how the right habits were crucial to the success of Olympic swimmer Michael Phelps, Starbucks CEO Howard Schultz, and civil-rights hero Martin Luther King, Jr.

We go inside Procter & Gamble, Target superstores, Rick Warren's Saddleback Church, NFL locker rooms, and the nation's largest hospitals and see how implementing so-called keystone habits can earn billions and mean the difference between failure and success, life and death.

At its core, The Power of Habit  contains an exhilarating argument: the key to exercising regularly, losing weight, raising exceptional children, becoming more productive, building revolutionary companies and social movements, and achieving success is understanding how habits work. Habits aren't destiny. As Charles Duhigg shows, by harnessing this new science, we can transform our businesses, our communities, and our lives.

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer s disease, Parkinson s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters."

In light of the novel corona virus outbreak in December 2019 and its subsequent impact on entire world as a global pandemic, the book attempts to provide integrated risk assessment on Covid -19 like pandemics, as well as to understand the societal, environment and economic impact of the outbreak in various sectors of development. It covers fundamental factors of global disease outbreaks and its coverage as major disaster through the complexity and severity of consequences, illustrating the dimensions of low frequency high intensity disasters. It brings together broad range of topics including basic concepts, isolation measure, role of governance and key technical advancements for containing the diseases. In addition, it also covers resilience analysis towards the impacts such outbreaks have on bio-diversity, ecosystem services and agricultural food production. It defines key exit strategies from the lessons learned and success stories of historical disease outbreaks. The book is presented in four parts, where part 1 familiarizes with fundamentals; part 2 focuses on integrated risk assessments; part 3 focuses on various measures and strategies of resilience; and part 4 suggests key lessons and recommendations. The book is a useful reading reference for scientific community, policy makers and professionals across the domains of health, environment, disasters and sustainable development. Book is specifically beneficial for postgraduate students, researchers, planners and field professionals.

How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state-dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley

This book explores the role of exaptation in diverse areas of life, with examples ranging from biology to economics, social sciences and architecture. The concept of exaptation, introduced in evolutionary biology by Gould and Vrba in 1982, describes the possibility that already existing traits can be exploited for new purposes throughout the evolutionary process. Edited by three active scholars in the fields of biology, physics and economics, the book presents an interdisciplinary collection of expert viewpoints illustrating the importance of exaptation for interpreting current reality in various fields of investigation. Using the lenses of exaptation, the contributing authors show how to view the overall macroscopic landscape as comprising many disciplines, all working in unity within a single complex system. This book is the first to discuss exaptation in both hard and soft disciplines and highlights the role of this concept in understanding the birth of innovation by identifying key elements and ideas. It also offers a comprehensive guide to the emerging interdisciplinary field of exaptation, provides didactic explanations of the basic concepts, and avoids excessive jargon and heavy formalism. Its target audience includes graduate students in physics, biology, mathematics, economics, psychology and architecture; it will also appeal to established researchers in the humanities who wish to explore or enter this new science-driven interdisciplinary field.

This book describes the multitude of interactions between plant, soil, and micro-organisms. It emphasizes on how growth and development in plants, starting from seed germination, is heavily influenced by the soil type. It describes the interactions established by plants with soil and inhabitant microbial community. The chapters describe how plants selectively promote certain microorganisms in the rhizospheric ecozone to derive multifarious benefits such as nutrient acquisition and protection from diseases. The diversity of these rhizospheric microbes and their interactions with plants largely depend on plant genotype, soils attributes, and several abiotic and biotic factors. Most of the studies concerned with plant-microbe interaction are focused on temperate regions, even though the tropical ecosystems are more diverse and need more attention. Therefore, it is crucial to understand how soil type and climatic conditions influence the plant-soil-microbes interaction in the tropics. Considering the significance of the subject, the present volume is designed to cover the most relevant aspects of rhizospheric microbial interactions in tropical ecosystems. Chapters include aspects related to the diversity of rhizospheric microbes, as well as modern tools and techniques to assess the rhizospheric microbiomes and their functional roles. The book also covers applications of rhizospheric microbes and evaluation of prospects improving agricultural practice and productivity through the use of microbiome technologies. This book will be extremely interesting to microbiologists, plant biologists, and ecologists.

This volume is a self-contained companion piece to Studying Vibrational Communication, published in 2014 within the same series. The field has expanded considerably since then, and has even acquired a name of its own: biotremology. In this context, the book reports on new concepts in this fascinating discipline, and features chapters on state-of-the art methods for studying behavior tied to substrate-borne vibrations, as well as an entire section on applied biotremology. Also included are a historical contribution by pioneers in the field and several chapters reviewing the advances that have been made regarding specific animal taxa. Other new topics covered are vibrational communication in vertebrates, multimodal communication, and biotremology in the classroom, as well as in art and music. Given its scope, the book will appeal to all those interested in communication and vibrational behavior, but also to those seeking to learn about an ancient mode of communication.