The Phytochemical Society of North America held its forty-fourth annual meeting in Ottawa, Ontario, Canada from July 24-28, 2004. This year's meeting was hosted by the University of Ottawa and the Canadian Forest Service, Great Lakes Forestry Centre and was held jointly with the International Society of Chemical Ecology. All of the chapters in this volume are based on papers presented in the symposium entitled "Chemical Ecology and Phytochemistry of Forest Ecosystems." The Symposium Committee, Mamdouh Abou-Zaid, John T. Arnason, Vincenzo deLuca, Constance Nozzolillo, and Bernard Philogene, assembled an international group of phytochemists and chemical ecologists working primarily in northern forest ecosystems. It was a unique interdisciplinary forum of scientists working on the cutting edge in their respective fields. While most of these scientists defy the traditional labels we are accustomed to, they brought to the symposium expertise in phytochemistry, insect biochemistry, molecular biology, genomics and proteomics, botany, entomology, microbiology, mathematics, and ecological modeling.
* A collection of papers presented at the 44th Annual meeting of the Phytochemical Society of North America
* Representation from a unique interdisciplinary forum of scientists
* Includes discussions on new genomics research in forest health

This book presents a variety of techniques designed to enhance and empower multi-disciplinary and multi-institutional machine learning research in healthcare informatics. It is intended to provide a unique compendium of current and emerging machine learning paradigms for healthcare informatics, reflecting the diversity, complexity, and depth and breadth of this multi-disciplinary area.

This volume continues the retrospective analyses of Volumes I and II, but goes beyond that in an attempt to understand how phenolic acids are partitioned in seedling-solution and seedling-microbe-soil-sand culture systems and how phenolic acid effects on seedlings may be related to the actual and/or conditional physicochemical properties (e.g., solubility, hydrophobicity, pKa, molecular structure and soil sorption/desorption) of simple phenolic acids. Specifically, it explores the quantitative partitioning (i.e., source-sink relationships) of benzoic and cinnamic acids in cucumber seedling-solution and cucumber seedling-microbe-soil-sand systems and how that partitioning may influence phenolic acid effects on cucumber seedlings. Regressions, correlations and conceptual and hypothetical models are used to achieve these objectives. Cucumber seedlings are used as a surrogate for phenolic acid sensitive herbaceous dicotyledonous weed seedlings. This volume was written specifically for researchers and their students interested in understanding how a range of simple phenolic acids and potentially other putative allelopathic compounds released from living plants and their litter and residues may modify soil chemistry, soil and rhizosphere microbial biology, seedling physiology and seedling growth. In addition, this volume describes the potential relationships, where they may exist, for direct transfer of organic compounds between plants, plant communication and plant-plant allelopathic interactions and addresses the following questions: Can physicochemical properties of phenolic acids be used as tools to help understand the complex behavior of phenolic acids and the ultimate effects of phenolic acids on sensitive seedlings? What insights do laboratory bioassays and the conceptual and hypothetical models of laboratory systems provide us concerning the potential behavior and effects of phenolic acids in field systems? What potential role may phenolic acids play in broadleaf-weed seedling emergence in wheat debris cover crop no-till systems?

This edited book is focused on SDG 15. This volume covers aspects of species and ecosystem modeling in understanding the complexity of ecological systems, restoration, protected area management, and species conservation. The book follows a systematic and situation-sensitive approach to discuss ecosystem and species modeling tools, approaches, science, case studies, opportunities, and gaps for enhancing conservation efforts, ensuring ecosystem resilience, and addressing sustainability issues. The book emphasizes on science, innovations, case studies, and strategic relevance as main pillars of using ecosystem and species modeling tools and implementing the outcomes and results. In addition, clear conceptual frameworks, elaborated methodologies, and their applications are included to support policy planning and interventions to reduce and reverse human encroachment in human-dominated natural ecosystems, their degradation, and loss of important species and ecosystem services. Essential information with a special focus on advances and opportunities in advancing the implementation of results and outputs of the modeling tools, challenges and constraints for addressing loss of ecosystem services, designing and implementing sustainable landscape restoration, environmental risk assessment, and finally understanding policy implications and concerns for mainstreaming modeling results in conservation planning and decision-making is included in the book. Further topics include ultimate translational value of modeling tools and efforts across transitional ecosystems and species habitat to provide better evidence to influence the nature-based solutions (NbS) and ecosystem health assessment using Red List of Ecosystems (RLE). The emerging roles of integrative socio-ecological as well as techno-cultural factors in promoting the relevance of ecosystem and species modeling is one of the key features of this book. This edited volume is of interest and useful to researchers, students, scholars, policy makers, forest managers, consultants, and policy makers in the fields of protected area management, forest department, conservation, modeling, climate change, and sustainability science, and also authors engaged in IPBES, IPCC, and several other assessments.

In this scientifically authoritative essay collection, Salzman, a seasoned and provocative environmentalist, demonstrates how evolutionary theory penetrates nearly all aspects of human society. She faults social justice movements for their short-sighted focus on human needs to the exclusion of nonhuman nature and stresses the potential of evolutionary thought for replacing religious and secular ideologies with an ecological paradigm for broad social change.

Salzman's special concern is the resurgence of irrationality, anti-intellectualism and anti-science attitudes.. She explodes the myth of genetic determinism promoted in popular media, discrediting the belief that natural selection involves violence. In place of the arbitrary "economism" of socialists and the free marketeers' faith in untrammeled economic growth, she envisions a human society modeled on interdependent self-regulating natural systems.

This volume is a self-contained companion piece to Studying Vibrational Communication, published in 2014 within the same series. The field has expanded considerably since then, and has even acquired a name of its own: biotremology. In this context, the book reports on new concepts in this fascinating discipline, and features chapters on state-of-the art methods for studying behavior tied to substrate-borne vibrations, as well as an entire section on applied biotremology. Also included are a historical contribution by pioneers in the field and several chapters reviewing the advances that have been made regarding specific animal taxa. Other new topics covered are vibrational communication in vertebrates, multimodal communication, and biotremology in the classroom, as well as in art and music. Given its scope, the book will appeal to all those interested in communication and vibrational behavior, but also to those seeking to learn about an ancient mode of communication.

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans.

Receptors in the Evolution and Development of the Brain: Matter into Mind presents the key role of receptors and their cognate ligands in wiring the mammalian brain from an evolutionary developmental biology perspective. It examines receptor function in the evolution and development of the nervous system in the large vertebrate brain, and discusses rapid eye movement sleep and apoptosis as mechanisms to destroy miswired neurons. Possible links between trophic deficits and connectional diseases including Alzheimer's, Parkinson's, and ALS are also discussed. This book is extremely useful to those with an interest in the molecular and cellular neurosciences, including those in cognitive and clinical branches of this subject, and anyone interested in how the incredibly complex human brain can build itself.

An all-in-one guide for helping caregivers of individuals with brain injury or degenerative disease to address speech, language, voice, memory, and swallowing impairment and to distinguish these problem areas from healthy aging. Advances in science mean that people are more likely to survive a stroke or live for many years after being diagnosed with a degenerative disease such as Parkinson's. But the communication deficits that often accompany a brain injury or chronic neurologic condition-including problems with speech, language, voice, memory, and/or swallowing-can severely impact quality of life. If you are a caregiver coping with these challenges, this all-in-one book can help you and your loved one. Written by a team of experts in speech-language pathology, each chapter focuses on a different aspect of caregiving and features relatable patient examples. Providing answers to common questions, definitions of complex medical terms, and lists of helpful resources, this book also: * touches on expected, age-related changes in communication, memory, swallowing, and hearing abilities, to name a few * offers practical strategies for caregivers to cope with speech, language, and voice problems and to maximize their loved one's ability to communicate * reveals how caregivers can assist their loved ones with swallowing challenges to maintain good nutrition and hydration * provides crucial information on how caregivers can handle grief and take care of themselves during the caregiving process * explains how to incorporate the arts, as well as a loved one's hobbies and interests, into their communication or memory recovery This comprehensive book will allow readers to take a more informed and active role in their loved one's care. Contributors: Marissa Barrera, Frederick DiCarlo, Lea Kaploun, Elizabeth Roberts, Teresa Signorelli Pisano

Handbook of Nutrition, Diet, and the Eye, Second Edition, thoroughly addresses common features and etiological factors on how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss are devastating. There are a range of ocular defects that have either their origin in nutritional deficiencies/excess or have been shown to respond favorably to nutritional components. Featuring a new section on animal model studies where both the ocular problem and dietary remedies can be varied, there are also new chapters on dietary supplements.

Biodiversity of Pantepui: The Pristine "Lost World" of the Neotropical Guiana Highlands provides the most updated and comprehensive knowledge on the biota, origin, and evolution of the Pantepui biogeographical province. It synthesizes historical information and recent discoveries, covering the main biogeographic patterns, evolutionary trends, and conservational efforts. Written by international experts on the biodiversity of this pristine land, this book explores what makes Pantepui a unique natural laboratory to study the origin and evolution of Neotropical biodiversity under the influence of only natural drivers. It discusses the organisms living in Pentepui, including algae, plants, several groups of invertebrates, birds, amphibians, reptiles, and mammals. The latter portion of the book delves into the effects of human activity and global warming on Pantepui, and current conservational efforts to combat these threats. Biodiversity of Pantepui is an important resource for researchers in ecology, biogeography, evolution, and conservation, who want to understand the biodiversity and natural history of this region, and how to help conserve and protect the Guiana Highlands from environmental and human damages.

Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine.

Sometimes history seems like a laundry list of malevolent monarchs, pompous presidents and dastardly dictators. But are they really the ones in the driving seat? Sapiens: A Graphic History – The Masters of History takes us on an immersive and hilarious ride through the human past to discover the forces that change our world, bring us together, and – just as often – tear us apart.

Grab a front-row seat to the greatest show on earth and explore the rise of money, religion and empire. Join our fabulous host Heroda Tush, as she wonders: which historical superhero will display the power to make civilisations rise and fall? Will Mr Random prove that luck and circumstance prevail? Will Lady Empire convince us of the irrefutable shaping force of conquerors? Or will Clashwoman beat them all to greatness by reminding us of the endless confrontations that seem to forever plague our species?

In this next volume of the bestselling graphic series, Yuval Noah Harari, David Vandermeulen and Daniel Casanave continue to present the complicated story of humankind with wit, empathy and originality. Alongside the unlikely cast of new characters, we are rejoined by the familiar faces of Yuval, Zoe, Professor Saraswati, Bill and Cindy (now Romans), Skyman and Captain Dollar. As they travel through time, space and human drama in search of truth, it's impossible not to wonder: why can’t we all just get along?

This third instalment in the Sapiens: A Graphic History series is an engaging, insightful, and colourful retelling of the story of humankind for curious minds of all ages, and can be browsed through on its own or read in sequence with Volumes One and Two.

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.

The most comprehensive and practical guide available for caregivers of children who have seizures and epilepsy, now completely updated. For more than 30 years, parents, caregivers, and health care providers have trusted Seizures and Epilepsy in Children to provide comprehensive, science-based information and practical answers to the most common questions about these conditions. In this new edition, completely revised and updated, a team of experts from Johns Hopkins Medicine offers guidance on: * diagnostic testing and the latest treatments * recommendations for the best devices, apps, and websites * driving, health insurance, and playing sports * navigating school and other environments * mental health issues and counseling * coping with disability * side effects from medications This new edition also features dedicated chapters on diet, complementary and alternative medicine, and rescue medicines. Seizures and Epilepsy in Children is the go-to resource for caregivers and families with children who have epilepsy and seizures.

While the field of vision science has grown significantly in the past three decades, there have been few comprehensive books that showed readers how to adopt a computional approach to understanding visual perception, along with the underlying mechanisms in the brain. Understanding Vision explains the computational principles and models of biological visual processing, and in particular, of primate vision. The book is written in such a way that vision scientists, unfamiliar with mathematical details, should be able to conceptually follow the theoretical principles and their relationship with physiological, anatomical, and psychological observations, without going through the more mathematical pages. For those with a physical science background, especially those from machine vision, this book serves as an analytical introduction to biological vision. It can be used as a textbook or a reference book in a vision course, or a computational neuroscience course for graduate students or advanced undergraduate students. It is also suitable for self-learning by motivated readers. in addition, for those with a focused interest in just one of the topics in the book, it is feasible to read just the chapter on this topic without having read or fully comprehended the other chapters. In particular, Chapter 2 presents a brief overview of experimental observations on biological vision; Chapter 3 is on encoding of visual inputs, Chapter 5 is on visual attentional selection driven by sensory inputs, and Chapter 6 is on visual perception or decoding. Including many examples that clearly illustrate the application of computational principles to experimental observations, Understanding Vision is valuable for students and researchers in computational neuroscience, vision science, machine and computer vision, as well as physicists interested in visual processes.

Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.