Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research.

While the field of vision science has grown significantly in the past three decades, there have been few comprehensive books that showed readers how to adopt a computional approach to understanding visual perception, along with the underlying mechanisms in the brain. Understanding Vision explains the computational principles and models of biological visual processing, and in particular, of primate vision. The book is written in such a way that vision scientists, unfamiliar with mathematical details, should be able to conceptually follow the theoretical principles and their relationship with physiological, anatomical, and psychological observations, without going through the more mathematical pages. For those with a physical science background, especially those from machine vision, this book serves as an analytical introduction to biological vision. It can be used as a textbook or a reference book in a vision course, or a computational neuroscience course for graduate students or advanced undergraduate students. It is also suitable for self-learning by motivated readers. in addition, for those with a focused interest in just one of the topics in the book, it is feasible to read just the chapter on this topic without having read or fully comprehended the other chapters. In particular, Chapter 2 presents a brief overview of experimental observations on biological vision; Chapter 3 is on encoding of visual inputs, Chapter 5 is on visual attentional selection driven by sensory inputs, and Chapter 6 is on visual perception or decoding. Including many examples that clearly illustrate the application of computational principles to experimental observations, Understanding Vision is valuable for students and researchers in computational neuroscience, vision science, machine and computer vision, as well as physicists interested in visual processes.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation; Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer; T-Cell Transformation and Oncogenesis by a2-Herpesviruses; Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis; Soluble Mediators of Inflammation During Tumor Development; Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells: Current Challenges and Future Directions.

Lucretius' account of the origin of life, the origin of species, and human prehistory (first century BC) is the longest and most detailed account extant from the ancient world. It is a mechanistic theory that does away with the need for any divine design, and has been seen as a forerunner of Darwin's theory of evolution. This commentary seeks to locate Lucretius in both the ancient and modern contexts. The recent revival of creationism makes this study particularly relevant to contemporary debate, and indeed, many of the central questions posed by creationists are those Lucretius attempts to answer.

This edited volume presents fundamentals as well as applications of oculomotor methods in industrial and clinical settings. The topical spectrum covers 1.) basics and background material, 2.) methods such as recording techniques, markov models, Levy flights, pupillometry and many more, as well as 3.) a broad range of applications in clinical and industrial settings. The target audience primarily comprises research experts and practitioners, but the book may also be beneficial for graduate students.

The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Cardiovascular, Respiratory, and Gastrointestinal Disorders, Seventh Edition includes the latest information on seminal topics such as prenatal diagnosis, genome and exome sequencing, public health genetics, genetic counseling, and management and treatment strategies. This comprehensive, yet practical, resource emphasizes theory and research fundamentals relating to applications of medical genetics across the full spectrum of inherited disorders and applications to medicine. Updated sections in this release cover the genetics of cardiovascular, respiratory and gastrointestinal disorders, with an emphasis on genetic determinants and new pathways for diagnosis, prevention and disease management. In addition, genetic researchers, students and health professionals will find new and fully revised chapters on the molecular genetics of congenital heart defects, inherited cardiomyopathies, hypertension, cystic fibrosis, asthma, hereditary pulmonary emphysema, inflammatory bowel disease, and bile pigment metabolism disorders among other conditions.

"Genes, Culture, and Human Evolution: A Synthesis"is a textbook on human evolution that offers students a unique combination of cultural anthropology and genetics.
Written by two geneticists---including a world-renowned scientist and founder of the Human Genome Diversity Project---and a socio-cultural anthropologist.
Based on recent findings in genetics and anthropology that indicate the analysis of human culture and evolution demands an integration of these fields of study.
Focuses on evolution---or, rather, co-evolution---viewed from the standpoint of genes and culture, and their inescapable interactions.
Unifies cultural and genetic concepts rather than rehashing nonempirical sociobiological musings.
Demonstrates that empirical genetic evidence, based on modern DNA analysis and population studies, provides an excellent foundation for understanding human cultural diversity.

This book is a collection of essays exploring adaptive systems from many perspectives, ranging from computational applications to models of adaptation in living and social systems. The essays on computation discuss history, theory, applications, and possible threats of adaptive and evolving computations systems. The modeling chapters cover topics such as evolution in microbial populations, the evolution of cooperation, and how ideas about evolution relate to economics.
The title Perspectives on Adaptation in Natural and Artificial Systems honors John Holland, whose 1975 Book, Adaptation in Natural and Artificial Systems has become a classic text for many disciplines in which adaptation play a central role. The essays brought together here were originally written to honor John Holland, and span most of the different areas touched by his wide-ranging and influential research career. The authors include some of the most prominent scientists in the fields of artificial intelligence evolutionary computation, and complex adaptive systems. Taken together, these essays present a broad modern picture of current research on adaptation as it relates to computers, living systems, society, and their complex interactions.

Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the "complexosome") is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the "interactomes") from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.

The brain is a cognitive organ, and regions of the brain that traverse brainstem and cortical sites orchestrate the expression of bodily sensibility: intelligent action. They can appear perfunctory or intimate, calculating a sum or selecting a mate. Schulkin presents neuroscientific research demonstrating that thought is not on one side and bodily sensibility on the other; from a biological point of view, they are integrated. Schulkin further argues that this integration has important implications for judgements about the emotions, art and music, moral sensibilities, attraction and revulsion, and our perpetual inclination to explain ourselves and our surroundings. He begins the book by setting forth a view of the emotions not as a bodily burden to be borne, but rather as a great source of information. He then moves on to other domains, claiming that underlying the experience of aesthetics in at least some instances is the interplay between expectation and disappointment from its infraction, and suggesting that, among other things, repulsion and attraction to the cries and joys of others consitutes moral responsiveness. This book should appeal to researchers in behavioral neuroscience, emotion, and psychophysiology, as well as cognitive and social psychologists and philosophers of mind.

In the tradition of My Stroke of Insight and Brain on Fire, this powerful memoir recounts Barbara Lipska's deadly brain cancer and explains its unforgettable lessons about the brain and mind. Neuroscientist Lipska was diagnosed early in 2015 with metastatic melanoma in her brain's frontal lobe. As the cancer progressed and was treated, she experienced behavioral and cognitive symptoms connected to a range of mental disorders, including dementia and her professional specialty, schizophrenia. Lipska's family and associates were alarmed by the changes in her behavior, which she failed to acknowledge herself. Gradually, after a course of immunotherapy, Lipska returned to normal functioning, amazingly recalled her experience, and through her knowledge of neuroscience identified the ways in which her brain changed during treatment. Lipska admits her condition was unusual; after recovery she was able to return to her research and resume her athletic training and compete in a triathalon. Most patients with similar brain cancers rarely survive to describe their ordeal. Lipska's memoir, coauthored with journalist Elaine McArdle, shows that strength and courage but also an encouraging support network are vital to recovery.

This book provides an up-to-date review and analysis of the carrot's nuclear and organellar genome structure and evolution. In addition, it highlights applications of carrot genomic information to elucidate the carrot's natural and agricultural history, reproductive biology, and the genetic basis of traits important in agriculture and human health. The carrot genome was sequenced in 2016, and its relatively small diploid genome, combined with the fact that it is the most complete root crop genome released to date and the first-ever Euasterid II genome to be sequenced, mean the carrot has an important role in the study of plant development and evolution. In addition, the carrot is among the top ten vegetables grown worldwide, and the abundant orange provitamin A carotenoids that account for its familiar orange color make it the richest crop source of vitamin A in the US diet, and in much of the world. This book includes the latest genetic maps, genetic tools and resources, and covers advances in genetic engineering that are relevant for plant breeders and biologists alike.

This volume, 9B, covers the infraorders of the Astacidea that were not covered in volume 9A (Enoplometopoidea, Nephropoidea and Glypheidea) as well as the Axiidea, Gebiidea and Anomura. With the publication of this ninth volume in the "Treatise on Zoology: The Crustacea," we depart from the sequence one would normally expect. Some crustacean groups never had a French version produced, namely, the orders Stomatopoda, Euphausiacea, Amphionidacea, and Decapoda; the largest contingent of these involved Decapoda a group of tremendous diversity and for which we have great depth of knowledge. The organization and production of these new chapters began independently from the other chapters and volumes. Originally envisioned by the editorial team to encompass volume 9 of the series, it quickly became evident that the depth of material for such a volume must involve the printing of separate fascicles. These new chapters are now nearing completion, and the decision was made to begin publication of volume 9 immediately rather than wait until after volumes 3 through 8 would appear.

Utilizing the flood of information derived from the Human Genome Project and corresponding efforts to elucidate the mouse genome, Genetic Influences on Neural and Behavioral Functions provides a scholarly catalog, organized logically, of relations between the expression of specific genes, nerve cell biology and behavior, normal and abnormal, in animals AND humans. Sample topics include genes in relation to schiziphrenia, panic disorder, epilepsy, alcoholism, sleep, eating disorders, and more.