Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term "The Glutamate-Glutamine Cycle." In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

The philosophically most challenging science today, arguably, is no longer physics but biology. It is hardly an exaggeration to state that Charles Darwin has shaped modern evolutionary biology more significantly than anyone else. Moreover, since Darwin's day, philosophers and scientists have realized the enormous philosophical potential of Darwinism and have tried to expand his insights well beyond the limits of biology. However, no consensus has been achieved. The aim of this collection of essays is to revive a comprehensive discussion of the meaning and the philosophical implications of "Darwinism." The contributors to Darwinism and Philosophy are international scholars from the fields of philosophy, science, and history of ideas. A strength of this collection is that it brings together sustained reflection from American and Continental philosophical traditions. The conclusions of the contributors vary, but taken together their essays successfully map the problems of interpreting "Darwinism."

This book focuses on fluxes of energy, carbon dioxide and matter in and above a Central European spruce forest. The transition from a forest affected by acid rain into a heterogeneous forest occurred as a result of wind throw, bark beetles and climate change. Scientific results obtained over the last 20 years at the FLUXNET site DE-Bay (Waldstein-Weidenbrunnen) are shown together with methods developed at the site, including the application of footprint models for data-quality analysis, the coupling between the trunk space and the atmosphere, the importance of the Damkoehler number for trace gas studies, and the turbulent conditions at a forest edge. In addition to the many experimental studies, the book also applies model studies such as higher-order closure models, Large-Eddy Simulations, and runoff models for the catchment and compares them with the experimental data. Moreover, by highlighting processes in the atmosphere it offers insights into the functioning of the ecosystem as a whole. It is of interest to ecologists, micrometeorologists and ecosystem modelers.

The study of the molecular events leading to cellular transformation and cancer has progressed significantly in the last decade, and it has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumour suppressor genes. To date only a limited number of transcription factors have been associated with cancer. This volume deals with several transcription factor families that were first identified in oncogenic retroviruses. Each chapter contains a description of the structure of the transcription factors, the nature of target genes, the regulation of their activities, and an explaination of how they can deregulate cell growth and differentiation. This text should be suitable for the specialist scientist and the advanced student

This volume presents methods for the analysis of genomic variability in vertebrate neurons and broadens our knowledge in the ways we understand the brain and its neurons. The chapters in this book are divided into 5 parts, and cover the following topics: principles and approaches for discovery of somatic mosaicism in the brain, aneuploidy and ploidy variation, DNA copy number variation, LINE-1 retrotransposition, and genetic and genomic mosaicism in aging and disease. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Genomic Mosaicism in Neurons and Other Cell Types is a valuable resource for learning about the latest techniques for the analysis of genome and genetic mosaicism in vertebrate neurons.

Evolutionary developmental biology or evo-devo is a field of biological research that compares the underlying mechanisms of developmental processes in different organisms to infer the ancestral condition of these processes and elucidate how they have evolved. It addresses questions about the developmental bases of evolutionary changes and evolution of developmental processes. The book's content is divided into three parts, the first of which discusses the theoretical background of evo-devo. The second part highlights new and emerging model organisms in the evo-devo field, while the third and last part explores the evo-devo approach in a broad comparative context. To the best of our knowledge, no other book combines these three evo-devo aspects: theoretical considerations, a comprehensive list of emerging model species, and comparative analyses of developmental processes. Given its scope, the book will offer readers a new perspective on the natural diversity of processes at work in cells and during the development of various animal groups, and expand the horizons of seasoned and young researchers alike.

This book discusses the latest developments in plant-mediated fabrication of metal and metal-oxide nanoparticles, and their characterization by using a variety of modern techniques. It explores in detail the application of nanoparticles in drug delivery, cancer treatment, catalysis, and as antimicrobial agent, antioxidant and the promoter of plant production and protection. Application of these nanoparticles in plant systems has started only recently and information is still scanty about their possible effects on plant growth and development. Accumulation and translocation of nanoparticles in plants, and the consequent growth response and stress modulation are not well understood. Plants exposed to these particles exhibit both positive and negative effects, depending on the concentration, size, and shape of the nanoparticles. The impact on plant growth and yield is often positive at lower concentrations and negative at higher ones. Exposure to some nanoparticles may improve the free-radical scavenging potential and antioxidant enzymatic activities in plants and alter the micro-RNAs expression that regulate the different morphological, physiological and metabolic processes in plant system, leading to improved plant growth and yields. The nanoparticles also carry out genetic reforms by efficient transfer of DNA or complete plastid genome into the respective plant genome due to their miniscule size and improved site-specific penetration. Moreover, controlled application of nanomaterials in the form of nanofertilizer offers a more synchronized nutrient fluidity with the uptake by the plant exposed, ensuring an increased nutrient availability. This book addresses these issues and many more. It covers fabrication of different/specific nanomaterials and their wide-range application in agriculture sector, encompassing the controlled release of nutrients, nutrient-use efficiency, genetic exchange, production of secondary metabolites, defense mechanisms, and the growth and productivity of plants exposed to different manufactured nanomaterials. The role of nanofertilizers and nano-biosensors for improving plant production and protection and the possible toxicities caused by certain nanomaterials, the aspects that are little explored by now, have also been generously elucidated.

Networks of Invasion bridges a conceptual gap between ecological network studies and invasion biology studies. This book contains chapters detailing pressing concerns regarding invasive species in food webs, but also extends the idea of networks of invasion to other systems, such as mutualistic networks or even the human microbiome. Chapters describe the tools, models, and empirical methods adapted for tackling invasions in ecological networks.

This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.

This book consolidates the information, results, experience and perspectives of different research groups working on Chilean Saltmarshes. Some aspects of these ecosystems such as their bio-geographical connectivity, flora and faunal components, the interaction between ecosystem components and especially the response of this kind of ecosystems to human and natural perturbations defines the Chilean Saltmarshes as an attractive systems for future studies, focused into test the theoretical and experimental aspects of saltmarshes and general ecology.

This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity - Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

This book provides insights into the current state of sorghum genomics. It particularly focuses on the tools and strategies employed in genome sequencing and analysis, public and private genomic resources and how all this information is leading to direct outcomes for plant breeders. The advent of affordable whole genome sequencing in combination with existing cereal functional genomics data has enabled the leveraging of the significant novel diversity available in sorghum, the genome of which was fully sequenced in 2009, providing an unmatched resource for the genetic improvement of sorghum and other grass species. Cultivated grain sorghum is a food and feed cereal crop adapted to hot and dry climates, and is a staple for 500 million of the world's poorest people. Globally, sorghum is also an important source of animal feed and forage, an emerging biofuel crop and model for C4 grasses, particularly genetically complex sugarcane.

The current scientific literature contains reviews and articles on specific aspects of pig production and farm animal welfare. This book is intended to be a reference text that covers all aspects of pig production, on the basis of scientific results. This work contains current, easy-to-understand scientific reviews on animal welfare with over 700 specific references to animal welfare. All aspects of animal welfare with respect to pigs are discussed, from genetic selection and breeding to transportation and slaughter. This work was written by scientific experts renowned for their knowledge and work in the area of pig welfare.Their common goal was to provide an in-depth review and empirical assessment of pig production concepts, knowledge and techniques in use today. Through scientific examples, the authors explain how improving animal welfare increases profitability. This work is intended for academics, researchers, students, animal welfare associations, industry and anyone who is involved in the production chain or concerned about the welfare of pigs being raised on farms.

The Migraine Brain, edited by David Borsook, Arne May, Peter J. Goadsby, and Richard Hargreaves, makes a major contribution to the field, addressing the increasingly sophisticated neuroimaging techniques that have allowed researchers to begin to define functional and anatomical characteristics of migraine and other less-common types of headache. Of particular focus is how imaging is changing the way we understand migraine. This includes changes in function, structure and chemistry of the migraine brain. Included are sections that focus on particular aspects of migraine, for example the migraine aura: those symptoms that cause visual sensitivity (blinding white light), sensory difficulty (loud noises, painful touch, and hot/cold spells), slurred language, and motor dysfunction.
Extensively illustrated throughout, The Migraine Brain provides a general overview of the history of migraine, its pathophysiology, as well as in-depth details on the Clinical Perspectives and the different imaging techniques in use (MR, fMRI, DTI, VBM, PET, fMRI, and MEG). It also includes details on modulation of the brain using such techniques as TMS. The book concludes with a discussion of future uses of imaging in the diagnosis and treatment of migraines and other headaches.
A collation of the top thinkers in the field and the only book of its kind, The Migraine Brain is necessary reading for neurologists and neuroscientists.

Drawing on shared research experiences and collaborative projects, this book offers a broad and timely perspective on research on the hand and its current challenges. It especially emphasizes the interdisciplinary context in which researchers need to be trained in contemporary science. From language to psychology, from neurology to the social sciences, and from art to philosophy and religion, the chapters discuss various aspects involved in hand research and therapy. On the basis of concrete and validated case studies, they approach hand function and gestures from different perspectives - not only neurological and medical, but also philosophical, evolutionary and anthropological. By highlighting the overlaps between different areas of research, the book seeks to foster better communication between researchers, and ultimately a better understanding of hand function and its recovery. It offers essential information and inspirations for students, researchers and practitioners in the fields of psychology, epistemology, bioengineering, neuroscience, anthropology and bioethics.

This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett's esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett's esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer's Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

This highly acclaimed book brings the cumulative results of a century and a half of kinship studies in anthropology into the focus of current debates on the origin of modern humans in Africa and on an entangled bit of human evolutionary history commonly subsumed under the heading of the "peopling of the Americas." This erudite study is based on a database of some 2,500 kinship vocabularies representing roughly 600 African languages, 140 Australian languages, 500 Austronesian languages, 200 Papuan languages, 350 languages of Eurasia (excluding Indo-Europeans), 440 North and Middle American Indian languages, and 200 South American languages. This valuable reference will take the reader to the dawn of kinship studies in the 19th century Western science in order to elicit the wider context of anthropological interest in kinship systems and the interdisciplinary salience of the phenomenon of kinship. The book also examines the founder of kinship studies in anthropology, American lawyer and Iroquois ethnographer, Lewis Henry Morgan, and the circumstances of his life that generated his interest in human kinship. The study ventures into the intricacies of scientific and quasi-scientific debates in the 19th century, and treats 19th century science as embedded in a myth featuring divinity, humanity and animality as principal characters. This account is divided into four sections, each of which is structured as a triad (philosophy, psychology and physiology; logic, semiotics and reproduction; religion, hermeneutics and evolution; law, grammar and speech). This far-reaching historical journey aims at formulating an idea of what human kinship might be all about, especially in the light of the widespread uncertainties about this question caused by the constructivist turn in anthropology. Eventually our ideas regarding human origins, ancient population dispersals and the homeland of modern humans are inextricably linked to our ideas about kinship. As a book that brings together evolutionary and sociocultural anthropology, The Genius of Kinship will be a critical addition for all Anthropology collections.

Using historical and anthropological perspectives to examine mind-body relationships in western thought, this book interweaves topics that are usually disconnected to tell a big, important story in the histories of medicine, science, philosophy, religion, and political rhetoric. Beginning with early debates during the Scientific Revolution about representation and reality, Martensen demonstrates how investigators such as Vesalius and Harvey sought to transform long-standing notions of the body as dominated by spirit-like humors into portrayals that emphasized its solid tissues. Subsequently, Descartes and Willis and their followers amended this 'new' philosophy to argue for the primacy of the cerebral hemispheres and cranial nerves as they downplayed the role of the spirit, passion, and the heart in human thought and behaviour. None of this occurred in a social vacuum, and the book places these medical and philosophical innovations in the context of the religious and political crises of the Reformation and English Civil War and its aftermath. Patrons and their interests are part of the story, as are patients and new formulations of gender. John Locke's psychology and the emergence in England of a constitutional monarchy figure prominently, as do opponents of the new doctrines of brain and nerves and the emergent social order. The book's concluding chapter discusses how debates over investigative methods and models of body order that first raged over 300 years ago continue to influence biomedicine and the broader culture today. No other book on western mind-body relationships has attempted this.

The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.
Individual chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.
The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

Authored by world-class scientists and scholars, the Handbook of Natural Resources, Second Edition, is an excellent reference for understanding the consequences of changing natural resources to the degradation of ecological integrity and the sustainability of life. Based on the content of the bestselling and CHOICE awarded Encyclopedia of Natural Resources, this new edition demonstrates the major challenges that the society is facing for the sustainability of all wellbeing on planet Earth. The experience, evidence, methods, and models used in studying natural resources are presented in six stand-alone volumes, arranged along the main systems: land, water, and air. It reviews state-of-the-art knowledge, highlights advances made in different areas, and provides guidance for the appropriate use of remote sensing data in the study of natural resources on a global scale. The six volumes in this set cover: Terrestrial Ecosystems and Biodiversity; Landscape and Land Capacity; Wetlands and Habitats; Fresh Water and Watersheds; Coastal and Marine Environments; and finally Atmosphere and Climate. Written in an easy-to-reference manner, the Handbook of Natural Resources, Second Edition, as a complete set, is essential for anyone looking for a deeper understanding of the science and management of natural resources. Public and private libraries, educational and research institutions, scientists, scholars, and resource managers will benefit enormously from this set. Individual volumes and chapters can also be used in a wide variety of both graduate and undergraduate courses in environmental science and natural science courses at different levels and disciplines, such as biology, geography, Earth system science, ecology, etc.

In recent years concerns over the use of results of scientific advances, expectations about how medical decisions are made, and demographic changes have raised ethical questions about how resources are allocated, and how the principles of beneficence, and respect for patient autonomy are applied. The effect that bioethics can have on policy decisions and health care delivery demand an enhanced approach to our understanding of such complex issues. This volume opens a window to how empirical social research can be used to illuminate and answer such quandaries and offers a practical resource for those wishing to engage in this type of research. Through a thorough look at both quantitative and qualitative methods utilized in key research investigations in bioethics, the book examines the impact of such investigations on clinical and policy decision-making, scholarship and on the advancement of theory. The varied sociological and anthropological research examples that are presented allow readers to better understand the richness and breadth of such work as well as relevant practical and theoretical approaches.
Last, but not least, our aim with this book is to stimulate further discussion of avenues toward a more solid integration of bioethics and empirical social research and, in that process, further our understanding of the complex bioethical environment surrounding us.
PracticalOffers insights into clinical and policy implications of empirical research
In-depthEnhances understanding of methodologies as applied to bioethics
Comprehensive--Gives a range of examples of empirical bioethics studies
InterdisciplinaryGeared to a wide audience
Reference sourceincludes a largenumber of references

Recent advances in protein structural biology, coupled with new developments in human genetics, have opened the door to understanding the molecular basis of many metabolic, physiological, and developmental processes in human biology. Medical pathologies, and their chemical therapies, are increasingly being described at the molecular level. For single-gene diseases, and some multi-gene conditions, identification of highly correlated genes immediately leads to identification of covalent structures of the actual chemical agents of the disease, namely the protein gene products. Once the primary sequence of a protein is ascertained, structural biologists work to determine its three-dimensional, biologically active structure, or to predict its probable fold and/or function by comparison to the data base of known protein structures. Similarly, three-dimensional structures of proteins produced by microbiological pathogens are the subject of intense study, for example, the proteins necessary for maturation of the human HIV virus. Once the three-dimensional structure of a protein is known or predicted, its function, as well as potential binding sites for drugs that inhibit its function, become tractable questions. The medical ramifications of the burgeoning results of protein structural biology, from gene replacement therapy to "rational" drug design, are well recognized by researchers in biomedical areas, and by a significant proportion of the general population. The purpose of this book is to introduce biomedical scientists to important areas of protein structural biology, and to provide an insightful orientation to the primary literature that shapes the field in each subject.
The chapters in this volume cover aspects of protein structural biology which have led to the recognition of fundamental relationships between protein structure and function.