From a leading crisis management expert, a breakthrough book about performance under pressure that will change the way you think about stress Upshift 1. a movement of a variable to a higher level e.g. of performance, growth, frequency. When we experience too much stress, we often feel like shutting down and escaping the source. Neurologists call this 'downshifting', where your thinking shifts from the cognitive and creative areas in the brain to the domains associated with survival. But with too little stress, we become disengaged and apathetic. So what happens in the middle zone - when we experience what psychologists call positive stress - and how can we best make use of it? In Upshift, international thought leader Ben Ramalingam takes readers on an epic journey from early humans' survival of the ice age to present times in our inescapable, pernicious and ever-shifting digital landscape. You will hear remarkable stories from a vast range of backgrounds, including scientists, gamers, performers and artists, athletes and health professionals and everyday people, all of whom carved new routes around perceived barriers using their powers to upshift. Whether discussing how city commuters navigate train cancellations to how astronauts deal with life-threatening incidents, Ramalingam presents a fascinating argument that we all have the power to innovate, whether or not we identify ourselves as creative or extraordinary. In a runaway world that is an engine for perpetual crisis, Upshift is not only an essential toolkit for survival, it is a roadmap for positive, and potentially life-changing transformation and influence. You don't have to shut down - you can upshift.

This book is concerned with recent advances in fitness landscapes. The concept of fitness landscapes originates from theoretical biology and refers to a framework for analysing and visualizing the relationships between genotypes, phenotypes and fitness. These relationships lay at the centre of attempts to mathematically describe evolutionary processes and evolutionary dynamics.

The book addresses recent advances in the understanding of fitness landscapes in evolutionary biology and evolutionary computation. In the volume, experts in the field of fitness landscapes present these findings in an integrated way to make it accessible to a number of audiences: senior undergraduate and graduate students in computer science, theoretical biology, physics, applied mathematics and engineering, but also researcher looking for a reference or/and entry point into using fitness landscapes for analysing algorithms. Also practitioners wanting to employ fitness landscape techniques for evaluating bio- and nature-inspired computing algorithms can find valuable material in the book. For teaching proposes, the book could also be used as a reference handbook.

This volume details several important databases and data mining tools. Data Mining Techniques for the Life Sciences, Second Edition guides readers through archives of macromolecular three-dimensional structures, databases of protein-protein interactions, thermodynamics information on protein and mutant stability, "Kbdock" protein domain structure database, PDB_REDO databank, erroneous sequences, substitution matrices, tools to align RNA sequences, interesting procedures for kinase family/subfamily classifications, new tools to predict protein crystallizability, metabolomics data, drug-target interaction predictions, and a recipe for protein-sequence-based function prediction and its implementation in the latest version of the ANNOTATOR software suite. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Data Mining Techniques for the Life Sciences, Second Edition aims to ensure successful results in the further study of this vital field.

This book offers new perspectives of transdisciplinary research, in methodological as well as theoretical respects. It provides insights in the two-fold bio-physical and the socio-cultural global embeddedness of local living conditions on the basis of selected empirical studies from Latin America, Asia, Africa, Australia and Europe. The theoretical foundations of ecological research and sustainability policies were developed at the end of the nineteenth century. They are largely based on investigations of living spaces and the evolution and differentiation of varied life forms. This perspective is embedded in the practical and theoretical European problem situations of the past and lacks social and cultural differentiation. The transformation of spatial and natural relations as a result of the globalization process is so radical that new theories are needed to solve 21st century ecological problems. Moreover, in view of the lack of an ontologically sound and promising strategy for transdisciplinary problem solving, as well as an acceptable consideration of the power of cultural schemas relating to natural living's interpretations, there is a strong need to focus on sustainable social practices, habits and routines, rather than on predominantly living spaces or eco-topes. This book elaborates on the transdisciplinary approach by reflecting on the theoretical heritage and a global perspective of sustainability, by focusing on the primary role of a social approach in sustainability research and by putting emphasis on cultural dimension of sustainability. It postulates that global sustainability is grounded in a global understanding of our everyday activities.

This book is the final installation in a three-volume series synthesizing 30 years of mercury research in the Florida Everglades. The first part of this book evaluates the occurrence of trends in both biota mercury concentrations and atmospheric mercury deposition. Through both empirical and deterministic analyses, the likely drivers of biota trends are identified. These analyses help lay the predicate for devising an overall strategy to mitigate and manage the Everglades mercury problem. The book concludes with a model analysis of the likely benefits and uncertainty attendant with implementing the leading candidate strategy for best reducing the Everglades mercury problem.

This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

Zebrafish (Danio rerio) play an integral role in biomedical research, enabling researchers to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. That, along with their low cost, easy manipulation, short reproductive cycles, and physiological homology to humans, has made zebrafish a vital model organism for neuroscience research. Zebrafish Protocols for Neurobehavioral Research addresses protocols for both larval and adult models, written by the leading experts in the field of zebrafish research. Part I of this book takes advantage of the high-throughput nature of larval models to offer protocols for research requiring high output, easily manipulated screens. The second half of the book focuses on the robust and sophisticated behaviors of adult zebrafish, suitable for the neurophenotyping of complex traits and multi-domain disorders. Importantly, these models complement each other, working together to provide researchers with valuable insights into neurobiology of normal and pathological behavior. Thorough and cutting-edge, this volume is a useful, authoritative reference guide that should hold a coveted spot in zebrafish laboratories across the globe.

How does it feel to be a police officer in the UK? What happens in the brains of officers, particularly in high-risk roles such as counter-terrorism and child sexual exploitation? Jessica Miller uses the most recent neuroscience and real-life examples to explore risks to individual resilience, be it trauma exposure, burnout or simply the daily pressure of adapting to life on the front line. A compulsory read for anyone with an interest in policing, the book offers practical, easy-to-follow resilience techniques applicable to anyone in the wider emergency responder community. The book also offers policy and operational recommendations to equip police officers with skills to face crime in a post-COVID world.

Genetic Regulatory Networks (GRNs) in biological organisms are primary engines for cells to enact their engagements with environments, via incessant, continually active coupling. In differentiated multicellular organisms, tremendous complexity has arisen in the course of evolution of life on earth. Engineering and science have so far achieved no working system that can compare with this complexity, depth and scope of organization. Abstracting the dynamics of genetic regulatory control to a computational framework in which artificial GRNs in artificial simulated cells differentiate while connected in a changing topology, it is possible to apply Darwinian evolution in silico to study the capacity of such developmental/differentiated GRNs to evolve. In this volume an evolutionary GRN paradigm is investigated for its evolvability and robustness in models of biological clocks, in simple differentiated multicellularity, and in evolving artificial developing 'organisms' which grow and express an ontogeny starting from a single cell interacting with its environment, eventually including a changing local neighbourhood of other cells. These methods may help us understand the genesis, organization, adaptive plasticity, and evolvability of differentiated biological systems, and may also provide a paradigm for transferring these principles of biology's success to computational and engineering challenges at a scale not previously conceivable.

This book provides a comprehensive look at nonhuman primate social inequalities as models for health differences associated with socioeconomic status in humans. The benefit of the socially-housed monkey model is that it provides the complexity of hierarchical structure and rank affiliation, i.e. both negative and positive aspects of social status. At the same time, nonhuman primates are more amenable to controlled experiments and more invasive studies that can be used in human beings to examine the effects of low status on brain development, neuroendocrine function, immunity, and eating behavior. Because all of these biological and behavioral substrates form the underpinnings of human illness, and are likely shared among primates, the nonhuman primate model can significantly advance our understanding of the best interventions in humans.

Bryophytes, which are important constituents of ecosystems globally and often dominate carbon and water dynamics at high latitudes and elevations, were also among the pioneers of terrestrial photosynthesis. Consequently, in addition to their present day ecological value, modern representatives of these groups contain the legacy of adaptations that led to the greening of Earth. This volume brings together experts on bryophyte photosynthesis whose research spans the genome and cell through whole plant and ecosystem function and combines that with historical perspectives on the role of algal, bryophyte and vascular plant ancestors on terrestrialization of the Earth. The eighteen well-illustrated chapters reveal unique physiological approaches to achieving carbon balance and dealing with environmental limitations and stresses that present an alternative, yet successful strategy for land plants.

Visualization of chemicals in tissues has seen incredible advances in the past several years. Visualization Techniques: From Immunohistochemistry to Magnetic Resonance Imaging provides practical advice from experts in the field as well as an excellent overview of some of the most important recent advances in visualization. This timely volume explores topics from immunohistochemistry for multiple neurochemicals, detecting expression levels of neurochemicals, following cellular processes and ionic movement, identifying polysynaptic pathways subserving physiological responses to identifying functional changes in vivo. Written for the popular Neuromethods series, this work includes the kind of detailed description and implementation advice that is crucial for getting optimal results in the lab. Meticulous and concise, Visualization Techniques: From Immunohistochemistry to Magnetic Resonance Imaging will prove invaluable for scientists seeking to gain a greater understanding of the practical skills, strengths, and pitfalls that these wonderful and exciting visualization techniques provide.

This timely encyclopedia presents an arsenal of evidence for evolution that goes beyond the typical textbook examples. Arguing for Evolution: An Encyclopedia for Understanding Science provides readers with a single source for the scientific evidence supporting evolution. The book shows how scientists have tested the predictions of evolutionary theory and created an unshakeable foundation of evidence supporting its truth. As such, it demonstrates how evolution serves as a case study for understanding the scientific method and presents a logical model for scientific inquiry. The evidence for evolution is presented historically and topically in an accessible, example-rich, and logical format, using an arsenal of examples that goes beyond the typical textbook matter. The chapters are structured around a series of hypotheses that the authors put to the test, amassing evidence on fossils, comparative anatomy, molecules, and evolutionary biology in order to conclude that evolution is scientific fact. Learning about this fascinating field is enhanced through "see for yourself" examples that include original data and figures from key historical and contemporary papers in evolutionary biology. More than 100 historical and contemporary examples of the evidence for evolution Images of places, people, and artifacts that have been important in the effort to understand life's origins

This work examines the waters of marine ports as unique integrated aquatic ecosystems. It regards marine ports as entities comprising components of natural and anthropogenic origin, including pelagic, periphytal and benthal subsystems. Using selected Black and Azov Sea ports as examples, the book discusses the hydrodynamics and water exchange, which are weakened in ports compared with open coastal zones. It reflects consequences of the presence of hydrobionts and the accumulation of organic matter, which are promoted by the variety of hard substrata and the absence of fishery. The book is divided into five main chapters. The first chapter describes the general characteristics of the marine ports at the northern coast of the Black and Azov Seas and their shipping channels. Chapters 2 to 4 discuss the main abiotic and biotic peculiarities of the pelagial, periphytal and benthal subsystems of those marine ports, and chapter 5 deals with tropho-dynamic processes in their ecosystems. A concluding section reflects recommendations how the ecosystems of ports in non-tidal seas may be ameliorated.

Increasing world population, unpredictable climate and various kind of biotic and abiotic stresses necessitate the sustainable increase in crop production through developing improved cultivars possessing enhanced genetic resilience against all odds. An exploration of these challenges and near possible solution to improve yield is addressed in this book. It comprehensively and coherently reviews the application of various aspect of rapidly growing omics technology including genomics, proteomics, transcriptomics and metabolomics for crop development. It provides detailed examination of how omics can help crop science and introduces the benefits of using these technologies to enhance crop production, resistance and other values. It also provides platform to ponder upon the integrative approach of omics to deal with complex biological problems. The book highlights crop improvement such as yield enhancement, biotic and abiotic resistance, genetic modification, bioremediation, food security etc. It explores how the different omics technology independently and collectively would be used to improve the quantitative and qualitative traits of crop plants. The book is useful for graduate and post-graduate students of life science including researchers who are keen to know about the application of omics technologies in the different area of plant science. This book is also an asset to the modern plant breeders, and agriculture biotechnologist.

Empirical studies of life science research and biotechnologies in Asia show how assemblages of life articulate bioethics governance with global moralities and reveal why the global harmonization of bioethical standards is contrived.

Modern industrial agriculture is not sustainable because of its heavy reliance on petroleum, a non-renewable source of the energy used in farming, and because of pollution caused by petroleum products such as fertilizers and pesticides. A systems analysis of farming suggests that agriculture will be more sustainable when services of nature, such as nutrient recycling by soil micro-organisms and natural controls of insects, replace the services now provided by energy from petroleum. Examples are drawn from the Southeastern USA, but lessons learned can be applied worldwide.

This volume focuses on those instances when benign and even beneficial relationships between microbes and their hosts opportunistically change and become detrimental toward the host. It examines the triggering events which can factor into these changes, such as reduction in the host's capacity for mounting an effective defensive response due to nutritional deprivation, coinfections and seemingly subtle environmental influences like the amounts of sunlight, temperature, and either water or air quality. The effects of environmental changes can be compounded when they necessitate a physical relocation of species, in turn changing the probability of encounter between microbe and host. The change also can result when pathogens, including virus species, either have modified the opportunist or attacked the host's protective natural microflora. The authors discuss these opportunistic interactions and assess their outcomes in both aquatic as well as terrestrial ecosystems, highlighting the impact on plant, invertebrate and vertebrate hosts.

This volume summarizes recent advances in environmental microbiology by providing fascinating insights into the diversity of microbial life that exists on our planet. The first two chapters present theoretical perspectives that help to consolidate our understanding of evolution as an adaptive process by which the niche and habitat of each species develop in a manner that interconnects individual components of an ecosystem. This results in communities that function by simultaneously coordinating their metabolic and physiologic actions. The third contribution addresses the fossil record of microorganisms, and the subsequent chapters then introduce the microbial life that currently exists in various terrestrial and aquatic ecosystems. Coverage of the geosphere addresses endolithic organisms, life in caves and the deep continental biosphere, including how subsurface microbial life may impact spent nuclear fuel repositories. The discussion of the hydrosphere includes hypersaline environments and arctic food chains. By better understanding examples from the micro biosphere, we can elucidate the many ways in which the niches of different species, both large and small, interconnect within the overlapping habitats of this world, which is governed by its microorganisms.

This book explores the socio-political implications of human heredity from the second half of the nineteenth century to the present postgenomic moment. It addresses three main phases in the politicization of heredity: the peak of radical eugenics (1900-1945), characterized by an aggressive ethos of supporting the transformation of human society via biological knowledge; the repositioning, after 1945, of biological thinking into a liberal-democratic, human rights framework; and the present postgenomic crisis in which the genome can no longer be understood as insulated from environmental signals. In Political Biology, Maurizio Meloni argues that thanks to the ascendancy of epigenetics we may be witnessing a return to soft heredity - the idea that these signals can cause changes in biology that are themselves transferable to succeeding generations. This book will be of great interest to scholars across science and technology studies, the philosophy and history of science, and political and social theory.

'Behavioral Neuroscience of Learning and Memory' brings together the opinions and expertise of some of the world's foremost neuroscientists in the field of learning and memory research. The volume provides a broad coverage of contemporary research and thinking in this field, focusing both on well established topics such as the medial temporal lobe memory system, as well as emerging areas of research such as the role of memory in decision making and the mechanisms of perceptual learning. Key intersecting themes include the molecular and cellular mechanisms of memory formation, the multiplicity of memory systems in the brain, and the way in which technological innovation is driving discovery. Unusually for a volume of this kind, this volume brings together research from both humans and animals-often relatively separate areas of discourse-to give a more comprehensive and integrated view of the field. The book will be of interest to both established researchers who wish to broaden their knowledge of topics outside of their specific areas of expertise, and for students who need a resource to help them make sense of the vast scientific literature on this subject.

This volume assembles the leading aggression researchers both at the preclinical and clinical level. They review the current state of knowledge about neural mechanisms of aggressive behavior and point to the need for innovative methodologies to further our understanding of this greatly understudied set of behaviors.

The "omics" era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.