The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

This volume presents articles from the leading experts in the field in nanobiotechnology, providing students and researchers with a comprehensive review of the newly emerging area of neuroscience.

All aspects of nanomaterials induced alteration in brain function are considered. Basic chapters on methods and ways to enhance nano-drug delivery into the brain are presented as well as chapters on functional and structural changes in the CNS, including gene expression and related issues. Particular attention is given to possible therapeutic advancement regarding nano-drug formulation and their role in neuroprotection.

Significant biological differences exist between men and women that contribute to sex-specific differences in cardiovascular disease (CVD) risk factors, pathophysiology, presentation, response to therapy, and prognosis. It is essential for clinicians to be cognizant of these sex-specific differences in order to reduce the disparity in diagnosis and management of cardiovascular diseases in both genders. Sex Differences in Cardiac Disease provides a timely review of the contemporary data on these sex-specific differences in pathophysiology, clinical presentation, diagnostic evaluation, and management of cardiovascular diseases that fills a void for clinicians in practice and training. With contributions from renowned experts in the field and guideline writers, the text provides a state-of-the-art review of each topic encompassing the full spectrum of CVD in men and women. Sex-specific guideline-based recommendations are highlighted when available. Tailored to meet the needs of the busy clinicians and researchers, this text provides concise practical data to care for men and women at risk for or with CVD. The book serves as an essential resource for researchers, cardiologists, obstetricians, gynecologists, internists, family practitioners, nurse practitioners and physician assistants, and respective trainees who treat men and women with CVD.

Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer's Disease, Parkinson's, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference.

Most projects in Landscape Ecology, at some point, define a species-habitat association. These models are inherently spatial, dealing with landscapes and their configurations. Whether coding behavioral rules for dispersal of simulated organisms through simulated landscapes, or designing the sampling extent of field surveys and experiments in real landscapes, landscape ecologists must make assumptions about how organisms experience and utilize the landscape. These convenient working postulates allow modelers to project the model in time and space, yet rarely are they explicitly considered. The early years of landscape ecology necessarily focused on the evolution of effective data sources, metrics, and statistical approaches that could truly capture the spatial and temporal patterns and processes of interest. Now that these tools are well established, we reflect on the ecological theories that underpin the assumptions commonly made during species distribution modeling and mapping. This is crucial for applying models to questions of global sustainability.

Due to the inherent use of GIS for much of this kind of research, and as several authors research involves the production of multicolored map figures, there would be an 8-page color insert. Additional color figures could be made available through a digital archive, or by cost contributions of the chapter authors. Where applicable, would be relevant chapters GIS data and model code available through a digital archive. The practice of data and code sharing is becoming standard in GIS studies, is an inherent method of this book, and will serve to add additional research value to the book for both academic and practitioner audiences."

Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable. This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease.

It's a Jungle in There pursues the hypothesis that the overarching theory of biology, Darwin's theory, should be the overarching theory of cognitive psychology. Taking this approach, David Rosenbaum, a cognitive psychologist and former editor of the Journal of Experimental Psychology: Human Perception and Performance, proposes that the phenomena of cognitive psychology can be understood as emergent interactions among dumb neural elements all competing and cooperating in a kind of inner jungle. Rosenbaum suggests that this perspective allows for the presentation of cognitive psychology in a new way, both for students (for whom the book is mainly intended) and for seasoned investigators (who may be looking for a fresh way to approach and understand their material). Rather than offering cognitive psychology as a rag-tag collection of miscellaneous facts, as has generally been the case in cognitive-psychology textbooks, this volume presents cognitive psychology under a single rubric: "It's a jungle in there." Written in a light-hearted way with continual reference to hypothetical neural creatures eking out their livings in a tough environment, this text is meant to provide an over-arching principle that can motivate more in-depth study of the mind and brain.

Accurate interpretation of the organic acid chromatographs obtained from the gas chromatography/mass spectrometry requires a significant amount of practice. Pattern recognition is an important factor and a skill that is gained through time and effort. A Quick Guide to Metabolic Disease Testing Interpretation, Second Edition, provides these example chromatographs demonstrating specific disease-related metabolites for the inborn error of metabolism diagnosed via this method. One or more representative chromatographs from each of the common disorders is presented, with the important compounds noted on the chromatographs. This is a must-have for laboratory and medical professionals who interpret testing for the diagnosis and monitoring of IEM.

Peripartum Cardiomyopathy: From Pathophysiology to Management covers the pathophysiology and the heterogenous mode of presentation of PPCM to assist in risk stratification and provide a guide for the acute and long-term management of women affected by this serious condition. Each chapter provides structured figures and practical algorithms as well as prints of electrocardiograms, echocardiographic, MRI images and several case studies throughout. This title is a must have reference for those doing basic research in this area as well as all healthcare providers caring for peripartum women, including obstetricians, general physicians, cardiologists, intensivists, as well as nurses caring for heart failure patients.

Brain Oscillations, Synchrony and Plasticity: Basic Principles and Application to Auditory-Related Disorders discusses the role of brain oscillations, especially with respect to the auditory system and how those oscillations are measured, change over the lifespan, and falter leading to a variety of psychiatric and neurological disorders. The book begins with a description of these cortical rhythm oscillations and how they function in both the normal and pathological brain. It explains how these oscillations are important to auditory, executive and attention brain networks and how they relate to the development, production and deterioration of speech and language. In addition, treatment of malfunctioning cortical rhythms are reviewed using neuromodulation, such as transcranial magnetic, direct current, random noise, and alternating current stimulation, as well as focused ultrasound. The book concludes by describing the potential role of oscillations in dyslexia, autism, schizophrenia and Alzheimer's disease.

Dual Antiplatelet Therapy for Coronary and Peripheral Arterial Disease is a complete reference containing updated information on the advantages and disadvantages of dual antiplatelet therapy, its duration, composition and anticipated changes. The basis for DAPT in arterial disease is discussed, allowing readers to understand platelet physiology and its relevance to ischemic events. Data on shorter than usual duration of DAPT, and on extended therapy beyond the recommendation of current guidelines is presented in great detail, summarizing a large body of evidence into concrete, relevant recommendation that is readily adaptable by practicing clinicians. A clinically relevant and updated compendium of data pertaining to this field is also presented, as well as the anticipated trends and innovations likely to occur in the next 3-5 years.

Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field.

Insect Anatomy: Structure and Function provides both morphological and anatomical descriptions of insect tissues and organs using updated methods. Insects play important roles in diverse ecosystems, with subsequent, tremendous impacts on human society through disease, agriculture effects, and more. Both beneficial and detrimental insect species continuously challenge agriculture and medicine. Written by international experts of insect morphology and anatomy, this book offers concise descriptions of all part of an insect’s anatomy, including the brain and nervous system, tracheal system, blood, reproductive organs, and kidney system.The book also covers external insect parts such as antennae, wings and different forms of insect epidermis. Insect tissues and organs are analyzed as they relate to gene and protein function in distinct types of cells, tissues, and organs.

Recent Advances in iPSC Disease Modeling, Volume One addresses how induced pluripotent stem cells can be used to model various diseases. This new volume teaches readers about current advances in the field, describing the use of induced pluripotent stem cells to model several diseases in vitro, and thus enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development and progression. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation specialists. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. Hence, these advantages have facilitated the identification of key targets and further defining on the molecular basis of several disorders.

Although scientists have discovered many fundamental physiological and behavioral mechanisms that comprise the stress response, most of current knowledge is based on laboratory experiments using domesticated or captive animals. Scientists are only beginning, however, to understand how stress impacts wild animals - by studying the nature of the stressful stimuli that animals in their natural environments have adapted to for survival, and what the mechanisms that allow that survival might be. This book summarizes, for the first time, several decades of work on understanding stress in natural contexts. The aim is two-fold. The first goal of this work is to place modern stress research into an evolutionary context. The stress response clearly did not evolve to cause disease, so that studying how animals use the stress response to survive in the wild should provide insight into why mechanisms evolved the way that they did. The second goal is to provide predictions on how wild animals might cope with the Anthropocene, the current period of Earth's history characterized by the massive human remodeling of habitats on a global scale. Conservation of species will rely upon how wild animals use their stress response to successfully cope with human-created stressors.

The most comprehensive and practical guide available for caregivers of children who have seizures and epilepsy, now completely updated. For more than 30 years, parents, caregivers, and health care providers have trusted Seizures and Epilepsy in Children to provide comprehensive, science-based information and practical answers to the most common questions about these conditions. In this new edition, completely revised and updated, a team of experts from Johns Hopkins Medicine offers guidance on: * diagnostic testing and the latest treatments * recommendations for the best devices, apps, and websites * driving, health insurance, and playing sports * navigating school and other environments * mental health issues and counseling * coping with disability * side effects from medications This new edition also features dedicated chapters on diet, complementary and alternative medicine, and rescue medicines. Seizures and Epilepsy in Children is the go-to resource for caregivers and families with children who have epilepsy and seizures.