Darwin takes a look at the life of this incredible man, from his birth, his ground-breaking publications and far-flung travels, Darwinism and his theories on evolution, all the way to his final days. Over 160 stunning images and illustrations are included within Darwin, ranging from personal diary entries (such as those he made when deciding whether to marry or not), letters and handwritten notes, as well as sketches from Darwin's famous works. Revealing the famous scientist's life in compelling detail, Darwin covers not only his scientific career and On the Origin of Species but his personal struggles also, allowing us to see what truly made the man.

Magnetic resonance imaging methods have taken a commanding position in brain studies because they allow scientists to follow brain activities in the living human. The ability to measure cerebral anatomy, neuronal firing and brain metabolism has extended and re-invigorated hopes of understanding the role that brain activity plays in human life. The brain has assumed a central role in our thinking of the world that can be traced back to the philosophies that are expressed in psychology, religion, literature, and everyday life. Brain scientists, planning and measuring brain activities by imaging methods, have consciously or unconsciously been influenced by these philosophical views. This book, in describing the experiments using imaging methods, traces how assumptions about the nature of brain function made in planning scientific experiments are the consequences of philosophical positions. Experiments that relate brain activities to observable behavior are shown to avoid the philosophical and psychological assumptions about mental processes that have been proposed to underlie these behaviors. These promising, empirical experiments are consistent with the philosophy of Pragmatism which, in judging hypotheses about understanding by their consequences, has questioned the value of everyday conceptualizations of brain activity for imaging studies.

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders.

This book offers an essential introduction to the latest advances in delayed genetic regulatory networks (GRNs) and presents cutting-edge work on the analysis and design of delayed GRNs in which the system parameters are subject to uncertain, stochastic and/or parameter-varying changes. Specifically, the types examined include delayed switching GRNs, delayed stochastic GRNs, delayed reaction-diffusion GRNs, delayed discrete-time GRNs, etc. In addition, the solvability of stability analysis, control and estimation problems involving delayed GRNs are addressed in terms of linear matrix inequality or M-matrix tests. The book offers a comprehensive reference guide for researchers and practitioners working in system sciences and applied mathematics, and a valuable source of information for senior undergraduates and graduates in these areas. Further, it addresses a gap in the literature by providing a unified and concise framework for the analysis and design of delayed GRNs.

This book presents a variety of techniques designed to enhance and empower multi-disciplinary and multi-institutional machine learning research in healthcare informatics. It is intended to provide a unique compendium of current and emerging machine learning paradigms for healthcare informatics, reflecting the diversity, complexity, and depth and breadth of this multi-disciplinary area.

Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

This book provides a comprehensive and authoritative review of the chemical analysis of UV filters in coastal waters and their impact on the marine environment. The sun care is today the most important sector within the cosmetics industry, with annual increases in sales. The main components of sunscreens, organic and inorganic UV filters, have been detected in many coastal regions, with the highest concentrations in coastal areas under high anthropogenic pressure. Moreover, these compounds have been found to be bioaccumulated in aquatic biota causing biological and toxicological responses; some organic UV filters act as endocrine disruptors in aquatic biota, affecting survival, behavior, growth, development and reproduction. On the other hand, inorganic UV filters, mainly based on nanoparticles, have been demonstrated to have various impacts on marine organisms, such as inducing oxidative stress in abalones, accumulating in microalgae, affecting the immune response in mussels, bleaching corals, and genotoxicity in fish, among others. All these effects of sunscreens on the marine environment highlight the need for more stringent and environmentally friendly regulations. This book covers the latest analytical methodologies used in assessing the impact of UV filters impact on marine waters, especially on marine biota, and also critiques the global regulation of UV filters and the environmental risk of using sunscreens. Featuring specific case studies of the environmental effects of sunscreens in the Mediterranean Sea and Hawaii, which highlight the importance of balancing human health with environmental health of coastal ecosystems, it will appeal not only to scientists and students from various disciplines (environmental chemistry, biology, ecology, biogeochemistry, fisheries and climate change among others), but also to environmental managers wanting to promote new restrictive regulations on the use of UV filters, and to professionals from the cosmetic industry interested in the development of eco-friendly sunscreens.

The Vanishing of a Species? is a serious treatise exploring the past evolution, present predicament and possible future extinction of a particular species on planet Earth. The species is Homo sapiens. The threat to the species is Homo sapiens. The author, a former professor of geology and geophysics, starts his exploration by putting man in context, both in terms of space and time. We find that in either case, man is not as pre-eminent as he may believe. While man is the most accomplished toolmaker this planet has ever seen, his technical progress is overpowering his social progress-an imbalance that sets the stage for his vanishing act, absent quick, corrective action. The author makes a compelling case that society's unrestricted material growth is the challenge of our times. Modern man's predicament refers broadly to man's collision course with nature-his attitude of ruthless exploitation leading to depletion of non-renewable resources, pollution of the environment, overpopulation, with its accompanying increase in human aggression, and other effects. After the agricultural and industrial-scientific revolutions, it is now time for the Human Revolution-a more realistic attitude on the part of man towards the universe, the earth and other forms of terrestrial life. Vanishing covers a wide spectrum from man's early beginnings to the modern problems of population increase, resource depletion, pollution, crime, and many more. The book addresses the roles that heredity (nature) and environment (nurture) play in shaping man's nature, and in particular, his current high level of aggression-a trait that stands in the way of the Human Revolution. The author calls for the humanists to communicate with the technologists through an interdisciplinary dialogue that may pave the way to the Human Revolution. Major works discussed in Vanishing include the Club of Rome's much reviewed 1972 work The Limits to Growth and updates thereto, as well as C.P. Snow's seminal 1959 lecture on The Two Cultures. Vanishing concludes that without the Human Revolution in short order, Homo sapiens may well turn out to be an evolutionary flash in the pan-occupying a dominating but fleeting position in earth history. Vanishing should appeal to all audiences. Recent economic turmoil around the globe, and increasing evidence of the serious strain placed on the earth by the demands of humankind, make the observations and recommendations raised within Vanishing deserving of the sober attention of all Homo sapiens interested in the survival and prosperity of their species.

What should we teach our children about where we come from? Is evolution a lie or good science? Is it incompatible with faith? Have scientists really detected evidence of a creator in nature?

From bestselling, Pulitzer Prize-winning author Edward Humes comes a dramatic story of faith, science, and courage unlike any since the famous Scopes Monkey Trial. Monkey Girl takes you behind the scenes of the recent war on evolution in Dover, Pennsylvania, when the town's school board decision to confront the controversy head-on thrust its students, then the entire community, onto the front lines of America's culture wars. Told from the perspectives of all sides of the battle, it is a riveting true story about an epic court case on the teaching of "intelligent design," and what happens when science and religion collide.

Through this book, the readers will learn about the different aspects of Actinobacteria- beginning with its ecology and occurrence, to the ways of its adaptation to harsh climates, and finally to its practical applications. The book also presents methods of identifying and characterizing this diverse group of bacteria through advanced techniques like MALDI-TOF, 16S rRNA analysis, etc. Different chapters describe the various biotechnological applications of Actinobacteria, including bioremediation, secondary metabolite production, and in producing antibiotics, anti-cancer therapeutics. It also provides insights into the applications in agriculture and forestry by inhibiting plant pathogenic bacteria's growth.

It is widely acknowledged that life has adapted to its environment, but the precise mechanism remains unknown since Natural Selection, Descent with Modification and Survival of the Fittest are metaphors that cannot be scientifically tested. In this unique text, invertebrate and vertebrate biologists illuminate the effects of physiologic stress on epigenetic responses in the process of evolutionary adaptation from unicellular organisms to invertebrates and vertebrates, respectively. This book offers a novel perspective on the mechanisms underlying evolution. Capacities for morphologic alterations and epigenetic adaptations subject to environmental stresses are demonstrated in both unicellular and multicellular organisms. Furthermore, the underlying cellular-molecular mechanisms that mediate stress for adaptation will be elucidated wherever possible. These include examples of 'reverse evolution' by Professor Guex for Ammonites and for mammals by Professor Torday and Dr. Miller. This provides empiric evidence that the conventional way of thinking about evolution as unidirectional is incorrect, leaving open the possibility that it is determined by cell-cell interactions, not sexual selection and reproductive strategy. Rather, the process of evolution can be productively traced through the conservation of an identifiable set of First Principles of Physiology that began with the unicellular form and have been consistently maintained, as reflected by the return to the unicellular state over the course of the life cycle.

Air pollution is an alarming problem, not only in terms of air quality, but also in relation to health issues. Toxic air pollutant concentrations produce harmful impacts on plant health and human health. Further, though there are various sources of air pollution, anthropogenic and biogenic sources are becoming increasingly problematic. A number of control methods have been applied to reduce the air pollutant concentrations so that their global environmental burden on plants as well as humans can be mitigated. However, as confirmed in numerous reports and studies, their concentrations continue to be very high and everyday cases related to air pollution have become exponentially high not only in developing countries but also in developed countries. In plants, toxic air quality has various adverse effects, including biochemical and physiological disorders, chronic diseases and/or lower yields. In humans, air pollutants affect the body's metabolism and immune system, lungs and central nervous system. This book provides an essential overview of air pollution, its impacts on plant and human health, and potential control strategies. The respective chapters cover general monitoring and characterization techniques for air pollutants, air quality modelling applications, plant and human health effects, risk assessment, and air pollution control policy. Given its scope, the book offers a valuable and unique resource for students of Environmental Science, Biological Science, Medical Science and Agriculture; and for environmental consultants, researchers and other professionals whose work involves air quality, plant and human related research.

This book aims to quantify and discuss how societies have directly and indirectly benefited from ecosystem services in Patagonia; not only in terms of provisioning and cultural services, but also regulating and supporting services. Patagonia, a region that stretches across two countries (ca. 10% in Chile and 90% in Argentina), is home to some of the most extensive wilderness areas on our planet. Natural grasslands comprise almost 30% of the Americas, including the Patagonian steppe, while Patagonian southern temperate forests are important for carbon sequestration and storage, play a pivotal role in water regulation, and have become widely recognized for their ecotourism value. However, profound changes are now underway that could affect key ecosystem functions and ultimately human well-being. In this context, one major challenge we face in Patagonia is that ecosystem services are often ignored in economic markets, government policies and land management practices. The book explores the synergies and trade-offs between conservation and economic development as natural landscapes and seascapes continue to degrade in Patagonia. Historically, economic markets have largely focused on the provisioning services (forest products, livestock) while neglecting the interdependent roles of regulating services (erosion and climate control), supporting services (nutrient cycling) and cultural services (recreation, local identity, tourism). Therefore, the present work focuses on ecosystem functions and ecosystem services, as well as on trends in biodiversity and the interactions between natural environments and land-use activities throughout Patagonia.

This writing is called: Scientific Creation, Our Life - Beginning To End. As stated, all facts are not pragmatic or seen by human eye. Where did all nature and life start ? What is the beginning ? Was it by The Big Bang Theory, or Beginning by God ? or some Intelligent Designer ? The miraculous human body is investigated in time. In Catastrophic development of life and all nature, there was an Earth Canopy of translucent, crystalline, ice and a Great Global Flood, a deluge, scientifically verified. Then, all life and nature is discussed as always coming in a trinity, which is the characteristic of and mode of the great I.D.

In this scientifically authoritative essay collection, Salzman, a seasoned and provocative environmentalist, demonstrates how evolutionary theory penetrates nearly all aspects of human society. She faults social justice movements for their short-sighted focus on human needs to the exclusion of nonhuman nature and stresses the potential of evolutionary thought for replacing religious and secular ideologies with an ecological paradigm for broad social change.

Salzman's special concern is the resurgence of irrationality, anti-intellectualism and anti-science attitudes.. She explodes the myth of genetic determinism promoted in popular media, discrediting the belief that natural selection involves violence. In place of the arbitrary "economism" of socialists and the free marketeers' faith in untrammeled economic growth, she envisions a human society modeled on interdependent self-regulating natural systems.

This book shows how to decompose high-dimensional microarrays into small subspaces (Small Matryoshkas, SMs), statistically analyze them, and perform cancer gene diagnosis. The information is useful for genetic experts, anyone who analyzes genetic data, and students to use as practical textbooks.Discriminant analysis is the best approach for microarray consisting of normal and cancer classes. Microarrays are linearly separable data (LSD, Fact 3). However, because most linear discriminant function (LDF) cannot discriminate LSD theoretically and error rates are high, no one had discovered Fact 3 until now. Hard-margin SVM (H-SVM) and Revised IP-OLDF (RIP) can find Fact3 easily. LSD has the Matryoshka structure and is easily decomposed into many SMs (Fact 4). Because all SMs are small samples and LSD, statistical methods analyze SMs easily. However, useful results cannot be obtained. On the other hand, H-SVM and RIP can discriminate two classes in SM entirely. RatioSV is the ratio of SV distance and discriminant range. The maximum RatioSVs of six microarrays is over 11.67%. This fact shows that SV separates two classes by window width (11.67%). Such easy discrimination has been unresolved since 1970. The reason is revealed by facts presented here, so this book can be read and enjoyed like a mystery novel. Many studies point out that it is difficult to separate signal and noise in a high-dimensional gene space. However, the definition of the signal is not clear. Convincing evidence is presented that LSD is a signal. Statistical analysis of the genes contained in the SM cannot provide useful information, but it shows that the discriminant score (DS) discriminated by RIP or H-SVM is easily LSD. For example, the Alon microarray has 2,000 genes which can be divided into 66 SMs. If 66 DSs are used as variables, the result is a 66-dimensional data. These signal data can be analyzed to find malignancy indicators by principal component analysis and cluster analysis.

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.

This Open Access volume provides in-depth analysis of the wide range of ethical issues associated with drug-resistant infectious diseases. Antimicrobial resistance (AMR) is widely recognized to be one of the greatest threats to global public health in coming decades; and it has thus become a major topic of discussion among leading bioethicists and scholars from related disciplines including economics, epidemiology, law, and political theory. Topics covered in this volume include responsible use of antimicrobials; control of multi-resistant hospital-acquired infections; privacy and data collection; antibiotic use in childhood and at the end of life; agricultural and veterinary sources of resistance; resistant HIV, tuberculosis, and malaria; mandatory treatment; and trade-offs between current and future generations. As the first book focused on ethical issues associated with drug resistance, it makes a timely contribution to debates regarding practice and policy that are of crucial importance to global public health in the 21st century.

This book highlights the impact of COVID-19 on environmental sustainability and SDG's, using various case studies. The year 2020 was a historical year mainly due to the pandemic caused by COVID-19 and it influenced or affected the global economy, business models and the industrial sectors, thus impacting sustainability in various ways. Given that sustainability has many faces and facets, it is worthwhile to deal with the relation (or impact) of COVID-19 on various elements of sustainability. This book presents how COVID-19 has influenced Environmental Sustainability along with the SDG's.

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

This volume presents the first collection of essays dedicated to the science fiction of microbiologist Joan Slonczewski. Posthuman Biopolitics consolidates the scholarly literature on Slonczewski's fiction and demonstrates fruitful lines of engagement for the critical, cultural, and theoretical treatment of her characters, plots, and storyworlds. Her novels treat feminism in relation to scientific practice, resistance to domination, pacifism versus militarism, the extension of human rights to nonhuman and posthuman actors, biopolitics and posthuman ethics, and symbiosis and communication across planetary scales. Posthuman Biopolitics explores the breadth and depth of Joan Slonczewski's vision, uncovering the reflective ethical practice that informs her science fiction.