Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

This volume presents protocols for Brachypodium genomics in numerous areas ranging from marker development, trait evolution, functional genomics, metabolomics, transcriptomics, genomics, and tilling. This book also explores techniques to study the widening genetic base of Brachypodium that will help researchers better understand the model plant using NGS technologies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Brachypodium Genomics: Methods and Protocols is a valuable resource for bench-oriented molecular biologists and computational biologists working towards further evolving this field.

This book supplies the evolutionary and genetic framework that Charles Murray, towards the end of Coming Apart: The State of White America 1960-2010, predicts will one day explain revolutionary change in American society. Murray's Coming Apart documents 50 years of changed college admissions, government incentives, mating and migration patterns that have wrought national divisions across indexes of marriage, industriousness, honesty, and religiosity. The framework discussed is life history evolution, a sub-discipline within evolutionary biology singly capable of explaining why violent crime, property crime, low marriage rates, father absence, early birth, low educational achievement, low income, poverty, lack of religiosity and reduced achievement striving will reliably co-occur as part of a complex. This complex augments facultatively, developmentally and evolutionarily in response to unpredictable and uncontrollable sources of mortality. The uncertain tenure of life wrought by unpredictable and uncontrollable mortality selects for a present-oriented use of bioenergetics resources recognizable as the social ills of Fishtown, Murray's archetypal working class community. In turn, the thirty years of life history literature herein reviewed confirms the biological logic of elite intermarriage and sequestration. The source of life history variation, policy implications, and demography are discussed.

This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. This receptor, a member of the opioid receptor family, was traditionally thought to be primarily involved in pain modulation. Recent new findings have shown its unique role in neuroprotection and many other functions. Many scientists from a number of independent laboratories have now confirmed that DOR can provide neuroprotection against hypoxic/ischemic injuries. They have also found that it plays a role in a variety of physiological and pathophysiological events such as hypoxic encephalopathy, epilepsy, acupuncture, Parkinson's disease, etc. by regulating ionic homeostasis, glutamate transportation and signaling, and balancing intracellular survival/death signals. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.

This book presents an analysis of the correlation between the mind and the body, a complex topic of study and discussion by scientists and philosophers. Drawing largely on neuroscience and philosophy, the author utilizes the scientific method and incorporates lessons learned from a vast array of sources. Based on the most recent cutting-edge scientific discoveries on the Mind-Body problem, Tomasi presents a full examination of multiple fields related to neuroscience. The volume offers a scientist-based and student-friendly journey into medicine, psychology, artificial intelligence, embodied cognition, and social, ecological and anthropological models of perception, to discover our truest self.

This highly acclaimed book brings the cumulative results of a century and a half of kinship studies in anthropology into the focus of current debates on the origin of modern humans in Africa and on an entangled bit of human evolutionary history commonly subsumed under the heading of the "peopling of the Americas." This erudite study is based on a database of some 2,500 kinship vocabularies representing roughly 600 African languages, 140 Australian languages, 500 Austronesian languages, 200 Papuan languages, 350 languages of Eurasia (excluding Indo-Europeans), 440 North and Middle American Indian languages, and 200 South American languages. This valuable reference will take the reader to the dawn of kinship studies in the 19th century Western science in order to elicit the wider context of anthropological interest in kinship systems and the interdisciplinary salience of the phenomenon of kinship. The book also examines the founder of kinship studies in anthropology, American lawyer and Iroquois ethnographer, Lewis Henry Morgan, and the circumstances of his life that generated his interest in human kinship. The study ventures into the intricacies of scientific and quasi-scientific debates in the 19th century, and treats 19th century science as embedded in a myth featuring divinity, humanity and animality as principal characters. This account is divided into four sections, each of which is structured as a triad (philosophy, psychology and physiology; logic, semiotics and reproduction; religion, hermeneutics and evolution; law, grammar and speech). This far-reaching historical journey aims at formulating an idea of what human kinship might be all about, especially in the light of the widespread uncertainties about this question caused by the constructivist turn in anthropology. Eventually our ideas regarding human origins, ancient population dispersals and the homeland of modern humans are inextricably linked to our ideas about kinship. As a book that brings together evolutionary and sociocultural anthropology, The Genius of Kinship will be a critical addition for all Anthropology collections.

What if the stories of trees and people are more closely linked than we ever imagined? Winner of the World Wildlife Fund's 2020 Jan Wolkers PrizeOne of Science News's "Favorite Books of 2020" A New York Times "New and Noteworthy" BookA 2020 Woodland Book of the YearGold Winner of the 2020 Foreword INDIES Award in Ecology & EnvironmentBronze Winner of the 2021 Independent Publisher Book Award in Environment/Ecology People across the world know that to tell how old a tree is, you count its rings. Few people, however, know that research into tree rings has also made amazing contributions to our understanding of Earth's climate history and its influences on human civilization over the past 2,000 years. In her captivating book Tree Story, Valerie Trouet reveals how the seemingly simple and relatively familiar concept of counting tree rings has inspired far-reaching scientific breakthroughs that illuminate the complex interactions between nature and people. Trouet, a leading tree-ring scientist, takes us out into the field, from remote African villages to radioactive Russian forests, offering readers an insider's look at tree-ring research, a discipline known as dendrochronology. Tracing her own professional journey while exploring dendrochronology's history and applications, Trouet describes the basics of how tell-tale tree cores are collected and dated with ring-by-ring precision, explaining the unexpected and momentous insights we've gained from the resulting samples. Blending popular science, travelogue, and cultural history, Tree Story highlights exciting findings of tree-ring research, including the fate of lost pirate treasure, successful strategies for surviving California wildfire, the secret to Genghis Khan's victories, the connection between Egyptian pharaohs and volcanoes, and even the role of olives in the fall of Rome. These fascinating tales are deftly woven together to show us how dendrochronology sheds light on global climate dynamics and uncovers the clear links between humans and our leafy neighbors. Trouet delights us with her dedication to the tangible appeal of studying trees, a discipline that has taken her to austere and beautiful landscapes around the globe and has enabled scientists to solve long-pondered mysteries of Earth and its human inhabitants.

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets.

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

This new edition captures the advances made in the field of evolutionary systems biology since the publication of the first edition. The first edition focused on laying the foundations of evolutionary systems biology as an interdisciplinary field, where a way of thinking and asking questions is combined with a wide variety of tools, both experimental and theoretical/computational. Since publication of the first edition, evolutionary systems biology is now a well-known term describing this growing field. The new edition provides an overview of the current status and future developments of this interdisciplinary field. Chapters highlight several key achievements from the last decade and outline exciting new developments, including an understanding of the interplay between complexity and predictability in evolutionary systems, new viewpoints and methods to study organisms in evolving populations at the level of the genome, gene regulatory network, and metabolic network, and better analysis and modeling techniques that will open new avenues of scientific inquiry.

The study of the molecular events leading to cellular transformation and cancer has progressed significantly in the last decade, and it has become apparent that many genes subject to modification in cancer are, in fact, transcription factors that govern the execution of the genetic programme of the cell. Transcription factors can behave either as oncogenes or as tumour suppressor genes. To date only a limited number of transcription factors have been associated with cancer. This volume deals with several transcription factor families that were first identified in oncogenic retroviruses. Each chapter contains a description of the structure of the transcription factors, the nature of target genes, the regulation of their activities, and an explaination of how they can deregulate cell growth and differentiation. This text should be suitable for the specialist scientist and the advanced student

This book deals with a rapidly growing field aiming at producing food and energy in a sustainable way for humans and their children. It is a discipline that addresses current issues: climate change, increasing food and fuel prices, poor-nation starvation, rich-nation obesity, water pollution, soil erosion, fertility loss, pest control and biodiversity depletion. This series gathers review articles that analyze current agricultural issues and knowledge, then proposes alternative solutions.

In this provocative text, a noted neuroscientist reexamines Freud's posthumously published Project of Scientific Psychology in the light of modern neuroscience. This expanded "thermodynamics of the mind" model includes robust conceptions of the cellular and neural processes that accompany creation of consciousness and memory, their contributions to such conditions as depression, dissociative disorders, and schizophrenia, and implications for practice, from imaging to talk-based therapies to pharmacotherapy. Central to this construct is Freud's proposal of specific "omega" neurons as the most volatile carriers of consciousness between mind and brain, which is applied to current issues regarding complexity and executive functioning. In addition, the book is extensively referenced, allowing readers to investigate these and related phenomena in greater detail. Among the topics covered: Neural reductionism in Freud's "Project" and neuropsychoanalysis. Thermodynamics and brain self-organization. Conflicting information and the dissociated mind. The Cartesian model of the mind and the binding problem. Neuroendocrine and immune response to stress. The concept of omega neurons and modern chaos theory. Rigorous, challenging, and occasionally startling, The Brain and Conscious Unity is a milestone in the neuroscience and mind/brain literature to be read and discussed by psychiatrists, psychologists, and neuropsychologists.

This work is motivated by the ongoing open question of how information in the outside world is represented and processed by the brain. Consequently, several novel methods are developed. A new mathematical formulation is proposed for the encoding and decoding of analog signals using integrate-and-fire neuron models. Based on this formulation, a novel algorithm, significantly faster than the state-of-the-art method, is proposed for reconstructing the input of the neuron. Two new identification methods are proposed for neural circuits comprising a filter in series with a spiking neuron model. These methods reduce the number of assumptions made by the state-of-the-art identification framework, allowing for a wider range of models of sensory processing circuits to be inferred directly from input-output observations. A third contribution is an algorithm that computes the spike time sequence generated by an integrate-and-fire neuron model in response to the output of a linear filter, given the input of the filter encoded with the same neuron model.

This book describes fundamental physical principles, together with their mathematical formulations, for modelling the propagation of signals in nerve fibres. Above all, it focuses on the complex electro-mechano-thermal process that produces an ensemble of waves composed of several components, besides the action potential. These components include mechanical waves in the biomembrane and axoplasm, together with the temperature change. Pursuing a step-by-step approach, the content moves from physics and mathematics, to describing the physiological effects, and finally to modelling the coupling effects. The assumptions and hypotheses used for modelling, as well as selected helpful concepts from continuum mechanics, are systematically explained, and the modelling is illustrated using the outcomes of numerical simulation. The book is chiefly intended for researchers and graduate students, providing them with a detailed description of how to model the complex physiological processes in nerve fibres.

Neuroendocrine Factors in Ulcer Pathogenesis: Role of Sensory Neurons in the Control of Gastric Mucosal Blood Flow and Protection; P. Holzer, et al. Sympathoadrenergic Regulation of Duodenal Mucosal Alkaline Secretion; L. Fandriks, C. Joenson. Potentiation of Intestinal Secretory Responses to Histamine: Pathophysiological Implications; P. Rangachari, et al. Braingut Interactions in Ulcer Pathogenesis: Neuroendocrine Control of Gastric Acid Secretion; Y. Osumi. Corticotropinreleasing Factor in Stressinduced Changes in Gastrointestinal Transit; T. Burks. Stress, Corticotrophinreleasing Factor; (CRF) and Gastric Function; H. Weiner. Novel Therapeutic Approaches to Gastrointestinal Ulceration: The Gastric Mucosal Barrier: A Dynamic, Multifunctional System; A. Garner, et al. New Approaches to Gastroprotection: Calcium Modulators; G.B. Glavin, A.M. Hall. Efficacy of Dopaminergic Agents in Peptic Ulcer Healing and Relapse Prevention: Further Indication of the Importance of Stomach Dopamine in the Stressorganoprotection Concept; P. Sikiric, et al. Dietary Factors Influencing Gastrointestinal Ulceration: The Luminal Regulatory System; F. Guarner, et al. 14 additional articles. Index.

This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett's esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett's esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer's Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.

Vents and seeps are the epitome of life in extreme environments, but there is much more to these systems than just black smokers or hydrocarbon seeps. Many other ecosystems are characterized by moving fluids and this book provides an overview of the different habitats, their specific conditions as well as the technical challenges that have to be met when studying them. The book provides the current state of the art and will be a valuable resource for everybody that has an interest in such environments.

This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of "clock" gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.

This book provides an overview of the latest advancements in the field of alien introgression in wheat. The discovery and wide application of molecular genetic techniques including molecular markers, in situ hybridization, and genomics has led to a surge in interspecific and intergeneric hybridization in recent decades. The work begins with the taxonomy of cereals, especially of those species which are potential gene sources for wheat improvement. The text then goes on to cover the origin of wheat, breeding in connection with alien introgressions, and the problems of producing intergeneric hybrids and backcross derivatives. These problems can include crossability, sterility, and unequal chromosome transmission. The work then covers alien introgressions according to the related species used, as well as new results in the field of genomics of wild wheat relatives and introgressions.

Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems. Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described. The chapter "Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses" is available open access under a CC BY 4.0 license via link.springer.com.