0
Your cart

Your cart is empty

Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues

Buy Now

High-dimensional Microarray Data Analysis - Cancer Gene Diagnosis and Malignancy Indexes by Microarray (Hardcover, 1st ed. 2019) Loot Price: R3,875
Discovery Miles 38 750
High-dimensional Microarray Data Analysis - Cancer Gene Diagnosis and Malignancy Indexes by Microarray (Hardcover, 1st ed....

High-dimensional Microarray Data Analysis - Cancer Gene Diagnosis and Malignancy Indexes by Microarray (Hardcover, 1st ed. 2019)

Shuichi Shinmura

 (sign in to rate)
Loot Price R3,875 Discovery Miles 38 750 | Repayment Terms: R363 pm x 12*

Bookmark and Share

Expected to ship within 10 - 15 working days

This book shows how to decompose high-dimensional microarrays into small subspaces (Small Matryoshkas, SMs), statistically analyze them, and perform cancer gene diagnosis. The information is useful for genetic experts, anyone who analyzes genetic data, and students to use as practical textbooks.Discriminant analysis is the best approach for microarray consisting of normal and cancer classes. Microarrays are linearly separable data (LSD, Fact 3). However, because most linear discriminant function (LDF) cannot discriminate LSD theoretically and error rates are high, no one had discovered Fact 3 until now. Hard-margin SVM (H-SVM) and Revised IP-OLDF (RIP) can find Fact3 easily. LSD has the Matryoshka structure and is easily decomposed into many SMs (Fact 4). Because all SMs are small samples and LSD, statistical methods analyze SMs easily. However, useful results cannot be obtained. On the other hand, H-SVM and RIP can discriminate two classes in SM entirely. RatioSV is the ratio of SV distance and discriminant range. The maximum RatioSVs of six microarrays is over 11.67%. This fact shows that SV separates two classes by window width (11.67%). Such easy discrimination has been unresolved since 1970. The reason is revealed by facts presented here, so this book can be read and enjoyed like a mystery novel. Many studies point out that it is difficult to separate signal and noise in a high-dimensional gene space. However, the definition of the signal is not clear. Convincing evidence is presented that LSD is a signal. Statistical analysis of the genes contained in the SM cannot provide useful information, but it shows that the discriminant score (DS) discriminated by RIP or H-SVM is easily LSD. For example, the Alon microarray has 2,000 genes which can be divided into 66 SMs. If 66 DSs are used as variables, the result is a 66-dimensional data. These signal data can be analyzed to find malignancy indicators by principal component analysis and cluster analysis.

General

Imprint: Springer Verlag, Singapore
Country of origin: Singapore
Release date: May 2019
First published: 2019
Authors: Shuichi Shinmura
Dimensions: 235 x 155mm (L x W)
Format: Hardcover
Pages: 419
Edition: 1st ed. 2019
ISBN-13: 978-981-13-5997-2
Categories: Books > Science & Mathematics > Mathematics > Probability & statistics
Books > Social sciences > Sociology, social studies > Social research & statistics > General
Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > General
Promotions
LSN: 981-13-5997-0
Barcode: 9789811359972

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!

You might also like..

Wat Moet Ons Met Ons Kerk Doen?
Jurie van den Heever Paperback  (1)
R310 Discovery Miles 3 100
The Awakened Brain - The Psychology Of…
Lisa Miller Paperback R340 R308 Discovery Miles 3 080
Cave Of Bones - A True Story Of…
Lee Berger Paperback  (1)
R420 R388 Discovery Miles 3 880
Integrated and Sustainable Environmental…
Maximiliano Cledon, Satinder Kaur Brar, … Hardcover R4,347 Discovery Miles 43 470
Mycotoxin Prevention and Control in…
Michael Appell, David Kendra, … Hardcover R3,567 R2,963 Discovery Miles 29 630
Brief Introduction to Fisheries
Xinjun Chen, Yingqi Zhou Hardcover R2,747 Discovery Miles 27 470
Pathogenic Neisseria - Genomics…
John K. Davies, Charlene M. Kahler Hardcover R7,115 Discovery Miles 71 150
Motor Cognition - What actions tell the…
Marc Jeannerod Hardcover R6,352 Discovery Miles 63 520
Exploring Personal Genomics
Joel T. Dudley, Konrad J. Karczewski Hardcover R4,570 Discovery Miles 45 700
The New Eugenics - Modifying Biological…
Conrad B Quintyn Paperback R795 R708 Discovery Miles 7 080
A Path through the Jungle…
Professor Steve Peters Paperback R495 Discovery Miles 4 950
Tundra-Taiga Biology
Robert M. M. Crawford Hardcover R4,572 Discovery Miles 45 720

See more

Partners